Clinical trials
Critically Ill Patients clinical trials
Below are recruiting critically ill patients clinical trials, each written for real people, not researchers. We’re tracking 317 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05713877RecruitingPhase 2
Melatonin to treat confusion in ICU patients
This Phase 2 trial tests whether melatonin can reduce delirium, a sudden confusion that can happen in the ICU. If you qualify, you may be given melatonin to see if it improves alertness and comfort during an expected longer ICU stay.
Montreal, QuebecAges 18 years+ - NCT05952648Recruiting
Test for pneumonia in ICU using fast DNA testing
This study checks whether a fast “DNA test” can help diagnose hospital-acquired or ventilator-associated pneumonia in very sick patients with sepsis. If the test is accurate, it may help doctors start the right treatment sooner.
BolognaAges 18 years+ - NCT06039501Recruiting
The Family Perspectives Project Pilot Trial
This study looks at how to improve communication between families and the care team when a loved one is on a breathing machine in the intensive care unit. It may help families feel more supported and involved in care decisions.
Los Angeles, CaliforniaAges 18 years+ - NCT07362862Recruiting
Electrical muscle stimulation to prevent ICU weakness
This trial tests a wearable device that uses mild electrical pulses to stimulate leg muscles, helping prevent muscle weakness in ICU patients with severe infections. It may help you recover strength faster and avoid long-term disability.
Rochester, MinnesotaAges 18–85 - NCT06867354Recruiting
Breathing difficulty in obese patients during weaning from ventilator
This study looks at how often obese patients have trouble breathing when doctors try to remove the breathing tube (weaning) in the ICU. The goal is to understand what causes this and how it affects recovery.
Paris, ParisAges 18 years+ - NCT07032987Recruiting
Improving sedation with a new care plan for ICU patients
This trial tests a new sedation protocol for adults in intensive care who need strong pain relief or sedation medicines. It aims to make sedation safer and more comfortable, and includes people on ECMO (a heart-lung machine) or a ventilator (breathing machine) for severe breathing problems.
London, LondonAges 18–100 - NCT06651879Recruiting
Ultrasound airway check in severe preeclampsia patients for C-section
This study compares two ways of using ultrasound to look at the airway in women with severe preeclampsia who need a C-section under general anesthesia. It aims to find which technique is better, so doctors can prepare more safely for your breathing tube placement.
Cairo, Cairo GovernorateAges Any age - NCT07188350Recruiting
Electrical muscle stimulation for patients on a breathing machine
This trial tests whether low-level electrical pulses to the leg muscles can help prevent weakness in patients who need a breathing tube (ventilator) for more than 48 hours. It aims to see if this treatment helps patients recover faster.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT07077174Recruiting
Permissive lung-protective ventilation for critically ill patients on a breathing machine
This trial tests whether a more lenient approach to lung-protective ventilation can improve outcomes for patients who need a breathing machine (ventilator) in the intensive care unit. It aims to find a balance that is safer for the lungs while still being effective.
AlmeloAges 18 years+ - NCT07409727RecruitingPhase 4
Acetylcysteine inhalation to prevent pneumonia in ventilated patients
This trial tests if breathing in a medication called acetylcysteine can help prevent lung infections in patients who are on a breathing machine. If you or a loved one is on a ventilator, this treatment might reduce the chance of getting ventilator-associated pneumonia.
CairoAges 18–64 - NCT07339397Recruiting
Joint stiffness in ICU patients on breathing machines
This trial studies how common joint stiffness becomes in ICU patients who are on a breathing machine and cannot move for at least 7 days. It may help doctors better prevent and treat this problem.
Elâzığ, ElaziğAges 18 years+ - NCT03793257Recruiting
ECMO patient registry for adults in Australia and New Zealand
This is a research registry for adults who need a breathing and/or heart support machine called ECMO while in the hospital. It collects information to better understand who receives ECMO and how patients do over time.
