Clinical trials
Fracture clinical trials
Below are recruiting fracture clinical trials, each written for real people, not researchers. We’re tracking 501 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06337292RecruitingPhase 3
Wound vacuum therapy for high-risk leg fractures
This trial tests if a special wound vacuum (negative pressure therapy) applied after surgery can lower the risk of infections and other complications in people with severe leg fractures. If you have a high-risk tibia or ankle fracture, this treatment may help you heal better.
Baltimore, MarylandAges 18 years+ - NCT06289478Recruiting
Tranexamic acid for bleeding during hip replacement surgery
This study tests whether a medicine called tranexamic acid (TXA), given as a shot into the hip joint or as a soak on the skin, can reduce bleeding during hip replacement surgery. It is for people over 60 who broke their hip from a simple fall and need a cementless hip replacement.
Bangkok, BangkokAges 60 years+ - NCT06293469Recruiting
Speeding up flap surgery for severe leg injuries
This trial tests whether performing flap surgery sooner after a severe leg injury below the knee leads to better outcomes. If you have an open fracture or dislocation that needs a flap, you may be able to join.
Sacramento, CaliforniaAges 18 years+ - NCT06286670Recruiting
Comparing one versus two implants for thigh bone breaks
This trial is testing whether using two metal implants to fix a broken thigh bone (near the knee) works better than using just one. It aims to help patients with certain types of fractures that need surgery.
Birmingham, AlabamaAges 18 years+ - NCT06249126Recruiting
Heel bone fusion for severe fractures
This trial tests whether fusing the joint just below the ankle (subtalar joint) during heel bone fracture repair helps people with severe fractures heal better. You may qualify if you have a specific type of broken heel bone and can return for follow-up visits for one year.
Orange, CaliforniaAges 18 years+ - NCT04976335Recruiting
Tests a gel that helps wrist tendon movement after fracture repair
This study looks at whether a bio-dissolving (self-absorbing) gel improves how well the wrist flexor tendons glide after surgery for a distal radius fracture. You may be randomly assigned to use the gel or not, and the researchers will measure wrist tendon and clinical outcomes to see if it helps.
Aurora, ColoradoAges 18 years+ - NCT06179004RecruitingPhase 3
Numbing medicine comparison for wrist surgery pain
This study compares two types of numbing medicine (bupivacaine and liposomal bupivacaine) given near the collarbone before wrist surgery to see which provides better pain relief afterward.
Chapel Hill, North CarolinaAges 18 years+ - NCT05642026RecruitingPhase 4
Continuous nerve block for pain from multiple broken ribs
This study tests a continuous nerve block—a numbing medicine delivered near the nerves—to reduce pain from rib fractures. It may help people with two or more broken ribs manage pain more effectively while recovering.
Lexington, KentuckyAges 18 years+ - NCT06113211RecruitingPhase 4
Non-opioid pain control after fracture surgery
This trial tests a combination of non-opioid medications to manage pain after surgery for a broken bone, aiming to reduce or avoid the use of opioids. It may help you control pain without the risks of strong painkillers.
Detroit, MichiganAges 18–80 - NCT06069154Enrolling by invitation
Freezing nerves for rib fracture pain
This study tests a procedure called cryoneurolysis, which uses cold to temporarily freeze nerves near broken ribs to relieve pain. It is for adults who have 1 to 6 recently broken ribs with at least moderate pain and are already getting a nerve block injection.
La Jolla, CaliforniaAges 18 years+ - NCT06055712Enrolling by invitationPhase 4
Antibiotics for children with open fractures
This trial tests whether giving antibiotics can prevent infections in children with mild open fractures (grade 1 or 2) that don't need surgery. It aims to find a safer, simpler treatment plan.
St Louis, MissouriAges birth–17 years - NCT05972005Recruiting
At-home rehab for older adults after a hip fracture
This trial tests a support program for people age 55+ after a hip fracture, focusing on better recovery at home (or a retirement home). It may help improve outcomes after leaving the hospital by providing guidance and follow-up tailored to you.
