Clinical trials
Coronary Artery Disease (Left Main) clinical trials
Below are recruiting coronary artery disease (left main) clinical trials, each written for real people, not researchers. We’re tracking 124 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06559332Recruiting
Heart artery checks during aortic valve replacement
This study tests different ways to check for blocked heart arteries in patients getting a new aortic valve through a tube in the leg. It aims to find the best approach to guide treatment.
BernAges 70 years+ - NCT06551662Recruiting
Balloon vs. stent for split artery blockages
This trial compares two ways to open a blocked artery that splits into two branches (a bifurcation): using a balloon coated with medicine (drug-coated balloon, or DCB) versus a drug-eluting stent (DES). The goal is to see which approach works better for patients with this type of blockage.
MilanAges 18 years+ - NCT06535568Recruiting
Comparing one vs two blood thinners after heart artery balloon treatment
This trial tests whether taking just one blood thinner (clopidogrel) is as safe and effective as taking two (clopidogrel plus aspirin) for older adults or people at high bleeding risk who have had a drug-coated balloon procedure to open blocked heart arteries.
Milan, MIAges Any age - NCT06489119Recruiting
Studying plaque types in coronary artery disease with advanced imaging
This trial uses advanced imaging (OCT) and single-cell analysis to study different types of plaque in people with coronary artery disease. It aims to understand how these plaque types differ at a cellular level, which could lead to better treatments.
Harbin, HeilongjiangAges 18–85 - NCT06271590Recruiting
Drug-coated balloon for small heart artery blockages
This trial tests a special balloon coated with a drug (sirolimus) to treat blockages in small heart arteries. If the balloon is successful, it may help keep the artery open without needing a permanent stent.
Gilbert, ArizonaAges 18–80 - NCT06399692RecruitingPhase 3
Choosing heart bypass or stents for women with heart disease
This study compares two common procedures to improve blood flow to the heart in women with blockages in multiple heart arteries. It aims to find which approach works better for women and may help guide future treatment decisions.
Glendale, CaliforniaAges 18 years+ - NCT06399705RecruitingPhase 3
Comparing bypass surgery versus stenting for Black and Hispanic patients with coronary artery disease
This study compares two common ways to treat blocked heart arteries: bypass surgery and stenting. It aims to find which works better for Black and Hispanic patients with multiple blockages.
Glendale, CaliforniaAges 18 years+ - NCT06374498Enrolling by invitation
Looking inside heart arteries to improve stent placement
This study tests a new imaging technique to help doctors see inside your heart arteries during a stent procedure. It may help guide treatment and improve outcomes for people with heart disease.
Boston, MassachusettsAges 18 years+ - NCT06373601Recruiting
Testing a drug-coated balloon for small heart arteries
This study tests a drug-coated balloon (DCB) that releases two medicines (sirolimus and paclitaxel) to open blocked small heart arteries. It may help people with stable chest pain or recent, controlled heart events who have a narrowed small vessel.
Mercogliano, Italy/AvellinoAges 18 years+ - NCT06259019Recruiting
Blood test during heart procedure to find disease markers
This trial uses a special device to take a small blood sample from your heart arteries during a planned procedure. It aims to find unique markers that could help doctors better understand and treat coronary artery disease.
BournemouthAges 18 years+ - NCT05799092Recruiting
Invasive vs non-invasive test for less-severe blocked heart arteries
This study compares two approaches to evaluating and treating people with symptoms of blocked heart arteries that are not “high-risk.” It may help doctors choose the safest, most effective next step for you by comparing invasive testing versus non-invasive evaluation.
Bucheon-siAges 19 years+ - NCT05831085Recruiting
Compare procedures to improve heart blood flow in diabetes
This study compares two ways to restore blood flow to the heart—stent placement (PCI) versus bypass surgery (CABG)—in people with diabetes and significant multi-vessel coronary artery disease. It looks at outcomes using both standard heart tests and additional imaging/functional measurements to guide the best revascularization strategy.
