Clinical trials
Disorder of Consciousness clinical trials
Below are recruiting disorder of consciousness clinical trials, each written for real people, not researchers. We’re tracking 60 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06097013Enrolling by invitation
Brain function study for consciousness disorders
This trial is testing a brain function evaluation system to help understand and possibly improve care for people with disorders of consciousness caused by brain injury, stroke, or lack of oxygen. It is for both acute (recent) and prolonged (lasting) cases.
BeijingAges 14–60 - NCT05682248Enrolling by invitation
Testing a brain assessment and stimulation system for unconsciousness
This trial studies a device and plan to assess brain function and deliver an intervention in people who are in a coma, minimally conscious state, or unresponsive arousal state after brain injury, stroke, or lack of oxygen. If you qualify, it may help doctors understand and potentially improve brain function over time.
BeijingAges 14–80 - NCT07183670Enrolling by invitation
Testing a Voice Valve to Remove Breathing Tubes in Prolonged Consciousness Disorders
This study tests a new way to help people with long-lasting disorders of consciousness get their tracheostomy tube removed using a voice valve. If you qualify, this might help improve recovery and communication.
Beijing, Beijing MunicipalityAges 18–80 - NCT07173634Enrolling by invitation
Speaking valve trial for tracheostomy removal in consciousness disorders
This trial tests whether using a speaking valve (a small one-way valve that lets you breathe and speak) helps people with a tracheostomy and long-term consciousness problems safely remove their tracheostomy tube, compared to a standard capping method.
Beijing, Beijing MunicipalityAges 18–80 - NCT06922162Recruiting
Tickle stimulation for people with disorders of consciousness
This study tests if tickling specific body parts can trigger measurable brain responses in people with disorders of consciousness. It uses a non-invasive brain imaging technique called fNIRS to see how the brain reacts, which could help doctors better understand your condition.
Liège, BelgiumAges 18 years+ - NCT07614074Recruiting
Understanding Recovery from Coma and Unconsciousness
This study follows patients who have been in a coma (deep unconsciousness) for at least 24 hours due to a brain injury. Researchers will track how patients recover over time to better understand which factors help predict who will wake up and how well they'll recover.
San Francisco, CaliforniaAges 18 years+ - NCT04442971Recruiting
Music therapy for consciousness recovery after brain injury
This trial studies whether music therapy can help improve the level of consciousness in people recovering from a traumatic brain injury. If you are in early neurological rehabilitation, it may be offered as an add-on approach to support recovery.
Hessisch OldendorfAges 18–85 - NCT07456020Recruiting
Measuring awareness after brain injury in the ICU
This study checks how awake and aware you are using two standard checklists (CRS-R and SECONDs). It's for people with recent brain injuries in intensive care who are still very dependent.
Hessisch Oldendorf, Lower SaxonyAges 18 years+ - NCT04978857Recruiting
Virtual reality for people with minimal consciousness
This study tests whether guided virtual reality (“VR”) and other senses-based stimulation can help patients in a state of minimal consciousness become more aware. It focuses on whether the experience is safe and tolerable, with the goal of supporting awakening.
AngersAges 18 years+ - NCT05010265Recruiting
Learning how to detect hidden awareness using brain signals
This study explores an ethical approach to detecting “covert consciousness,” meaning a person may be aware even if they cannot show it clearly. It involves people connected to patients with disorders of consciousness, including caregivers and specialists, and uses information related to MRI or EEG brain testing done for clinical care.
Boston, MassachusettsAges 18 years+ - NCT07385508Recruiting
Rehabilitation study for people with disorders of consciousness
This study looks at how different types of rehabilitation (alone or combined) affect recovery in people with disorders of consciousness after a brain injury. It aims to find the best approaches to help improve outcomes.
Messina, SicilyAges 18–90 - NCT07539740Recruiting
Brain Stimulation to Help Improve Consciousness After Brain Injury
This study tests whether a non-invasive brain stimulation technique called transcranial theta-burst stimulation (tTIs) can help patients recover consciousness after severe brain injury. The treatment aims to improve responsiveness in people in vegetative states or minimally conscious states.
