Clinical trials
Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer) clinical trials
Below are recruiting chronic wound of the lower limb (leg ulcer or foot ulcer) clinical trials, each written for real people, not researchers. We’re tracking 173 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07039396Recruiting
NeoThelium FT for diabetic foot ulcers
This trial tests a new treatment called NeoThelium FT for diabetic foot ulcers. It aims to see if the treatment is safe and helps heal the ulcer. You may join if you have a diabetic foot ulcer that is not infected.
Alexandria, LouisianaAges 18 years+ - NCT07021222Recruiting
Preventing foot sores in diabetes
This study looks at ways to prevent foot sores in people with type 2 diabetes. It enrolls two groups: those at risk but without past sores, and those whose sores have healed for at least 6 months.
Bologna, BOAges 18–75 - NCT06952998RecruitingPhase 4
Platelet-rich plasma for diabetic foot ulcers with artery disease
This trial tests if a special treatment made from your own blood (platelet-rich plasma) can help heal foot ulcers in people with diabetes and poor circulation in their legs. The goal is to see if it improves wound healing compared to standard care.
Bilbao, BizkaiaAges 18 years+ - NCT06938685Recruiting
Testing a new wound treatment for diabetic foot ulcers
This trial tests a new wound covering called NeoThelium FT to help diabetic foot ulcers heal. It is for people whose ulcer has not improved much with standard care and is not infected or too deep.
Alexandria, LouisianaAges 18 years+ - NCT06437028Recruiting
Membrane allograft for diabetic foot ulcers
This trial tests a special membrane made from donated birth tissue (perinatal membrane) placed on a diabetic foot ulcer to help it heal faster. It's for people with diabetes whose foot ulcer hasn't healed after standard care for 4 weeks to a year.
Monroe, North CarolinaAges 18 years+ - NCT05950659Recruiting
Wearable insoles to prevent repeat diabetic foot ulcers
This trial tests special sensory insoles (called Orpyx Sensory Insoles) to help prevent diabetic foot ulcers from coming back. It aims to reduce high-pressure foot spots for people who already had a healed nerve-related ulcer.
Baltimore, MarylandAges 18 years+ - NCT05758545Recruiting
Device treatment for diabetic foot ulcers with poor blood flow
This trial tests whether COMS One is safe and effective for healing a specific diabetic foot ulcer. It may help people whose ulcer is not healing well, especially when blood flow to the foot is limited.
Mesa, ArizonaAges 22–90 - NCT05415878Recruiting
Comparing removable boot designs for diabetic foot ulcers
This study compares different removable cast walkers (special boots) to see which is easier for people with diabetic foot ulcers to use. If you join, you'll try one of these boots and share your experience, which may help heal your ulcer while keeping you mobile.
North Chicago, IllinoisAges 18 years+ - NCT04533152Recruiting
Study risk factors for healing in diabetic foot ulcers
This study looks at what factors affect outcomes in adults with diabetic foot ulcers. It may help doctors better predict healing and complications by better understanding what influences progress.
CaenAges 18 years+ - NCT04058639Recruiting
Custom felt dressing trial for diabetic foot ulcers
This trial tests whether a special padded (felt) dressing can help heal diabetic foot ulcers with nerve-related injury. If you have a foot wound caused by diabetic nerve problems, the study may offer a shorter treatment time.
MoldeAges 45–80 - NCT02047084Enrolling by invitation
Test graft skin vs Apligraf for venous leg ulcers
This trial compares a new type of donated skin graft (human allograft) to Apligraf for treating venous leg ulcers that have not healed with standard care. It aims to see which option heals ulcers better and more safely.
Greenville, South CarolinaAges 21–90 - NCT05169814RecruitingEarly Phase 1
Microbubble treatment for certain burn and wound types
This early-stage study tests micro/nanobubbles placed on or used for certain types of difficult wounds, including burns and some pressure or diabetic foot ulcers, especially when there has been tissue injury from radiation. It may help wounds heal faster or more effectively, but it is still being studied in early phases.
