Clinical trials
Clinical High Risk clinical trials
Below are recruiting clinical high risk clinical trials, each written for real people, not researchers. We’re tracking 552 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07100990RecruitingPhase 3
Early versus rescue plasma exchange for optic neuritis or transverse myelitis
This study tests whether starting plasma exchange early (right after steroids) is better than waiting to see if steroids are enough for people with severe optic neuritis or transverse myelitis. It may help preserve vision or movement by stopping inflammation sooner.
Birmingham, AlabamaAges 18 years+ - NCT06274645Recruiting
Study of IVUS for Complex Heart Procedures
This study will look at how using a special ultrasound (IVUS) during a heart procedure (PCI) can help people with complex blockages, such as heavy calcium or multiple narrowings. It aims to see if this approach improves outcomes.
ShanghaiAges 18 years+ - NCT05886517Recruiting
Transcatheter aortic valve in patients too high-risk for surgery
This trial looks at placing a new aortic valve through the groin (transfemoral) without needing on-site heart surgery for people who are considered very high risk for standard open-heart valve surgery. It aims to measure early outcomes to see how safe and effective this approach is for frail or complex patients.
Acquaviva delle Fonti, BariAges 75–120 - NCT07046078RecruitingPhase 2
Chemo, radiation, and donor transplant for older adults with high-risk AML
This trial tests a combination of chemotherapy (FLAG-Ida) followed by low-dose total body radiation and a stem cell transplant from a donor. It is for people age 60 and older with newly diagnosed high-risk blood cancers, aiming to improve outcomes with a less intense transplant preparative regimen.
Seattle, WashingtonAges 18 years+ - NCT04263038RecruitingPhase 4
Watchful waiting versus blood thinners for small lung clots
This trial compares close monitoring (“watch and wait”) versus taking the blood thinner rivaroxaban in people with a small type of lung blood clot. It aims to find out whether low-risk patients can safely avoid or reduce anticoagulation while still staying healthy.
Woluwe-Saint-Lambert, Brussels CapitalAges 18 years+ - NCT06831773Recruiting
Carbon ion radiation for high-grade brain tumors
This trial tests a precise type of radiation called carbon ion radiotherapy for people with aggressive brain tumors (high-grade gliomas). It aims to see if this treatment is safe and effective for patients who have not had radiation to the head before.
Wuwei, GansuAges 14–80 - NCT07391774RecruitingPhase 3
Hormone therapy with or without chemo for early breast cancer
This trial tests whether skipping chemotherapy and using only hormone therapy with a drug called ribociclib works as well as chemotherapy followed by hormone therapy with ribociclib for certain early breast cancers that have a low risk of coming back.
Jonesboro, ArkansasAges 18 years+ - NCT07405814Recruiting
Testing a new treatment for high cholesterol
This trial tests a new medicine, Artisterol, to see if it can lower cholesterol in people with mildly high levels. It may be an option if you haven't tried other treatments or can't take statins.
LodzAges 18–70 - NCT05674799Recruiting
Program to lower future obesity and diabetes risks
This trial tests a lifestyle and coaching program (NDPP-NextGen) to help reduce the chances of obesity and diabetes risk passing to the next generation. It’s for people planning a pregnancy soon and who may be at higher risk due to body weight.
Winston-Salem, North CarolinaAges 18–39 - NCT04948658Recruiting
Freezing ovarian tissue to protect future fertility
This study looks at storing ovarian (ovary) tissue by freezing it for people at higher risk of losing fertility. It may help preserve options for having biological children later, especially for certain genetic conditions, cancer-related risks, or planned gonad removal.
Bethesda, MarylandAges 2–35 - NCT07519733Recruiting
Exercise Testing Before High-Risk Surgery
This study tests whether a simple exercise test before surgery can help doctors better predict and prevent complications in older adults undergoing major operations. You'll do a gentle exercise test on a stationary bike or treadmill to measure your fitness level.
New Haven, ConnecticutAges 45 years+ - NCT05738252Recruiting
Frailty tests to assess surgical risk in gynecologic cancers
This trial studies simple “frailty” assessments (tests of strength, memory, and daily functioning) to better predict risk in people with gynecologic cancers who are planning or having surgery. If you qualify, the results may help doctors identify who needs extra support before and after surgery.
