Clinical trials
Claudication clinical trials
Below are recruiting claudication clinical trials, each written for real people, not researchers. We’re tracking 26 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05132439RecruitingPhase 3
Metformin to improve walking in leg artery blockage
This Phase 3 study tests whether metformin can help people with intermittent claudication (leg pain when walking) walk farther. It compares how well metformin works on walking ability alongside standard (already recommended) heart and blood-vessel medicines.
Pittsburgh, PennsylvaniaAges 35–89 - NCT05457738Recruiting
Home walking program using a smartphone app for leg artery pain
This trial tests whether a home-based walking (exercise) plan, guided by a new smartphone app, can help people with intermittent claudication caused by blocked leg arteries. It may help improve walking comfort and ability by using a structured, app-supported exercise routine.
ReimsAges 18 years+ - NCT06114732Recruiting
Walking improvement study for leg pain from PAD
This study tests if a combination of a behavioral program and electrical stimulation (TENS) can help people with peripheral artery disease walk farther with less pain. It aims to boost physical activity and quality of life.
Glasgow, LanarkshireAges 18 years+ - NCT06299956Recruiting
Supervised exercise for leg pain due to blocked arteries
This trial tests whether a supervised exercise program can help people with leg pain caused by blocked arteries. It may improve your walking ability and reduce pain when you walk.
SlagelseAges 18 years+ - NCT05145478Recruiting
Real-world outcomes after Shockwave treatment for blocked leg artery
This study follows what happens in real life after using Shockwave’s device (intravascular lithotripsy) to treat a hard, calcified blockage in the common femoral artery, then completing standard treatment. It may help doctors understand which patients benefit and what results to expect.
New Haven, ConnecticutAges 18 years+ - NCT05216731Recruiting
Compare bypass versus stent treatment for leg artery blockages
This study compares two ways to treat long blockages in the superficial femoral artery (a main artery in the thigh): bypass surgery versus an endovascular (stent/through-a-vessel) procedure. It may help people with painful leg claudication to choose the approach most likely to keep blood flowing and improve symptoms.
BordeauxAges 18 years+ - NCT06657976RecruitingPhase 2
Beetroot juice and exercise for PAD
This study tests whether beetroot juice, which contains natural nitrates that help blood vessels relax, combined with exercise, can improve walking ability in people with peripheral artery disease (PAD). You might be able to join if you have PAD, can walk without a walker, and are willing to avoid beet products for a while.
Chicago, IllinoisAges 50 years+ - NCT03594344Recruiting
Extra hyperbaric oxygen after leg amputation wounds heal
This study tests whether giving extra treatments with hyperbaric (pressure) oxygen after a leg amputation can improve healing or recovery. It’s meant for people whose amputation happened due to long-lasting infection or poor blood flow and who can attend follow-up visits.
OsloAges 18–90 - NCT03845036Recruiting
Diet and exercise study for leg circulation problems
This study looks at how diet changes and an exercise program may improve walking and leg symptoms in people with peripheral artery disease (PAD). You may be eligible if you have a history of claudication (leg pain with walking) and tests or treatment history show PAD.
Oklahoma City, OklahomaAges 40 years+ - NCT04434586Recruiting
Imaging test to guide treatment of blocked thigh arteries
This study tests whether a detailed eye-like scan (optical coherence tomography) helps doctors choose better treatment for blockages in the thigh-to-knee artery. It may help improve healing and outcomes by guiding how the procedure is done.
LilleAges 18 years+ - NCT04635436Recruiting
Split-walking training for one-sided leg weakness when walking hurts
This trial tests whether a “split gait” walking training method can improve walking balance and how you move when you have one-sided leg problems and pain or limitations when walking. It may help reduce walking difficulties by training your stepping pattern safely.
Milan, MIAges 18–70 - NCT04912323Recruiting
Drug dissolving stent for blocked below-knee arteries
This trial studies a drug-eluting dissolving scaffold placed in blocked arteries below the knee to improve blood flow. It may help people whose leg circulation problems are severe enough to limit walking or threaten the limb, but only if their blockages fit specific imaging and procedure requirements.
