Clinical trials
Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer) clinical trials
Below are recruiting chronic wound of the lower limb (leg ulcer or foot ulcer) clinical trials, each written for real people, not researchers. We’re tracking 178 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06618612Recruiting
Wound matrix for diabetic foot ulcers
This study tests if a special wound dressing (collagen matrix with antimicrobial) plus standard care helps diabetic foot ulcers heal better than standard care alone. It's for people with diabetes who have a foot sore that hasn't healed for at least 4 weeks.
Clevland, OhioAges 18 years+ - NCT06767501Recruiting
Amnion graft for diabetic foot ulcers vs. standard care
This trial tests whether a special amnion membrane graft can help heal diabetic foot ulcers better than standard care alone. If you have a diabetic foot ulcer that hasn't healed after standard treatment, this study may offer a new option.
Roanoke, VirginiaAges 18 years+ - NCT06852976RecruitingPhase 2
Gel treatment for diabetic foot ulcers study
This trial tests a new gel (MDI-1228-mesylate) applied to diabetic foot ulcers to see if it helps them heal faster than standard care alone. It is for people who have had a foot ulcer for at least 12 weeks and are already receiving standard treatment.
Durham, North CarolinaAges 18–75 - NCT06938685Recruiting
Testing a new wound treatment for diabetic foot ulcers
This trial tests a new wound covering called NeoThelium FT to help diabetic foot ulcers heal. It is for people whose ulcer has not improved much with standard care and is not infected or too deep.
Alexandria, LouisianaAges 18 years+ - NCT06952998RecruitingPhase 4
Platelet-rich plasma for diabetic foot ulcers with artery disease
This trial tests if a special treatment made from your own blood (platelet-rich plasma) can help heal foot ulcers in people with diabetes and poor circulation in their legs. The goal is to see if it improves wound healing compared to standard care.
Bilbao, BizkaiaAges 18 years+ - NCT07014176RecruitingPhase 4
Tissue graft for diabetic foot ulcers
This study tests whether a special tissue graft made from amniotic membrane (the sac around a baby) helps heal diabetic foot ulcers faster than standard care alone. You may be able to join if you have a diabetic foot ulcer that hasn't healed and you meet certain health and size criteria.
Santa Rosa, CaliforniaAges 18 years+ - NCT07021222Recruiting
Preventing foot sores in diabetes
This study looks at ways to prevent foot sores in people with type 2 diabetes. It enrolls two groups: those at risk but without past sores, and those whose sores have healed for at least 6 months.
Bologna, BOAges 18–75 - NCT07039396Recruiting
NeoThelium FT for diabetic foot ulcers
This trial tests a new treatment called NeoThelium FT for diabetic foot ulcers. It aims to see if the treatment is safe and helps heal the ulcer. You may join if you have a diabetic foot ulcer that is not infected.
Alexandria, LouisianaAges 18 years+ - NCT07109895Recruiting
Custom Insole with Nerve Stimulation for Diabetic Foot Ulcers
This trial tests a custom insole that uses mild electrical stimulation to help heal diabetic foot ulcers. It aims to reduce pain and improve wound healing compared to standard care.
Lahore, Punjab ProvinceAges 18–60 - NCT07119983Recruiting
Stress ball for pain relief during diabetic foot wound cleaning
This study tests whether squeezing a stress ball during wound cleaning (debridement) can help reduce pain and distress for people with diabetic foot ulcers. If you're having this procedure for the first time and have mild pain or more, this simple technique may offer comfort.
Mersin, TarsusAges 18 years+ - NCT07188337Recruiting
Diabetic foot ulcer patient study
This study looks at the health records of people with diabetic foot ulcers to understand their characteristics. It may help improve care for future patients.
Gorgan, Outside of the USAges Any age - NCT07488247RecruitingPhase 3
Light-Activated Gel for Diabetic Foot Ulcers
This trial tests a gel containing a light-activated drug (chlorin E6) for diabetic foot ulcers. The gel is applied to the ulcer and then activated with a special light to help the wound heal. It may be a good option if you have a foot ulcer that hasn't healed in 6 weeks or more.