Hamilton, OntarioAges 55–110 - NCT06557057Recruiting
Aromatase inhibitors and diabetes risk in breast cancer
This study looks at how aromatase inhibitors, a type of hormone therapy for breast cancer, affect blood sugar and diabetes risk. It compares women taking these drugs to those on tamoxifen or healthy women, to see if there are changes in glucose control.
Rochester, MinnesotaAges Any age - NCT06825377Recruiting
Comparing high-protein vs. standard nutrition for ICU patients
This trial tests whether a high-protein diet or standard protein diet is better for critically ill patients who are at risk for refeeding syndrome (dangerous shifts in fluids and minerals when starting nutrition after starvation). The goal is to see which type of nutrition helps recovery.
TehranAges 18–65 - NCT02958462Recruiting
Clinic study for early blood or bone marrow warning signs
This study follows people who may have early, unclear blood count problems or certain genetic/immune patterns that can later lead to bone marrow failure or blood cancers. It may help doctors better understand risks over time and guide earlier care.
Scottsdale, ArizonaAges 18 years+ - NCT07628738RecruitingPhase 2
Lower-dose radiation for early-stage NK/T-cell lymphoma after chemotherapy
This study tests whether patients with a specific type of blood cancer (NK/T-cell lymphoma) in the nose or sinuses who have responded well to chemotherapy can be safely treated with reduced radiation doses instead of standard high-dose radiation. The goal is to reduce side effects while maintaining effective treatment.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07611773Recruiting
Brain Stimulation for Depression Treatment Planning
This study tests whether brain scans can predict which people with depression will benefit from transcranial direct current stimulation (tDCS)—a non-invasive treatment that uses mild electrical pulses to stimulate brain areas related to mood. You would use a small home device and complete brain monitoring sessions.
ValenciaAges 18 years+ - NCT05817955RecruitingPhase 2
Azacitidine plus ruxolitinib for higher-risk MDS/MPN
This Phase 2 study tests whether combining azacitidine and ruxolitinib can better control higher-risk bone marrow diseases (MDS/MPN, including CMML). It may help patients who are not good candidates for a stem cell transplant and who can safely take these medicines.
Nanjing, JiangsuAges 18–80 - NCT07813767RecruitingPhase 3
Early antibiotic treatment guided by a blood test to prevent severe infection
This study tests whether giving an early antibiotic (meropenem) based on a new blood test (PSP) can prevent serious infections (sepsis) in people who come to the emergency department with signs of infection. The goal is to find out if this approach helps them get better faster and avoid more severe illness.
Athens, AtticaAges 18 years+ - NCT07725250Recruiting
AI-guided blood pressure trial for stage I-II hypertension
This study tests whether combining artificial intelligence with personalized medicine can help lower blood pressure in people with stage I or II hypertension (140/90 or higher). If you have high blood pressure and can walk without help, this trial may be for you.
La Jolla, CaliforniaAges 18 years+ - NCT07296315RecruitingPhase 2
Testing a new treatment for mild-to-moderate ulcerative colitis
This study tests an investigational drug for people with active mild-to-moderate ulcerative colitis. It aims to see if the drug can improve symptoms without needing advanced treatments like biologics.
Miami, FloridaAges 16 years+ - NCT06539767Recruiting
Brain aneurysm risk study using MRI
This study looks at people with brain aneurysms to understand which ones are more likely to cause problems. It uses a special MRI to get detailed images and help predict risk.
Guangzhou, GuangdongAges 18–80 - NCT07193589RecruitingPhase 2
Testing ZL-82 tablets for moderate to severe eczema
This study tests if an oral tablet called ZL-82 can help people with moderate to severe atopic dermatitis (eczema) that hasn't responded well to other treatments. It aims to find a new option for controlling this chronic skin condition.
Chengdu, SichuanAges 18–75 - NCT05440851Recruiting
Testing different treatments for severe breathing failure in ICU
This platform trial studies which treatment works best for adults with sudden, severe breathing failure needing oxygen or a breathing machine in the ICU. It may help patients by matching them to the most appropriate treatment strategy and tracking outcomes to improve care.
Tucson, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for clinical high risk?
- Yes. Clin2 currently lists 552 recruiting clinical high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a clinical high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a clinical high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.