Clinical trials
Degenerative Disease clinical trials
Below are recruiting degenerative disease clinical trials, each written for real people, not researchers. We’re tracking 117 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02435940Recruiting
Registry for inherited eye vision conditions
This study is a registry, meaning it collects information about people with inherited retinal (retina) diseases. It may help researchers learn how these conditions progress and connect you with future studies or treatments.
Columbia, MarylandAges Any age - NCT06660524RecruitingPhase 4
Calcium-phosphorus therapy for heart valve disease
This trial tests a treatment to lower high calcium and phosphorus levels in your blood, which may slow down calcium buildup in heart valves. It may help people with kidney problems who have valve disease.
Beijing, Beijing MunicipalityAges 50 years+ - NCT04775537Recruiting
OssiMend bone graft for lumbar spine fusion surgery
This trial studies whether OssiMend bone graft helps heal a lumbar spine fusion for people whose disc disease has not improved with non-surgical care. It may be an option if you need back surgery due to specific spine wear-and-tear changes.
Encinitas, CaliforniaAges 18 years+ - NCT06226272Recruiting
Study of Stryker spine device results
This trial is checking how well a Stryker spine device works in people who need spine surgery. Eligibility depends on the specific device and is decided by the study doctors.
Jacksonville, FloridaAges 18 years+ - NCT06000319Enrolling by invitation
NMP fibers for spine fusion surgery
This study tests a new material called NMP fibers used during spine fusion surgery to treat conditions like degenerative disc disease, spinal stenosis, or spondylolisthesis. The goal is to see how well it works for patients having fusion in the neck or lower back.
Jasper, AlabamaAges 18 years+ - NCT05691231Enrolling by invitation
Follow-up study for the NuVasive Simplify Disc implant
This study checks how safe and how well a specific artificial disc (the NuVasive Simplify Disc) works over the long term at two implant sizes/levels. It is for people who were already enrolled in an earlier disc study and are still willing to participate.
Charlotte, North CarolinaAges 18 years+ - NCT06320899Recruiting
Comparing different rods for lower back spine surgery
This study tests two types of rods (mid/high-flex vs low-flex) used during back surgery for people with degenerative spine problems in the lower back. The goal is to see which type helps reduce pain and improve movement better.
AarbergAges 18–99 - NCT07757178Recruiting
Dementia lived experiences study
This study explores the personal stories and experiences of people with dementia, their families, and caregivers to help improve care and support. Participation involves sharing your experiences in interviews or other tasks.
Nottingham, EnglandAges 18–99 - NCT07207096Recruiting
Study of complementary medicine for Parkinson's disease
This study looks at patients with Parkinson's disease who visit a clinic that offers complementary medicine (like natural therapies). It aims to learn more about their experiences and health outcomes.
LondonAges 18 years+ - NCT06462729RecruitingPhase 1/Phase 2
Testing a new bone graft for lower back fusion surgery
This trial tests a new bone graft material called LDGraft for people who need a single-level lower back fusion (anterior lumbar interbody fusion). It aims to see if the new graft is as good as or better than current options for helping bones heal together.
Fort Wayne, IndianaAges 22–80 - NCT04467944Recruiting
Lumbar fusion outcomes with arthritis in nearby spine segments
This study looks at how well lumbar fusion surgery works long-term when the joint just above or below (adjacent segment) already shows wear-and-tear. It may help predict who benefits most and guide treatment planning.
Beijing, Beijing MunicipalityAges 18–80 - NCT05296889Recruiting
Safety follow-up for Ennovate cervical device
This study checks how safely and effectively a cervical device (Ennovate® Cervical) works after it’s been used in routine care. It may help by monitoring real-world safety and performance over time.
Hamburg, Free and Hanseatic City of HamburgAges 18 years+ - NCT03322306Enrolling by invitation
Genetic testing study for inherited neurological conditions
This trial looks for genetic causes of inherited (in family) neurological diseases by using genetic screening. If you might have an inherited neurological condition, this study may help explain why symptoms happen and guide future care.
