Clinical trials
Coronary Artery Disease (Left Main) clinical trials
Below are recruiting coronary artery disease (left main) clinical trials, each written for real people, not researchers. We’re tracking 124 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05923489Recruiting
Follow-up angiography after stent placement in high-risk patients
This study checks how routine repeat heart blood-vessel imaging (angiography) after stent placement may help high-risk patients. It is meant for people who had a successful stent procedure and have certain higher-risk heart features.
Hangzhou, ZhejiangAges 18 years+ - NCT07019350Recruiting
Smart stenting for heart artery branch blockages
This trial tests a new way to treat complex blockages in heart arteries where a side branch is also narrowed. It uses a drug-coated balloon to open the side branch, aiming to improve blood flow and reduce the need for repeat procedures.
GwangjuAges 19 years+ - NCT06657326Recruiting
New stent for high bleeding risk patients
This trial tests a new type of stent (BioFreedom Ultra) compared to a standard one (BioFreedom) in people who have a high risk of bleeding. Both stents release medicine to keep arteries open, and the study checks if the newer stent works better with a shorter course of blood thinners.
Johor Bahru, JohorAges 18 years+ - NCT07193693Recruiting
Study on why doctors don't use heart imaging during stent placement
This study looks at reasons doctors may or may not use a special camera inside the heart arteries (called OCT or IVUS) during a procedure to open blocked arteries. It may help understand how to improve care for people with complex blockages.
BergamoAges 18 years+ - NCT05700877RecruitingPhase 4
Screening and treatment for silent heart artery disease in type 2 diabetes
This trial tests a screening and intervention approach for “silent” coronary artery disease (heart artery narrowing without major symptoms) in people with type 2 diabetes. It may help prevent future heart problems by finding higher-risk cases early and starting the right treatment plan.
OdenseAges 55–75 - NCT05824520Recruiting
CT blood-flow test guided treatment versus usual care
This trial compares a treatment plan guided by a special CT scan measurement of blood flow (called CT-derived FFR) versus standard medical therapy. It may help doctors choose the safest, most effective treatment based on how restricted blood flow looks on CT.
Hangzhou, ZhejiangAges 18 years+ - NCT07380217Recruiting
Using heart pump support for complex high-risk procedures
This trial is testing whether using a special heart pump (PulseCath iVAC2L) during complex, high-risk angioplasty can help people with very weak hearts. It's for people who need a procedure for complicated coronary artery blockages.
AmsterdamAges 18 years+ - NCT05936606Recruiting
Personalized blood thinner choice after stent placement
This trial tests whether tailoring anti-platelet (blood clot prevention) treatment can better protect people at higher risk of heart or blood-vessel problems after a drug-eluting stent. It may help prevent future clots and complications, especially in patients with certain high-risk health conditions or complex stent/scar tissue features.
SeoulAges 19–80 - NCT05292651Recruiting
Stent placement strategy study for blocked heart arteries
This study compares how best to place a coronary stent (a small tube to keep an artery open) using modern techniques. It may help improve how safely and effectively stents are delivered in people with certain types of narrowed heart arteries.
DordrechtAges 18–100 - NCT07835178Recruiting
High-pressure cutting balloon for hardened heart artery blockages
This study tests a special balloon that can cut through hardened calcium in heart arteries before placing a stent. It may help people with severe artery calcification get a better stent placement.
Xi'an, ShaanxiAges 18 years+ - NCT05438121Recruiting
Tests a drug-coated balloon to stabilize clogged heart arteries
This trial studies whether a drug-coated balloon can better treat new, narrowed spots in multiple coronary arteries and “stabilize” the plaque. It may help improve blood flow after a procedure called balloon angioplasty for selected patients.
Ansan-si, Gyeonggi-doAges 18–85 - NCT07610538Recruiting
Low-dose IL-2 study after heart bypass surgery
This study tests whether a low dose of a natural immune-boosting protein (IL-2) given after heart bypass surgery can help reduce heart damage. The treatment aims to activate special immune cells that protect heart tissue.