GrazAges 18–90 - NCT05712395Recruiting
Pain-free exercise program for people with leg artery disease
This trial tests a new kind of exercise that is meant to be non-ischemic (not reduce blood flow) and pain-free, to see if it helps people with peripheral artery disease (PAD) who get leg pain when walking. You may be eligible if you have PAD confirmed by specific treadmill and blood-pressure measurements and meet the exercise and health safety requirements.
Oklahoma City, OklahomaAges 40 years+ - NCT06041880Recruiting
Calf Stretching for Better Walking in PAD
This study tests whether a simple daily calf-stretching routine can improve walking ability and blood flow in people with peripheral artery disease. It offers a non-drug, non-surgical approach that you can do at home.
University Park, PennsylvaniaAges 40–85 - NCT06082466Recruiting
Comparing two types of leg bypass surgery
This study compares two types of bypass surgery for blocked leg arteries. One uses a standard vein from your own body, and the other uses a vein supported by a special metal frame. The goal is to see which works better and lasts longer.
SalzburgAges 18 years+ - NCT06399809RecruitingPhase 2
Fisetin for better walking in peripheral artery disease
This study tests whether a supplement called fisetin can help reduce leg pain and improve walking ability in people with peripheral artery disease (PAD). If you have PAD and are 50 or older, you may be able to join and help see if fisetin can make walking easier.
Chicago, IllinoisAges 50 years+ - NCT06409949Recruiting
MitoQ for leg pain from blocked arteries
This study tests whether MitoQ, a supplement that protects cells, can improve leg pain and walking ability in people with peripheral artery disease. It aims to see if it helps the tiny blood vessels and muscle fibers in the leg.
Omaha, NebraskaAges 21 years+ - NCT06410521Recruiting
Personalized exercise program for peripheral arterial disease
This trial tests a personalized exercise program for people with peripheral arterial disease (PAD), a condition that causes leg pain when walking. The goal is to see if a tailored exercise plan can help reduce pain, improve walking distance, and boost quality of life.
Vila RealAges 18 years+ - NCT06448390Recruiting
Exercise study for leg pain from blocked arteries
This trial tests if a supervised exercise program can improve walking ability in people with leg pain caused by blocked arteries (claudication). You may qualify if you have calf pain after walking short distances that goes away with rest.
ÅlesundAges 18 years+ - NCT06529185Recruiting
Breathing device for COPD patients with leg pain
This trial tests if a breathing device (Breather) can help men with COPD who also have leg pain from blocked leg arteries (intermittent claudication) walk farther without pain. If you have both conditions, this study may offer a new way to improve your walking ability.
DokkiAges 50–60 - NCT06686121RecruitingPhase 3
Improving walking after leg artery surgery for PAD
This trial tests whether drinking beetroot juice and doing home-based exercise can improve walking ability after you've had a procedure to open up blocked leg arteries. It's for people who are ready to start a walking program and want to avoid surgery.
Tucson, ArizonaAges 18 years+ - NCT07233798Recruiting
Dural pulsation in lumbar spinal stenosis
This study looks at a natural movement called dural pulsation (pulsing of the spinal sac) in people with lumbar spinal stenosis. It might help doctors understand the condition better and could lead to better treatments for your back or leg pain.
Pendik, IstanbulAges 18–85 - NCT02842424RecruitingPhase 4
Ramipril for walking pain from blocked leg arteries
This study tests whether ramipril (a blood-pressure medicine) can improve leg muscle problems linked to poor blood flow in people with chronic claudication—pain that limits walking. It’s mainly looking at changes related to oxidative stress and muscle scarring (fibrosis).
Omaha, NebraskaAges 18–90 - NCT03203239Recruiting
Red light treatment for circulation problems in leg arteries
This study tests whether a red-light therapy can improve symptoms or function in people with peripheral artery disease (poor blood flow to the legs). You may qualify if your leg circulation test is abnormal and you can safely take part in the study.
Milwaukee, WisconsinAges 18–85
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Common questions
- Are there clinical trials for claudication?
- Yes. Clin2 currently lists 26 recruiting claudication studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a claudication trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a claudication trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.