Guangzhou, GuangdongAges 18–70 - NCT06617377Recruiting
Can MRI predict brain recovery after cardiac arrest?
This study uses brain scans (MRI) to try to predict whether people who are still unconscious after a cardiac arrest will recover. It is looking for adults who are in a coma and have not woken up after being taken off sedation medicines for at least three days.
ToulouseAges 18 years+ - NCT06568536Recruiting
EEG Study to Predict Recovery After Brain Injury
This study uses a special EEG test to measure brain activity in people who are not fully conscious after a recent brain injury. The goal is to find better ways to know if someone will wake up and recover thinking abilities.
Boston, MassachusettsAges 18 years+ - NCT06389344Recruiting
Esketamine for consciousness after brain injury
This trial tests whether a medication called esketamine can help improve consciousness in people who have been in a coma or minimally conscious state after a brain injury. It is for patients who are about to have surgery, and aims to see if the drug can wake them up more.
Beijing, Beijing MunicipalityAges 16–65 - NCT07761507Recruiting
Ear stimulation to help wake up after brain bleed surgery
This trial tests a gentle ear stimulation device that may help people regain consciousness after surgery for a brain bleed. It is done while the person is in the hospital and may improve recovery.
BeijingAges 18–75 - NCT05539807Enrolling by invitation
Mindfulness program for binge-eating symptoms
This study looks at whether a mindfulness approach can help reduce symptoms related to binge eating. You may be eligible if you’re 16 or older and feel your eating problems involve binge eating.
Bergen, BergenAges 16 years+ - NCT06426615Recruiting
Understanding brain signals in unresponsive states after injury
This study looks at brain activity in people who are unresponsive after a brain injury. It uses advanced brain scans to see if there are hidden signs of consciousness, which could help doctors better understand and care for these patients.
Leuven, Vlaams-BrabantAges 18 years+ - NCT07127224Recruiting
Predicting recovery with smell tests in coma
This study tests whether a simple smell test can help predict recovery of consciousness in patients who remain in a coma or minimally conscious state after a severe brain injury. If you or your loved one has been unresponsive for several days after sedation is stopped, this trial may provide useful information about prognosis.
Paris, GHU Psychiatrie Et NeurosciencesAges 18 years+ - NCT07228286RecruitingEarly Phase 1
Using brain stimulation to help restore consciousness
This trial tests whether electrical stimulation of a deep brain area can improve awareness in people who have been in a coma-like state for at least 3 months after a brain injury. It aims to help those who have limited or no ability to communicate or use objects.
Boston, MassachusettsAges 18–55 - NCT07719595Recruiting
Vagus nerve stimulation for coma after brain injury
This trial tests if a gentle electrical stimulation of the vagus nerve (a nerve in the neck) can help people regain consciousness after a severe traumatic brain injury. It is for patients who are in a coma or minimally conscious state, and the treatment is given along with standard ICU care.
Stony Brook, New YorkAges 18 years+ - NCT04050995Recruiting
Testing MuSICCA to measure awareness in children
This study tests a tool called MuSICCA to check awareness in children and teens who are being evaluated for a disorder of consciousness. The results may help clinicians better understand a child’s awareness and guide care decisions.
Atlanta, GeorgiaAges 2–18 - NCT05187000Recruiting
Personalized brain stimulation for patients in coma after brain injury
This study tests whether personalized repetitive brain stimulation (rTMS) can improve symptoms in people diagnosed with disorders of consciousness after a recent brain injury. It compares treatment in a steady, safe way and checks whether the stimulation target matches your brain scan.
Guangzhou, GuangdongAges 18–70 - NCT05213169RecruitingPhase 2/Phase 3
Apomorphine for severe unresponsive brain injuries
This trial tests whether apomorphine can improve care or outcomes for people in an unresponsive wakefulness or minimally conscious state after a brain injury. It is designed for patients who are medically stable and not currently on certain brain- or heart- affecting medicines.
Liège, LiegeAges 18–80
Hear when a new Disorder of Consciousness trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for disorder of consciousness?
- Yes. Clin2 currently lists 60 recruiting disorder of consciousness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a disorder of consciousness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a disorder of consciousness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.