Clinical trials
Genetic Disease clinical trials
Below are recruiting genetic disease clinical trials, each written for real people, not researchers. We’re tracking 224 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06705543Recruiting
Genetic study of complex heart defects in unborn babies
This study looks at the genetic material in the fluid around the baby (amniotic fluid) and in the placenta to better understand complex heart defects in unborn babies. The goal is to find new clues that could help doctors care for these babies before and after birth.
BordeauxAges 18 years+ - NCT05473637Recruiting
Study causes of small vessel brain disease in stroke and memory issues
This trial looks at people who may have “small vessel” problems in the brain, which can cause stroke, memory trouble, walking changes, movement symptoms, or headaches. It may help researchers better understand the genetic and non-genetic causes, which could improve future diagnosis and treatment.
TaipeiAges 18 years+ - NCT04472338Recruiting
Prostate cancer screening for people with higher genetic risk
This study looks at prostate cancer screening for people who may be at higher risk because of a specific inherited (genetic) change. It may help your care team find the best screening approach to catch aggressive prostate cancer earlier.
Duarte, CaliforniaAges 40 years+ - NCT04854213Recruiting
Study checks radiation effects in colon cancer lung-limited spread
This trial studies how targeted radiation (SBRT) affects cancer biology and immune cells in people with colon cancer that has spread only to a small number of lung nodules. Your tumor tissue will be analyzed to see what changes after treatment.
Naples, NAPOLIAges 18–80 - NCT05930899Recruiting
Study tissue and blood samples from heart disease patients
This study builds a biobank, meaning it collects and stores your health information, blood, and possibly heart-related samples to help researchers learn why heart conditions happen. You might join if you have certain heart diagnoses and are having cardiac surgery for a problem other than an aortic valve issue.
Montreal, QuebecAges 19 years+ - NCT02824822Recruiting
Genetic test study for heart rhythm risk in people with seizures
This study checks whether genetic markers are linked to heart rhythm problems in people with epilepsy or seizure-related events, and in some close relatives. It may help doctors better spot who is at risk for dangerous heart rhythm issues.
Rochester, MinnesotaAges 18–50 - NCT02923440Recruiting
Donate DNA and help build a congenital heart study database
This study creates a DNA bank and a French database for babies and children with certain types of congenital heart defects, to better understand genetic causes. You’ll be asked to have a blood test and share consent, even though care can continue as usual at the study hospital.
MarseilleAges Any age - NCT06561906Recruiting
Early Alzheimer's detection using scans, genetics and blood
This study uses brain scans, blood tests, and genetic information to find early signs of Alzheimer's disease before memory problems start. It aims to predict who might develop Alzheimer's in the future.
Nanjing, JiangsuAges 50–79 - NCT00710112Recruiting
Genetic risk study in very low birth-weight babies
This study looks at genetic differences to understand why some very low birth-weight babies develop certain health problems. It may help doctors predict risk and tailor care for these babies.
Milwaukee, WisconsinAges Any age - NCT05851209Recruiting
Study biomarkers in people with moderate aortic valve narrowing
This study looks at blood and/or body signals (called biomarkers) to understand why aortic valve narrowing may worsen and what outcomes people have. You may be able to help researchers by undergoing regular heart care plus additional testing like MRI or CT if you qualify.
BonnAges 18 years+ - NCT03305835Recruiting
Genetic testing for inherited kidney stone causes
This study uses genetic testing to look for inherited (“monogenic”) reasons some people get kidney stones. It may help explain the cause of stones and calcium-related problems, which can guide future care for you or your family.
Rochester, MinnesotaAges Any age - NCT05649098RecruitingEarly Phase 1
Testing dupilumab for itchy inherited genetic skin disorders
This early trial tests whether dupilumab can reduce itching in people with certain inherited (genetic) inflammatory skin conditions. It may help by calming skin inflammation that causes ongoing itch and sleep problems.
Chicago, IllinoisAges 6 months+ - NCT01558479Recruiting
Parkinson’s genetics study for adults in affected families
This study looks at genetic (inherited) factors in Parkinson’s disease. It may help researchers better understand why Parkinson’s happens and could guide future prevention or treatments.
Atlanta, GeorgiaAges 18 years+ - NCT06377033Recruiting
Using health records to advance genomic medicine for all
This study uses electronic health records to learn how to improve genomic medicine across a diverse health system. It may help make DNA-based healthcare more accessible and effective for people with certain conditions.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05799118Recruiting
Genetic modifiers study for inherited blood disorders
This study looks at how your genes can affect inherited blood conditions like sickle cell disease and thalassemia. It may help researchers understand why symptoms differ from person to person, which could guide better future treatments.
Boston, MassachusettsAges 2 years+ - NCT01316783Enrolling by invitation
Genetics study of obesity, diabetes, and heart risk
This study looks at genetic differences in adults from African diaspora groups to better understand risks for obesity, type 2 diabetes, and heart disease. You may help scientists learn why these conditions are more common in certain communities.
Bethesda, MarylandAges 18–120 - NCT06455384Recruiting
Studying a digital tool for genetic testing services
This trial tests a new online tool called the Genetics Navigator, which helps people access genetic testing services more easily. If you or your child have been referred for genetic testing at Mount Sinai Hospital or SickKids in Toronto, this study may help you manage the process online.
Toronto, OntarioAges 18 years+ - NCT05990179Recruiting
Screening newborns for rare diseases using genetics
This trial offers free genetic screening for rare diseases in newborns. It aims to find health conditions early so babies can get the right care sooner.
New York, New YorkAges 1 day–1 month - NCT03855657Recruiting
Biobank study of gut microbes, genes, and blood chemistry
This study collects samples to learn how gut microbes, genetics, and body chemistry may relate to Crohn’s disease or ulcerative colitis. Your information and samples may help researchers understand disease patterns, but it does not test a new drug.
Hong KongAges 18 years+ - NCT06102070Recruiting
Genetic study of severe infections
This study looks for genetic reasons why some people get very serious infections. If you or a family member has had a rare, severe infection, researchers will analyze your DNA to find genes that might make you more vulnerable.
Paris, Île-de-France RegionAges Any age - NCT06393894Recruiting
Latvian Early Atherosclerosis Registry Study
This study is gathering information from people with early heart artery blockages (occurring before age 55 for men or 65 for women) who need or have had treatment like stents or bypass. It helps doctors understand long-term outcomes.
RigaAges 18–65 - NCT05339048Enrolling by invitation
Study of adults from Colombia’s Caribbean coast
This study follows adults who were born or are from Colombia’s Caribbean coast. The goal is to learn about health patterns in this community, but you would not be able to join if you meet certain medical or disability-related criteria.
Cartagena, Departamento de BolívarAges 18–80 - NCT06376279Enrolling by invitation
Genetic testing for metabolic diseases
This trial uses genetic testing to find the cause of suspected metabolic diseases, including some cases of epilepsy. It may help you get a clearer diagnosis and guide treatment.
Ages Any age - NCT00272883Recruiting
Study genes in congenital muscle weakness
This research study looks at genes and molecules to better understand congenital myopathies (birth-related muscle weakness). It may help explain the cause of symptoms and improve future diagnoses for you and your family.
Boston, MassachusettsAges Any age
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Common questions
- Are there clinical trials for genetic disease?
- Yes. Clin2 currently lists 224 recruiting genetic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a genetic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a genetic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.