Clinical trials
Glioma clinical trials
Below are recruiting glioma clinical trials, each written for real people, not researchers. We’re tracking 339 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04274283Recruiting
Study of brain tumor samples and blood tests
This trial studies newly diagnosed or progressing brain tumors (grade 2–4 gliomas) to better understand the disease using tumor tissue and blood samples. It may help doctors learn which treatments could work best for different tumor types by matching tumor material to blood results.
BirminghamAges 16 years+ - NCT04541082RecruitingPhase 1
Oral ONC206 for recurrent brain and spinal tumors
This early-phase study tests an oral medicine called ONC206 in adults with recurrent, rare brain or spinal cord tumors. The goal is to find a safe dose and look for signs the treatment can shrink or control the cancer.
Bethesda, MarylandAges 18 years+ - NCT04648462Recruiting
Proton therapy planning for certain brain tumors
This study builds and tests how proton therapy planning could better protect the brain compared with standard radiation (photon therapy) for adults with certain brain tumors. It may help reduce radiation to sensitive areas like the hippocampus, with the goal of better long-term brain function.
Maastricht, LimburgAges 18 years+ - NCT04794972RecruitingPhase 1
Testing a targeted antibody for advanced solid tumors
This Phase 1 trial tests a new antibody drug (GNC-039) that targets a specific feature found on some cancer cells. It is for adults with solid tumors that have come back or stopped responding to standard treatment, aiming to see safety and early signs of effectiveness.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04945148RecruitingPhase 2
Metformin plus radiation and chemo for glioblastoma subtype
This Phase 2 study tests whether adding metformin to standard radiation and temozolomide (chemo) can improve outcomes for people with newly diagnosed glioblastoma of a specific metabolic subtype. It aims to see if this combination is safer and more effective than standard treatment alone.
Suresnes, Hauts de SeineAges 18 years+ - NCT05049148Recruiting
Study platelets in brain and spinal tumors
This study looks at how blood “platelets” may be involved in brain or spinal (medullary) tumors by testing tumor tissue taken during surgery or biopsy. It may help researchers understand disease biology and guide future treatments.
ParisAges 18 years+ - NCT05190172Recruiting
Proton versus photon radiation for IDH-mutated brain tumors
This trial compares two types of radiation—proton therapy versus photon (standard) therapy—for adults with an IDH-mutated grade 2 or 3 brain tumor. The goal is to see which approach works better and/or causes fewer side effects while treating the tumor.
OsloAges 18–65 - NCT05226494RecruitingPhase 1
Test drug fb-PMT in recurrent brain cancer patients
This Phase 1 study tests how safe and tolerable fb-PMT is for people with glioblastoma that has come back. It also helps doctors learn the best way to give it and what side effects to watch for.
New Haven, ConnecticutAges 18 years+ - NCT05254197Recruiting
Brain tumor monitoring study with follow-up brain scans
This study follows people with lower-grade (WHO grade 2 or less) brain tumors using repeat MRI scans over time. It helps doctors understand how these tumors change and which patients may safely delay treatment at first.
SeoulAges 18 years+ - NCT05271240RecruitingPhase 3
Targeted brain-artery drug added to standard treatment for new GBM
This Phase 3 trial tests whether delivering a cancer drug directly into brain blood vessels, along with standard radiation and temozolomide, works better than standard treatment alone in newly diagnosed glioblastoma (GBM). The goal is to improve control of the tumor while comparing side effects between the two approaches.
New York, New YorkAges 18 years+ - NCT05274919Recruiting
Brain tumor MRI pattern study to map tumor genetics
This study uses special “pattern mapping” from brain MRI scans to see whether MRI images reflect a brain tumor’s genetic type. It may help doctors better match MRI findings to tumor characteristics using scans they may already need for diagnosis.
LeidenAges 18 years+ - NCT05293197RecruitingPhase 1
Safety study of repeated blood-brain barrier opening for pediatric brain tumors
This Phase 1 study tests whether a device can safely and repeatedly open the blood-brain barrier (a protective shield in the brain) in children with malignant brain tumors. It aims to help the tumor treatment work better while watching for safety issues.