Hong Kong, ShatinAges 18–80 - NCT04469387Recruiting
Reduce adjacent back pain after lumbar surgery
This trial looks at whether a limited decompression (a careful nerve-space “freeing” procedure) can help prevent future problems in the spinal level next to your planned surgery. It targets people with spinal canal narrowing next to the surgery level but who do not yet have symptoms there.
Beijing, Beijing MunicipalityAges 18–80 - NCT04734756Enrolling by invitation
Dragonfly device study for leaking mitral valve in high-risk patients
This trial tests the safety and effectiveness of a heart procedure that repairs a leaking mitral valve through thin tubes, using the Dragonfly system. It’s for people who have significant mitral valve leak symptoms but are considered high risk for open-heart surgery.
Hangzhou, ZhejiangAges 18 years+ - NCT07605715Recruiting
Catheter vs. Surgery for Leaky Mitral Valve
This study compares two ways to fix a leaky mitral valve (a heart valve that doesn't close properly): one using a thin tube inserted through blood vessels (catheter) versus traditional open-heart surgery. The goal is to see which approach works better and is safer for older adults.
Los Angeles, CaliforniaAges 60 years+ - NCT07265544Recruiting
Liver disease study using advanced tissue analysis
This study uses advanced techniques to analyze liver tissue samples from people with various liver conditions. It aims to better understand how liver diseases develop and progress, which may help improve future treatments.
Guangzhou, GuangdongAges Any age - NCT04770571Enrolling by invitation
Study of posterior neck and upper-back spine fixation systems
This trial studies specific surgical hardware used to stabilize the back of the neck and upper back during spine surgery. It may help surgeons compare outcomes for people needing fixation for trauma, instability, failed prior fusion, tumors, or certain degenerative conditions.
Orange, CaliforniaAges 18 years+ - NCT07360977Recruiting
Broccoli supplement for Parkinson's and multiple sclerosis
This trial tests a natural compound (from broccoli sprouts) called glucoraphanin, which may help protect brain cells in people with Parkinson's disease or multiple sclerosis. It aims to see if taking this supplement can slow down or improve symptoms.
MessinaAges 1–75 - NCT07563777Recruiting
Long-term study of human aging and health
This is a long-term research study that follows people over time to understand how humans age. Researchers will collect information about your health and lifestyle to learn what helps people stay healthier as they get older.
Boulder, ColoradoAges 18 years+ - NCT03233646Recruiting
Retina scans in memory and nerve disorders
This study uses pictures of the back of your eye (retinal imaging) to look for differences in people with neurodegenerative diseases and compares them with people without these conditions. It may help researchers understand eye changes that could connect to brain or nerve health.
Durham, North CarolinaAges 18 years+ - NCT03153670Recruiting
Brain scan study for people with deep brain stimulators
This study uses a 3‑tesla MRI (a type of detailed brain scan) in people who have deep brain stimulation (DBS) electrodes. The goal is to improve understanding of how the brain works; the scan is not meant to provide direct treatment benefit.
Toronto, OntarioAges 18–85 - NCT06657248Recruiting
Study of a new partial knee implant for inner knee arthritis
This study tests how well a new partial knee implant works and how safe it is for people with arthritis on the inner side of the knee who still have healthy knee ligaments and can bend their knee well.
Potsdam, BrandenburgAges 18–75 - NCT06650046Recruiting
Topping-off technique for lower back arthritis
This trial tests a 'topping-off' surgical technique for people with arthritis and disc problems in the lower back. If you have tried 3 months of non-surgical treatments without success, this surgery may be an option to relieve pain and improve function.
Jinan, ShandongAges 18–85
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Common questions
- Are there clinical trials for degenerative disease?
- Yes. Clin2 currently lists 117 recruiting degenerative disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a degenerative disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a degenerative disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.