Clinical trials
Efficacy and Safety clinical trials
Below are recruiting efficacy and safety clinical trials, each written for real people, not researchers. We’re tracking 2,831 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06590259RecruitingPhase 2
Ablation plus drug therapy for colorectal cancer liver metastases
This trial tests a combination treatment that uses heat or cold (ablation) to destroy liver tumors along with medicines that boost your immune system to fight cancer. It is for people whose colorectal cancer has spread to the liver and who could not have surgery, or whose first treatment stopped working.
ShanghaiAges 18–75 - NCT07093866RecruitingPhase 2
Targeted drug combo for advanced prostate cancer
This trial tests a combination of two drugs—disitamab vedotin (a targeted antibody-drug that attacks HER2-positive cancer cells) and abiraterone (a hormone therapy)—to see if they can slow or shrink prostate cancer that has spread and become resistant to standard treatments.
Nanjing, JiangsuAges 18–75 - NCT07018947RecruitingPhase 2
Atezolizumab and bevacizumab before and after surgery for liver cancer
This trial tests whether adding two drugs (atezolizumab and bevacizumab) before and after surgery can lower the chance of liver cancer coming back in people with high-risk HCC. You must be eligible for surgical removal of your tumor.
Badalona, BarcelonaAges 18 years+ - NCT06588855RecruitingPhase 3
Study of afimkibart for moderate to severe ulcerative colitis
This trial is testing a new medication called afimkibart (RO7790121) for people with moderate to severe ulcerative colitis. It aims to see if this treatment can help reduce inflammation and improve symptoms in people who haven't had success with other therapies.
Dothan, AlabamaAges 16–80 - NCT06636552RecruitingPhase 2
Alternating drug combo plus daratumumab for newly diagnosed plasma cell leukemia
This trial tests a new treatment plan for people newly diagnosed with primary plasma cell leukemia (pPCL). It uses two different drug combinations that include daratumumab, given one after the other, followed by maintenance daratumumab. The goal is to see if this approach is safe and works well.
Athens, AtticaAges 18–80 - NCT05776173Recruiting
Gene-modified stem cell treatment for transfusion-dependent thalassemia
This trial tests whether giving you your own (autologous) gene-modified blood stem cells can improve transfusion-dependent beta-thalassemia and its safety. It may help people who do not have a fully matched donor and need an alternative approach to care.
ShanghaiAges 6–35 - NCT07147114RecruitingPhase 4
Combined macitentan and dapagliflozin for heart failure with lung high blood pressure
This trial tests whether adding two medications—macitentan and dapagliflozin—together is safe and effective for people with heart failure and a certain type of high blood pressure in the lungs. It might help improve your symptoms and daily function.
BusanAges 19 years+ - NCT06239311RecruitingPhase 3
Methotrexate vs placebo for adults with eczema
This trial tests if methotrexate, a medication that calms the immune system, can help adults with moderate-to-severe eczema that hasn't improved with creams or other treatments. You'll either receive methotrexate or a placebo to see which works better.
Prague, Praha 1Ages 18 years+ - NCT06585345RecruitingPhase 1/Phase 2
CD7 CAR-T for relapsed or refractory acute leukemia
This trial tests a new immune therapy called CD7 CAR-T cells for people with acute leukemia that has come back or hasn't gotten better with standard treatments. It aims to see if this treatment is safe and can help control the leukemia.
Chengdu, SichuanAges 14–65 - NCT07412470RecruitingPhase 2/Phase 3
Testing frexalimab vs tacrolimus for new kidney transplant patients
This trial compares a new drug called frexalimab to the standard drug tacrolimus in people who are getting their first kidney transplant. The goal is to see if frexalimab works better and has a safer side effect profile.
Boston, MassachusettsAges 18–70 - NCT06924996Enrolling by invitation
Thrombectomy for large stroke in back of the brain
This trial is testing whether a clot removal procedure, called endovascular thrombectomy, can help people who have a large stroke in the back part of the brain. To be eligible, the stroke must be from a blocked artery in the base of the skull, and the stroke must be severe and recent.
Beijing, Beijing MunicipalityAges 18–80 - NCT07122024RecruitingPhase 4
Testing a dual therapy for H. pylori treatment
This trial tests a two-drug treatment (keverprazan and amoxicillin) for people who have H. pylori and have not been treated for it before. The goal is to see if this newer combination works well and is safe.
