Clinical trials
Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer) clinical trials
Below are recruiting chronic wound of the lower limb (leg ulcer or foot ulcer) clinical trials, each written for real people, not researchers. We’re tracking 178 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06449638Recruiting
Testing new wound treatments for hard-to-heal diabetic foot ulcers
This trial compares several advanced wound treatments (called CAMPs) plus standard care versus standard care alone for diabetic foot ulcers that are slow to heal. The goal is to see if adding these treatments helps ulcers close faster.
Omaha, NebraskaAges 18 years+ - NCT06564831Recruiting
Placental graft for diabetic foot ulcers
This study tests whether a special placental tissue graft placed on a diabetic foot ulcer helps it heal faster than standard wound care alone. It is for people with a diabetic foot ulcer that has not healed after 4 weeks of usual care.
Clinton Township, MichiganAges 18 years+ - NCT04164641Recruiting
Test software-guided walking analysis to help prevent foot ulcers
This study checks whether a computer system that analyzes your walking can help change gait (how you walk) to reduce the chance of diabetic foot ulcers coming back or leading to amputation. It is meant for adults who have had a healed diabetic foot ulcer before.
Baltimore, MarylandAges 18–90 - NCT06153589Recruiting
Music therapy for leg ulcer pain relief
This trial tests whether listening to music during wound cleaning can reduce pain for people with leg ulcers caused by vein or artery problems. It aims to make the procedure more comfortable.
Fort-de-FranceAges 18 years+ - NCT06811909Recruiting
BR-AC for hard-to-heal leg ulcers
This study tests a treatment called BR-AC, made from donated birth tissue, for leg ulcers caused by poor vein function that haven't healed with standard care. The goal is to see if adding BR-AC helps these ulcers heal faster than standard care alone.
Guntersville, AlabamaAges 18 years+ - NCT07465640Recruiting
Pulsed magnetic field therapy for diabetic foot ulcers
This trial tests a device called CRAD ULCER X-01 that uses gentle magnetic pulses to help heal diabetic foot ulcers. It may help people with a diabetic foot ulcer that is not too deep and is at an early stage.
Kuala LumpurAges 18 years+ - NCT05313165Recruiting
Stent procedure for poor blood flow in the leg ulcers and gangrene
This trial tests a new minimally invasive procedure (placing a small stent) to improve blood flow to a severely threatened foot or lower leg. It may help people whose ulcers or gangrene are not treatable with standard bypass or other surgeries.
La Jolla, CaliforniaAges 18–95 - NCT06104969Recruiting
Biomarkers for active diabetic foot ulcers
This study is looking for people with diabetes who have an open foot or ankle ulcer. Researchers want to collect samples to find biomarkers, which are natural signs in the body that could help improve treatment and healing. It may be a good fit if you have a diabetic foot ulcer and are not currently in another drug trial for ulcers.
Tucson, ArizonaAges 18 years+ - NCT06124586Recruiting
Early angioplasty for diabetic foot ulcers
This trial tests if an early procedure to open blocked leg arteries (angioplasty) helps heal foot ulcers in people with type 2 diabetes. It aims to improve blood flow and prevent amputation.
DüsseldorfAges 18 years+ - NCT06197412RecruitingPhase 4
Yunnan Baiyao for diabetic foot ulcers at different stages
This study tests whether Yunnan Baiyao, a traditional Chinese herbal medicine, helps heal diabetic foot ulcers at different stages. It looks at how well the medicine works and why, while providing standard wound care.
BeijingAges 18–80 - NCT06764953Recruiting
Amnion membrane graft for non-healing leg ulcers
This study tests a special amnion membrane graft to help heal chronic leg ulcers that haven't improved with standard care. The graft is placed on the wound to support healing, and results are compared with standard treatment alone.
Roanoke, VirginiaAges 18 years+ - NCT02047084Enrolling by invitation
Test graft skin vs Apligraf for venous leg ulcers
This trial compares a new type of donated skin graft (human allograft) to Apligraf for treating venous leg ulcers that have not healed with standard care. It aims to see which option heals ulcers better and more safely.
