Clinical trials
Degenerative Disease clinical trials
Below are recruiting degenerative disease clinical trials, each written for real people, not researchers. We’re tracking 117 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07386548Recruiting
Biologic injection for low back disc problems
This study tests if an injection can help people with a herniated disc in the lower back who have not gotten better with other treatments and are already planning surgery. It aims to see if the injection can reduce symptoms and possibly avoid or improve surgery outcomes.
Manhattan, New YorkAges 18 years+ - NCT04880356Recruiting
Study of very rare inherited brain diseases over time
This study follows adults over time who have a very rare inherited brain disease, or whose illness seems like it may run in families. The goal is to better understand these conditions and how they progress.
Milan, MilanoAges 18 years+ - NCT07370493Enrolling by invitation
Study of a two-level disc implant for the neck
This study looks back at patients who already have a Prodisc C Vivo device in two levels of their neck spine. The goal is to learn how well the surgery works over time.
RecklinghausenAges Any age - NCT06075966Enrolling by invitation
A new surgery for lumbar disc disease without fusion
This trial tests a surgical technique that treats a damaged disc in your lower back without permanently fusing the bones together. It may be an option if you have had at least 3 months of other treatments like physical therapy or medication and they have not helped enough.
Jinan, ShandongAges 18–85 - NCT06940453Recruiting
A new cage for spinal fusion surgery
This trial is testing a new device called the CONDUIT cage for a type of back surgery called anterior lumbar interbody fusion (ALIF). The surgery helps treat degenerative disc disease in the lower back by fusing two vertebrae together using a cage to support the spine. The study will see how well this cage works in patients who are already scheduled for this surgery.
Dublin, LeinsterAges 18 years+ - NCT07142174Recruiting
New implant for neck pain and nerve compression
This trial tests a new type of implant that is placed in the back of your neck to help open up space for nerves and improve spine alignment. It may help people with pain, numbness, or weakness from a pinched nerve or spinal cord compression caused by wear-and-tear changes.
RiyadhAges 18 years+ - NCT07017634RecruitingPhase 3
Novosis Putty for spine fusion in lumbar disc disease
This trial tests a new bone graft putty (Novosis Putty) used during a specific type of spine fusion surgery (TLIF) to treat a worn-out disc causing low back and leg pain. The goal is to see if it works as well as or better than current options.
Little Rock, ArkansasAges 21–80 - NCT07254806RecruitingPhase 3
Cell therapy for low back pain from disc disease
This study tests if injecting a special cell therapy into a damaged spinal disc can reduce chronic low back pain. It is for people who have had low back pain for at least 6 months and haven't gotten enough relief from other treatments like physical therapy or pain medication.
Birmingham, AlabamaAges 18–75 - NCT05287867Recruiting
Study for painful degenerative disc disease treatment
This trial is testing a treatment approach for people with long-lasting, painful worn-out discs in the lower back (and sometimes leg pain). It looks for people who tried common non-surgical options without enough relief and who may be headed toward a lumbar procedure.
Broomfield, ColoradoAges 25–65 - NCT06209684Recruiting
Carbon fiber screws vs titanium for spine surgery
This trial compares a new carbon fiber screw system to standard titanium screws for people needing spinal fusion surgery to treat degenerative spine conditions. It aims to see which type of screw works better for pain and stability.
BolognaAges 18 years+ - NCT06506656Recruiting
Testing Hyadrol gel for hip or thumb arthritis pain
This study tests whether a combination of hyaluronic acid and adelmidrol (a gel called Hyadrol) can reduce pain and improve joint function in people with arthritis of the hip or thumb. It may help if you have persistent pain and are not already on other treatments.
RomaAges 40 years+ - NCT06778447Recruiting
Disc injection for chronic low back pain
This study tests whether injecting a special disc material (nucleus pulposus allograft) into the damaged discs of your lower back can safely reduce pain and improve function. It's for people with long-term, moderate to severe low back pain from disc disease that hasn't gotten better with other treatments.
