Clinical trials
Disorder of Consciousness clinical trials
Below are recruiting disorder of consciousness clinical trials, each written for real people, not researchers. We’re tracking 51 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07183670Enrolling by invitation
Testing a Voice Valve to Remove Breathing Tubes in Prolonged Consciousness Disorders
This study tests a new way to help people with long-lasting disorders of consciousness get their tracheostomy tube removed using a voice valve. If you qualify, this might help improve recovery and communication.
Beijing, Beijing MunicipalityAges 18–80 - NCT07173634Enrolling by invitation
Speaking valve trial for tracheostomy removal in consciousness disorders
This trial tests whether using a speaking valve (a small one-way valve that lets you breathe and speak) helps people with a tracheostomy and long-term consciousness problems safely remove their tracheostomy tube, compared to a standard capping method.
Beijing, Beijing MunicipalityAges 18–80 - NCT07456020Recruiting
Measuring awareness after brain injury in the ICU
This study checks how awake and aware you are using two standard checklists (CRS-R and SECONDs). It's for people with recent brain injuries in intensive care who are still very dependent.
Hessisch Oldendorf, Lower SaxonyAges 18 years+ - NCT05010265Recruiting
Learning how to detect hidden awareness using brain signals
This study explores an ethical approach to detecting “covert consciousness,” meaning a person may be aware even if they cannot show it clearly. It involves people connected to patients with disorders of consciousness, including caregivers and specialists, and uses information related to MRI or EEG brain testing done for clinical care.
Boston, MassachusettsAges 18 years+ - NCT07385508Recruiting
Rehabilitation study for people with disorders of consciousness
This study looks at how different types of rehabilitation (alone or combined) affect recovery in people with disorders of consciousness after a brain injury. It aims to find the best approaches to help improve outcomes.
Messina, SicilyAges 18–90 - NCT07539740Recruiting
Brain Stimulation to Help Improve Consciousness After Brain Injury
This study tests whether a non-invasive brain stimulation technique called transcranial theta-burst stimulation (tTIs) can help patients recover consciousness after severe brain injury. The treatment aims to improve responsiveness in people in vegetative states or minimally conscious states.
Guangzhou, GuangdongAges 18–70 - NCT06617377Recruiting
Can MRI predict brain recovery after cardiac arrest?
This study uses brain scans (MRI) to try to predict whether people who are still unconscious after a cardiac arrest will recover. It is looking for adults who are in a coma and have not woken up after being taken off sedation medicines for at least three days.
ToulouseAges 18 years+ - NCT06568536Recruiting
EEG Study to Predict Recovery After Brain Injury
This study uses a special EEG test to measure brain activity in people who are not fully conscious after a recent brain injury. The goal is to find better ways to know if someone will wake up and recover thinking abilities.
Boston, MassachusettsAges 18 years+ - NCT07761507Recruiting
Ear stimulation to help wake up after brain bleed surgery
This trial tests a gentle ear stimulation device that may help people regain consciousness after surgery for a brain bleed. It is done while the person is in the hospital and may improve recovery.
BeijingAges 18–75 - NCT05539807Enrolling by invitation
Mindfulness program for binge-eating symptoms
This study looks at whether a mindfulness approach can help reduce symptoms related to binge eating. You may be eligible if you’re 16 or older and feel your eating problems involve binge eating.
Bergen, BergenAges 16 years+ - NCT06426615Recruiting
Understanding brain signals in unresponsive states after injury
This study looks at brain activity in people who are unresponsive after a brain injury. It uses advanced brain scans to see if there are hidden signs of consciousness, which could help doctors better understand and care for these patients.
Leuven, Vlaams-BrabantAges 18 years+ - NCT07127224Recruiting
Predicting recovery with smell tests in coma
This study tests whether a simple smell test can help predict recovery of consciousness in patients who remain in a coma or minimally conscious state after a severe brain injury. If you or your loved one has been unresponsive for several days after sedation is stopped, this trial may provide useful information about prognosis.