Cambridge, CambridgeshireAges 18 years+ - NCT05786131Recruiting
Stent treatment: fix all blocked arteries vs culprit only
This trial compares two ways of doing a stent procedure in people who had an NSTEMI heart attack: fixing all significant blockages versus fixing only the “culprit” blockage. It may help find which approach is safer and more effective for preventing complications.
GrazAges 18 years+ - NCT06445608Recruiting
Study of a heart pump for high-risk angioplasty
This trial tests a temporary heart pump (called the KARDION Cory P4) used during a high-risk angioplasty (stenting) procedure. The pump helps keep blood flowing in patients whose heart is weak or who have complex blockages, aiming to make the procedure safer.
Chandler, ArizonaAges 18–90 - NCT06908499Recruiting
Long-term follow-up of a stent study for chronic total occlusions
This study looks at the long-term (10-year) outcomes of a specific stenting technique for patients with a chronic total occlusion (a complete blockage that has been there for at least 3 months) in a major heart artery. It aims to see how well the procedure works over time.
Pune, MaharashtraAges 19 years+ - NCT06662500Recruiting
Shockwave balloon for hard heart blockages trial
This trial tests a new balloon catheter that uses sound waves to break up hard calcium blockages in heart arteries. It may be an option for people with stable chest pain or who have recovered from a recent heart attack, and who have a single, tough blockage.
La Jolla, CaliforniaAges 18 years+ - NCT04014803RecruitingPhase 4
Aspirin plus one blood thinner versus aspirin plus clopidogrel
This trial compares two common “blood thinner” combinations to prevent problems after a PCI procedure for complex blocked heart arteries. It may help your care team find which combination works better for people with higher-risk artery patterns.
SeoulAges 19–75 - NCT07035171Recruiting
Pre-surgery exercise for heart bypass patients
This study tests whether starting a supervised exercise program before your first heart bypass surgery (CABG) is possible and helpful. If you are waiting for elective CABG and speak Danish, you may be able to join a prehabilitation program to get stronger before your operation.
CopenhagenAges 18 years+ - NCT07259278Recruiting
Heart rehab program with smart app support
This trial uses a smartphone app to guide exercise for people with coronary heart disease who are at low risk of complications. It aims to help you recover safely at home with remote support from doctors.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07230847Recruiting
Healing of drug-coated vs. standard stents in high-bleeding-risk patients
This trial compares two types of stents (a drug-coated stent and a standard drug-eluting stent) in people with acute coronary syndrome who also have a high risk of bleeding. It uses a special camera to look at how the artery heals one month after the stent is placed.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04944615Recruiting
IVUS-guided stent placement for blocked heart artery using longer guidance
This trial compares two ways to place a stent (a small mesh tube) for a completely blocked heart artery: using an IVUS camera inside the artery versus using a standard x-ray approach. It may help people get better heart outcomes by improving how accurately the stent is placed in long-term blockages.
BeijingAges 18 years+ - NCT07657676RecruitingPhase 4
Study of mazdutide for heart artery plaque in people who are overweight
This study tests whether mazdutide, a medicine that may help with weight and blood sugar, can reduce plaque buildup in the heart's arteries. It is for people who are overweight or obese and have some narrowing in their heart arteries but do not need immediate procedures like stents.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06788275Recruiting
Can exercise improve blood vessel health after a heart attack?
This study looks at whether aerobic exercise can improve blood vessel health in people who have had a heart attack or chest pain (angina). If you qualify, you'll join a monitored exercise program.
Alicante, AlicanteAges 45–75 - NCT07587099Recruiting
Single vs. Dual Blood Thinners After Balloon Heart Treatment
This study compares whether patients who receive a special drug-coated balloon to open a blocked heart artery (without a stent) need to take one or two blood-thinning medications afterward. The goal is to find the safest and most effective approach for preventing future blockages.
Beijing, Beijing MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for coronary artery disease (left main)?
- Yes. Clin2 currently lists 124 recruiting coronary artery disease (left main) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a coronary artery disease (left main) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a coronary artery disease (left main) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.