Clinical trials
Heart failure clinical trials
A condition where the heart can’t pump blood as well as it should. We’re tracking 981 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05859048Recruiting
Care plan to help high-risk people spot heart failure early
This trial tests a multidisciplinary care approach aimed at helping people with high risk for heart failure get diagnosed earlier. It may help you catch heart failure sooner if it starts, so treatment can begin earlier.
Vancouver, British ColumbiaAges 40 years+ - NCT05873543Recruiting
Smartphone-based exercise program for heart failure recovery
This trial tests whether a hybrid heart-rehabilitation program that uses a smartphone helps people with heart failure feel better and safely exercise. If you’re eligible, you’ll likely get guided exercise training with help from a phone app.
TaipeiAges 18–80 - NCT05873881RecruitingPhase 3
Colchicine and vitamin B1 for ischemic heart failure
This study tests whether colchicine and thiamine (vitamin B1) can improve outcomes in people with heart failure caused by blocked or narrowed heart arteries. It’s mainly for people with moderate-to-severe symptoms and reduced heart pumping ability.
Hamilton, OntarioAges 45 years+ - NCT05873634Recruiting
Using health records and testing to study heart failure types
This study combines electronic health record data and detailed heart testing to better understand different heart failure types and what treatments may work best for each. It mainly enrolls people with known heart failure, and also some people without heart failure for comparison.
Sacramento, CaliforniaAges 30 years+ - NCT05888688Recruiting
Studying muscle loss in people with heart failure or diabetes
This study looks at sarcopenia, which is age-related loss of muscle, in people with certain types of heart failure or in people with stable type 2 diabetes but no symptoms. The goal is to better understand muscle changes and what might help people stay stronger.
Leicester, LeicestershireAges 18 years+ - NCT05931614Recruiting
Trial of limited vs normal drinking in heart failure
This study tests whether drinking a different amount of fluid (either more liberal or more restricted) is better for people with heart failure. You may be guided to follow one drinking plan and monitored to see how it affects symptoms and safety.
StockholmAges 18 years+ - NCT05934487Recruiting
Monitoring device trial for stable heart failure symptoms
This trial tests whether a wearable home monitoring system (myCordella™) can help people with moderate heart failure (NYHA class II or III) by tracking heart pressure and supporting follow-up care. It may help detect changes earlier so clinicians can adjust treatment sooner.
Phoenix, ArizonaAges 18 years+ - NCT05942287Recruiting
Weight and weight loss study in heart failure with weak pumping
This study looks at how obesity and weight loss affect people living with heart failure where the heart pumping strength is reduced. It uses heart imaging (MRI) to measure the heart and may help clarify what weight changes do for symptoms and heart function.
Jersey, JerseyAges 18–85 - NCT05960890Recruiting
Study of chronic heart failure after hospital discharge
This study follows adults with chronic or newly diagnosed heart failure to learn how patients do after they leave the hospital, mainly while taking heart medicines by mouth. It may help researchers better understand which patients have different outcomes and needs.
Taizhou, JiangsuAges 18 years+ - NCT06015776Recruiting
Heart cell signals after menopause
This trial studies how heart cells communicate after menopause. Researchers are looking at a chemical signal called purinergic signaling during heart surgery.
Boston, MassachusettsAges 30–88 - NCT06032780Recruiting
Exercise training for chronic heart failure
This study tests if a specific type of leg-strengthening exercise (eccentric resistance training) can help people with stable chronic heart failure feel better and move more easily. If you have heart failure and are not in an acute or very severe stage, this might be an option to improve your daily life.
Rawalpindi, Punjab ProvinceAges 18 years+ - NCT06061549RecruitingPhase 1
Gene therapy for stiff heart failure (preserved EF)
This trial tests a one-time gene therapy for people with heart failure who still have normal pumping strength (preserved ejection fraction). It aims to improve how heart cells handle calcium, which may help the heart relax better and ease symptoms.
Durham, North CarolinaAges 50 years+ - NCT06081543Recruiting
Ketogenic vs. Mixed Diet for Heart Failure
This study compares a ketogenic (low-carb, high-fat) diet to a standard mixed diet in people with heart failure. It aims to see if the ketogenic diet can improve heart function and symptoms.
Columbus, OhioAges 18–80 - NCT06176131Recruiting
Telemedicine support for heart failure after hospital
This study tests a care program that uses telemedicine to help people with serious heart failure stay stable after leaving the hospital. It focuses on those who needed multiple hospital stays recently.
FrederiksbergAges Any age - NCT06205225Recruiting
Mobile health program for heart failure self-care
This study tests a mobile health program (phone app and coaching) to help people with heart failure better manage their condition at home. It aims to improve self-care and reduce hospital visits.
Chicago, IllinoisAges 18 years+ - NCT06222762Recruiting
Personalized exercise follow-up for chronic heart failure
This study tests whether a personalized exercise program can help people with chronic heart failure feel better and stay active. It is for patients who are already in a cardiac rehab program and have stable heart failure.
BrestAges 18–80 - NCT06253104Recruiting
Tracking muscle changes in acute heart failure
This study measures how thigh muscles change in people hospitalized with severe heart failure. It aims to understand muscle loss during this condition and how it relates to recovery.
Boston, MassachusettsAges 18–100 - NCT06278844Recruiting
Pacing method to improve exercise in heart failure
This study tests a new way to pace the heart in people with heart failure who need a pacemaker. It aims to see if this pacing method helps them exercise more easily.
Edegem, AntwerpAges 18 years+ - NCT06279988Recruiting
Heart failure study for all types and stages
This study is looking at people with any type of heart failure, whether it's stable and managed at home or newly diagnosed in the hospital. The goal is to learn more about how to improve care, no matter what your ejection fraction level is.
Casale Monferrato, ALAges 18 years+ - NCT06286423RecruitingPhase 4
Colchicine for acute heart failure with low pumping strength
This trial tests if the anti-inflammatory drug colchicine can help people hospitalized with acute heart failure and a weak heart pump. It may benefit those with elevated inflammation markers.
Charlottesville, VirginiaAges 18 years+ - NCT06297707Recruiting
Aquatic strength training for chronic heart failure
This trial tests whether high-intensity resistance training in water can improve strength and function in people with chronic heart failure. It's designed for those who are stable on medication and not yet in a rehab program.
Cairo, DokkiAges 45–60 - NCT06299436Recruiting
Heart muscle function testing in right heart failure
This trial studies how the right side of the heart works in people with heart failure. It uses special monitoring to understand muscle function and may help doctors find better ways to treat right heart failure.
Baltimore, MarylandAges 18–90 - NCT06313684Recruiting
Hybrid cardiac rehab for heart failure patients
This study tests a hybrid cardiac rehab program (both at the clinic and at home) for people with heart failure. It combines supervised exercise sessions with remote support to help improve your heart health and daily function.
SantiagoAges 18 years+ - NCT06062966RecruitingPhase 1
Study of anakinra for advanced heart failure on inotrope therapy
This study tests whether a drug called anakinra can improve how your heart responds to inotrope therapy (medicines that help your heart pump). It is for people with advanced heart failure who are already on a steady dose of these medicines and have signs of inflammation. The goal is to see if blocking inflammation helps your heart work better.
Richmond, VirginiaAges 21 years+
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Common questions
- Are there clinical trials for heart failure?
- Yes. Clin2 currently lists 981 recruiting heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.