Clinical trials
Major Surgery clinical trials
Below are recruiting major surgery clinical trials, each written for real people, not researchers. We’re tracking 95 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07331441Recruiting
Nerve block for pain relief after major upper abdominal surgery
This trial tests a nerve block given near the ribs to see if it reduces pain after surgeries like gastric, liver, gallbladder, or pancreatic surgery. It may help you need less pain medicine after the operation.
ShanghaiAges 18–85 - NCT07510451Recruiting
Predicting low blood pressure during major aortic surgery
This trial tests a new monitoring tool that predicts drops in blood pressure before they happen during major aortic surgery. It may help doctors keep your blood pressure more stable during the procedure.
Poznan, PoznańAges 18 years+ - NCT06802224RecruitingPhase 4
Medication to prevent kidney injury after major surgery
This study compares two medications given during surgery to see which one better protects the kidneys after the procedure. If you are having major non-cardiac surgery that lasts at least 2 hours and you need medication to support your blood pressure, this trial may be a good fit.
San Francisco, CaliforniaAges 18 years+ - NCT04266574Recruiting
Blood pressure–guided care for older or frail surgical patients
This study tests a goal-based blood pressure treatment approach during major surgery for people at higher risk (often older or frail with high blood pressure). The goal is to see if this BRAIN-targeted strategy can improve how patients do after surgery.
Rozzano, MilanAges 18 years+ - NCT07394816Recruiting
Can ultrasound-guided pain blocks reduce lung complications after abdominal surgery?
This study tests whether using ultrasound-guided pain blocks (fascial plane blocks) during major abdominal surgery can reduce lung complications after surgery, especially in older adults. It may offer better pain control and faster recovery.
Yenimahalle, AnkaraAges 65 years+ - NCT05673499Recruiting
Monitoring oxygen and brain signals during major newborn surgery
This study checks how well newborn babies’ brains are getting oxygen and how brain activity changes while they have certain major surgeries. It may help doctors better monitor brain safety during surgery in newborns with specific conditions.
New York, New YorkAges Up to 1.1 years - NCT07339449Recruiting
Monitoring during surgery to reduce time on a breathing tube
This study tests whether special monitors used during major abdominal surgery can help high-risk patients wake up sooner and need a breathing tube for less time after the operation.
Zagreb, CroatiaAges 50 years+ - NCT07008040Enrolling by invitation
Silver dressing to prevent infection after heart surgery
This trial tests whether a special silver dressing placed on the surgical wound after heart surgery can prevent infections. If you are scheduled for heart surgery through a breastbone cut, you may be eligible to join.
JeddahAges 18 years+ - NCT04461301Recruiting
Exercise training before surgery for older adults with low fitness
This study tests a pre-surgery “exercise and health training” program for older adults who are having major surgery and are already less fit than expected. It aims to help people tolerate surgery better and reduce complications by improving fitness beforehand.
Bern, Canton of BernAges 65 years+ - NCT05981105Recruiting
Recovery and Chronic Pain After Knee Replacement
This study tests a special recovery program after knee replacement surgery to see if it helps reduce long-term pain. You may be eligible if you are having a first-time knee replacement for osteoarthritis, are between 18 and 65, and live near the hospital.
New York, New YorkAges 18–75 - NCT04934683Enrolling by invitationPhase 4
Medication study during major surgery to protect blood pressure
This trial tests how well an “induction agent” medication works during major surgery to help keep blood pressure stable. It may help prevent complications in people at higher risk, especially those staying overnight in the hospital.
Omaha, NebraskaAges 45 years+ - NCT06480539RecruitingPhase 4
Dexmedetomidine for Better Sleep After Lung Surgery in Older Adults
This study tests whether giving a medicine called dexmedetomidine at night can help older adults sleep better and feel less tired after lung surgery. If you are 60 or older and having lung surgery through small cuts (thoracoscopy), you may be able to join.
Genk, LimburgAges 60 years+ - NCT07385430RecruitingPhase 1
Study of LGW16-03 to highlight nerves during surgery
This trial tests a dye called LGW16-03 that may help surgeons see nerves more clearly during open surgery. It is for people who are already scheduled for surgery where a major nerve will be exposed.
Lebanon, New HampshireAges 18 years+ - NCT07709975Recruiting
Pain relief and early movement for older ICU patients
This study tests different ways to manage pain and help older patients get moving again sooner after major surgery. If you are 65 or older and in the ICU, this trial may help you recover more comfortably and quickly.
Istanbul, IstanbulAges 65 years+ - NCT04825847Recruiting
Testing brain changes after major surgery in older adults
This study looks at how memory and thinking change after major surgery in people age 70 and older. It may help doctors understand who is at risk and how to reduce problems with thinking after surgery.
Montreal, QuebecAges 70 years+ - NCT05275218Recruiting
Preventing sudden kidney injury after major surgery
This trial tests whether a specific prevention intervention can reduce the chance of acute kidney injury (a sudden kidney problem) after major surgery compared with usual care. It focuses on people considered higher risk after their operation.
MünsterAges 18 years+ - NCT05694338Recruiting
Study frailty during major surgery for gut cancer
This trial studies how “frailty” affects people with gastrointestinal (gut) cancer who are about to have major surgery, sometimes after chemotherapy or other treatment beforehand. It may help doctors better prepare and support patients through surgery.
East Corning, New YorkAges 18 years+ - NCT05886725Recruiting
At-home walking test to help recovery after major surgery
This study looks at how a simple at-home walking pattern test, done before and after major surgery, relates to how older adults recover. It may help doctors better understand recovery and possibly tailor support after surgery.
Chicago, IllinoisAges 60 years+ - NCT06620588Recruiting
Preparing older adults for major surgery
This trial tests a program to help prepare adults over 65 who are having major non-cardiac surgery. It focuses on those who are frail and may need extra support before and after the operation.
Singapore, SingaporeAges 65–100 - NCT06887153Recruiting
Pain medicine use after major surgery
This study looks at how different pain medicines are used together after major surgery and how well they control pain. It may help improve pain relief for people having planned bone, belly, or chest surgeries.
KampalaAges 18 years+ - NCT06988176Recruiting
Frailty and muscle strength in older adults having major surgery
This study looks at how frailty and muscle strength affect recovery in adults 65 and older who are having planned major abdominal surgery. The goal is to see if simple tests can help predict outcomes and guide better care.
Chapel Hill, North CarolinaAges 65 years+ - NCT07010081Recruiting
Using a health app after major surgery
This study asks people who had major surgery at Jessa Hospital in Hasselt to fill out surveys on a digital health app. It looks at how helpful the app is for recovery after surgery.
Hasselt, LimburgAges 18 years+ - NCT07345169Recruiting
Immune and inflammation study in ICU patients
This study looks at how your immune system and inflammation affect your recovery in the intensive care unit. Researchers want to understand why some patients do better than others.
ParisAges 18 years+ - NCT06957912Recruiting
Ear nerve stimulation for recovery after major surgery
This trial tests if stimulating a nerve in your ear (vagus nerve) before and after noncardiac surgery can improve your recovery. It's for adults aged 18 to 84 having planned or time-sensitive surgery lasting at least 2 hours.
Beijing, Beijing MunicipalityAges 18–85
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Common questions
- Are there clinical trials for major surgery?
- Yes. Clin2 currently lists 95 recruiting major surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.