Clinical trials
High Grade Glioma (III or IV) clinical trials
Below are recruiting high grade glioma (iii or iv) clinical trials, each written for real people, not researchers. We’re tracking 1,259 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02683512Recruiting
Study of GBE deficiency in GSD IV and APBD
This study follows people with GBE deficiency caused by GSD IV or APBD to better understand how the condition works over time. It may help researchers and clinicians plan future care and treatments.
Durham, North CarolinaAges birth–90 years - NCT01050504Recruiting
Donate blood and tissue to study recurrent or metastatic cancers
This study collects and studies blood and, when possible, small tissue samples from people with prostate or bladder/urothelial cancer that has come back or spread. The goal is to better understand these cancers and support future research that may lead to better care.
Seattle, WashingtonAges 18 years+ - NCT07744126RecruitingPhase 2
Combination drug therapy for head and neck cancer that has spread
This trial tests a new combination of two drugs (telisotuzumab adizutecan and pembrolizumab) for people with head and neck cancer that has come back or spread and cannot be cured with local treatments. The goal is to see if this combination can help control the cancer and to find the best dose.
Duarte, CaliforniaAges 18 years+ - NCT07288034RecruitingPhase 2
Immunotherapy biomarkers for advanced lung cancer
This study looks at blood and tissue biomarkers to predict how well immunotherapy (with or without chemotherapy) works for advanced non-small cell lung cancer. It also helps decide the best second treatment if the first one stops working.
Goodyear, ArizonaAges 18 years+ - NCT07091630RecruitingPhase 3
A study of empasiprubart for chronic inflammatory demyelinating polyneuropathy (CIDP)
This study tests a new medicine called Empasiprubart for adults with ongoing CIDP. It aims to see if fewer symptoms return and if it can replace current treatments.
Birmingham, AlabamaAges 18 years+ - NCT04305834RecruitingPhase 2
Abemaciclib plus hormone pills for metastatic breast cancer in older adults
This Phase 2 study tests whether abemaciclib combined with standard hormone (endocrine) therapy can better control metastatic breast cancer in people age 70 and older. It may help if your cancer has already grown despite prior hormone therapy and/or other cancer medicines.
Duarte, CaliforniaAges 70 years+ - NCT06820463RecruitingPhase 2
Study of telisotuzumab adizutecan plus chemo for metastatic colorectal cancer
This trial tests a new drug combination for people with metastatic colorectal cancer. The study includes an experimental antibody-drug conjugate (telisotuzumab adizutecan) plus standard chemotherapy and targeted therapies, to see if it works better than current options.
Duarte, CaliforniaAges 18 years+ - NCT05406999RecruitingPhase 2
Intense hormone treatment before prostate surgery for high-risk cancer
This Phase 2 trial studies giving strong hormone-based treatment before prostate surgery to shrink and control high-risk, locally advanced prostate cancer. It may help improve surgical success and reduce cancer spread risk, but it requires careful health checks and prior-treatment limits.
Nanjing, JiangsuAges 18–80 - NCT04945603Recruiting
Study for poor-grade brain bleed from a ruptured aneurysm
This trial is enrolling people who come to the emergency room with a serious brain bleed caused by a ruptured brain aneurysm. It aims to test care strategies for patients with poor-grade injuries, who may have worse outcomes than typical cases.
BergamoAges 18 years+ - NCT07860840Recruiting
Visual training before robot-assisted walking for stroke survivors
This study tests whether a special visual training program before using a walking robot can improve walking recovery in people who have had a stroke or similar brain injury within the last 6 months and have trouble sensing their affected side. If you join, you might get this extra visual practice to help your brain relearn movement.
Negrar, ItalyAges 18–80 - NCT07868861RecruitingPhase 1
Nasal ondansetron versus IV injection in healthy adults
This trial tests a new nasal spray form of ondansetron (a medicine that prevents nausea and vomiting) to see how well the body absorbs it compared with the IV (into the vein) form. It is for healthy adults to help understand how the nasal spray works.
JerusalemAges 18–65 - NCT06279663Recruiting
Comparing bypass surgery vs stenting for high-risk heart attacks
This study compares two common treatments (bypass surgery vs. stenting) for people having a high-risk heart attack that involves blockages in multiple arteries. It aims to find which approach leads to better long-term outcomes.
