Clinical trials
Knee Surgery clinical trials
Below are recruiting knee surgery clinical trials, each written for real people, not researchers. We’re tracking 77 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07394582Recruiting
Pre-surgery optimization for hip or knee replacement
This trial tests a program to improve your health before hip or knee replacement surgery. It aims to help you recover better and reduce risks.
Innsbruck, TyrolAges 18–99 - NCT07333560Recruiting
Predicting recovery after hip or knee replacement
This study is developing a tool that uses machine learning to predict how well you will recover after hip or knee replacement surgery. It aims to help doctors create better recovery plans for people like you.
BolognaAges 18 years+ - NCT06563531Recruiting
Do compression stockings help after hip or knee replacement?
This trial looks at whether compression stockings are still needed for people who have a new hip or knee joint and are following a modern "fast-track" recovery program. It aims to find out if these stockings are necessary to prevent blood clots when people are up and moving quickly after surgery.
BrestAges 18 years+ - NCT06942689RecruitingPhase 4
Finding the best dose of numbing medicine for knee surgery pain
This trial tests different amounts of a long-lasting numbing medicine (liposomal bupivacaine) injected near the nerve in your thigh to see which volume works best for controlling pain after knee surgery. If you qualify, you may receive better pain relief and need fewer opioids.
Nanjing, JiangsuAges 18–85 - NCT06586840Recruiting
Adding an extra nerve block to knee replacement
This trial tests if adding a special nerve block behind the knee (IPACK) to a standard thigh block helps control pain better after total knee replacement. It may lead to less pain and faster recovery.
AydinAges 18–85 - NCT06665438RecruitingPhase 3
Pain relief after knee arthroscopy: numbing injection with added medication
This trial tests whether adding dexmedetomidine to a numbing injection (bupivacaine) inside the knee joint provides better pain relief after arthroscopic ACL reconstruction. It aims to help patients recover more comfortably after surgery.
AsyutAges 18–65 - NCT07377669Enrolling by invitation
Partial knee replacement plus ACL repair study
This study tests a combination surgery: repairing the torn ACL at the same time as replacing only the damaged part of your knee. It's designed for active people with arthritis in one knee compartment and a fully torn ACL.
BolognaAges 18–75 - NCT03747146Recruiting
Enhanced recovery plan for knee replacement pain control
This study tests an “enhanced recovery” approach for people getting total knee replacement, focused on better pain control using regional anesthesia and a home pain medicine plan. It may help you recover more comfortably and follow the care plan more smoothly after surgery.
New York, New YorkAges 18–65 - NCT07687966RecruitingPhase 2
Study of CBP-0276 for pain after major orthopedic surgery
This trial tests if a new medicine, CBP-0276, can help reduce the amount of opioids needed for pain after major bone surgery. It may help manage pain with fewer side effects.
Mexico CityAges 40–75 - NCT07356323Recruiting
Study on antibacterial drape for hip or knee replacement
This trial tests if a special antibacterial drape reduces contamination during hip or knee replacement surgery. The drape is placed over the skin to help prevent infection.
Fishers, IndianaAges 22 years+ - NCT05381818Recruiting
Breathing muscle training before joint surgery
This trial tests whether strengthening breathing muscles before total joint surgery can lower the chance of lung complications after the operation. It may help people who already have breathing problems or a history of smoking.
Jacksonville, FloridaAges 18–100 - NCT07241572Recruiting
Heart injury risk during below-knee surgery
This trial checks for heart muscle injury during surgery on the lower leg (below the knee). It helps doctors understand how to better protect patients having this type of operation.
AnkaraAges 18 years+ - NCT07501013Recruiting
Shoulder and knee surgery outcomes study
This study looks at how well different types of shoulder and knee surgeries work for sports injuries. It aims to help improve future care by following patients' recovery after common procedures like fixing torn cartilage or repairing ligaments.
Hangzhou, ZhejiangAges 8–80 - NCT06989229Recruiting
Nutritional care before and after joint replacement surgery
This trial tests if special nutritional support before and after hip or knee replacement helps you recover faster. It is for people having planned (not emergency) surgery.
Brno, CzechiaAges 18 years+ - NCT06145516Recruiting
Sleep program to ease pain after joint replacement
This study tests whether a sleep program can help with pain after knee or hip replacement. If you have insomnia and arthritis pain, you may be able to join before your surgery.
Uppsala, UpplandAges 18–100 - NCT07090928RecruitingPhase 4
Numbing medicine for less pain after knee scope surgery
This study tests whether giving bupivacaine (a numbing medicine) around the time of knee arthroscopy can reduce pain at the surgery sites and help you move your knee better after the operation.
Peshawar, KPKAges 18–70 - NCT06784882RecruitingPhase 4
Continuous vs. single-injection nerve block for outpatient knee replacement
This trial compares two types of nerve blocks for pain control after total knee replacement. You will receive either a one-time injection or a continuous block that delivers medication through a small tube. The goal is to see which method provides better pain relief while allowing you to go home the same day.
La Jolla, CaliforniaAges 18 years+ - NCT05981105Recruiting
Recovery and Chronic Pain After Knee Replacement
This study tests a special recovery program after knee replacement surgery to see if it helps reduce long-term pain. You may be eligible if you are having a first-time knee replacement for osteoarthritis, are between 18 and 65, and live near the hospital.
New York, New YorkAges 18–75 - NCT06893302Recruiting
Bone marrow injection during knee scope for cartilage or meniscus
This trial tests if adding a bone marrow injection to standard knee arthroscopy helps your knee heal better. It is for people with a torn meniscus or damaged cartilage who have healthy knee joints without arthritis.
New York, New YorkAges 18–64 - NCT06737770Recruiting
Bone-anchored leg implant study
This study tests a bone-anchored implant (directly attached to the thighbone) for people with a single leg amputation above the knee. It aims to see if this implant helps with pain, movement, and skin issues caused by a traditional socket prosthetic.
BolognaAges 18–65 - NCT07574762Recruiting
Knee Replacement: Computer Navigation vs. Robotic Surgery
This study compares two advanced surgical techniques for knee replacement in patients with knee arthritis. Researchers want to see if robotic-assisted surgery offers any advantages over computer-guided navigation surgery for placing the artificial knee.
Paris, ParisAges 18 years+ - NCT07020312RecruitingPhase 2
Brain training to improve muscle recovery after joint surgery
This trial tests whether brain-computer interface training can help you regain muscle control more effectively after knee or hip surgery. It focuses on four common procedures and uses neurofeedback to optimize muscle activation during recovery.
Chicago, IllinoisAges 18 years+ - NCT06896240Recruiting
Fiber smoothie trial for knee replacement patients
This trial tests if drinking a special fiber smoothie for 2 weeks before knee revision surgery can reduce inflammation and improve recovery. It is for people who are scheduled for knee replacement and have certain chronic health conditions.
New York, New YorkAges 40–80 - NCT07090616Recruiting
Comparing two knee braces after ACL surgery
This study compares two different knee braces used after ACL surgery to see which one helps people recover better. If you are having your first ACL reconstruction, you may be able to join and help find out if one brace works better than the other.
Chicago, IllinoisAges 18 years+
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Common questions
- Are there clinical trials for knee surgery?
- Yes. Clin2 currently lists 77 recruiting knee surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.