Clinical trials
Degenerative Disease clinical trials
Below are recruiting degenerative disease clinical trials, each written for real people, not researchers. We’re tracking 118 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05357378Recruiting
Hip replacement study using a reverse hip implant
This trial looks at how safe and well a specific “reverse” hip implant works in people who need their first total hip replacement. It may help by improving pain and hip function, while closely tracking safety during and after surgery.
Miami, FloridaAges 50–75 - NCT05238740Recruiting
Compare fusion results after two spine surgeries with added biologics
This study compares two types of spine surgery (ALIF or XLIF) for one spinal level, and tests how well the bones fuse when a specific bone-forming product is used. It also looks at how patients feel and function after surgery.
BernAges 18–70 - NCT05037968Recruiting
Test bone graft materials for multi-level back fusion surgery
This trial compares two bone-graft materials to help bones heal after back fusion surgery using a rod/screw system. It may help people who have ongoing back or leg pain despite at least 3 months of non-surgical treatments.
Hartford, ConnecticutAges 18 years+ - NCT04982965RecruitingEarly Phase 1
Study brain changes behind cannabis pain relief
This early study looks at how the brain may respond to cannabis to reduce long-lasting lower back pain. You may be asked to follow strict rules about cannabis, opioids, and safety checks (including MRI) to help researchers understand the brain mechanisms.
La Jolla, CaliforniaAges 21–65 - NCT04689854Enrolling by invitation
Cervical spine surgery implant study for neck disc problems
This trial studies specific neck (cervical) spine implants used during surgery for degenerative disc disease or neck instability, along with a particular kind of bone grafting and supporting hardware. It may help patients by testing whether these devices and the planned fusion approach work safely and effectively in real-world surgery.
Orange, CaliforniaAges 18 years+ - NCT04679844Recruiting
Test bone putty for back fusion versus bone graft alternatives
This study compares a ready-to-use bone putty to standard bone graft materials (with or without your own bone) during back fusion surgery for unstable lower back problems. It looks at whether the putty works as well or better to help the bones fuse and heal.
Irvine, CaliforniaAges 18 years+ - NCT04388332Recruiting
Neck surgery compares two bone graft materials
This study compares two materials used during neck surgery for degenerative disc disease: donor bone (structural allograft) versus a titanium cage (Tritanium C). It aims to see which option works better for healing the fused neck bones and improving symptoms.
Pittsburgh, PennsylvaniaAges 18–80 - NCT04204135Enrolling by invitation
Tracking hip flexor weakness after specific spine surgeries
This trial follows how hip flexor strength changes after two types of lower-back surgeries (ALIF or LLIF). It may help doctors better predict and prevent weakness in the hip and leg after surgery.
Chicago, IllinoisAges Up to 65 years - NCT03649490Enrolling by invitation
Testing new spinal implant materials for XLIF fusion
This study compares different advanced materials used in a specific spinal fusion surgery (XLIF). It aims to see which implant material helps the bone fuse well and safely over time.
Hartford, ConnecticutAges 18–80 - NCT07001969Enrolling by invitation
Percutaneous facet spine fixation for instability
This study tests a minimally invasive procedure to fix unstable vertebrae in the neck or lower back using a small incision. It may help people with spinal instability causing nerve symptoms or pressure on the spinal cord.
Cairo, ShoroukAges Any age - NCT06534658Recruiting
Brain Imaging Study for Dementia and MCI
This study uses advanced brain scans (MRI and molecular imaging) to get a clearer picture of dementia and mild cognitive impairment (MCI). It aims to learn more about how the brain changes in these conditions, which could help improve diagnosis and treatment.
Beijing, Beijing MunicipalityAges 50–85 - NCT05227924Recruiting
Testing safety and performance of a hip implant device type
This study checks how safe and well a specific brand of hip implant (SYMBOL range) works in people getting a total hip replacement. It may help by confirming the device performs as expected for primary or revision surgeries.
BeaumontAges 18 years+ - NCT07462624Recruiting
Comparing treatments for a failing surgical aortic valve
This trial compares two ways to treat a failing aortic valve that was replaced with a tissue valve during surgery: another surgical replacement or a less invasive catheter-based valve-in-valve procedure. It is for people with low to intermediate surgical risk who are between 18 and 75 years old.
Leipzig, SaxonyAges 18–75 - NCT06335095Recruiting
Spine disease and walking analysis study for adults 50–85
This study looks at how spine conditions affect the way people walk. Researchers will analyze your walking patterns to better understand spine disease and help guide future treatments.
LisbonAges 50–85 - NCT07222787Recruiting
Testing a new spinal implant for lower back fusion
This trial tests a new spinal implant system (CORUS-LX) for fusing two lower back discs that are causing pain. It is meant for people with severe, long-lasting back or leg pain that hasn't improved with non-surgical treatments.
Scottsdale, ArizonaAges 18–80 - NCT07133724Recruiting
Digital health study for lumbar spine wear and tear
This study uses digital tools to measure how lumbar degeneration affects walking. It aims to find early signs of spine problems in people without current back pain.
TaipeiAges 50–80 - NCT07085247Recruiting
Role of bacteria in lower back disc disease
This trial looks at whether a specific bacteria, Cutibacterium acnes, is linked to disc problems in the lower back. If you're having surgery for a herniated disc, your tissue sample may help researchers understand the cause.
BrnoAges 18 years+ - NCT06435494Enrolling by invitation
Using patient reports to improve shoulder care across clinics
This study tests whether asking patients about their shoulder symptoms using a phone or computer app can help doctors and therapists work together to improve care. It is for adults with shoulder pain that started without a sudden injury.
Gentofte Municipality, HellerupAges 18–120 - NCT05137665Recruiting
Study tracks ALS and health markers over time at home
This study follows people with ALS and healthy volunteers to measure how specific body fluids, symptoms, and at-home tracking change over time. It may help researchers find early signs of disease changes and better ways to measure treatment effects.
Phoenix, ArizonaAges 18 years+ - NCT03653156Recruiting
Aging and brain study for mild memory loss and dementia
This study checks how age affects memory and thinking, and compares people with mild memory problems, Alzheimer’s disease types, vascular dementia, and healthy controls. You may help researchers understand brain changes using thinking tests, MRI scans, and blood or spinal fluid tests.
Hefei, AnhuiAges 18 years+ - NCT07213700Recruiting
Alzheimer's disease long-term study
This study follows people with Alzheimer's disease over time to learn more about the condition and improve future care. It is an observational study, meaning participants receive their usual care while researchers collect information.
MelbourneAges 18 years+ - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age
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Common questions
- Are there clinical trials for degenerative disease?
- Yes. Clin2 currently lists 118 recruiting degenerative disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a degenerative disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a degenerative disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.