Clinical trials
Major Depression Severe clinical trials
Below are recruiting major depression severe clinical trials, each written for real people, not researchers. We’re tracking 279 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06076317Recruiting
Telemedicine monitoring for depression after hospitalization
This trial tests whether regular video check-ins with a psychiatrist can improve recovery after a hospital stay for depression. You may be eligible if you started or changed an antidepressant or anti-anxiety medication while in the hospital and can use a computer or smartphone for video calls.
ParisAges 18 years+ - NCT06132581Recruiting
Brain stimulation for pleasure loss in depression
This study tests a new type of brain stimulation to see if it can help people with depression who have lost the ability to feel pleasure. It uses MRI scans to guide the treatment and may help improve motivation and goal-setting.
Tallahassee, FloridaAges 18–65 - NCT06213324RecruitingPhase 4
Ketamine's effects on brain circuits in depression
This trial studies how ketamine affects brain circuits in people with depression compared to healthy volunteers. It involves a single infusion of ketamine and brain scans before and after.
New York, New YorkAges 18–65 - NCT06323785Recruiting
Whole-body hyperthermia for depression
This trial tests whether safely raising your body temperature (whole-body hyperthermia) can help relieve depression. It's for people with moderate to severe major depression who are not currently taking antidepressants.
ZurichAges 18–65 - NCT06404320Recruiting
Exercise program for treatment-resistant depression
This study tests whether a physical activity program can help adults whose depression hasn’t improved after trying at least two antidepressants. If you’re sedentary, between 18 and 65, and have treatment-resistant depression, this program might offer a new way to feel better through exercise.
Toronto, OntarioAges 18–65 - NCT06410599RecruitingPhase 2
Medication boost for tough-to-treat chronic depression
This trial tests a new medication added to your current treatment for chronic depression that hasn't gotten better with at least two antidepressants and 12 therapy sessions. It might help when standard treatments aren't enough.
Tübingen, Baden-WürtembergAges 18–64 - NCT06443216Recruiting
Sleep modulation to treat depression
This study tests whether adjusting sleep patterns can help treat depression. It uses gentle brain stimulation (tDCS or TMS) and sound to study sleep's effect on mood.
GenevaAges 30–60 - NCT06559826RecruitingPhase 2
Ketamine therapy with or without talk for depression
This study compares ketamine alone to ketamine combined with psychotherapy for treating depression. It may help if you have moderate to severe depression and want to see if adding talk therapy improves results.
New York, New YorkAges 18–90 - NCT06580145RecruitingPhase 2
Leucine for midlife depression
This study tests whether leucine, a common amino acid supplement, can help treat moderate to severe depression in people aged 40–65. You'll have blood tests, an MRI, and a lumbar puncture to measure changes in your brain.
Atlanta, GeorgiaAges 35–65 - NCT06729541Recruiting
Precision treatments for common mental disorders
This study is developing more personalized treatments for schizophrenia, depression, or bipolar disorder. It may help find the best treatment approach for your specific situation.
Beijing, Beijing MunicipalityAges 18–65 - NCT06766526Recruiting
Online support for emotional adjustment after prostate cancer
This trial tests an online support program to help men cope with emotional distress after prostate cancer. You participate from home using a computer or smartphone.
LinköpingAges 18 years+ - NCT06824415Recruiting
Sleep TMS for depression
This trial tests whether a type of brain stimulation called TMS (transcranial magnetic stimulation), given during sleep, can improve depression. It's for adults who have not gotten enough relief from antidepressant medication.
Stanford, CaliforniaAges 18–65 - NCT06976840Recruiting
Rapid antidepressant effects of new brain stimulation methods
This trial tests whether two types of non-invasive brain stimulation can quickly improve depression symptoms. It may be an option for adults with major depression who are not currently taking psychiatric medication.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07003997RecruitingPhase 2
JAK inhibitor for depression with inflammation
This trial tests a JAK inhibitor (a type of anti-inflammatory drug) for depression that is linked to inflammation. If you have depression or bipolar depression and a high CRP level (a marker of inflammation), you may be eligible.
Atlanta, GeorgiaAges 25–55 - NCT07104916RecruitingPhase 2
Mindfulness and psilocybin therapy for PTSD
This study tests whether a combination of mindfulness training and a single dose of psilocybin can help reduce PTSD symptoms. It is for people with moderate-to-severe PTSD who are not on certain medications and do not have major health problems.
Columbus, OhioAges 21–65 - NCT07129941Recruiting
Unified group therapy for anxiety and depression
This study tests a group therapy program for adults aged 18-40 with anxiety or depression. It aims to help people learn skills to manage their emotions and symptoms together in a supportive group setting at a university clinic.
Bergen, VestlandAges 18–40 - NCT07140575Recruiting
Brain stimulation for teens with depression in the hospital
This trial tests if a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help teens with depression who haven't gotten enough relief from therapy or medication. It's designed for youth who are currently in the hospital or planning to be admitted.
Toronto, OntarioAges 14–19 - NCT07230990Recruiting
Brain Stimulation Study for Depression
This study uses a special type of brain stimulation (rTMS, which uses magnetic pulses) to treat depression. It focuses on part of the brain called the orbitofrontal cortex and aims to understand how stimulating it helps improve mood.
Boston, MassachusettsAges 18–65 - NCT07242105Recruiting
Improving brain activity in depression
This study tests if a type of brain stimulation (TMS) can improve brain function in people with depression. It also includes a small group of epilepsy patients who are already having brain monitoring. The goal is to find new ways to treat depression by targeting specific brain areas.
Iowa City, CaliforniaAges 18–65 - NCT07300969RecruitingPhase 2
Testing DT-101 for adults with depression
This trial tests a new medicine called DT-101 to see if it helps people with depression. It is for adults who have had more than one depressive episode in their life.
Bentonville, ArkansasAges 18–75 - NCT07349706Recruiting
Breathing exercise for dementia risk reduction
This trial tests a simple breathing exercise done for about 5–10 minutes each day for 8 weeks. It aims to see if this exercise can reduce your risk of dementia. If you are between 60 and 80 years old and have at least one risk factor for dementia, this study may be a fit for you.
Tallahassee, FloridaAges 60–80 - NCT07377682Recruiting
Trazodone for depression with mild memory problems
This study tests how well the antidepressant trazodone works in older adults with major depression and mild cognitive impairment (early memory or thinking problems). It looks at real-world results in people starting this treatment.
Lodz, PolandAges 55 years+ - NCT07383467Recruiting
Single session help for teens with anxiety or depression
This trial offers a one-time digital self-help program for Hong Kong teens aged 12 to 17 who feel anxious or down. It aims to see if a single session can make a difference.
Hong KongAges 12–17 - NCT07404085Recruiting
Cognitive training with medication for mood disorders
This trial tests if a medication can boost the effects of cognitive training in people with bipolar disorder or recurrent depression who have memory or thinking problems. It aims to improve daily functioning.
Frederiksberg, Capital Region of DenmarkAges 40–75
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Common questions
- Are there clinical trials for major depression severe?
- Yes. Clin2 currently lists 279 recruiting major depression severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.