Clinical trials
Coronary artery disease clinical trials
Narrowing of the arteries that supply blood to the heart. We’re tracking 731 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05055297Recruiting
Drug-coated balloon for severe leg artery blockage in lower legs
This trial studies a “drug-coated balloon” procedure to improve blood flow in people with severe, long-lasting poor circulation in the lower leg arteries. It may help reduce repeat blockage after treatment for selected artery lesions below the knee.
Chandler, ArizonaAges 18 years+ - NCT06276374Recruiting
Dual antiplatelet therapy after carotid artery stenting for high bleeding risk
This trial tests if taking two blood thinners (dual antiplatelet therapy) after a carotid artery stenting procedure is safe and effective for patients who have a higher risk of bleeding. It focuses on people with significant blockages in the neck arteries who are also at increased risk for serious bleeding or brain bleeds.
SeoulAges 19 years+ - NCT05852704RecruitingPhase 3
Dapagliflozin to prevent irregular heart rhythm after bypass surgery
This trial looks at whether dapagliflozin (a diabetes medicine that helps the kidneys and heart) can lower the chance of atrial fibrillation, an irregular heart rhythm, after coronary artery bypass (CABG) surgery. If you’re scheduled for planned bypass surgery, this study may help reduce post-operative rhythm problems.
BrnoAges 18 years+ - NCT07445997Recruiting
HbA1c and kidney injury after heart bypass surgery
This study looks at whether blood sugar levels (HbA1c) before surgery are linked to kidney problems after coronary artery bypass surgery. It may help doctors understand how to reduce risks for people with diabetes or high blood sugar.
BursaAges 18 years+ - NCT03667196Recruiting
Test opening blocked heart arteries using two different procedures
This trial studies whether two ways of threading a device to open a long-term blocked coronary artery are both safe and effective. You may qualify if you have a chronic total blockage and heart-related symptoms, and you can follow the study follow-up plan.
AnyangAges 19 years+ - NCT07352111Recruiting
Heart risk in those with family history of heart attack
This study looks at people who have a family history of heart disease but no known heart problems or symptoms. It aims to understand if hidden plaque buildup in the arteries may be present.
MilanAges 40–70 - NCT00573027Recruiting
Study of heart pain from small artery heart disease
This trial studies people who have chest pain (angina) due to problems with the heart’s small arteries, not a big blockage. It aims to test whether treatment approaches can help these patients by better understanding the cause of their heart-related symptoms.
Los Angeles, CaliforniaAges 18 years+ - NCT07315997Recruiting
Heart health study for people with rheumatoid arthritis
This study looks at whether calcium in the heart arteries and a blood test (troponin) can help predict heart disease risk in people with rheumatoid arthritis. It may help doctors better prevent heart attacks and strokes.
Boston, MassachusettsAges 35–79 - NCT07485738Recruiting
Blood flow during bypass surgery and graft recovery
This study looks at how blood flow readings during coronary artery bypass surgery relate to whether the new grafts stay open and how well patients recover. It aims to help improve long-term results for people needing bypass surgery.
New York, New YorkAges 18 years+ - NCT07613294RecruitingPhase 3
Testing lepodisiran to reduce heart plaque buildup
This study tests whether a new medicine called lepodisiran can shrink plaque in heart arteries for adults with high Lp(a) (a type of cholesterol linked to heart disease) who have had a heart event or are at serious risk. The trial uses CT scans to monitor changes in your arteries.
La Jolla, CaliforniaAges 45–80 - NCT04822649Recruiting
Assessing exercise capacity in people with heart microvascular problems
This study looks at how well you can exercise and how your body composition relates to tiny blood-vessel problems in the heart. It may help doctors better understand symptoms and function in people who don’t have major blockages in the large heart arteries.
SeoulAges 20–80 - NCT05152888RecruitingPhase 4
Testing a cholesterol drug to improve heart blood flow on scans
This trial studies whether lowering LDL (“bad cholesterol”) with a PCSK-9 inhibitor (evolocumab) improves blood flow to the heart, measured by special PET scans. It’s for people over a certain age who have stable coronary artery disease and a higher risk of heart problems.