Napa, CaliforniaAges 22–85 - NCT05595226Recruiting
Ultrasound-guided mitral valve repair to improve heart outcomes
This study looks at whether using a special heart ultrasound during surgery (called RT3D-TEE) can lead to better results for people having mitral valve repair. It’s mainly for certain types of chronic mitral valve leakage.
Beijing, Beijing MunicipalityAges 18–80 - NCT07127380Recruiting
Comparing two types of spine surgery for disc-related low back pain
This study compares two different surgery methods (Mini-TLIF and MIDLIF) for treating low back pain caused by worn-out discs in the lower back. The goal is to see which one offers better recovery, fewer complications, and lower costs.
Lodz, Łódź VoivodeshipAges 18 years+ - NCT03197363Enrolling by invitation
Long-term study of adults living in Białystok
This study follows adults living in Białystok over time to learn about health and life patterns. If you’re invited to take part and agree, it may help researchers better understand community health.
BialystokAges 20–80 - NCT05029726RecruitingPhase 4
Numbing medicine during back surgery to reduce pain
This trial tests a regional anesthesia (numbing medicine given near nerves) during minimally invasive lumbar spine surgery. The goal is to see if it helps control pain around surgery and improves recovery comfort.
Chicago, IllinoisAges 18–80 - NCT04418830Enrolling by invitation
Study of a spine cage implant for degenerative back problems
This trial studies how well specific lumbar (lower back) implant “cages” help fuse vertebrae in people with degenerative disc disease, spinal slippage, narrowing, curvature, or forward-bending deformity. It may help by testing an approach to improve stability and reduce symptoms after surgery.
La Jolla, CaliforniaAges 18 years+ - NCT05655650Recruiting
Finding blood or brain markers in Alzheimer’s disease
This study looks for “biomarkers,” or measurable signs, that help identify Alzheimer’s disease. It may help doctors diagnose Alzheimer’s more accurately by comparing people with Alzheimer’s to others where the diagnosis is different.
Hong Kong, Hong HongAges 20 years+ - NCT06485206Recruiting
Hybrid disc replacement and fusion for two-level neck disease
This study tests a combination of a disc replacement (Mobi-C) and a spinal fusion (ACDF) for people with degenerative disc disease at two levels in the neck. The goal is to see if this approach is safe and effective for relieving pain and nerve symptoms.
Sacramento, CaliforniaAges 22–69 - NCT07126821Recruiting
Brain disease diagnosis study using vision and language
This trial tests a new computer model that combines brain MRI scans and clinical data to help diagnose brain diseases. It may help doctors make more accurate diagnoses.
Changsha, HunanAges Any age - NCT05327972RecruitingPhase 2
Botox injections for painful degenerative rotator cuff disease
This Phase 2 study tests whether botulinum toxin (Botox) injections can reduce pain from long-lasting degenerative rotator cuff problems. You may be eligible if you have shoulder pain for over a month and ultrasound evidence of specific tendon irritation.
Paris, ParisAges 41 years+ - NCT06075979Recruiting
Microbes and spine health: a surgical study
This study looks at whether certain microbes (tiny living things) are linked to spine problems like herniated discs or narrow spinal canals. It involves people who need spine surgery, and the findings might help explain why some spines wear out faster.
Jinan, ShandongAges 18–85 - NCT04079179RecruitingPhase 2
Cobimetinib for difficult Langerhans cell and similar disorders
This Phase 2 trial studies cobimetinib, a medicine that targets a specific growth-and-signal pathway, to treat stubborn (refractory or worsening) Langerhans cell histiocytosis and related disorders. It may help shrink active disease or stop disease from progressing.
Phoenix, ArizonaAges Any age - NCT03167203Enrolling by invitationPhase 1/Phase 2
Safety check after stem-cell eye treatment
This study follows people who previously received an embryonic stem-cell–derived treatment for macular (central) vision loss. Its goal is to watch for long-term side effects and better understand how safe the treatment is over time.
Kansas City, MissouriAges 18 years+
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Common questions
- Are there clinical trials for degenerative disease?
- Yes. Clin2 currently lists 117 recruiting degenerative disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a degenerative disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a degenerative disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.