Clinical trials
Glioma clinical trials
Below are recruiting glioma clinical trials, each written for real people, not researchers. We’re tracking 333 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06660056RecruitingPhase 1
GC001 injection for returning or growing high-grade brain tumors
This trial tests a new drug, GC001, injected directly into the tumor in people with high-grade gliomas (WHO grade 3 or 4) that have come back or are growing. It may be an option if standard treatments have stopped working.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07306299RecruitingPhase 1
MRNA vaccine for recurrent high-grade glioma
This trial tests a new mRNA vaccine for people with a type of brain tumor called high-grade glioma that has come back or progressed. The vaccine is designed to help your immune system recognize and attack the tumor cells.
Hangzhou, ZhejiangAges 16 years+ - NCT07286929Recruiting
Study on vision and space problems in people with parietal lobe glioma
This study looks at how vision and spatial awareness problems change over time in people with a glioma in the parietal lobe (a part of the brain). It may help doctors better understand and support these patients.
MilanAges 18 years+ - NCT06687681RecruitingPhase 2
Natural killer cell therapy for brain tumors
This trial tests a new treatment using donated natural killer (NK) cells injected into the body to fight high-grade brain tumors. It might help people with certain types of aggressive gliomas that are newly diagnosed.
TehranAges 3–70 - NCT06016452RecruitingPhase 2
Chlorophyllin for brain radiation damage in glioma patients
This trial tests if chlorophyllin can help manage brain damage caused by radiation therapy in people with diffuse glioma. It may reduce symptoms or prevent them from getting worse.
Mumbai, MaharashtraAges 18–70 - NCT07179328RecruitingPhase 1
Focused ultrasound for glioblastoma during standard chemo
This trial tests whether focused ultrasound can safely open the blood-brain barrier to help your chemotherapy work better. It is for people with glioblastoma who have already completed standard surgery and chemo-radiation and are now on maintenance chemo.
Toronto, OntarioAges 18–85 - NCT07074756Recruiting
Home-based treatment support for people with glioma
This study tests a digital platform that helps you manage your glioma treatment at home. It aims to make it easier to follow your treatment plan and stay connected with your care team.
Jacksonville, FloridaAges 18 years+ - NCT06975332Recruiting
Targeted radiation therapy for recurrent high-grade glioma
This trial tests a new radiation treatment that targets tumor cells directly. It may help people with a specific type of aggressive brain tumor that has grown after standard treatments.
Warsaw, PolandAges 18–80 - NCT06896110Enrolling by invitationPhase 1
Spinal chemo and immunotherapy for recurrent high-grade glioma
This trial tests a combination of two drugs—azacitidine and nivolumab—given directly into the spinal fluid for people whose high-grade glioma has come back after initial treatment. The goal is to see if this approach can safely target the tumor and slow its growth.
Iowa City, IowaAges 13 years+ - NCT04135807RecruitingEarly Phase 1
Implantable device test for operable brain tumor patients
This early-phase trial tests a tiny implanted device placed during brain tumor surgery. It delivers very small doses of medicine directly to the tumor area for a short time, aiming to see if this approach is safe and workable in patients with certain gliomas.
Boston, MassachusettsAges 18 years+ - NCT06712875RecruitingPhase 1/Phase 2
Brain cancer drug combo for kids with BRAF mutations
This trial tests a combination of targeted therapy (dabrafenib and trametinib) and immunotherapy (nivolumab) for children and young adults with certain BRAF gene changes in their glioma. It aims to see if this drug combination can shrink tumors or stop them from growing.
Washington D.C., District of ColumbiaAges 1–26 - NCT06018363RecruitingPhase 1/Phase 2
Cell therapy for recurrent high-grade glioma
This trial tests a new cell therapy (QH104) for people with an aggressive brain tumor called high-grade glioma that has come back or worsened after standard treatment. The therapy targets a specific protein (B7-H3) on tumor cells to try to fight the cancer.
Suzhou, JiangsuAges 18–70 - NCT06624371RecruitingPhase 1
Atovaquone with radiation for children with brain tumors
This trial tests adding atovaquone to standard radiation therapy for children with aggressive brain tumors like high-grade glioma (a fast-growing brain cancer) or medulloblastoma. The goal is to see if this drug, which targets energy production in cancer cells, can make radiation work better.