Boston, MassachusettsAges 50–90 - NCT04792320Recruiting
Probiotics and fiber for kidney disease with leg artery blockage
This study tests whether an oral absorbent plus probiotics can improve gut health and circulation in people who have chronic kidney disease and symptomatic peripheral artery disease (PAD). It will also track changes in blood markers and how well blood vessels function.
TaipeiAges 20 years+ - NCT07508865Recruiting
Sustainable anesthesia for heart bypass surgery
This trial studies a sustainable anesthesia approach for people having planned coronary artery bypass graft surgery (a type of open-heart surgery to improve blood flow to the heart). It aims to see if this method is safe and effective for patients at the study hospital.
Temuco, AraucaniaAges 18 years+ - NCT07265349RecruitingPhase 1/Phase 2
Stem cells plus bypass surgery for chronic heart failure
This trial tests whether injecting stem cells from umbilical cord tissue into the heart muscle during bypass surgery can improve heart function in people with chronic heart failure. It is for patients who are already scheduled for bypass surgery and have a weakened heart pump (LVEF between 21% and 40%).
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06673953Recruiting
Breathing training for heart surgery recovery with neck posture problems
This trial tests whether a breathing exercise device can improve heart and lung function in men who had heart bypass surgery at least 3 months ago and also have neck pain from poor posture. It may help you breathe better and feel stronger after surgery.
Giza, Giza GovernorateAges 45–55 - NCT06657976RecruitingPhase 2
Beetroot juice and exercise for PAD
This study tests whether beetroot juice, which contains natural nitrates that help blood vessels relax, combined with exercise, can improve walking ability in people with peripheral artery disease (PAD). You might be able to join if you have PAD, can walk without a walker, and are willing to avoid beet products for a while.
Chicago, IllinoisAges 50 years+ - NCT07725887Recruiting
Structured physical therapy for high-risk heart bypass patients
This trial tests a structured physical therapy program for patients at high risk who are getting heart bypass surgery. The therapy is done in the hospital before and after surgery to help you recover better.
Istanbul, EyupsultanAges 18–90 - NCT03132129Recruiting
Heart imaging study in adults with type 2 diabetes
This study looks for early, “silent” changes in heart function in adults with type 2 diabetes, even if you feel okay. It uses heart scans and looks for factors that may help explain why these changes happen.
LeicesterAges 50–75 - NCT03195556Recruiting
Test ultrasound contrast to improve blood flow in legs
This study checks whether using a special ultrasound with contrast can improve blood flow in people with peripheral artery disease (PAD). If you have leg circulation problems, it may help doctors measure and potentially enhance how well blood reaches your limb.
Portland, OregonAges 19–99 - NCT04126148Recruiting
Breathing test to measure heart oxygen use
This study measures how well the heart uses oxygen during a breathing-based test. It aims to validate a way to assess heart blood flow in people with suspected or known coronary artery disease, using special heart imaging and a heart blood-flow measurement during an angiogram.
Montreal, QuebecAges 18 years+ - NCT04252950Recruiting
Exercise program after blood-flow procedures for leg artery disease
This study tests whether a community-based exercise program helps people recover and improve walking after a procedure to restore blood flow in the leg arteries. It may help if your main problem is leg circulation problems and you’re able to take part in exercise safely.
Minneapolis, MinnesotaAges 40–90 - NCT04779008Recruiting
Remote arm treatment to help blood flow after heart bypass
This trial studies whether a simple, at-home type of treatment using brief arm blood-flow changes can improve blood flow to the heart and outcomes after CABG (heart bypass surgery). It may help some people recover better by protecting the heart around the time of surgery.
Zhengzhou, HenanAges 18–80 - NCT04794530RecruitingPhase 3
Cocoa extract trial for walking problems in blocked leg arteries
This Phase 3 study tests whether cocoa extract (cocoa flavanols) can improve walking ability and circulation in people with peripheral artery disease (PAD). It may help people who have PAD-related walking limits and can safely avoid competing cocoa sources and caffeine.
Chicago, IllinoisAges 55 years+
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Common questions
- Are there clinical trials for coronary artery disease?
- Yes. Clin2 currently lists 731 recruiting coronary artery disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a coronary artery disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a coronary artery disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.