Clinical trials
Glioma clinical trials
Below are recruiting glioma clinical trials, each written for real people, not researchers. We’re tracking 339 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06712875RecruitingPhase 1/Phase 2
Brain cancer drug combo for kids with BRAF mutations
This trial tests a combination of targeted therapy (dabrafenib and trametinib) and immunotherapy (nivolumab) for children and young adults with certain BRAF gene changes in their glioma. It aims to see if this drug combination can shrink tumors or stop them from growing.
Washington D.C., District of ColumbiaAges 1–26 - NCT06975332Recruiting
Targeted radiation therapy for recurrent high-grade glioma
This trial tests a new radiation treatment that targets tumor cells directly. It may help people with a specific type of aggressive brain tumor that has grown after standard treatments.
Warsaw, PolandAges 18–80 - NCT07179328RecruitingPhase 1
Focused ultrasound for glioblastoma during standard chemo
This trial tests whether focused ultrasound can safely open the blood-brain barrier to help your chemotherapy work better. It is for people with glioblastoma who have already completed standard surgery and chemo-radiation and are now on maintenance chemo.
Toronto, OntarioAges 18–85 - NCT07286929Recruiting
Study on vision and space problems in people with parietal lobe glioma
This study looks at how vision and spatial awareness problems change over time in people with a glioma in the parietal lobe (a part of the brain). It may help doctors better understand and support these patients.
MilanAges 18 years+ - NCT07306299RecruitingPhase 1
MRNA vaccine for recurrent high-grade glioma
This trial tests a new mRNA vaccine for people with a type of brain tumor called high-grade glioma that has come back or progressed. The vaccine is designed to help your immune system recognize and attack the tumor cells.
Hangzhou, ZhejiangAges 16 years+ - NCT05538130RecruitingPhase 1
Study medicine for BRAF-mutated advanced solid tumors
This Phase 1 trial studies how PF-07799544 works and what dose is safest in people with advanced cancer that has a specific genetic change called BRAF V600. You may receive it alone or with another treatment, depending on the tumor group, to see if it can treat the cancer.
Birmingham, AlabamaAges 16 years+ - NCT05303519RecruitingPhase 3
Safusidenib for IDH1-mutant glioma after main treatment
This Phase 3 trial tests safusidenib, a targeted medicine, to help stop or slow the return of certain brain tumors with an IDH1 mutation. It focuses on people after initial treatment (surgery and/or radiation and temozolomide), aiming to improve outcomes during maintenance therapy.
Birmingham, AlabamaAges 18 years+ - NCT07374692Recruiting
Study of treatments for advanced brain and spinal cord tumors
This study looks at how different treatments work for people with advanced brain or spinal cord tumors that have come back. It helps doctors learn more about these tumors and how to better treat them.
Bethesda, MarylandAges 15–120 - NCT02619890Recruiting
Brain tumor registry using clinical and brain scan information
This study collects information about people with brain gliomas, including what treatments they receive and what their brain scans show. It’s meant to help researchers better understand these tumors and how they respond to first- or second-line therapy.
SeoulAges 18 years+ - NCT07675070Recruiting
Temozolomide (Amitzo) for grade III or IV brain tumors
This trial studies a new form of the chemotherapy drug temozolomide (called Amitzo) in people with aggressive brain tumors (grade III or IV gliomas). It aims to see if the drug is safe and effective, and is for patients who need treatment for a new diagnosis or for tumors that have come back after standard care.
TehranAges 18–80 - NCT00870129Recruiting
MRI mapping to plan radiation for certain brain tumors
This study uses MRI scans to find higher-risk areas in certain brain and other solid tumors and help plan radiation treatment. It also looks for changes in tumor “metabolites” (chemicals in the tumor) that may relate to how the tumor behaves.
New York, New YorkAges 18 years+ - NCT07612917Recruiting
Brain Activity Changes in Glioma Patients During Treatment
This study tracks how brain activity and connections change in patients with gliomas (brain tumors) as they receive treatment. Researchers use special brain scans to understand how treatment affects the brain's function, which may help improve care for glioma patients in the future.
