Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 819 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05644522Recruiting
At-home brace study for leg support and walking
This study tests an at-home wearable activity monitor and brace-related walking support for people who already use a knee-ankle-foot brace. It may help researchers understand how brace use and day-to-day movement relate to walking ability.
Chicago, IllinoisAges 18–89 - NCT05655156Recruiting
Study of a pig-tissue implant for serious knee ligament injuries
This trial studies an implant made from pig tissue for people with multiple injured knee ligaments. It aims to see how well the implant works and whether people can safely follow the required rehabilitation plan.
Stoke-on-TrentAges 18 years+ - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT05672784Recruiting
Knee numbing injections during knee replacement surgery
This trial compares two ways of numbing a knee area during planned knee replacement surgery: a nerve block alone versus a nerve block plus additional numbing medicine near the back of the knee. It may help doctors find which approach improves pain control and recovery while keeping side effects low.
ZagazigAges 21–60 - NCT05675618Recruiting
Returning to Golf After Joint Replacement Surgery
This study focuses on helping people get back to golfing after common orthopedic (bone/joint) surgeries like hip or knee or shoulder replacement. You may be asked to complete follow-up questionnaires to track recovery and return-to-golf progress.
New York, New YorkAges 18 years+ - NCT05754632Recruiting
Blood flow restriction exercises after ACL surgery in teens
This trial tests whether a special type of exercise that uses a cuff (blood flow restriction training, or BFRT) can help teens recover after ACL reconstruction. It’s designed to see if adding BFRT to standard rehab improves strength and return to sport.
Farmington, ConnecticutAges 12–18 - NCT05761015RecruitingPhase 4
Test of an NSAID to help osteoarthritis pain when walking
This trial studies whether taking an anti-inflammatory pain medicine (an NSAID) can reduce hip or knee osteoarthritis pain during walking. It may help people who have had walking pain for at least 3 months and don’t already take NSAIDs.
Clermont-FerrandAges 50–70 - NCT05780359Recruiting
Testing a drug-coated stent for leg artery blockages
This study tests whether a special “drug-eluting” stent placed in a leg artery works safely and improves blood flow for people with peripheral artery disease. It may help reduce re-narrowing and improve walking, depending on your blockage details and overall health.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05785884Recruiting
Diet program to help knee osteoarthritis pain
This trial studies whether different diet approaches can reduce knee pain in people with knee osteoarthritis who have certain eating patterns. It may help by changing diet-related factors that can affect inflammation and pain.
Birmingham, AlabamaAges 40–75 - NCT05788016Recruiting
Help planning an opioid taper before knee or hip surgery
This study looks at a plan to safely reduce (taper) opioid pain medicines before total knee or hip replacement surgery. It may help people who are already taking opioids and are preparing for surgery in the next 1 to 2 months.
Birmingham, AlabamaAges 18 years+ - NCT05792189Recruiting
Knee fracture surgery: plates vs knee replacement for older adults
This trial compares two ways to treat certain lower-thigh (distal femur) fractures near the knee: using plates/screws or doing a knee replacement. It aims to see which option works better for recovery and long-term outcomes.
Gainesville, FloridaAges 55–100 - NCT05818410Recruiting
Brain and tech training after below-knee leg loss
This study looks at how your brain works with assistive technology after losing a leg below the knee. It may help researchers improve how prosthetic devices feel and function by measuring brain and movement signals during training.
BrusselsAges 18–65 - NCT05917028Recruiting
Nonsurgical injections to reduce knee osteoarthritis pain
This study tests a procedure called transcatheter arterial micro-embolization (a targeted injection done through blood vessels) to lessen pain from knee osteoarthritis. It may help people who still have significant pain despite standard “non-surgical” treatments like therapy and joint injections.
Seoul, Seodaemun-guAges 50 years+ - NCT05933720Recruiting
Study drug peptides for blocked leg artery disease
This study tests how well a drug called Slavinorm® (regulatory polypeptides) works and is safe for adults with blocked arteries in the legs due to atherosclerosis. You might be considered if you have confirmed leg artery blockage and can safely do a treadmill walking test.
RyazanAges 18–80 - NCT05946044Recruiting
Preventing Knee Arthritis in People at Higher Risk
This study looks at ways to help prevent knee osteoarthritis before it starts. It is designed for women with higher body weight who currently have no arthritis signs on scans and do not have much knee pain.
Boston, MassachusettsAges 50 years+ - NCT05985785Recruiting
Bone Marrow vs Steroid Injection for Knee Arthritis
This study compares two different knee injections—one using your own concentrated bone marrow cells (BMAC) and the other using a steroid (cortisone)—to see which works better for long-term knee pain from osteoarthritis.
Chicago, IllinoisAges 18–70 - NCT05986292RecruitingPhase 2
Study of new treatments for chronic pain
This study tests new treatments for chronic pain that lasts at least 3 months. Participants must stop their regular pain medicines and use only a rescue painkiller if needed. The goal is to find better ways to manage long-term pain.
Birmingham, AlabamaAges 18 years+ - NCT05992038Recruiting
Bone putty as gap filler in knee realignment surgery
This trial tests a new bone putty used to fill the small gap created during realignment surgery for knee osteoarthritis. It aims to see if the putty helps the bone heal better and reduces pain.
Utrecht, UtrechtAges 18 years+ - NCT06071429Recruiting
Dissolvable medicine stent for leg artery disease
This trial tests a new dissolvable stent that slowly releases medicine to keep your lower-leg artery open. It is for people with severe leg pain or small wounds due to poor blood flow, and who are not eligible for other stents.
New York, New YorkAges 18 years+ - NCT06073106Recruiting
Frailty prevention study for older Asian adults
This trial tests a program to prevent frailty in people aged 50 and older of Asian descent who have recently been diagnosed with a stroke, traumatic brain injury, knee osteoarthritis, or breast cancer. The goal is to help you stay strong and healthy as you recover.
Singapore, SingaporeAges 50 years+ - NCT06074744Recruiting
Nerve blocks for knee replacement pain relief
This study compares two types of nerve blocks (subsartorial and femoral) to see which provides better pain control after knee replacement surgery. Both are injections that numb the nerves around your knee to help with recovery.
LucerneAges 18 years+ - NCT06075940Recruiting
A dissolving stent for blocked leg arteries below the knee
This study tests a new bioresorbable scaffold (like a temporary mesh) that slowly dissolves, releasing medication to keep your below-the-knee artery open. It is for people with severely blocked leg arteries causing pain or wounds at rest (Rutherford 4 or 5).
Randwick, New South WalesAges 18 years+ - NCT06080347Recruiting
Anti-inflammatory diet for knee osteoarthritis
This study tests whether an anti-inflammatory diet can help with knee osteoarthritis. If you have OA in one knee and are open to changing your eating habits, you may be able to join.
San Diego, CaliforniaAges 18 years+ - NCT06088602Recruiting
Cold therapy for pain after knee replacement
This trial tests a cold treatment called cryoneurolysis to reduce pain after knee replacement surgery. It may help you move better and use less pain medication.
HvidovreAges 18 years+
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 819 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.