Clinical trials
Mental Health (Depression) clinical trials
Below are recruiting mental health (depression) clinical trials, each written for real people, not researchers. We’re tracking 310 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06773949Recruiting
Exercise before rTMS for hard-to-treat depression
This trial tests if doing exercise before repetitive transcranial magnetic stimulation (rTMS) can improve depression symptoms in people who haven't gotten better with standard treatments.
Ottawa, OntarioAges 18–75 - NCT06152705Recruiting
fMRI-Guided vs. Standard Brain Stimulation for Depression
This study compares two types of repetitive transcranial magnetic stimulation (rTMS) to treat depression. One type uses a brain scan (fMRI) to guide the treatment, while the other uses a standard approach. It may help people whose depression hasn't improved with medication.
Ottawa, OntarioAges 18 years+ - NCT07163013Recruiting
Digital therapy for teens with depression
This trial tests a digital therapy (a phone- or computer-based program) that teaches you skills to manage depression. It is designed for Chinese-speaking teens who have moderate to severe depression and are not currently receiving other treatment.
ChongqingAges 12–18 - NCT06417437RecruitingPhase 4
Brain-computer interface test for depression
This trial tests a non-invasive brain-computer interface (BCI) to help people with depression. It may be a good fit for teenagers and adults who are right-handed, Han Chinese, and have moderate to severe depression without other major health problems.
Shanghai, Shanghai MunicipalityAges 12 years+ - NCT05836090Recruiting
Family Spirit Strengths program for pregnant people and caregivers
This trial tests a family-focused program to support mental health and reduce risks related to substance use. It may help you if you’re pregnant or caring for a child 24 months or younger and you’re experiencing depression/anxiety and/or substance-use risk.
Chinle, ArizonaAges 14 years+ - NCT07278752Enrolling by invitation
Social media and emotions in teens study
This study looks at how social media affects teenagers' emotions and daily experiences. Participants will use a smartphone app to track their feelings and social media use over time.
Dallas, TexasAges 13–18 - NCT07138664Recruiting
Mental health program for teens in Malaysia
This trial tests a program to help young teenagers in Malaysia who are experiencing anxiety or depression. The program aims to improve mental health and well-being.
Kota Kinabalu, SabahAges 12–14 - NCT05497115Recruiting
Care model to improve access to mental health after trauma
This trial tests a practical care plan to help people get mental health support after a traumatic injury, especially if screening suggests risk for PTSD or depression. It may help you connect faster to the right kind of treatment after your injury.
Washington, VirginiaAges 16 years+ - NCT07287878Recruiting
Brain stimulation to improve social reward in depression
This trial tests a new type of brain stimulation called temporal interference stimulation to see if it can improve how people with depression experience social rewards. You may be eligible if you have depression with certain features like increased appetite, weight gain, or feeling very sensitive to rejection, and you are between 16 and 60 years old.
Shanghai, ChinaAges 16–65 - NCT06013488Recruiting
Character strengths coaching to reduce work stress for health workers
This trial tests a coaching program that uses your personal character strengths to help reduce work stress and improve your wellbeing. It is for rural ASHA health workers in Sehore, Madhya Pradesh who already provide depression care in their communities.
Bhopal, Madhya PradeshAges 18 years+ - NCT07390786Recruiting
Family support program after ICU stay
This study tests a collaborative care program for family members of ICU recovery patients, designed to improve mental health support after a loved one's hospitalization.
Charleston, South CarolinaAges 18 years+ - NCT04069091Recruiting
Program to help mothers with depression during pregnancy or after birth
This trial studies a maternal depression prevention and early help program for people who screen positive for depression. It may help improve mental health during pregnancy or the postpartum period and support health for both parent and child.
Helsinki, UusimaaAges Any age - NCT06773338Recruiting
Can playing Tetris improve mental health for migrants?
This study tests if playing the game Tetris can help reduce stress and improve mood for Arabic-speaking immigrants who have applied for asylum. You would play Tetris a few times and report how you feel.
The Hague, NLAges 18 years+ - NCT07364799Recruiting
Sound therapy for stress in detained teens
This trial tests a multi-sensory therapy called SoundHeal for teens in juvenile detention. It uses sound and vibration to help with stress, anxiety, depression, or substance use.
San Luis Obispo, CaliforniaAges 12–18 - NCT06239545Recruiting
JoyPop app for mental health support in young adults
This trial tests a mobile app called JoyPop designed to help young adults manage their mental health while they wait for services. It aims to see if using the app can improve well-being and reduce distress.
Thunder Bay, OntarioAges 18–25 - NCT07334561Recruiting
Brain stimulation for depression and pain
This study tests a non-invasive brain stimulation treatment (transcranial electrical stimulation) for people who have both depression and chronic pain. It aims to see if this treatment can help improve mood and reduce pain.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06518720RecruitingPhase 2
Psilocybin for Chronic Nerve Pain and Depression
This trial tests whether psilocybin (a psychedelic medication) can help people who have both chronic nerve pain and depression that hasn't responded to standard treatments. The goal is to see if it can reduce pain and improve mood.
Toronto, OntarioAges 18–65 - NCT06404632Recruiting
Healthy habits group program for adults with and without disabilities
This study tests a group program called LEV-G that helps adults build healthy everyday habits. It includes people with and without disabilities, and may support your health and well-being.
Stockholm, Stockholm, SwedenAges 15–80 - NCT07033780RecruitingPhase 1
Brain stimulation study for depression treatment
This trial tests a new type of brain stimulation called theta-burst stimulation to see if it helps treat depression. It is for people aged 18-50 who are currently experiencing a major depressive episode and are on a stable antidepressant regimen.
Toronto, OntarioAges 18–50 - NCT07499219Enrolling by invitation
Digital help for students waiting for mental health support
This study tests a short digital program for students who are on a waiting list for psychological treatment. It aims to see if the program can provide support while they wait.
Oslo, OsloAges 18–80 - NCT07031661Recruiting
Bipolar disorder risk study for teens and children
This study follows children and teens who may be at higher risk for bipolar disorder to develop a prediction model. It includes three groups: those with a parent who has bipolar disorder, those with atypical depression, and healthy volunteers.
Shanghai, Shanghai MunicipalityAges 6–18 - NCT06891300RecruitingPhase 2/Phase 3
Ketamine for Suicidal Thoughts in Depression
This study tests if ketamine can help reduce suicidal thoughts in people with major depression. You'll receive ketamine treatment and be monitored closely.
Ottawa, OntarioAges 18–65 - NCT06635486Recruiting
Mental health support for Venezuelans in Lima
This study offers mental health support to Venezuelan adults living in Lima who are feeling anxious, depressed, or have experienced trauma. It will check if you have signs of depression, anxiety, or post-traumatic stress and provide help if you do.
LimaAges 18 years+ - NCT05991154Recruiting
JoyPop app study for Indigenous young adults on a wait-list
This study tests a mobile app called JoyPop designed to help improve mental health and well-being. It is for Indigenous young adults who are waiting for counseling services at Dilico Anishinabek Family Care.
Thunder Bay, OntarioAges 18–25
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Common questions
- Are there clinical trials for mental health (depression)?
- Yes. Clin2 currently lists 310 recruiting mental health (depression) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental health (depression) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental health (depression) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.