ParisAges 5–17 - NCT05331521RecruitingPhase 3
Study to improve brain function in newly diagnosed glioma patients
This Phase 3 study tests a treatment plan after surgery to improve brain function and quality of life in adults with newly diagnosed, specific types of brain tumors (gliomas). It may help you keep thinking clearly and living better while your tumor is treated with standard medicines.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT05355701RecruitingPhase 1
Testing a new drug for advanced cancers with BRAF changes
This Phase 1 trial studies PF-07799933, a new medicine, in people whose advanced solid tumors have specific BRAF genetic changes. It may help if your cancer has continued to grow after standard treatments, and there may be specific options depending on your cancer type and past therapies.
Fayetteville, ArkansasAges 16 years+ - NCT05386043Recruiting
Study brain tumor testing with MRI and extra tissue samples
This study looks at how brain tumors look on MRI and what biopsy tissue shows, using samples taken during planned surgery. It may help improve understanding of tumor biology and future treatment planning.
Indianapolis, IndianaAges 18 years+ - NCT05460507RecruitingPhase 1
Re-treating brain tumor with radioactive liposome after prior dose
This Phase 1 trial tests whether a radioactive treatment delivered in tiny fat “packets” is safe and tolerable when given again to people whose glioma (brain tumor) came back after a previous similar treatment. It also looks at how well this re-treatment works in carefully selected patients.
San Antonio, TexasAges 18 years+ - NCT05464992Recruiting
PET/MRI scan study using a special brain MRI technique
This trial studies whether a special type of MRI during a PET/MRI scan (called CEST) can help doctors better evaluate brain tumors and tumor return after treatment. It may improve how well scans show where disease is before surgery or when tumors come back.
StrasbourgAges 18 years+ - NCT05500391RecruitingPhase 2
Testing whether remote nurse monitoring works like in-person checks
This Phase 2 study compares two ways of checking your cancer follow-up: a doctor or nurse visits in person versus remote monitoring by phone and imaging. The goal is to see whether remote monitoring can safely replace or match in-person care for certain low-risk cancers and after surgery.
AmiensAges 18 years+ - NCT05512403RecruitingPhase 3
Test of FDOPA PET scan to evaluate a brain tumor
This study checks how well an FDOPA PET scan can identify and describe a specific type of brain tumor at the beginning. Results may help doctors decide on the best next steps for diagnosis and treatment planning.
Vandœuvre-lès-NancyAges 18–75 - NCT05556473RecruitingPhase 1
Tryptophan PET/CT scan study for different tumors
This early-phase study tests a special PET/CT scan using labeled tryptophan to help doctors see how different tumors behave. The goal is to learn whether this scan can better identify and measure cancers in the brain or elsewhere.
Detroit, MichiganAges 18 years+ - NCT05564949Recruiting
Ketogenic diet for brain tumors after standard treatment
This trial studies whether a very low-carbohydrate diet (a ketogenic diet) can help people with certain brain tumors. It’s meant as an added treatment alongside the usual care to see if it’s safe and potentially beneficial.
Chaïdári, AthensAges 18–80 - NCT05576103Recruiting
Study of brain tumor thinking and MRI during radiation
This study follows adults with a primary brain tumor to understand how thinking skills and brain images change over time during radiation therapy. It may help researchers measure treatment effects and better track brain changes.
San Diego, CaliforniaAges 18–99 - NCT05588141RecruitingPhase 1/Phase 2
Zotiraciclib for recurrent brain tumors with IDH mutations
This early-phase study tests zotiraciclib in people with recurring diffuse gliomas (brain tumors) that have an IDH1 or IDH2 mutation. It may help slow the tumor or shrink it by targeting a specific change in tumor biology.
Bethesda, MarylandAges 15 years+ - NCT05622409Recruiting
Tissue and genetic data registry for diffuse glioma in adults
This study collects tumor tissue and basic medical information to better understand the genes involved in adult diffuse glioma. It may help future treatments by building a detailed research database and matching patients to study arms.
Kaohsiung CityAges 20 years+
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Common questions
- Are there clinical trials for glioma?
- Yes. Clin2 currently lists 339 recruiting glioma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a glioma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a glioma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.