Atlanta, GeorgiaAges 2–25 - NCT06482905RecruitingPhase 1
CAR-T cell therapy for recurrent grade 4 brain tumors
This trial tests a new treatment called TX103 CAR-T cells for people with a grade 4 glioma (like glioblastoma) that has come back or gotten worse after standard treatment. The therapy uses your own immune cells that are specially trained to attack a marker called B7-H3 found on tumor cells.
Phoenix, ArizonaAges 18–75 - NCT06444412RecruitingPhase 2
Testing a new PET scan to detect brain tumor recurrence
This trial tests a special imaging scan called Ga-68 PSMA-11 PET/CT to see if it can better detect when a glioma brain tumor has come back or progressed. It is for people who have already had standard treatment and are planning surgery for a suspected recurrence.
Rochester, MinnesotaAges 18 years+ - NCT06410248RecruitingPhase 1
Triapine with temozolomide for recurrent glioblastoma
This trial is testing a combination of two drugs, triapine and temozolomide, for people whose glioblastoma has come back. The goal is to see if this combination can help control the tumor.
Chicago, IllinoisAges 18 years+ - NCT06397560Recruiting
Proton radiation for returning brain tumors
This trial tests a new type of proton radiation therapy given at a lower dose rate to treat brain tumors that have come back after previous radiation. The goal is to see if it's safe and effective.
Boca Raton, FloridaAges 18 years+ - NCT05717153RecruitingEarly Phase 1
Test drugs through the tumor to study brain tumor metabolism
This early-phase study tests two drugs (DFMO and AMXT 1501) given directly into the tumor to see how they affect tumor biology and metabolism. Researchers may learn whether this approach could be safer and helpful for people with diffuse or high-grade glioma.
Rochester, MinnesotaAges 18 years+ - NCT05979064Recruiting
Belly fat graft for recurrent brain tumor
This study tests if a piece of your own belly fat (omentum) placed in the brain during tumor surgery can help fight recurrent glioblastoma. It is for people who are already scheduled for surgery to remove their brain tumor.
New York, New YorkAges 18 years+ - NCT05956821RecruitingPhase 1/Phase 2
Study drug for young people with recurring brain glioma
This Phase 1/2 trial tests a study treatment for children and young adults under 22 whose brain glioma has come back or isn’t responding to prior treatment. It’s designed to see whether the treatment is safe and effective for shrinking tumors in this situation.
Miami, FloridaAges 1–21 - NCT05298995RecruitingPhase 1
GD2 CAR T-cell treatment for pediatric brain tumors
This trial tests a special immune-cell therapy (GD2 CAR T cells) made for pediatric brain tumor patients. It uses a planned treatment plan and monitoring to see if the therapy is safe and can work against the tumor.
Roma, ItalyAges 6 months–30 years - NCT05303519RecruitingPhase 3
Safusidenib for IDH1-mutant glioma after main treatment
This Phase 3 trial tests safusidenib, a targeted medicine, to help stop or slow the return of certain brain tumors with an IDH1 mutation. It focuses on people after initial treatment (surgery and/or radiation and temozolomide), aiming to improve outcomes during maintenance therapy.
Birmingham, AlabamaAges 18 years+ - NCT04870944RecruitingPhase 1/Phase 2
CBL0137 for children with advanced solid or brain tumors
This early-phase study tests CBL0137 in children and teens whose cancer has come back or is not responding to treatment. It is also for some specific hard-to-treat brain tumors, to see if the drug is safe and can work against the cancer.
Birmingham, AlabamaAges 1–21 - NCT04865315Recruiting
Donate tumor samples to build organoid tissue from glioma
This study collects tumor tissue during brain surgery to create lab-grown “organoids” (mini models of the tumor). It aims to build a tissue bank that researchers can use to better study gliomas and develop treatments.
Maastricht, LimburgAges 18 years+
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Common questions
- Are there clinical trials for glioma?
- Yes. Clin2 currently lists 333 recruiting glioma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a glioma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a glioma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.