Hangzhou, ZhejiangAges 18–65 - NCT05927428RecruitingPhase 2
Eye drops for neurotrophic corneal ulcers
This Phase 2 trial tests BRM424 eye drops in adults with neurotrophic keratitis (a weakened, slow-healing cornea) to see if they help and are safe over 28 days. You may be able to join if your condition matches Stage 2 or Stage 3 and you meet the safety rules.
Leland, North CarolinaAges 18 years+ - NCT07392346RecruitingPhase 2
Fruquintinib combo for advanced gastric cancer after immunotherapy
This trial tests a combination of targeted therapy (fruquintinib), chemotherapy (nab-paclitaxel), and two immunotherapies (iparomlimab and tuvonralimab) for people with advanced stomach or gastroesophageal junction cancer whose first treatment with a PD-1/PD-L1 inhibitor stopped working. The goal is to see if this new combination can shrink tumors and improve outcomes.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07388576Recruiting
AP-Brain supplement for attention in healthy young adults
This trial tests a supplement called AP-Brain to see if it helps with attention and focus in healthy young adults (ages 18–39) who feel they have attention problems. It compares different doses to find the safest and most effective one.
London, OntarioAges 18–39 - NCT06880380RecruitingPhase 1
CAR-T cell therapy for functional HIV cure
This trial tests whether CAR-T cells can help control HIV without daily antivirals. It is for people with well-controlled HIV who want to explore a potential functional cure.
Tianjin, Tianjin MunicipalityAges 18–65 - NCT07387952Recruiting
Fecal transplant with nutrition help for chronic constipation
This trial tests if a fecal microbiota transplant combined with nutritional support can improve chronic constipation that hasn't gotten better with standard treatments. It's a small early study to see if the approach is safe and works.
BeijingAges 18–70 - NCT06950242Enrolling by invitation
Laser balloon for narrowed brain arteries
This trial tests a new laser balloon catheter to widen narrowed arteries in the brain that cause stroke symptoms. It may help if you have a severely blocked artery and are healthy enough for the procedure.
Changzhou, JiangsuAges 18–80 - NCT07492693RecruitingPhase 2
Preventing low platelets from chemo in GI cancers
This trial tests if hetrombopag can prevent low platelet counts caused by chemotherapy in people with gastrointestinal cancers. It may help reduce the risk of bleeding and the need for platelet transfusions.
ShanghaiAges 18 years+ - NCT07374679Recruiting
Long-term safety and effectiveness of stem cells for rotator cuff disease
This study follows up with people who already received an experimental stem cell treatment for rotator cuff disease in a previous trial. It aims to check if the treatment remains safe and effective over time.
Seoul, KoreaAges 19 years+ - NCT07371572RecruitingPhase 3
Steroid Injection for Hand Osteoarthritis
This study tests whether a steroid injection into the muscle can reduce pain and improve hand function in people with hand osteoarthritis. It is for those whose pain is moderate to severe and hasn't been helped enough by standard pain medications.
Ubbergen, GelderlandAges 16 years+ - NCT07005752RecruitingPhase 4
CnU capsule for cholesterol gallstones
This trial tests if CnU capsules shrink cholesterol gallstones in people who have stones smaller than 15 millimeters. It aims to help people dissolve stones without surgery.
Ansan, Gyeonggi-doAges 19 years+ - NCT07452744Enrolling by invitation
Picroliv for non-alcoholic fatty liver disease
This study tests a plant-based medicine called Picroliv for people with non-alcoholic fatty liver disease (NAFLD). It aims to see if it is safe and can reduce fat in the liver.
Chandigarh, ChandigarhAges 18–60 - NCT07362927RecruitingEarly Phase 1
Gene therapy trial for diabetic macular edema
This study tests a new gene therapy called LX111 for diabetic macular edema (DME) that has not improved enough with previous injections. It aims to see if a single treatment can reduce swelling and improve vision.
ShanghaiAges 18 years+
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Common questions
- Are there clinical trials for efficacy and safety?
- Yes. Clin2 currently lists 2,831 recruiting efficacy and safety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a efficacy and safety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a efficacy and safety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.