Karachi, SindhAges 18 years+ - NCT07581145RecruitingPhase 3
Semaglutide for Faster Healing of Diabetic Foot Ulcers
This study tests whether a diabetes medication called semaglutide can help foot ulcers heal faster in people with type 2 diabetes. If it works, it could offer a new treatment option for a common and serious diabetes complication.
CopenhagenAges 18–90 - NCT05169814RecruitingEarly Phase 1
Microbubble treatment for certain burn and wound types
This early-stage study tests micro/nanobubbles placed on or used for certain types of difficult wounds, including burns and some pressure or diabetic foot ulcers, especially when there has been tissue injury from radiation. It may help wounds heal faster or more effectively, but it is still being studied in early phases.
Orange, CaliforniaAges 18 years+ - NCT06075940Recruiting
A dissolving stent for blocked leg arteries below the knee
This study tests a new bioresorbable scaffold (like a temporary mesh) that slowly dissolves, releasing medication to keep your below-the-knee artery open. It is for people with severely blocked leg arteries causing pain or wounds at rest (Rutherford 4 or 5).
Randwick, New South WalesAges 18 years+ - NCT07143175Recruiting
Foot Care Navigator Pilot for Diabetes Patients
This trial tests a patient navigator program to help people with diabetes who have had two or more toes amputated due to a foot ulcer. It aims to support recovery and follow-up care.
Atlanta, GeorgiaAges 18 years+ - NCT07223268Recruiting
Support program for diabetic foot problems
This study tests a program that provides extra help and resources to people with diabetes who have a foot ulcer or a toe amputation. The goal is to see if this support helps them manage their condition and avoid future problems.
Atlanta, GeorgiaAges 18 years+ - NCT05287646Recruiting
Track how your residual limb moves while walking with a prosthesis
This study uses a special X-ray and markers to measure how your leg and skin move inside your prosthetic socket while you walk. It may help researchers better understand fit and comfort for people with transtibial (below-knee) amputations.
New York, New YorkAges 18 years+ - NCT05473065Recruiting
Test-drive plan for a safer prosthetic foot
This study tests a “test-drive” approach to help improve walking stability using different prosthetic feet. You may be asked to try study prosthetic feet during walking tests to see what helps your balance and comfort.
Minneapolis, MinnesotaAges 18–89 - NCT04658693Recruiting
Restore leg sensation in diabetic nerve damage with safe stimulation
This study tests a treatment that delivers mild stimulation to help bring back lower-limb feeling in people with diabetic nerve damage (or an insensate foot) and may also protect nerves. If you qualify and can safely take part in testing and follow-up, it could improve sensation and walking comfort.
Cleveland, OhioAges 18 years+ - NCT06918561Recruiting
NeoThelium FT for chronic open wounds
This trial tests a new skin-like graft called NeoThelium FT to see if it helps chronic open wounds heal faster. It is for adults with a non-infected wound that has been open for at least 4 weeks and is not a diabetic, pressure, or burn wound.
Denham Springs, LouisianaAges 18 years+ - NCT06327113RecruitingPhase 2
Antibiotic wound spray for hard-to-heal chronic wounds
This study tests a wound spray containing antibiotics to treat chronic wounds that haven't healed with standard care. It might help if you have a wound on your leg, arm, or trunk that has been present for over 4 weeks and is not getting smaller.
Los Angeles, CaliforniaAges 18 years+ - NCT05228340Recruiting
Treating toe ulcers by releasing tight tendons to prevent recurrence
This study looks at whether a minor procedure on a toe (called a flexor tenotomy) can reduce the chance that diabetic toe ulcers come back. It is for adults with diabetes who have nerve damage in the feet and have had toe ulcers before.
Amsterdam, North HollandAges 18 years+ - NCT05613985Recruiting
Ultrasound light added to usual care for infected diabetic foot ulcers
This trial tests whether adding the VULNOFAST Plus/VULNOLIGHT system to usual care can heal infected diabetic foot ulcers more safely and effectively. It compares the added treatment plus usual care versus usual care alone.
ArezzoAges 18 years+
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Common questions
- Are there clinical trials for chronic wound of the lower limb (leg ulcer or foot ulcer)?
- Yes. Clin2 currently lists 178 recruiting chronic wound of the lower limb (leg ulcer or foot ulcer) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic wound of the lower limb (leg ulcer or foot ulcer) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic wound of the lower limb (leg ulcer or foot ulcer) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.