Novosibirsk, Novosibirsk OblAges 18 years+ - NCT07835178Recruiting
High-pressure cutting balloon for hardened heart artery blockages
This study tests a special balloon that can cut through hardened calcium in heart arteries before placing a stent. It may help people with severe artery calcification get a better stent placement.
Xi'an, ShaanxiAges 18 years+ - NCT07815561RecruitingPhase 1
Testing a new drug for safety in healthy adults
This study tests a new medicine called SAB01 in healthy adults to see if it is safe and how the body handles it. It is a first-in-human trial, meaning this is the first time the drug is given to people.
Cypress, CaliforniaAges 18–55 - NCT06488586Recruiting
Ketamine vs Esketamine for treatment-resistant depression
This trial compares two forms of ketamine—given by IV or as a nasal spray—in people with major depression that hasn't improved after trying at least two other antidepressants. The goal is to see which treatment works better.
Kingston, OntarioAges 18–75 - NCT07778212Recruiting
New drug combo for aggressive lymphoma
This trial tests a new combination of drugs for people newly diagnosed with an aggressive type of lymphoma called diffuse large B-cell lymphoma (DLBCL). The combo includes orelabrutinib plus standard chemo-immunotherapy, and may help improve outcomes for those at intermediate or high risk.
Xiamen, FujianAges 18 years+ - NCT07771023Enrolling by invitation
Exercise for people who had aortic repair
This trial looks at whether a supervised exercise program can improve fitness and quality of life in adults who were born with a narrowed aorta (coarctation) and had surgery to fix it as a baby or child. It aims to see if exercise is safe and helpful for heart health and daily energy, without placing extra strain on the repaired area.
LjubljanaAges 18 years+ - NCT07770100RecruitingPhase 2
Matching immunotherapy and targeted radiation for advanced cancer
This trial tests combining immunotherapy (a treatment that boosts your immune system to fight cancer) with a targeted type of radiation called SBRT, which precisely delivers high-dose radiation to multiple cancer spots. The main goal is to see if this combination helps control metastatic cancer (cancer that has spread) better than standard care.
Lexington, KentuckyAges 18–99 - NCT02919644RecruitingPhase 2
Cancer vaccine made from your own cells after bowel cancer surgery
This trial tests whether a personalized vaccine—made from your own immune cells mixed with your own tumor material—can help prevent colorectal cancer from coming back after curative surgery. It may help your immune system recognize and fight any remaining cancer cells.
Meldola, FCAges 19 years+ - NCT07740941RecruitingPhase 2
Neoadjuvant, spare-adjuvant (NASA) in stage IIIB-IV (M1a) melanoma
This trial tests whether giving immunotherapy before surgery and possibly skipping some after may help people with advanced but removable melanoma. It aims to see if this approach can reduce the chance of the cancer coming back.
Chapel Hill, North CarolinaAges 18 years+ - NCT07704580RecruitingPhase 1/Phase 2
Sarilumab for active rheumatoid arthritis
This trial tests sarilumab, an injected antibody that blocks a key protein involved in inflammation, for people with moderate-to-severe rheumatoid arthritis (RA) who haven't had success with standard treatments. The goal is to see if adding sarilumab can help control joint pain and swelling.
Centennial, ColoradoAges 18 years+ - NCT06574126RecruitingPhase 2
CAR T-cell therapy for high-risk smoldering myeloma
This trial tests a new CAR T-cell therapy (cilta-cel) for people with high-risk smoldering multiple myeloma. It aims to prevent progression to active myeloma.
SalamancaAges 18 years+ - NCT07678684RecruitingPhase 2
Study of HF1K16 plus bevacizumab for recurrent glioma
This trial tests a new combination of two drugs, HF1K16 and bevacizumab, for people whose glioma has come back or grown after prior treatment. It aims to see if this combination can help when standard options are no longer working or tolerable.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07619599RecruitingPhase 1
PET Scan to Track Lung Cancer Treatment Response
This study uses a special PET imaging scan to help doctors see how well pembrolizumab (an immunotherapy drug) is working against advanced non-small cell lung cancer. You'll receive the scan along with your regular pembrolizumab treatment and possible radiation therapy to help measure treatment response.
Duarte, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for high grade glioma (iii or iv)?
- Yes. Clin2 currently lists 1,259 recruiting high grade glioma (iii or iv) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high grade glioma (iii or iv) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high grade glioma (iii or iv) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.