Clinical trials
Major Surgery clinical trials
Below are recruiting major surgery clinical trials, each written for real people, not researchers. We’re tracking 84 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07510451Recruiting
Predicting low blood pressure during major aortic surgery
This trial tests a new monitoring tool that predicts drops in blood pressure before they happen during major aortic surgery. It may help doctors keep your blood pressure more stable during the procedure.
Poznan, PoznańAges 18 years+ - NCT06802224RecruitingPhase 4
Medication to prevent kidney injury after major surgery
This study compares two medications given during surgery to see which one better protects the kidneys after the procedure. If you are having major non-cardiac surgery that lasts at least 2 hours and you need medication to support your blood pressure, this trial may be a good fit.
San Francisco, CaliforniaAges 18 years+ - NCT04266574Recruiting
Blood pressure–guided care for older or frail surgical patients
This study tests a goal-based blood pressure treatment approach during major surgery for people at higher risk (often older or frail with high blood pressure). The goal is to see if this BRAIN-targeted strategy can improve how patients do after surgery.
Rozzano, MilanAges 18 years+ - NCT07394816Recruiting
Can ultrasound-guided pain blocks reduce lung complications after abdominal surgery?
This study tests whether using ultrasound-guided pain blocks (fascial plane blocks) during major abdominal surgery can reduce lung complications after surgery, especially in older adults. It may offer better pain control and faster recovery.
Yenimahalle, AnkaraAges 65 years+ - NCT07339449Recruiting
Monitoring during surgery to reduce time on a breathing tube
This study tests whether special monitors used during major abdominal surgery can help high-risk patients wake up sooner and need a breathing tube for less time after the operation.
Zagreb, CroatiaAges 50 years+ - NCT05673499Recruiting
Monitoring oxygen and brain signals during major newborn surgery
This study checks how well newborn babies’ brains are getting oxygen and how brain activity changes while they have certain major surgeries. It may help doctors better monitor brain safety during surgery in newborns with specific conditions.
New York, New YorkAges Up to 1.1 years - NCT07008040Enrolling by invitation
Silver dressing to prevent infection after heart surgery
This trial tests whether a special silver dressing placed on the surgical wound after heart surgery can prevent infections. If you are scheduled for heart surgery through a breastbone cut, you may be eligible to join.
JeddahAges 18 years+ - NCT04461301Recruiting
Exercise training before surgery for older adults with low fitness
This study tests a pre-surgery “exercise and health training” program for older adults who are having major surgery and are already less fit than expected. It aims to help people tolerate surgery better and reduce complications by improving fitness beforehand.
Bern, Canton of BernAges 65 years+ - NCT07709975Recruiting
Pain relief and early movement for older ICU patients
This study tests different ways to manage pain and help older patients get moving again sooner after major surgery. If you are 65 or older and in the ICU, this trial may help you recover more comfortably and quickly.
Istanbul, IstanbulAges 65 years+ - NCT07385430RecruitingPhase 1
Study of LGW16-03 to highlight nerves during surgery
This trial tests a dye called LGW16-03 that may help surgeons see nerves more clearly during open surgery. It is for people who are already scheduled for surgery where a major nerve will be exposed.
Lebanon, New HampshireAges 18 years+ - NCT07345169Recruiting
Immune and inflammation study in ICU patients
This study looks at how your immune system and inflammation affect your recovery in the intensive care unit. Researchers want to understand why some patients do better than others.
ParisAges 18 years+ - NCT07010081Recruiting
Using a health app after major surgery
This study asks people who had major surgery at Jessa Hospital in Hasselt to fill out surveys on a digital health app. It looks at how helpful the app is for recovery after surgery.
Hasselt, LimburgAges 18 years+ - NCT05886725Recruiting
At-home walking test to help recovery after major surgery
This study looks at how a simple at-home walking pattern test, done before and after major surgery, relates to how older adults recover. It may help doctors better understand recovery and possibly tailor support after surgery.
Chicago, IllinoisAges 60 years+ - NCT04934683Enrolling by invitationPhase 4
Medication study during major surgery to protect blood pressure
This trial tests how well an “induction agent” medication works during major surgery to help keep blood pressure stable. It may help prevent complications in people at higher risk, especially those staying overnight in the hospital.
Omaha, NebraskaAges 45 years+ - NCT06957912Recruiting
Ear nerve stimulation for recovery after major surgery
This trial tests if stimulating a nerve in your ear (vagus nerve) before and after noncardiac surgery can improve your recovery. It's for adults aged 18 to 84 having planned or time-sensitive surgery lasting at least 2 hours.
Beijing, Beijing MunicipalityAges 18–85 - NCT07222072RecruitingPhase 4
Methadone to reduce opioid use after spine surgery
This study tests whether giving methadone during and after major spine surgery can help reduce the need for other opioid pain medicines later. It is for adults having multilevel fusion in the lower or mid-back.
Cleveland, OhioAges 18–72 - NCT07862777Recruiting
Predicting lung problems after major abdominal surgery in older adults
This study looks at whether a simple test from your blood and your physical health rating can help predict if you might have lung problems after a major surgery on your belly area. The goal is to help doctors plan better care for older patients during and after surgery.
Yenimahalle, AnkaraAges 65 years+ - NCT06267378Recruiting
Frailty and its effects on older patients having major gut surgery
This study looks at how frailty affects recovery and outcomes for patients aged 70 and older who are having planned surgery to remove colorectal cancer. The goal is to better understand frailty's impact so care can be improved.
Doncaster, South YorkshireAges 18 years+ - NCT07804706Recruiting
Blood test and heart response before cancer surgery
This study looks at whether a simple blood test and how your heart responds during anesthesia can predict complications after major cancer surgery. It may help doctors better prepare patients for surgery.
Ankara, Yeni̇mahalleAges 18 years+ - NCT06513598Recruiting
Finding infection signs after abdominal cancer surgery
This study looks for ways to better predict and catch infections after major abdominal cancer surgery. If you are having surgery for certain cancers (esophagus, stomach, pancreas, liver, bile ducts, colon, or rectum), the researchers will check your blood and other samples for early signs of infection so they can start treatment sooner.
VilniusAges 18 years+ - NCT07790172Recruiting
Risk factors for incisional hernia after major abdominal surgery
This study looks at why some people develop an incisional hernia (a bulge near a surgery scar) after major abdominal surgery. By joining, you may help researchers identify risk factors to improve future surgical care.
SohagAges 18 years+ - NCT07783464Recruiting
Heart rate variability and delirium after major abdominal surgery in older adults
This study looks at whether heart rate variability (a measure of your heart's ability to adapt to stress) can help predict delirium (confusion or disorientation) after major abdominal surgery in older adults. You may qualify if you are 65-85 years old, having major abdominal surgery, and do not have serious heart, nervous system, or memory problems.
Nanjing, JiangsuAges 65–85 - NCT07687966RecruitingPhase 2
Study of CBP-0276 for pain after major orthopedic surgery
This trial tests if a new medicine, CBP-0276, can help reduce the amount of opioids needed for pain after major bone surgery. It may help manage pain with fewer side effects.
Mexico CityAges 40–75 - NCT04103372Recruiting
MRI check for early rectal cancer or large polyps
This trial uses a special MRI before treatment to better understand early rectal cancer or suspicious large polyps. It may help doctors choose care that avoids bigger surgery when possible.
Reading, BerkshireAges 16–100
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Common questions
- Are there clinical trials for major surgery?
- Yes. Clin2 currently lists 84 recruiting major surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.