Paris, GHU Psychiatrie Et NeurosciencesAges 18 years+ - NCT07228286RecruitingEarly Phase 1
Using brain stimulation to help restore consciousness
This trial tests whether electrical stimulation of a deep brain area can improve awareness in people who have been in a coma-like state for at least 3 months after a brain injury. It aims to help those who have limited or no ability to communicate or use objects.
Boston, MassachusettsAges 18–55 - NCT05922644Recruiting
Spinal cord stimulation for consciousness recovery after brain bleed
This trial studies whether short-term spinal cord stimulation can help people regain consciousness after an intracerebral hemorrhage (brain bleed). It’s mainly for patients whose brain function tests suggest they are in a minimally conscious state and who are medically stable enough for the procedure.
Beijing, Beijing MunicipalityAges 18–65 - NCT07719595Recruiting
Vagus nerve stimulation for coma after brain injury
This trial tests if a gentle electrical stimulation of the vagus nerve (a nerve in the neck) can help people regain consciousness after a severe traumatic brain injury. It is for patients who are in a coma or minimally conscious state, and the treatment is given along with standard ICU care.
Stony Brook, New YorkAges 18 years+ - NCT06635291Recruiting
Better Diagnosis for Children with Brain Injury
This study tests new ways to evaluate children with severe brain injuries who are in a vegetative or minimally conscious state. The goal is to improve diagnosis and care for children with serious disorders of consciousness after a brain injury.
Bosisio Parini, LeccoAges 2 months–25 years - NCT06515132Recruiting
Spinal cord stimulation for consciousness after brain injury
This trial tests whether spinal cord stimulation can help people who have been minimally conscious for months after a brain injury. It aims to improve awareness and responsiveness by using mild electrical pulses.
Fuzhou, FujianAges 18–65 - NCT05213169RecruitingPhase 2/Phase 3
Apomorphine for severe unresponsive brain injuries
This trial tests whether apomorphine can improve care or outcomes for people in an unresponsive wakefulness or minimally conscious state after a brain injury. It is designed for patients who are medically stable and not currently on certain brain- or heart- affecting medicines.
Liège, LiegeAges 18–80 - NCT07208942Recruiting
Testing brain signals from rectal stimulation in consciousness disorders
This study looks at brain signals in people with disorders of consciousness to see how the body senses signals from the rectum. It may help us understand how the brain and body communicate in these conditions.
Hefei, AnhuiAges 18 years+ - NCT04050995Recruiting
Testing MuSICCA to measure awareness in children
This study tests a tool called MuSICCA to check awareness in children and teens who are being evaluated for a disorder of consciousness. The results may help clinicians better understand a child’s awareness and guide care decisions.
Atlanta, GeorgiaAges 2–18 - NCT06236503Recruiting
Brain stimulation for minimally conscious state
This trial tests a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) to see if it can help people in a minimally conscious state. The goal is to improve awareness and responsiveness.
Messina, ItaliaAges 18–75 - NCT05706831Recruiting
Music and gentle brain stimulation after neurological injury
This trial tests whether combining music with gentle electrical brain stimulation can improve symptoms after a neurologic event, such as language and attention problems. It’s meant for adults who are living with effects of stroke and certain levels of reduced awareness.
Bari, BaAges 18 years+ - NCT06647433Recruiting
Risk in healthcare decisions for consciousness disorders
This study explores how families and healthcare workers think about risk when making decisions for someone in a disorder of consciousness. It aims to understand these perspectives to improve care.
London, LondonAges 18 years+ - NCT06469983Recruiting
Robotic vs. traditional standing therapy for severe brain injury
This trial compares using a robotic device versus standard therapy to help people with severe brain injury practice standing. It tests whether the robotic approach leads to better recovery of standing ability.
Sant'Angelo dei Lombardi, AvellinoAges 18–75
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Common questions
- Are there clinical trials for disorder of consciousness?
- Yes. Clin2 currently lists 51 recruiting disorder of consciousness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a disorder of consciousness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a disorder of consciousness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.