Clinical trials
Heart failure clinical trials
A condition where the heart can’t pump blood as well as it should. We’re tracking 981 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05063955Recruiting
Study muscle changes in people with heart failure
This study looks at the reasons for age-related muscle loss (sarcopenia) in people with heart failure. It may help researchers understand what is causing muscle weakness and how it could be treated in the future.
Aarhus NAges 18–90 - NCT05064709Recruiting
Test device for heart failure symptoms in some patients
This study tests whether a heart-related device called CCM can improve symptoms and daily function in people with heart failure and a moderately reduced pumping strength. It may help if you’ve had recent heart-failure-related hospital care or urgent treatment and your heart and overall health fit the study limits.
Birmingham, AlabamaAges 18 years+ - NCT05250349Recruiting
Ultrasound brain blood flow and thinking in stable heart failure
This trial studies whether a noninvasive ultrasound test of blood flow in the brain, along with memory and thinking questionnaires, can help explain thinking changes in people with stable heart failure. It may help researchers better understand why some people develop cognitive (thinking) difficulties as heart failure progresses.
Krakow, MPAges 18 years+ - NCT05292716Recruiting
MitraClip for advanced heart failure with leaky mitral valve
This trial studies whether the MitraClip procedure can improve outcomes for people with advanced heart failure caused by significant leakage of the mitral valve. It focuses on people who still have severe symptoms and poor quality of life despite the best available heart medications.
Brescia, LombardyAges 18–90 - NCT05388097Recruiting
Quality program to reduce hospital readmissions for heart failure
This trial tests whether a new hospital “quality improvement” program can lower the chances of coming back to the hospital after being admitted for acute heart failure. It focuses on social needs (like resources and support) that can affect recovery and readmissions.
Olathe, KansasAges 18–99 - NCT05416879Recruiting
Lifestyle support for women newly diagnosed with heart failure
This study looks at how lifestyle behaviors affect people in the weeks after a new heart failure diagnosis. It may help you learn safer physical activity and understand what supports you while you adjust to treatment.
Newcastle upon TyneAges 18 years+ - NCT05417490Recruiting
Study of why people join PRADO and telemedicine for heart failure
This study looks at what influences whether people with heart failure choose to join PRADO and telemedicine support after a hospital stay. Your answers can help the team understand barriers and improve future participation and care.
MontpellierAges 18 years+ - NCT05422859Recruiting
Using a mobile app in heart failure care networks
This trial tests whether a mobile and digital app can be used by people with heart failure who receive care in specific clinics in Berlin or Brandenburg. It may help support communication and care by putting information and tools in your phone.
Berlin, DeutschlandAges 18 years+ - NCT05448833Recruiting
Testing a wireless sensor to monitor left heart pressure
This study tests whether a small wireless sensor can safely measure and track pressure in the left upper heart chamber in people with advanced chronic heart failure. It may help the care team better understand pressure changes that are linked to fluid buildup and symptoms, alongside your usual heart medicines.
Petah TikvaAges 22–88 - NCT05508256RecruitingPhase 4
Ablation for atrial fibrillation in heart failure with preserved function
This trial tests whether a catheter procedure that treats atrial fibrillation works better than standard care for people with heart failure with preserved ejection fraction. It aims to improve heart rhythm symptoms and overall outcomes compared with conventional treatment.
BerlinAges 18 years+ - NCT05568069Recruiting
Study of defibrillator implants for non-ischemic weak heart
This study looks at whether implantable defibrillators can reduce dangerous heart rhythms in people with non-ischemic cardiomyopathy (heart weakness not caused by blocked heart arteries), a heart scar, and very low pumping strength despite best treatment. It compares different approaches to choosing which patients should receive these devices.
High Wycombe, BuckinghamshireAges 18 years+ - NCT05573997Recruiting
Testing new ultrasound measures of heart muscle function in heart failure
This study looks at whether a special kind of heart ultrasound can better measure how well the heart muscle works in people admitted with heart failure. It may help doctors understand heart function using clearer ultrasound “biomarkers” soon after hospital admission.
