Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07313449Recruiting
Knee replacement study: 1-year results for a specific prosthesis
This study looks at how well a certain type of cemented total knee replacement works after at least one year. It may help doctors understand long-term outcomes for this specific knee implant.
StrasbourgAges 18 years+ - NCT07313020Enrolling by invitationEarly Phase 1
Handheld imaging to track stem cells in knee osteoarthritis
This trial tests a new handheld imaging device (MPI) to track stem cells injected into the knee. It aims to see if the device can safely monitor how the stem cells move and work in people with knee osteoarthritis.
Haikou, HainanAges 18–75 - NCT07306221Recruiting
Balance training after ACL surgery using visual guides
This study tests if a special video-based balance training program helps people recover knee function better after ACL reconstruction surgery. It is designed for patients who had surgery within the past year using their own hamstring tendon.
BeijingAges 18–45 - NCT07303998Recruiting
Brain stimulation and chair yoga for knee pain in Alzheimer's
This study tests two treatments together for people with Alzheimer's who also have chronic knee pain: a gentle brain stimulation (tDCS) and online chair yoga. The goal is to see if these can reduce knee pain and improve daily life.
Tucson, ArizonaAges 60 years+ - NCT07304323Recruiting
Predicting recovery after hip or knee replacement in 2018
This trial is for people who had hip or knee replacement surgery in 2018 at a specific hospital in Milan and then went to its rehabilitation unit. Researchers will use your medical records to build and test a tool that predicts recovery after joint replacement.
MilanAges 18 years+ - NCT07301242Recruiting
Study of ciprofol in older adults having limb surgery
This trial studies how the drug ciprofol works in older adults undergoing elective orthopedic limb surgery. The goal is to understand how the body processes the drug and how it affects patients, which may help improve its use for anesthesia in the elderly.
ShanghaiAges 65 years+ - NCT07281651Recruiting
Understanding pain sensitivity in knee pain and fibromyalgia
This study looks at how the brain and nerves process pain in people with knee pain or fibromyalgia. It compares them to pain-free people to understand differences in muscle signals.
Derby, DerbyshireAges 40 years+ - NCT07282782RecruitingPhase 4
Vancomycin for knee replacement surgery
This trial is testing the antibiotic vancomycin to prevent infections after total knee replacement. It may help if you are having your first knee replacement and are not severely overweight or diabetic.
San Diego, CaliforniaAges 18 years+ - NCT07271849RecruitingPhase 4
Timing of Nalbuphine for Pain and Blood Pressure in Older Knee Surgery Patients
This study tests whether giving the pain medicine nalbuphine at different times during knee replacement surgery affects blood pressure and pain control in older adults. It may help find the best timing to reduce pain and keep vital signs stable.
Jinan, ShandongAges 65–90 - NCT07264296Enrolling by invitation
Infection after bone cancer surgery with a big joint implant
This trial studies infections that happen after surgery for bone cancer where a large artificial joint is placed. It aims to understand why some patients get infections, which may lead to better prevention or treatment.
GothenburgAges Any age - NCT06532929Recruiting
Recovery after sports surgery with Teknimed products
This study is checking how well people recover after sports surgery using Teknimed products. It is for patients who had or will have a surgery with these products, and aims to see how the products perform in real life.
Aubenas, ArdècheAges 18 years+ - NCT05050409Recruiting
Program to help recovery after knee replacement surgery
This trial tests a supportive, coach-like “embedded” program designed to help you stay engaged and ready for recovery after one knee replacement. It may be helpful if you want extra support before and after surgery to follow through with your recovery plan.
Fort Sam Houston, TexasAges 18 years+ - NCT07265154Recruiting
Gait training with AI for above-knee amputees
This trial tests a new way to help people with above-knee amputations improve how they walk, using artificial intelligence to guide their gait training. It may help you walk more naturally and safely.
Banhā, BenhaAges 16–50 - NCT07251699Enrolling by invitation
Early weight bearing and knee exercises for tibial plateau fractures
This study tests if starting to put weight on your leg and doing knee exercises soon after surgery helps patients with a specific type of tibial plateau fracture recover better.
Giza, Giza GovernorateAges 25–50 - NCT07241572Recruiting
Heart injury risk during below-knee surgery
This trial checks for heart muscle injury during surgery on the lower leg (below the knee). It helps doctors understand how to better protect patients having this type of operation.
AnkaraAges 18 years+ - NCT05917028Recruiting
Nonsurgical injections to reduce knee osteoarthritis pain
This study tests a procedure called transcatheter arterial micro-embolization (a targeted injection done through blood vessels) to lessen pain from knee osteoarthritis. It may help people who still have significant pain despite standard “non-surgical” treatments like therapy and joint injections.
Seoul, Seodaemun-guAges 50 years+ - NCT06505525Recruiting
ACL reconstruction: adding extra support vs standard surgery
This trial compares two surgical techniques for ACL reconstruction. The standard method repairs the ACL inside the knee joint, while the new method also adds extra support outside the joint. The study aims to see which approach gives better stability and recovery for people with specific risk factors, like being a young athlete or having a chronic ACL tear.
São Paulo, São PauloAges 14–40 - NCT07231471Recruiting
Platelet-rich plasma for muscle and joint pain
This study tests whether an injection of your own platelet-rich plasma (PRP) can help heal muscle, tendon, or joint problems that haven't gotten better with other treatments like physical therapy or medications.
Salt Lake City, UtahAges 18 years+ - NCT07239232Recruiting
Knee balance and position sense in women with period pain
This study looks at how well young women with painful periods sense their knee position and keep their balance. It may help understand if period pain affects movement and coordination.
GizaAges 18–25 - NCT07237867Recruiting
Nerve stimulation for knee pain in athletes
This study tests if a mild electrical current to a nerve in the groin area can improve thigh muscle strength in athletes with long-standing jumper's knee (patellar tendinopathy). The goal is to see if this treatment can help reduce pain and improve function.
Barcelona, BarcelonaAges 18–40 - NCT06863636RecruitingPhase 3
Combination painkiller vs celecoxib for osteoarthritis flare-ups
This study tests whether a combination of two pain relievers (celecoxib and acetaminophen) works better than celecoxib alone for sudden, severe osteoarthritis pain in the knee or hip.
Mexico CityAges 40 years+ - NCT07215572Recruiting
Group physical therapy for veterans with knee osteoarthritis
This trial studies whether a group physical therapy program can help veterans with knee osteoarthritis. It aims to see if this approach is practical and effective for improving knee pain and function.
Durham, North CarolinaAges Any age - NCT07213778RecruitingPhase 3
Comparing a new drug to aspirin for blood clot prevention after knee replacement
This trial tests a new medicine called REGN7508 against aspirin to prevent blood clots after total knee replacement surgery. It may help if you are having a planned knee replacement and are in good health.
La Mesa, CaliforniaAges 18 years+ - NCT07214311RecruitingPhase 2/Phase 3
Preventing repeat knee infection after joint-saving surgery
This trial tests a new medicine called PLG0206 to help prevent a knee infection from coming back after a procedure to clean the joint while keeping the artificial knee in place. If you qualify, you'll receive the study medicine or a placebo along with standard antibiotics.
Sarasota, FloridaAges 18–85
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.