Clinical trials
Hydrocephalus clinical trials
Below are recruiting hydrocephalus clinical trials, each written for real people, not researchers. We’re tracking 42 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06563817RecruitingPhase 2
Testing rapamycin for fluid buildup after a brain bleed
This trial tests whether the drug rapamycin can help people whose brain ventricles stay enlarged after a bleed, causing walking, memory, or bladder issues. If you qualify, you may receive rapamycin to see if it improves your symptoms and reduces fluid buildup.
Beijing, Beijing MunicipalityAges 18–70 - NCT06693752RecruitingPhase 2
Ultrasound test for fluid on the brain in babies
This trial uses a special ultrasound with contrast to study fluid on the brain (hydrocephalus) in newborn babies. The aim is to learn more about the condition and improve treatment options.
Philadelphia, PennsylvaniaAges 1 minute–1.5 years - NCT06428734Recruiting
Outcomes study for normal pressure hydrocephalus
This study follows people with idiopathic normal pressure hydrocephalus (iNPH) to track their health outcomes over time. It helps doctors understand how the condition naturally progresses without surgery.
Beijing, Beijing MunicipalityAges 18–80 - NCT04998175Recruiting
Study of blood and brain data in normal pressure hydrocephalus
This study collects different kinds of health information (“multi-omics” data, like blood-based markers) in people with idiopathic normal pressure hydrocephalus (iNPH). It aims to better understand the condition and how it may relate to treatment, such as shunt surgery.
Hangzhou, ZhejiangAges 60–90 - NCT00670735Recruiting
Research registry collecting data on hydrocephalus treatment
This study collects information about people with hydrocephalus when they have certain brain fluid (CSF) procedures. The goal is to better understand different patient groups and treatments across multiple centers.
Birmingham, AlabamaAges Up to 18 years - NCT06310213Enrolling by invitation
Non-invasive pressure monitor for babies with hydrocephalus risk
This study tests a new, non-invasive way to monitor pressure in the brain for babies at risk of hydrocephalus. It uses a special contact lens and a small sticker, so no needles or surgery are needed.
Indianapolis, IndianaAges birth–1 year - NCT07427836Recruiting
Better diagnosis and surgery choice for normal pressure hydrocephalus
This study uses a combination of tests (like brain scans, walking tests, and memory checks) to more accurately diagnose a brain fluid condition called 'normal pressure hydrocephalus' and to decide if surgery might help. The goal is to improve treatment choices for people with this condition.
MilanAges 60–85 - NCT06488248Recruiting
Comparing two surgeries for fluid buildup in the brain
This study compares two surgical treatments for normal pressure hydrocephalus (fluid buildup in the brain). It tests whether a less invasive procedure (endoscopic third ventriculostomy) works as well as the standard shunt surgery to improve walking, memory, and bladder control.
BaselAges 40 years+ - NCT04011566Recruiting
Testing a shunt sensor in people with symptom-free hydrocephalus shunts
This study checks how well a device called ShuntCheck works for monitoring a ventriculoperitoneal (VP) shunt in people who feel okay (no symptoms) with normal pressure hydrocephalus. It may help improve future shunt checks during routine care.
Tampa, FloridaAges 40 years+ - NCT04177914RecruitingPhase 3
Compare endoscopy vs shunt surgery for infant hydrocephalus
This Phase 3 study compares two common surgery options to treat hydrocephalus (extra fluid in the brain) in infants. It aims to find which approach works better and is safer for babies who have symptoms and need a first permanent treatment.
Birmingham, AlabamaAges 1 day–2 years - NCT04309487Recruiting
Check shunt blockage using ShuntCheck versus a scan
This study tests whether a device called ShuntCheck can accurately tell if a VP (ventriculoperitoneal) shunt is blocked in people with normal pressure hydrocephalus. If it works well, it may help doctors find shunt problems faster and more safely.