Thessaloniki, Central MacedoniaAges 18 years+ - NCT05577819Recruiting
Screening for ATTR heart amyloid in older HFpEF patients
This study looks at how often a specific heart condition (ATTR amyloid) occurs in people age 65+ who have HFpEF. It also tries to predict who might have it, using a special heart scan, and may help your care team identify it earlier.
Boston, MassachusettsAges 65 years+ - NCT05627440Recruiting
Protein diet program to improve muscle strength in heart failure
This trial tests whether adding dietary protein can help skeletal muscles recover and function better in people living with heart failure. It may help with strength, muscle wasting, and overall ability to do daily activities.
Boston, MassachusettsAges 18–100 - NCT05632432Recruiting
Heart tissue grafts to help the heart after surgery
This trial tests whether transplanting tiny heart “micrografts” from the left heart chamber area can improve heart function after cardiac surgery. It is meant for people with weakened heart pumping and heart failure symptoms despite medicine.
Helsinki, UusimaaAges 18–75 - NCT05647213RecruitingPhase 1
Skin biopsy study of stem-cell therapy for congenital heart disease
This early study takes a small skin sample to make a personalized type of heart stem cells in the future. It is testing whether this approach is safe and feasible for people with complex single-chamber congenital heart disease and advanced heart failure.
Rochester, MinnesotaAges 18–40 - NCT05650658Recruiting
Compare two heart pacing options in people with weak heart function
This trial compares two types of “left-side” heart pacing to see which one works better in people with weak heart pumping. It may help guide the best pacing choice for improving heart function and symptoms.
Gilbert, ArizonaAges 18 years+ - NCT05696652Recruiting
Exercise training study for people with heart failure
This study looks for blood and other markers that can explain how people with heart failure respond to exercise training. It may help researchers better tailor exercise or treatment plans for heart failure in the future.
Stanford, CaliforniaAges 18–89 - NCT05746923Recruiting
Heart failure hospital registry for adults in Krakow area
This registry collects information from adults who were recently hospitalized for acute heart failure. It helps researchers better understand who is affected and how care is delivered after hospitalization.
KrakowAges 18 years+ - NCT05770349Recruiting
Heart failure patients having bypass surgery are studied
This study looks at tiny structures inside heart muscle cells (especially “power stations” in the cells) in people with certain types of heart failure who are getting coronary bypass surgery. It may help researchers better understand what changes happen in the heart and how this could guide future care.
TomskAges 18 years+ - NCT05775432Recruiting
Study outcomes for people receiving heart transplants
This study follows people with severe (end-stage) heart failure who are evaluated for and receive a heart transplant. It helps doctors understand what outcomes to expect after transplant, which can guide future care.
Xi'an, ShaanxiAges 3–80 - NCT05797649Recruiting
Test a pleural fluid blood marker to tell heart failure vs others
This study checks whether a substance called NT-proBNP in pleural fluid can better identify if fluid around the lung is caused by heart failure. If you fit, the results may help doctors choose faster, more accurate diagnosis for your pleural effusion.
Hong Kong, New TerritoriesAges 18 years+ - NCT05839067Recruiting
Support program for U.S. veterans living with heart failure
This trial supports U.S. Veterans who have heart failure, to see whether the added support improves health and well-being. You may be able to join if you meet the age, diagnosis, and communication requirements.
Gainesville, FloridaAges 18 years+ - NCT05852509Recruiting
Digital exercise program for heart failure family caregivers
This study tests a digital (phone-based) exercise program for older people who care for someone with heart failure. It may help you increase safe physical activity while also supporting the caregiver role.
Aurora, ColoradoAges 50 years+
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Common questions
- Are there clinical trials for heart failure?
- Yes. Clin2 currently lists 981 recruiting heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.