Greenville, South CarolinaAges 21–90 - NCT06527131Recruiting
Pulsed magnetic field therapy for Charcot foot ulcers
This trial tests whether pulsed electromagnetic field stimulation can help heal foot ulcers caused by Charcot foot disease. It is for adults aged 50 to 70.
GizaAges 50–70 - NCT07161830Recruiting
Skin repair treatment for diabetic foot ulcers
This study tests a special skin repair matrix for diabetic foot ulcers that are not healing well with standard care. The treatment may help the wound close and heal faster.
Evergreen Park, IllinoisAges 18 years+ - NCT03687580Recruiting
At-home laser treatment for diabetic foot ulcers
This trial tests whether an at-home low-level laser can help diabetic foot ulcers heal. You may be able to do treatments yourself or with a caregiver, but you must meet specific wound, circulation, and safety requirements.
Toronto, OntarioAges 18–95 - NCT05950659Recruiting
Wearable insoles to prevent repeat diabetic foot ulcers
This trial tests special sensory insoles (called Orpyx Sensory Insoles) to help prevent diabetic foot ulcers from coming back. It aims to reduce high-pressure foot spots for people who already had a healed nerve-related ulcer.
Baltimore, MarylandAges 18 years+ - NCT07536373RecruitingPhase 3
Colchicine to prevent amputation after leg artery treatment
This study tests whether a medication called colchicine can help prevent amputation in people with severe leg blood flow problems who just had surgery or a catheter procedure to restore blood flow. Colchicine is an anti-inflammatory drug that may help protect the leg tissue after treatment.
Taipei, TaipeiAges 18 years+ - NCT04058639Recruiting
Custom felt dressing trial for diabetic foot ulcers
This trial tests whether a special padded (felt) dressing can help heal diabetic foot ulcers with nerve-related injury. If you have a foot wound caused by diabetic nerve problems, the study may offer a shorter treatment time.
MoldeAges 45–80 - NCT04533152Recruiting
Study risk factors for healing in diabetic foot ulcers
This study looks at what factors affect outcomes in adults with diabetic foot ulcers. It may help doctors better predict healing and complications by better understanding what influences progress.
CaenAges 18 years+ - NCT05132179Recruiting
Testing two antiseptic creams for diabetic foot ulcers
This study compares two topical (applied on the skin) antimicrobial agents—Dakin’s and Prontosan—to help heal diabetic foot ulcers. You may be eligible if you have a diabetic foot ulcer that has been present for at least 3 weeks and is large enough.
Uddevalla, TrollhattanAges 18–100 - NCT05603273Recruiting
Non-weight-bearing exercise to help diabetic foot ulcers heal faster
This study tests whether guided exercises that keep weight off your ulcer can speed healing of diabetic foot ulcers. It may help reduce pressure on the wound while monitoring safety and progress over the study.
Ann Arbor, MichiganAges 18–75 - NCT05758545Recruiting
Device treatment for diabetic foot ulcers with poor blood flow
This trial tests whether COMS One is safe and effective for healing a specific diabetic foot ulcer. It may help people whose ulcer is not healing well, especially when blood flow to the foot is limited.
Mesa, ArizonaAges 22–90 - NCT07291817Recruiting
Negative pressure treatment for diabetic foot ulcers
This trial tests a device that uses gentle suction (negative pressure) to help heal diabetic foot ulcers. It may help people with poor blood flow in their legs who have not healed with other treatments.
SingaporeAges 21–99 - NCT06437028Recruiting
Membrane allograft for diabetic foot ulcers
This trial tests a special membrane made from donated birth tissue (perinatal membrane) placed on a diabetic foot ulcer to help it heal faster. It's for people with diabetes whose foot ulcer hasn't healed after standard care for 4 weeks to a year.
Monroe, North CarolinaAges 18 years+
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Common questions
- Are there clinical trials for chronic wound of the lower limb (leg ulcer or foot ulcer)?
- Yes. Clin2 currently lists 178 recruiting chronic wound of the lower limb (leg ulcer or foot ulcer) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic wound of the lower limb (leg ulcer or foot ulcer) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic wound of the lower limb (leg ulcer or foot ulcer) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.