Clinical trials
High Grade Glioma (III or IV) clinical trials
Below are recruiting high grade glioma (iii or iv) clinical trials, each written for real people, not researchers. We’re tracking 1,259 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07614958RecruitingPhase 3
Testing a new cholesterol medicine against bempedoic acid
This study compares two new medicines—obicetrapib and bempedoic acid—to see which one better lowers cholesterol in people whose cholesterol remains high despite taking standard medications. If your cholesterol isn't controlled well enough with current drugs, this trial may help you access an experimental treatment.
Stockton-on-TeesAges 18 years+ - NCT07612020RecruitingPhase 1
How Well a New Injection Works Compared to IV
This study tests a new medicine called empasiprubart that can be injected under the skin using an autoinjector (like an EpiPen). Researchers want to see how much of the medicine gets into your bloodstream and whether the injection works as well as an IV infusion. You'll be a healthy volunteer helping them understand if this new delivery method is effective.
Mount Royal, QuebecAges 18–65 - NCT07611890RecruitingPhase 4
Comparing two medications to reduce heart stress during cardiac surgery
This trial tests whether dexmedetomidine or lignocaine better prevents dangerous heart-rate and blood-pressure changes when a breathing tube is placed during heart surgery. If you're having cardiac surgery and are at high risk for heart complications, this study may help protect your heart during the procedure.
Rawalpindi, Punjab ProvinceAges 18–65 - NCT03564236Recruiting
Nasal high-flow oxygen for COPD flare-ups in hospital
This trial tests whether a special type of oxygen delivered through the nose (high-flow nasal oxygen) helps people hospitalized for a COPD flare-up. It is likely meant for people with significant breathing problems and recent repeat flare-ups.
ArnhemAges Any age - NCT07594626RecruitingPhase 1/Phase 2
BMS-986504 and Pemetrexed for Advanced Tumors With MTAP Loss
This trial tests a new drug (BMS-986504) combined with an existing chemotherapy (pemetrexed) for advanced solid cancers that have a specific genetic change called MTAP deletion. The trial aims to see if this combination can slow or stop tumor growth in patients whose cancer has progressed despite prior treatment.
Chicago, IllinoisAges 18 years+ - NCT07581002RecruitingPhase 2/Phase 3
New AML Treatment With Three Drug Combination Study
This study tests a new three-drug combination (pivekimab sunirine, venetoclax, and azacitidine) for newly diagnosed acute myeloid leukemia in patients who cannot tolerate intensive chemotherapy. The goal is to see if this combination is safe and effective at controlling the disease.
Duarte, CaliforniaAges 18 years+ - NCT07530445RecruitingPhase 2
Immunotherapy plus chemotherapy for advanced biliary tract cancer
This study tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus chemotherapy and a targeted drug (lenvatinib) for biliary tract cancer that has spread or cannot be surgically removed. The goal is to slow cancer growth in patients whose cancer has progressed after one prior treatment.
GuangzhouAges 18–70 - NCT07520487Recruiting
Ketamine Plus Spinal Anesthesia for Older Adults Undergoing Leg Surgery
This study tests whether adding ketamine (a type of anesthetic medication) to spinal anesthesia—numbing medication injected near the spine—can make the numbness last longer for older adults having leg surgery. The goal is to see if this combination improves pain control after surgery.
Cairo, Giza GovernorateAges 65 years+ - NCT06758882RecruitingPhase 2
Surgery with or without apalutamide for high-risk prostate cancer that has spread a little
This trial tests whether adding the drug apalutamide before and after surgery helps men with high-risk prostate cancer that has spread to a few spots (seen on a special PET scan). You would also receive standard hormone therapy.
Torino, ToAges 18–80 - NCT06762782RecruitingPhase 2
Lenvatinib after liver cancer surgery to prevent recurrence
This trial tests whether taking lenvatinib after liver cancer surgery can lower the chance of the cancer coming back. It is for people who have a high risk of recurrence and have recently had their liver tumor completely removed.
Nanjing, JiangsuAges 18–80 - NCT07483970RecruitingPhase 1
JL19001 alone or with BCG for high-risk non-muscle invasive bladder cancer
This trial tests a new drug called JL19001, given alone or with BCG (a standard bladder cancer treatment), for people with high-risk bladder cancer that hasn't spread into the bladder muscle. The goal is to see if it can help prevent the cancer from coming back or getting worse.
