Clinical trials
Chronic pain clinical trials
Pain that lasts for months or longer, often after the original cause has healed. We’re tracking 828 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05383157Recruiting
Brief mindfulness program for chronic pain in Ukraine
This study tests whether a short mindfulness practice can help people manage long-term (chronic) pain. You may be able to take part if your chronic pain diagnosis is confirmed by a doctor and you can complete the study activities.
VinnitsaAges 18 years+ - NCT05840354Recruiting
Brain stimulation plus steroid shots for chronic spinal pain
This trial studies whether adding rTMS (a non-invasive brain stimulation treatment) to steroid joint injections can better reduce chronic spinal pain. It’s designed for people who already need repeated steroid joint injections to manage pain.
London, OntarioAges 18 years+ - NCT05991440Recruiting
Race and income differences in chronic low back pain study
This study looks at how race and income affect chronic low back pain. Researchers want to understand differences in pain and daily function between Black and White adults with long-lasting back pain.
St Louis, MissouriAges 18–85 - NCT06219408Recruiting
Stepped care for chronic pain and PTSD
This study tests a stepped-care program that combines complementary health approaches for people who have both chronic pain and PTSD. It aims to help patients manage both conditions together using treatments like acupuncture, massage, or mind-body therapy.
Seattle, WashingtonAges 18 years+ - NCT06273462RecruitingPhase 2
Testing PEA for Chronic Inflammatory Pain
This study tests a natural supplement called palmitoylethanolamide (PEA) to see if it can help people with long-term inflammatory pain that hasn't gotten better with other treatments.
San Diego, CaliforniaAges Any age - NCT06281431Recruiting
Study comparing two needle types for nerve blocks to reduce pain
This trial compares a special echogenic (ultrasound-visible) needle with a standard needle for nerve blocks during surgery. The goal is to see which works better for preventing both short-term and long-term pain after operations like chest, abdomen, or limb surgeries.
Chongqing, Chongqing MunicipalityAges 18–70 - NCT06442566RecruitingPhase 1/Phase 2
Enhancing opioid therapy for chronic pain with buprenorphine, counseling, and brain stimulation
This study is testing whether adding a medication (buprenorphine), counseling, and a type of brain stimulation (TMS) can improve long-term opioid therapy for chronic pain. If you have been taking prescription opioids daily for at least 3 months and have extra risk factors for opioid-related problems, this trial may offer you new ways to manage pain and reduce risks.
Charleston, South CarolinaAges 18 years+ - NCT07684092Enrolling by invitation
Diaphragmatic breathing and electroacupuncture for chronic neck pain
This trial tests whether combining diaphragmatic breathing exercises with electroacupuncture can reduce chronic neck pain. It is designed for people with moderate pain and specific breathing issues.
Lahore, Punjab ProvinceAges 20–50 - NCT06655844Recruiting
Sana Device for chronic pain from Lyme disease
This study tests the Sana device—a special light and sound tool—to see if it can help reduce chronic nerve pain in people with Post-Treatment Lyme Disease Syndrome. You may be able to join if you have ongoing nerve pain after Lyme treatment and meet a few basic health and medication rules.
New York, New YorkAges 18 years+ - NCT06661681Recruiting
Cognitive functional therapy for chronic shoulder pain
This study tests a new type of therapy called Cognitive Functional Therapy (CFT) for people with ongoing shoulder pain. It focuses on how you move and think about your pain, and aims to help you manage better without surgery or injections.
João Pessoa, ParaíbaAges 18–60 - NCT06688864Recruiting
App-based support for chronic pain in underserved adults
This study tests a smartphone app (EPIO) to help people with chronic pain manage their daily life. It is designed for adults who are Black and/or LGBTQ+ and face added challenges because of limited resources.
Rochester, MinnesotaAges 18 years+ - NCT06697457Recruiting
Comparing exercises for chronic neck pain
This trial tests different types of exercise to see which works best for people with long-lasting neck pain. You may join if your neck pain has lasted at least 3 months and is at least a 5 out of 10 in intensity.
Muğla, MenteşeAges 18–55 - NCT06784141Recruiting
Comparing two types of cognitive behavioral therapy for chronic pain
This trial tests two different ways of doing cognitive behavioral therapy (CBT) for chronic pain — one is a standard approach, the other is tailored to your personal pain network. The goal is to see which method helps you better manage your pain and improve your quality of life.
LandauAges 18 years+ - NCT06854809Recruiting
Cognitive therapy vs. exercises for chronic shoulder pain
This study compares two non-surgical treatments for long-lasting shoulder pain: a new approach called cognitive functional therapy that combines movement with education, versus standard exercises. If you have chronic shoulder pain and are looking for a drug-free option, this trial may help you find which treatment works better.
São Carlos, São PauloAges 18–65 - NCT06969456Recruiting
Exercise and nerve stimulation for chronic back pain
This study looks at whether combining exercise with a type of nerve stimulation (called neuromodulation) can help people with long-term spinal pain that has nerve involvement. It may be an option if you have had pain for at least 6 months and it is severe.
Valencia, ValenciaAges 18–70 - NCT06983678Recruiting
Quitting smoking and pain sensitivity study
This study looks at how quitting smoking affects pain sensitivity in people who smoke, especially those with chronic low back pain. Researchers will use brain scans and daily surveys to understand these changes.
Durham, North CarolinaAges 21–65 - NCT06994988Recruiting
Smart band-aid study for chronic pain in women
This trial tests a special band-aid that measures chronic pain. Women with chronic pain or healthy women may join to help researchers learn how this device works.
Chicago, IllinoisAges 18 years+ - NCT07038434Recruiting
Using artificial intelligence to measure pain in chronic pain patients
This study uses artificial intelligence to better understand and measure pain in people with chronic pain. The goal is to develop smarter ways to assess pain automatically, which could lead to better treatment.
Salerno, ItalyAges 18 years+ - NCT07212829Recruiting
Brain stimulation during exercise for chronic pain
This trial tests whether adding gentle brain stimulation (tDCS) to exercise can help people with chronic widespread pain (like fibromyalgia). It aims to see if this combination reduces pain better than exercise alone.
JetteAges 18–70 - NCT07245121Recruiting
Sugar water injections for chronic knee arthritis pain
This trial tests whether injecting a sugar-water solution around the nerves of the knee can reduce chronic pain from osteoarthritis. It is for people with long-term knee pain, stiffness, and cracking who have not had recent knee treatments or surgery.
Athens, AtticaAges 38 years+ - NCT07453524Recruiting
Understanding what matters to people with chronic pain
This study asks people with chronic pain about their preferences and experiences. Your answers will help doctors understand what matters most to patients like you.
BrusselsAges 18 years+ - NCT07272551Enrolling by invitation
Polyvagal therapy for chronic neck pain
This trial tests a new approach based on the polyvagal theory to help people with long-term neck pain. It uses gentle exercises and techniques to calm the nervous system and reduce pain.
Istanbul, MaltepeAges 18–50 - NCT06686875Enrolling by invitation
Chronic belly pain after sleeve gastrectomy study
This study looks at long-term belly pain in people who had a sleeve gastrectomy 3 months to 5 years ago. It aims to understand the pain better to help future patients.
WarsawAges 18 years+ - NCT07436806Recruiting
Comparing nerve blocks for pain after chest surgery
This trial compares two types of nerve blocks to see which one better prevents long-term pain after video-assisted chest surgery. It may help find a way to reduce chronic pain after your procedure.
Istanbul, BagcilarAges 18–75
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Common questions
- Are there clinical trials for chronic pain?
- Yes. Clin2 currently lists 828 recruiting chronic pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.