Clinical trials
Heart failure clinical trials
A condition where the heart can’t pump blood as well as it should. We’re tracking 947 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07057323Enrolling by invitation
Coronary sinus reducer for heart failure with preserved pumping function
This trial tests a device placed in a heart vein to improve symptoms in people whose heart pumps normally but still causes shortness of breath and fatigue. The device may help relieve pressure in the heart and improve daily life.
Rochester, MinnesotaAges 18 years+ - NCT07050706Enrolling by invitation
Heart failure and protein levels in the blood
This trial checks if a protein called PRMT5 in the blood is linked to heart function in people with heart failure. It compares healthy volunteers and those with heart failure to see if this protein can help understand the condition better.
Shenzhen, GuangdongAges 18 years+ - NCT07037459RecruitingPhase 3
A study of a new drug for heart failure with obesity
This trial tests a medication called maridebart cafraglutide for people with heart failure (where the heart doesn't pump as well as it should) and obesity. The goal is to see if it can help improve symptoms and outcomes.
Birmingham, AlabamaAges 18–99 - NCT07518030Recruiting
Telemedicine support for heart failure medication adjustment
This study tests whether remote check-ins via phone or video can help safely increase heart failure medications to target doses. You'll use a device to share weight, blood pressure, and heart rate with your doctor, who will adjust your medicines based on how you're doing.
PiacenzaAges 18 years+ - NCT07038356RecruitingPhase 3
Continuing empagliflozin during heart failure hospitalizations
This study tests whether continuing empagliflozin (a heart failure medicine) during a hospital stay for heart failure is beneficial compared to stopping it. Participation may help improve recovery and reduce complications.
Jena, ThuringiaAges 18 years+ - NCT07023536Recruiting
Heart rehab program from home for chronic heart failure
This trial tests a cardiac telerehabilitation program for people with chronic heart failure. It is designed to see if doing rehab at home using digital tools helps improve health and quality of life.
SalernoAges 18 years+ - NCT05960890Recruiting
Study of chronic heart failure after hospital discharge
This study follows adults with chronic or newly diagnosed heart failure to learn how patients do after they leave the hospital, mainly while taking heart medicines by mouth. It may help researchers better understand which patients have different outcomes and needs.
Taizhou, JiangsuAges 18 years+ - NCT07008365RecruitingPhase 3
Measuring belly pressure and ultrasound to guide fluid removal in heart failure
This trial tests whether using belly pressure and bedside ultrasound can help doctors better manage fluid removal (decongestion) in people hospitalized with heart failure. The goal is to see if this approach leads to better outcomes.
ZaragozaAges 18–100 - NCT06993220Recruiting
Reducing fluid buildup in heart failure patients at discharge
This trial is for people hospitalized with heart failure and signs of fluid overload, such as swelling or fluid in the lungs. It aims to check if patients still have extra fluid when they go home, which may help improve their recovery.
Sant Joan Despí, BarcelonaAges 18 years+ - NCT06999369Enrolling by invitation
Heart failure nutrition app study
This study tests a digital nutrition tool to help people with heart failure improve their health. It is for patients recently hospitalized or seeing their doctor regularly.
Walnut Creek, CaliforniaAges 18–89 - NCT06989580Recruiting
Heart failure monitoring with a wireless implant
This trial is testing a special monitor (BIOMONITOR) that tracks your heart function and sends data wirelessly to your doctor. It aims to help manage heart failure by catching early signs of trouble so you can get treatment sooner.
GenkAges 18 years+ - NCT07601724Recruiting
How fluid buildup affects sleep apnea in heart failure
This study looks at how excess fluid in the body affects sleep apnea (pauses in breathing during sleep) in people hospitalized with heart failure. Researchers will measure sleep apnea before and after treatment to reduce the fluid, which may help doctors better manage both conditions together.
JerusalemAges 18 years+ - NCT06979726RecruitingPhase 4
Lasix under the skin for heart failure symptoms
This study tests a way to give a common water pill (called Lasix, or furosemide) under the skin using a small pump at home, instead of in the hospital. It may help people with heart failure who have fluid buildup that isn't getting better with oral water pills.
Gainesville, FloridaAges 18–80 - NCT06965504Recruiting
Heart failure medications with an Impella heart pump for cardiogenic shock
This study tests whether a special heart pump (Impella 5.5) can help patients with severe heart failure (cardiogenic shock) safely start and increase their heart failure medications. The goal is to see if this approach can help the heart recover and improve outcomes.
Tampa, FloridaAges 18–80 - NCT06961929Recruiting
Heat and Heart Failure Study
This study looks at how heat affects the body in people with stable heart failure compared to healthy volunteers. It may help researchers understand how to better manage heart failure in daily life.
Dallas, TexasAges 45 years+ - NCT06933875Recruiting
Palliative care support for heart failure patients
This study tests a program to bring palliative care (extra support for comfort and quality of life) to people hospitalized with heart failure. Your doctor will take part, and if you qualify, you may get this additional care during your stay.
New Haven, ConnecticutAges 18 years+ - NCT06939985Recruiting
Heart health and metabolism registry for heart failure
This trial is a registry that will follow people with different types of chronic heart failure to better understand how heart health and metabolism are linked. It may help doctors improve care for future patients.
ShanghaiAges 18 years+ - NCT06937320Enrolling by invitationPhase 2
Testing ketone supplements for heart failure with preserved ejection fraction (HFpEF)
This study tests whether a special dietary supplement (ketone esters) can improve exercise ability and heart function in people with a type of heart failure where the heart pumps well but is stiff (HFpEF). You might join if you have stable symptoms, an ejection fraction of 50% or higher, and signs of fluid buildup in the heart.
Durham, North CarolinaAges 18 years+ - NCT06671015Recruiting
Comparing breathing support methods after a breathing tube is removed in people with heart failure
This study compares two types of breathing support—a high-flow nasal cannula and noninvasive ventilation—to see which one better prevents the need for re-inserting a breathing tube in people with systolic heart failure who are at high risk for breathing problems after the tube is removed.
New Haven, ConnecticutAges 18 years+ - NCT06915584Recruiting
Drug management study for heart failure
This study looks at how medications are managed in people with heart failure, especially those who have been in the hospital recently for worsening symptoms. It aims to improve treatment strategies.
Rome, RMAges 18 years+ - NCT06909682Recruiting
AI monitoring with wearables for chronic heart failure
This trial tests an AI system that uses wearable devices and mini-invasive tools to monitor people with chronic heart failure. The goal is to detect changes early and help manage the condition at home.
SalernoAges 19 years+ - NCT06699056Recruiting
AI heart monitor study for ejection fraction
This study uses an AI-powered wearable monitor to check how well your heart pumps blood (ejection fraction) from a simple EKG recording. It may help doctors quickly assess heart function without extra tests.
Orange, CaliforniaAges 18 years+ - NCT06895070Recruiting
Heart transplant study using a special preservation machine
This trial tests a special machine that preserves donor hearts for longer periods before transplant. It may help people waiting for a heart transplant who need a heart from a donor that may be older or has some heart risks.
La Jolla, CaliforniaAges 18 years+ - NCT06885164Recruiting
Remote heart monitoring for heart failure patients
This trial tests whether remote monitoring of heart function can help manage heart failure. It may be an option if you have symptoms like shortness of breath or fatigue (NYHA class II or higher) and are between 18 and 90 years old.
Aalborg, DenmarkAges 18–90
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Common questions
- Are there clinical trials for heart failure?
- Yes. Clin2 currently lists 947 recruiting heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.