Major Depressive Episode clinical trials

Study of NBI-1065845 for depression that hasn't fully responded to treatment

This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.

DT120 Treatment for Major Depression

This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.

A new pill for depression when current treatment isn't working well enough

This trial tests an investigational medication (NBI-1065845) added to your current antidepressant to see if it can improve depressive symptoms. It is for people with moderate to severe depression who have not fully responded to their current antidepressant.

Home bright light therapy for teen depression

This study tests whether a bright light therapy device you can use at home can help improve depression symptoms in teenagers aged 13-17. It compares the results of using the light with a non-active placebo device.

Seltorexant for Depression in Adults and Older Adults

This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.

Long-term effects of TMS for depression

This study looks at how well the benefits of transcranial magnetic stimulation (TMS) last over time for people with depression that didn't get better with other treatments. It also uses brain scans to find markers that might predict who will keep doing well.

Home brain stimulation for depression

This trial tests if a gentle electrical current applied to the head at home can help reduce symptoms of major depression. You would use a device for short sessions over several weeks, while continuing your usual care.

Testing a new drug for depression that hasn't fully responded to treatment

This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.

ABX-002 for major depression (add-on treatment)

This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.

Medication intensification after first treatment failure in mood and psychosis

This Phase 3 study tests a stronger medication approach after your first current treatment hasn’t worked well enough. It targets people with schizophrenia, major depressive disorder, or bipolar depression who still have significant symptoms and life impact.

Lumateperone for Hard-to-Treat Depression in Older Adults

This study tests lumateperone, a new medication added to your current antidepressant, to help treat depression that hasn't improved with other treatments. It's designed for people age 60 and older who have tried at least two antidepressants without success.

Closed-loop brain stimulation for hard-to-treat bipolar depression

This trial tests a closed-loop deep brain stimulation system for people with bipolar II disorder whose depression has not responded to standard treatments. The device sends targeted electrical pulses to the brain based on real-time activity, aiming to reduce depression symptoms.

Stress management and gentle movement for Asian Americans with depression

This study tests whether learning stress management and gentle movement (like Tai Chi or Qigong) can help Asian Americans with depression and physical symptoms. It may offer a way to feel better that you can do from home in online group sessions.

Low-Intensity Magnetic Stimulation for Major Depression

This study tests whether low-intensity transcranial magnetic stimulation can help treat major depressive disorder and looks at how it affects certain brain chemicals. It's for people currently getting depression treatment who are not pregnant and have no metal implants or certain health conditions.

ALTO-100 in Bipolar Disorder With Depression (BD-D)

Brain stimulation for teens with depression

This trial tests if a gentle electrical brain stimulation called tACS can help teens with depression who are already on stable medication. The treatment is added to their usual medication to see if it improves mood.

Does mother’s depression affect baby’s attention to emotions?

This study looks at how babies of mothers with depression pay attention to emotional faces. Researchers want to learn if these babies show different patterns of attention to happy or sad cues, which could help understand early development.

Testing lacosamide for hard-to-treat bipolar depression

This study tests if a medication called lacosamide can help people with bipolar depression that has not improved with at least two other treatments. It's for those with moderate to severe depression in bipolar I or II.

Ketamine and therapy for alcohol use disorder and depression

This trial tests if combining ketamine infusions with weekly therapy can help people who have both alcohol use disorder and hard-to-treat depression. You may qualify if you drink at least moderately, have treatment-resistant depression, and are willing to attend 8 therapy sessions.

Metabolomics study during ECT for depression

This study measures changes in your blood and/or body chemistry while you receive electroconvulsive therapy (ECT) for a severe mood episode. The goal is to understand biological signals related to ECT and treatment-resistant depression, which may help improve future care.

Testing a new antidepressant pill for depression

This study tests an experimental oral pill called azetukalner against a placebo to see if it safely reduces symptoms of major depressive disorder. It is for adults who are currently in a depressive episode lasting 6 weeks to 2 years and have not already tried multiple antidepressants that failed.

Using smartphone markers to manage depression symptoms

This study tests whether using a smartphone app to track your mood and behavior can help you manage depression symptoms better. You'll use digital tools to monitor your own progress and learn self-management strategies.

Testing a new ketamine-like drug for hard-to-treat depression

This study tests a new experimental drug (2R,6R)-HNK, a chemical related to ketamine, given by IV infusion to see if it can help people with depression that hasn't improved with other treatments. The goal is to find a new option for people who have not found relief from standard antidepressants.

Psilocybin brain imaging trial for depression

This study tests whether a single dose of psilocybin (a psychedelic compound) can help treat depression by looking at brain changes on MRI. It is designed for people with moderate-to-severe depression who have not responded well to other treatments.