Chengdu, SichuanAges 18 years+ - NCT07489287RecruitingPhase 1
GB-5267 for platinum-resistant ovarian, peritoneal, or fallopian tube cancer
This trial tests a new cell therapy (GB-5267) for people with platinum-resistant ovarian, peritoneal, or fallopian tube cancer. It requires multiple tumor biopsies and aims to see if the treatment can help when standard chemo stops working.
Buffalo, New YorkAges 18 years+ - NCT05601700RecruitingPhase 3
Letrozole for low-grade ovarian cancer that uses hormones
This study tests whether letrozole, a hormone-blocking medicine, can help people with newly diagnosed low-grade serous ovarian cancer that has hormone receptor proteins (ER and/or PgR) after surgery. It compares outcomes to see if blocking estrogen can slow the cancer’s return or progression.
Arezzo, ARAges 18 years+ - NCT07447531Recruiting
MRI and blood test to track brain tumor changes
This study tests whether a special MRI scan and a blood test can help predict how a specific type of brain tumor (malignant glioma) changes over time. It is for people starting standard radiation and chemotherapy on a special machine that combines MRI and radiation.
Iowa City, IowaAges 21 years+ - NCT07450599RecruitingPhase 2
Darolutamide plus hormone therapy before prostate cancer surgery
This trial tests a medicine called darolutamide taken with hormone therapy (ADT) before surgery to remove the prostate. It is for men with a high-risk prostate cancer that has not spread to other parts of the body.
Hefei, AnhuiAges 18 years+ - NCT07439822Enrolling by invitationPhase 4
High-flow oxygen for patients at risk of low oxygen during endoscopy
This trial tests whether high-flow oxygen therapy can prevent low oxygen levels in patients at risk during a digestive endoscopy with deep sedation. It might help if you have obesity, stable lung or heart disease, or sleep apnea.
Valladolid, ValladolidAges 18 years+ - NCT07432607Recruiting
High-Flow Nasal Oxygen vs Face Mask for Heart Surgery
This trial compares two ways of giving oxygen during a heart surgery that uses small chest cuts. One method is a face mask, the other is a high-flow nasal tube. The study will see which keeps your oxygen levels better while you are awake but relaxed.
Istanbul, KARTALAges 18–75 - NCT07407894Recruiting
Probiotic study for healthy aging in midlife adults
This trial tests a probiotic supplement called iVS-1 to see if it can slow biological aging in healthy adults aged 40-75. Researchers want to learn if this probiotic may help support health as you age.
New Port Richey, FloridaAges 40–75 - NCT07408635RecruitingPhase 2
New Immunotherapy Plus Chemotherapy Before Lung Cancer Surgery
This trial tests a new combination of an immunotherapy drug (IBI363) plus chemotherapy before surgery in people with Stage III lung cancer that can't be removed at first. The goal is to shrink the tumor so it can be surgically removed.
ShanghaiAges 18 years+ - NCT07410975RecruitingPhase 2
Immunotherapy and chemo before surgery for lung cancer
This trial tests combining two immunotherapy drugs (anti-CTLA-4 antibody and sintilimab) with chemotherapy before surgery for stage II-III non-small cell lung cancer. The goal is to see if this approach helps shrink tumors and improve outcomes.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07406685RecruitingPhase 4
Comparing two bone medicines after stopping denosumab
This study compares two medicines (ibandronate and zoledronic acid) to see which one works better at keeping bones strong after stopping denosumab (Prolia). It's for postmenopausal women with mild to moderate bone thinning.
TaipeiAges 50–85 - NCT07398872Enrolling by invitationPhase 1
Gene therapy trial for children with ML4
This trial tests a gene therapy given by a one-time injection into the spinal fluid for children with Mucolipidosis type IV. It aims to see if the therapy is safe and can help slow or stop the disease.
Hangzhou, ZhejiangAges 1.5 years–8 years - NCT06427343RecruitingPhase 4
IV iron: low dose vs high dose for heart failure with low iron
This study compares two different doses of IV iron (low vs high) to see which works better for people with heart failure and low iron levels. It may help you feel less tired and breathe easier.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07387367RecruitingPhase 3
Comparing two drugs for adenovirus after stem cell transplant
This trial tests a new drug, brincidofovir (BCV), against an existing drug, cidofovir (CDV), for treating adenovirus infection in people who recently had a stem cell transplant. The goal is to see which works better with fewer side effects.
Phoenix, ArizonaAges 2 months+
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Common questions
- Are there clinical trials for high grade glioma (iii or iv)?
- Yes. Clin2 currently lists 1,259 recruiting high grade glioma (iii or iv) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high grade glioma (iii or iv) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high grade glioma (iii or iv) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.