Orange, CaliforniaAges 18 years+ - NCT06075940Recruiting
A dissolving stent for blocked leg arteries below the knee
This study tests a new bioresorbable scaffold (like a temporary mesh) that slowly dissolves, releasing medication to keep your below-the-knee artery open. It is for people with severely blocked leg arteries causing pain or wounds at rest (Rutherford 4 or 5).
Randwick, New South WalesAges 18 years+ - NCT07223268Recruiting
Support program for diabetic foot problems
This study tests a program that provides extra help and resources to people with diabetes who have a foot ulcer or a toe amputation. The goal is to see if this support helps them manage their condition and avoid future problems.
Atlanta, GeorgiaAges 18 years+ - NCT07143175Recruiting
Foot Care Navigator Pilot for Diabetes Patients
This trial tests a patient navigator program to help people with diabetes who have had two or more toes amputated due to a foot ulcer. It aims to support recovery and follow-up care.
Atlanta, GeorgiaAges 18 years+ - NCT05228340Recruiting
Treating toe ulcers by releasing tight tendons to prevent recurrence
This study looks at whether a minor procedure on a toe (called a flexor tenotomy) can reduce the chance that diabetic toe ulcers come back. It is for adults with diabetes who have nerve damage in the feet and have had toe ulcers before.
Amsterdam, North HollandAges 18 years+ - NCT07863115Recruiting
Preventing blood clots after leg injury with a cast
This study looks at a simple checklist to see who is at risk for blood clots after a leg injury that requires a cast or brace. It also checks how well people follow blood-thinning medication to prevent these clots.
MonastirAges 18 years+ - NCT07482137Recruiting
Electroacupuncture for diabetic foot wounds
This trial tests whether electroacupuncture at a specific point (ST-36) can help heal diabetic foot ulcers. It may be an option for people with diabetic foot sores that have not healed well.
Nanjing, JiangsuAges 18–75 - NCT07126197Enrolling by invitation
Lymphovenous bypass for diabetic nerve pain
This study tests if a surgery called lymphovenous bypass can reduce nerve pain caused by diabetes. It may help people with diabetic peripheral neuropathy, even if they have foot ulcers.
TaipeiAges 20–80 - NCT06278935Recruiting
Adapting lifestyle offloading for diabetic foot ulcers
This trial tests a lifestyle-based offloading program for people with diabetic foot ulcers (DFUs). It aims to see if a tailored approach can help healing and prevent complications, using telehealth for support.
Los Angeles, CaliforniaAges 21 years+ - NCT06979284Recruiting
Ultrasound-guided angioplasty for severe leg pain or wounds
This study tests whether using a special ultrasound probe inside the artery during a leg procedure helps doctors open blockages more safely and effectively. It aims to improve blood flow and save the leg for people with severe peripheral artery disease who have pain, wounds, or gangrene.
Montreal, QuebecAges 18 years+ - NCT06918561Recruiting
NeoThelium FT for chronic open wounds
This trial tests a new skin-like graft called NeoThelium FT to see if it helps chronic open wounds heal faster. It is for adults with a non-infected wound that has been open for at least 4 weeks and is not a diabetic, pressure, or burn wound.
Denham Springs, LouisianaAges 18 years+ - NCT05613985Recruiting
Ultrasound light added to usual care for infected diabetic foot ulcers
This trial tests whether adding the VULNOFAST Plus/VULNOLIGHT system to usual care can heal infected diabetic foot ulcers more safely and effectively. It compares the added treatment plus usual care versus usual care alone.
ArezzoAges 18 years+ - NCT06327113RecruitingPhase 2
Antibiotic wound spray for hard-to-heal chronic wounds
This study tests a wound spray containing antibiotics to treat chronic wounds that haven't healed with standard care. It might help if you have a wound on your leg, arm, or trunk that has been present for over 4 weeks and is not getting smaller.
Los Angeles, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for chronic wound of the lower limb (leg ulcer or foot ulcer)?
- Yes. Clin2 currently lists 173 recruiting chronic wound of the lower limb (leg ulcer or foot ulcer) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic wound of the lower limb (leg ulcer or foot ulcer) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic wound of the lower limb (leg ulcer or foot ulcer) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.