Linz, Upper AustriaAges 18–64 - NCT06896110Enrolling by invitationPhase 1
Spinal chemo and immunotherapy for recurrent high-grade glioma
This trial tests a combination of two drugs—azacitidine and nivolumab—given directly into the spinal fluid for people whose high-grade glioma has come back after initial treatment. The goal is to see if this approach can safely target the tumor and slow its growth.
Iowa City, IowaAges 13 years+ - NCT06492486RecruitingPhase 2
Brain tumor radiation study using AI planning
This trial tests a new way to plan radiation therapy for brain tumors (gliomas) using artificial intelligence. It aims to make treatment more precise and personalized for people with either aggressive (GBM) or slower-growing (IDH-mutant) gliomas.
Mumbai, MaharatshtraAges 18–70 - NCT05212272Recruiting
MRI plus cognitive testing during glioma chemoradiation
This study uses MRI scans and related brain/cognitive testing while you receive standard chemotherapy and radiation for a high-grade brain tumor. It aims to see how MRI measures and brain testing may relate to your treatment response or brain function.
Winston-Salem, North CarolinaAges 18 years+ - NCT07750457Recruiting
Proton versus standard radiation for slow-growing brain tumors
This trial compares two types of radiation therapy (proton beams vs. standard photon x-rays) for people with certain slow-growing brain tumors (gliomas) that have a specific gene change. The goal is to see which type better preserves thinking skills and quality of life while treating the tumor.
EssenAges 18 years+ - NCT06794736Recruiting
Study on metabolic profiles in lower-grade gliomas
This study looks at how lower-grade gliomas (a type of slow-growing brain tumor) use energy. It may help doctors better understand the tumor and choose the best treatment for you.
Bari, ApuliaAges 18 years+ - NCT04775485RecruitingPhase 2
Targeted medicine for children with certain brain or solid tumors
This Phase 2 study tests tovorafenib, a targeted cancer medicine, in children and young adults whose tumors have specific BRAF or RAF changes. It is for cancers that have come back or grown despite previous treatment, with measurable signs on scans.
San Francisco, CaliforniaAges 6 months–25 years - NCT04316039RecruitingPhase 2/Phase 3
Radiation alone or with temozolomide for brain tumor after surgery
This trial compares standard radiation therapy versus radiation plus a chemotherapy medicine called temozolomide in people with a newly diagnosed low-grade (WHO grade II) brain glioma after surgery. It’s designed to see if adding temozolomide improves outcomes while managing side effects.
Chengdu, SichuanAges 18–70 - NCT06747728Recruiting
Bevacizumab before surgery for new high-grade brain tumors
This trial tests whether giving bevacizumab (a drug that blocks blood vessel growth) before surgery helps treat newly diagnosed high-grade gliomas. It may be an option for adults who have not had prior anti-angiogenic therapy.
Zhengzhou, HenanAges 18 years+ - NCT07710040RecruitingPhase 1
Proton radiation before surgery for high-grade brain tumors
This trial tests proton radiation therapy given before surgery for people with a single, high-grade brain tumor. The goal is to see if pre-surgery radiation helps with treatment outcomes.
Obninsk, Kaluga OblastAges 18 years+ - NCT07655869RecruitingEarly Phase 1
Lu177-DOTA-EB-RGD2 therapy for returning high-grade glioma
This trial tests a radioactive drug that targets a protein on tumor blood vessels to treat glioblastoma that has come back after standard treatment. It may help shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05964569RecruitingPhase 2
Personalized planning for proton radiation in low-grade brain tumors
This Phase 2 study tests a personalized, computer-guided way to plan proton beam radiation for adults with low-grade glioma. The goal is to see if the approach is feasible and can improve how treatment is planned.
HeidelbergAges 18 years+ - NCT06381570RecruitingEarly Phase 1
Vinblastine and tovorafenib for recurring pediatric low-grade glioma
This trial is testing a combination of two drugs, vinblastine and tovorafenib, for children and young adults (up to age 25) whose low-grade glioma has come back or worsened after prior treatment. It is for people whose tumor has a specific change in a gene called BRAF or CRAF.
Toronto, OntarioAges birth–25 years
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Common questions
- Are there clinical trials for glioma?
- Yes. Clin2 currently lists 339 recruiting glioma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a glioma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a glioma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.