Tampa, FloridaAges 40 years+ - NCT04471740Recruiting
Study of hydrocephalus and sleep apnea
This study looks at people who may have normal-pressure hydrocephalus (fluid-related swelling in the brain) and also focuses on sleep apnea. It may help researchers understand whether treating or studying sleep issues could improve symptoms related to this condition.
Valencia, ValenciaAges 18 years+ - NCT04746625Recruiting
Test of an adjustable valve system for hydrocephalus shunts
This trial checks how safe and well a specific adjustable valve (Polaris 24) works in people with hydrocephalus who need a valve shunt. You may be eligible if you already have this valve implanted for a first shunt, a shunt replacement, or after an endoscopic procedure failed, and you do not have certain infection, bleeding, or heart-circulation conditions.
MarseilleAges Any age - NCT05910944Recruiting
Study of early iNPH signs using brain scans
This European study looks at people with early (prodromal) signs of idiopathic normal pressure hydrocephalus (iNPH), a condition that can affect walking and thinking. It uses brain imaging and brief walking/cognitive checks to see who has this early pattern and may benefit from further evaluation.
KuopioAges Any age - NCT06642129Recruiting
Study on spinal fluid pressure management in shunt surgery
This study watches how the pressure of spinal fluid around the brain and spine changes during surgery for communicating hydrocephalus. It aims to help doctors better manage a shunt that drains extra fluid from the lower back to the belly.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT06994949RecruitingPhase 1
CSF flow study for babies with hemorrhagic hydrocephalus
This trial looks at how fluid moves in the brain of premature babies with hydrocephalus after bleeding. It uses special imaging to see if the fluid is flowing properly, which could help guide treatment.
Houston, TexasAges Up to 6 months - NCT07103681Recruiting
Brain scan study for normal pressure hydrocephalus
This study looks at brain scans and spinal fluid in people with normal pressure hydrocephalus (NPH) to understand how it affects thinking and walking. If you have NPH and are 60 or older, this research may help find better ways to diagnose and treat you.
LondonAges 60 years+ - NCT06368648Recruiting
Study of a new forehead sensor for brain pressure monitoring
This study tests a new sensor that measures brain pressure from outside the head. It is for people who are already in the hospital getting their brain pressure and blood pressure monitored continuously.
Sacramento, CaliforniaAges 18 years+ - NCT05001750RecruitingPhase 1
Preventing EVD infections with antibiotics before device placement
This early-stage study tests whether giving preventive (prophylactic) antibiotics helps prevent infections when an external brain fluid drain (EVD) is placed and used. It may help lower the chance of serious infections around the drain.
The Bronx, New YorkAges 18 years+ - NCT07050628Recruiting
Shunt flow test with wearable device
This study tests a small, wearable device that measures how fluid flows through your shunt during daily activities and sleep. It aims to help doctors better understand shunt function without needing repeated scans or hospital visits.
Chicago, IllinoisAges 2 years+ - NCT04099823Recruiting
MRI study of spinal fluid flow in memory or balance problems
This study uses MRI to look at how spinal fluid moves inside and around the brain. It aims to better understand conditions that can affect thinking, memory, balance, and coordination—such as normal pressure hydrocephalus—or compare with healthy people.
Rochester, MinnesotaAges 18 years+ - NCT05546996Recruiting
Study of pressure readings from existing brain drains
This study collects brain pressure measurements using an external ventricular drain you may already have. It may help researchers better understand how these drains and pressures relate.
Houston, TexasAges 1–21 - NCT05915000Recruiting
CSF protein tests to predict shunt response in hydrocephalus
This study looks at fluid-based “CSF” protein markers to predict how well a brain shunt works in adults with chronic hydrocephalus (fluid buildup). If you qualify, your CSF sample may help doctors better estimate your likely response to treatment.
Valencia, ValenciaAges 18 years+
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Hydrocephalus trials by city
Studies with a site in or near these metro areas.
Hydrocephalus trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for hydrocephalus?
- Yes. Clin2 currently lists 42 recruiting hydrocephalus studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hydrocephalus trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hydrocephalus trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.