Canberra, Australian Capital TerritoryAges 18 years+ - NCT03822949Recruiting
Bright light exposure during heart surgery for better recovery
This trial tests whether using bright light at the right time during and after heart surgery helps patients recover more comfortably. It focuses on people having a specific type of open-heart surgery and checks certain heart rhythm and safety factors.
Denver, ColoradoAges 18–90 - NCT05160987Recruiting
Sedation choice for ICU patients on breathing machines
This study compares two sedation medicines—remimazolam vs midazolam—for very sick ICU patients who are on a breathing machine. It looks at whether one sedative works better or is safer for keeping patients comfortable while they’re critically ill.
Guangzhou, GuangdongAges 18–80 - NCT05647135Recruiting
High-protein tube feeds for multiple trauma ICU patients
This trial studies whether very high protein tube-feeding helps critically ill adults with multiple injuries recover better in the ICU. It compares feeding approaches during the time you need breathing support.
BucharestAges 18 years+ - NCT05865314Recruiting
Nutrition plus early therapy for adults in long ICU stays
This trial studies whether a planned nutrition plan, along with early physiotherapy (physical therapy), can improve outcomes for adults who expect to stay in the ICU for at least 7 days. It includes people who need feeding through a tube and/or special IV nutrition while on a breathing machine.
Geneva, Canton of GenevaAges 18 years+ - NCT06966869Recruiting
Fentanyl patch absorption in ICU patients
This study looks at how well fentanyl patches work in ICU patients who are not stable. It aims to understand if the patch is absorbed properly in these patients.
Tel Aviv, IsraelAges 18–70 - NCT07460141Recruiting
Blood tests to predict death risk after surgery in the ICU
This study is looking at whether certain blood tests can help predict the risk of death after surgery in ICU patients. If you have had surgery and are now in the ICU, your blood samples may help doctors learn more.
TrabzonAges 18 years+ - NCT07656311Enrolling by invitation
Platelet size as early warning for cancer ICU patients
This study looks at whether the size of platelets in your blood when you enter the intensive care unit (ICU) can help predict your chances of recovery. It focuses on adults with cancer who are in the ICU for more than 24 hours and aims to find early signs of risk.
AnkaraAges 18 years+ - NCT06840756RecruitingPhase 4
Does donor-patient sex matching improve blood transfusion outcomes?
This trial tests whether giving ICU patients blood from a donor of the same sex (male-to-male or female-to-female) leads to better recovery compared to mismatched transfusions. The goal is to see if matching donor and patient sex makes a difference in how well patients do.
Hamilton, OntarioAges 18 years+ - NCT07313956Enrolling by invitation
Breathing machine method study in the ICU
This study looks at how different settings on the breathing machine (ventilator) are used for critically ill adults in the ICU. It may help doctors improve care for people who need a breathing tube.
Chicago, IllinoisAges 18 years+ - NCT06791889Recruiting
Tracking bacteria in blood of ICU sepsis patients
This study uses a highly sensitive blood test (DdPCR) to quickly find and monitor harmful bacteria in ICU patients with sepsis, aiming to improve early detection and treatment.
WuhanAges 18 years+ - NCT07737353Recruiting
Education for families of ICU patients with tracheostomy
This study tests whether a structured education program for family members of ICU patients who need a tracheostomy helps them feel more prepared and less stressed. You would be asked to attend training sessions and fill out some questionnaires.
Giresun, GiresunAges 18 years+ - NCT05673408Recruiting
Check how well a blood pressure cuff reads in critically ill patients
This study tests whether a noninvasive blood pressure (NIBP) cuff gives accurate readings in people being cared for in intensive care or the operating room. It will compare the cuff’s numbers to blood pressure measured through an arterial line in different patient groups.
Jacksonville, FloridaAges Any age
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Common questions
- Are there clinical trials for critically ill patients?
- Yes. Clin2 currently lists 317 recruiting critically ill patients studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a critically ill patients trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a critically ill patients trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.