Palo Alto, CaliforniaAges 20 years+ - NCT05829889Recruiting
FFR test versus angiogram to guide left main heart treatment
This trial compares two ways to decide how to treat a narrowed “left main” coronary artery: a pressure-based test (FFR) versus standard X-ray imaging (angiography). It aims to see which approach better helps choose safe, appropriate treatment using a stent when appropriate.
Hong KongAges 20 years+ - NCT05807841Recruiting
AI ultrasound during stent placement in heart artery blockages
This trial tests an artificial-intelligence tool that uses a heart ultrasound to help guide stent treatment. It may help doctors choose the best way to treat blockages and improve stent results for people with symptoms from reduced blood flow to the heart.
Bucheon-siAges 19 years+ - NCT05650411Recruiting
Test new drug-eluting stent with less blood thinner
This study compares a new type of “drug-eluting” stent (a tiny scaffold that slowly releases medicine) and a single blood-thinner plan versus the usual two-drug blood thinner plan after stent placement in the left main coronary artery. It aims to see if the simpler plan can work while keeping the stent safe.
Zurich, Canton of ZurichAges 18 years+ - NCT04124120Recruiting
Single vs multiple bypass grafts for women heart surgery
This study compares outcomes of using one bypass graft versus multiple bypass grafts during coronary artery bypass surgery in women. It aims to see which approach leads to better recovery and heart outcomes for eligible patients.
Los Angeles, CaliforniaAges 18 years+ - NCT03217006Recruiting
Compare one vs multiple heart artery grafts for bypass
This study looks at whether using one artery graft or multiple artery grafts during heart bypass surgery works better for people with specific coronary artery disease. You may be randomized to one approach, and the trial team will follow outcomes after surgery.
Boulder, ColoradoAges 18–70 - NCT01311323Recruiting
Testing heart procedures to fully open blocked coronary arteries
This trial compares different ways to treat serious heart artery blockages in people with a recent heart attack or unstable chest pain. It aims to see which revascularization approach works best when doctors think the heart arteries can be fully treated.
Chrzanów, MalopolskaAges 18 years+ - NCT01341327Recruiting
Study of treatment choices for left main artery narrowing
This observational study looks at people with a significantly narrowed “left main” heart artery and records treatment decisions and follow-up outcomes. It may help doctors better understand which care approaches work best for this condition in real-world practice.
ShanghaiAges 18 years+ - NCT05865600Recruiting
PET/CT guided planning for treatment in chronic coronary disease
This trial uses a heart scan (PET/CT) to better estimate blood flow in people with long-term coronary artery disease. It aims to help doctors choose the best treatment strategy and decide who may need more invasive testing or procedures.
Herning, Central JutlandAges 18 years+ - NCT04795193Enrolling by invitation
Minithoracotomy vs open surgery for multiple blocked heart arteries
This trial compares two types of bypass surgery for people with multiple blocked heart arteries, to see which one better improves quality of life and how well the bypasses stay open. You may be assigned based on your preferences, and the study also tracks heart scan and follow-up results.
Beijing, Beijing MunicipalityAges 25–85 - NCT06436092Recruiting
Stent treatment for left main coronary artery disease
This trial studies a new way to treat blockages in the left main coronary artery using a drug-coated stent. It aims to find out if a careful approach with a single stent and temporary side-branch support works well for people with heart disease.
Ichinomiya, Aichi-kenAges 18 years+ - NCT06425120RecruitingPhase 4
Xuesaitong for heart disease risk factors
This trial tests whether Xuesaitong soft capsules can improve major risk factors in people with stable coronary heart disease who are already on cholesterol-lowering and antiplatelet medications. You may be able to join if you have chronic coronary artery disease and certain signs of inflammation.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05491668Recruiting
Testing heart artery narrowing before planned stent procedure
This study checks how severely blocked a coronary artery is using measurements taken during a planned heart catheterization, to help guide whether and how to do a stent (PCI). It may help doctors choose the best treatment plan for people with about 70% or more narrowing.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for coronary artery disease (left main)?
- Yes. Clin2 currently lists 124 recruiting coronary artery disease (left main) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a coronary artery disease (left main) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a coronary artery disease (left main) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.