Kingston, OntarioAges 55 years+ - NCT05964140RecruitingPhase 3
Testing antibiotics after jaw fracture surgery
This trial studies whether giving (or how giving) antibiotics affects outcomes after surgery for a broken lower jaw (mandible). It may help reduce infection risk and antibiotic-related side effects if the right approach is chosen for the right patients.
Blackburn, LancashireAges 18 years+ - NCT05022485Recruiting
Check infection prevention in high-risk tibia fractures using a special nail
This study follows people age 18+ who broke the tibia (shin bone) and are at higher risk for infection. It compares a standard internal metal nail to a special coated nail to see which one lowers infection problems and supports healing.
InnsbruckAges 18 years+ - NCT05877014RecruitingPhase 3
Compare two fixation methods for adult arm shaft fractures
This trial tests whether one surgical technique (for stabilizing the upper-arm bone using a rod placed inside the bone) works better than another for adult humeral shaft fractures. It may help find the approach that leads to better healing and recovery.
DijonAges 18 years+ - NCT05851898RecruitingPhase 4
Tested medicine to prevent depression after hip or leg fractures
This trial studies whether a type of antidepressant medicine (a serotonin–norepinephrine reuptake inhibitor) can prevent depression after a lower-extremity fragility fracture that was treated with surgery. It’s mainly for older adults, and aims to see if starting this medicine early reduces later depression symptoms.
Winston-Salem, North CarolinaAges 65 years+ - NCT05766670RecruitingPhase 3
Calcium and antibiotic placed inside tibia nail for open fractures
This Phase 3 study tests whether a calcium/antibiotic “depot” released from an intramedullary nail can lower infection risk in certain open tibia fractures. It may help by delivering antibiotics right at the fracture area while the nail fixes the bone.
Los Angeles, CaliforniaAges 18 years+ - NCT05686278Recruiting
Study of long-term outcomes after hip hemiarthroplasty
This is an observational study that follows people over time after hip hemiarthroplasty (a partial hip replacement). It aims to understand how well Corin hip devices work long-term in everyday care, and what outcomes to expect.
Amboise, FranceAges 18 years+ - NCT05680987Recruiting
Surgery method study for certain thighbone fractures
This study looks at a specific surgical fixation method (how the thighbone pieces are held together) for distal femur or femoral shaft fractures. It aims to compare outcomes and see if this approach works well, especially by tracking results after surgery.
San Diego, CaliforniaAges 18 years+ - NCT05548972Enrolling by invitation
Follow-up study of a hip replacement to improve implant wear
This study checks how well a specific hip replacement bearing surface (called dual mobility with Vivacit-E or Longevity) performs over time in real-world patients. It may help people by tracking long-term safety and performance to guide better hip replacement choices.
Little Rock, ArkansasAges 18–80 - NCT05514405Recruiting
Testing two anesthesia medicines to prevent confusion after surgery
This trial tests whether using remimazolam or propofol during hip or knee replacement surgery can lower the risk of postoperative delirium, a sudden, short-term confusion that can happen after anesthesia. It may help people who are at higher risk of postoperative confusion by finding the safer anesthesia approach.
SeoulAges 65–100 - NCT05521958Enrolling by invitation
Gene activity study in severe leg muscle swelling after fracture
This study looks at gene activity (what genes are “turned on or off”) in the lower leg in people with acute compartment syndrome after a tibia (shin bone) injury. The goal is to better understand what is happening in the body and potentially guide future treatment decisions.
Salt Lake City, UtahAges 18–90 - NCT05421741RecruitingPhase 4
Antibiotic-coated nail to help prevent infection
This trial studies a special nail for certain broken shin bones to lower the chance of infection after surgery. If you qualify, the study team will help you receive the antibiotic-coated nail and will follow you closely for about a year.
Gainesville, FloridaAges 18 years+ - NCT05425355RecruitingPhase 4
IV versus oral acetaminophen after hip-fracture surgery
This trial compares giving acetaminophen (Tylenol) through a vein versus by mouth after hip-fracture surgery. It may help find which method works better for pain control and recovery in adults.
Toronto, OntarioAges 60 years+
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Common questions
- Are there clinical trials for fracture?
- Yes. Clin2 currently lists 501 recruiting fracture studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a fracture trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a fracture trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.