Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06534684Recruiting
Brain stimulation (iTBS) for depression and thinking changes
This study tests whether a type of brain stimulation called iTBS can improve depression and thinking skills. It uses a magnetic coil over the scalp and is done on multiple days.
TromsøAges 22–65 - NCT06542094Recruiting
Brain stimulation for severe depression that hasn't improved with other treatments
This trial tests if deep brain stimulation (a device that sends tiny electrical pulses to mood-related brain areas) can help people with tough-to-treat depression. It uses brain-signal monitoring to see which patterns predict improvement.
Chengdu, SichuanAges 18–65 - NCT07758010Recruiting
Brain stimulation for treatment-resistant depression
This study tests a type of brain stimulation called cTBS (continuous theta burst stimulation) applied to a specific part of the brain (the precuneus) to see if it helps with treatment-resistant depression. It aims to provide a new option for people who haven't found relief from standard treatments.
Belmont, MassachusettsAges 18 years+ - NCT07749521Recruiting
Treating depressed parents of children with behavioural problems
This study tests a virtual group treatment to help parents with mild to moderate depression improve their own wellbeing and better support their child's emotional and behavioural health. If you are a parent with depression and have a child aged 6-11 who is struggling emotionally or behaviourally, this trial may be for you.
Toronto, OntarioAges 18 years+ - NCT05616559Recruiting
Precision-guided treatment for single-episode depression
This study tests a more personalized approach to treating depression in people who have had one episode. It uses questionnaires and brain scans (for some participants) to help decide which treatment approach may work best.
CopenhagenAges 18–65 - NCT07699445RecruitingPhase 4
Lumateperone for weight and mood in bipolar depression
This study tests if lumateperone, a medication for bipolar depression, can also help with weight and aging in people with obesity. You may qualify if you have bipolar I depression and a body mass index (BMI) over 30.
Boston, MassachusettsAges 18–65 - NCT07703722RecruitingPhase 3
Psilocybin and therapy for depression with trauma
This trial tests psilocybin (a compound from certain mushrooms) combined with a structured therapy to see if it helps people with depression linked to trauma. It focuses on how the treatment affects the connection between the gut and brain.
Islamabad, CapitalAges 18–60 - NCT07696871RecruitingPhase 1/Phase 2
Cannabidiol oil for treatment-resistant depression
This trial tests if cannabidiol (CBD) oil can help people with major depression that has not improved with standard antidepressants. You will take CBD oil or a placebo while continuing your current antidepressant treatment to see if it improves your symptoms.
Tubarão, Santa CatarinaAges 18–69 - NCT07681492Recruiting
Depression, aging, and antidepressants: a belief study
This trial studies how depression and antidepressants affect belief updating in older adults. You may join if you are over 65, have major depression, and are starting a new antidepressant. The goal is to learn more about how your brain adjusts beliefs over time.
RennesAges 65 years+ - NCT07673913Recruiting
Blood markers and brain stimulation for hard-to-treat depression
This study is testing whether a new type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with treatment-resistant depression (depression that hasn't improved with standard medicines). It also looks at certain blood markers to see if they can predict how well someone will respond to this treatment.
Ankara, AnkaraAges 18–55 - NCT07680140RecruitingPhase 4
Using biomarkers to choose depression treatment
This study uses a blood test (biomarker) to help pick the antidepressant that might work best for you. It compares two treatments—standard antidepressants and ketamine—in people with major depression who haven't gotten enough relief from one prior treatment.
New York, New YorkAges 18–70 - NCT07651436Recruiting
Depression screening in patients on kidney dialysis
This study tests whether nurses can effectively screen for depression in patients receiving regular kidney dialysis treatment. The goal is to find the best way to identify depression early so patients can get help.
AnnecyAges 18 years+ - NCT07611773Recruiting
Brain Stimulation for Depression Treatment Planning
This study tests whether brain scans can predict which people with depression will benefit from transcranial direct current stimulation (tDCS)—a non-invasive treatment that uses mild electrical pulses to stimulate brain areas related to mood. You would use a small home device and complete brain monitoring sessions.
ValenciaAges 18 years+ - NCT07603804Recruiting
Accelerated Brain Stimulation for Treatment-Resistant Depression
This study tests an accelerated form of iTBS (a non-invasive brain stimulation technique) for depression that hasn't improved with antidepressant medications. The goal is to help people with major depression who haven't responded adequately to at least one antidepressant drug.
IstanbulAges 18–65 - NCT06049433Recruiting
Mental health support for new and expecting mothers
This study tests a program to help pregnant women and new mothers who may be at risk for depression after childbirth. The program offers extra support and resources to improve your mental health and well-being.
Salt Lake City, UtahAges 18 years+ - NCT07576686Recruiting
AI-assisted therapy for depression and anxiety
This trial tests a computer-guided cognitive behavioral therapy (CBT)—a proven talk therapy approach—to help treat mild depression and anxiety. The program runs for 10 weeks with weekly sessions, and AI helps guide your therapist or the process itself.
NišAges 18 years+ - NCT06415838Recruiting
Behavioral activation for depression in older adults
This trial tests a simple, practical therapy called behavioral activation to help older adults with depression feel better. It's done in your local community, not in a hospital.
Eskilstuna, SörmlandAges 65 years+ - NCT07562191RecruitingPhase 2
Inhaled DMT for major depression
This trial tests if inhaling DMT can help treat moderate to severe major depression. You may qualify if your depression has lasted at least two weeks and you have not changed medications recently.
Fortaleza, CearáAges 18 years+ - NCT06163625Recruiting
Brain activity and memory in treatment-resistant depression
This study looks at how the brain's frontal lobe (DLPFC) works during memory tasks in people with treatment-resistant depression. It compares brain activity between depressed patients and healthy controls using MRI and possibly a brain stimulation technique (rTMS). It aims to understand why some people don't respond to standard treatments.
Toronto, OntarioAges 18–65 - NCT07543328Recruiting
Light therapy added to antidepressants for depression with body symptoms
This study tests whether a special light treatment applied to the scalp (transcranial photobiomodulation) can help people with depression who aren't getting better with antidepressants alone. The light therapy is added to your current medication to see if it reduces both mood symptoms and physical complaints like pain or fatigue.
TaipeiAges 18–65 - NCT07500714Recruiting
Digital therapy for depression using AI
This study uses a smartphone app and artificial intelligence to deliver a special type of talk therapy for people with moderate to severe depression. It aims to provide personalized care without needing to change your current treatment.
Taichung, TaichungAges 18–75 - NCT05958940Recruiting
Bright light therapy study for depression
This trial studies whether daily bright light therapy can reduce depressive symptoms. It’s for adults with depression (including some with bipolar depression), and you would fill out questionnaires and be screened for safety.
EindhovenAges 18–65 - NCT07490782Recruiting
Nutrition study for college students with depression
This trial tests whether changes in diet can help improve mild to moderate depression in college students. If you are currently getting treatment or are open to it, you may be able to join.
La Jolla, CaliforniaAges 18 years+ - NCT07474363Recruiting
Depression differences between men and women
This study looks at how depression affects men and women differently, including symptoms, strength to cope (resilience), and feelings of stigma. It aims to understand these differences to improve treatment.
Eskişehir, EskişehirAges 18–65
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,419 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.