Clinical trials
Metastases clinical trials
Below are recruiting metastases clinical trials, each written for real people, not researchers. We’re tracking 449 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05768490RecruitingPhase 3
Radiation plus targeted pills for EGFR lung cancer brain spots
This Phase 3 study tests whether giving brain radiation early or later, along with almonertinib (a targeted pill), works better for people with EGFR-mutated non-small cell lung cancer that has a small number of brain metastases. It aims to control brain disease while checking safety and effectiveness in a carefully selected group.
Guangdong, GuangzhouAges 18–75 - NCT05797077RecruitingPhase 3
After-surgery blood test–guided therapy for colon cancer liver spread
This Phase 3 trial tests whether an added “maintenance” treatment after liver surgery can help prevent colorectal cancer from coming back. It is only for people whose blood test (ctDNA) still shows signs of cancer after their operation.
Guangzhou, GuangdongAges 18–75 - NCT05794971RecruitingPhase 3
Regorafenib with irinotecan beads for colorectal liver spread
This Phase 3 trial tests whether adding a pill called regorafenib to irinotecan “drug-eluting” beads placed in the liver can shrink colorectal cancer that has spread mainly to the liver after standard chemotherapy stops working. If you qualify, it may offer a new combination approach for controlling liver tumors.
Guangdong, GuangzhouAges 18–70 - NCT04616495Recruiting
Liver transplant for colorectal cancer that can’t be removed
This trial studies liver transplantation for people with colorectal cancer that has spread to the liver but cannot be surgically removed. It aims to see if transplant can improve outcomes when the cancer is limited to the liver.
ValenciaAges 18–65 - NCT04863612Recruiting
SBRT for spinal tumors with possible spinal cord pressure
This study looks at treating spinal metastases (spread to the spine from a solid cancer) using SBRT, a focused type of radiation. It aims to control tumor growth and relieve or prevent spinal cord compression, sometimes alongside surgery.
Leuven, Vlaams BrabantAges 18–99 - NCT05265169Recruiting
Tested microwave ablation to treat liver metastases from colon cancer
This study tests whether a specific heating treatment (microwave ablation) can completely destroy small colon cancer spots in the liver. It may help patients who have limited liver tumors and need a precise, minimally invasive option.
Miami, FloridaAges 18 years+ - NCT05495399Recruiting
Radiation after limited spine surgery for spine metastases
This study tests whether radiation given after limited surgery helps control cancer that has spread to a small area of the spine. It may help reduce tumor growth in the treated spine area and improve local control after operation.
TaipeiAges 20 years+ - NCT06243003RecruitingPhase 1/Phase 2
Brain radiation for SCLC with brain metastases
This trial tests a new radiation approach for people with small cell lung cancer that has spread to the brain. It combines whole-brain radiation that avoids the memory centers, followed by focused radiation to the tumors, while you also receive standard chemotherapy and immunotherapy.
ShanghaiAges 18 years+ - NCT03222895Recruiting
Mapping lymph node spread in resectable esophageal cancer
This study looks at how esophageal (or esophagus-stomach junction) cancer spreads to nearby lymph nodes. Results may help doctors understand where cancer cells are likely to be, potentially improving future surgery planning.
Houston, TexasAges 18 years+ - NCT06265350Recruiting
Freezing lung tumors plus immunotherapy for liver cancer with lung spread
This study tests a combination of treatments—freezing the lung tumors (cryoablation) plus two drugs (cardonilizumab and bevacizumab)—for people with liver cancer that has spread only to their lungs. It may be an option if your first treatment stopped working but your liver tumors are under control.
Guanzhou, GuangdongAges 18–75 - NCT05346367Recruiting
Targeted brain radiation to improve treatment benefit and limit side effects
This study tests a more targeted form of stereotactic (precise) brain radiation for people with brain metastases from large cell cancer. It aims to improve the balance between effectiveness and side effects by carefully focusing where the radiation goes.
Leidschendam, South HollandAges 18 years+ - NCT06349278Recruiting
Surgery for pancreatic cancer with limited liver spread after chemo
This trial is for people with pancreatic cancer that has spread to the liver (3 spots or fewer). It tests whether removing both the original tumor and the liver spots after a specific chemotherapy (FOLFIRINOX) can be helpful. You may be eligible if the chemo shrinks the tumors enough and you are healthy enough for surgery.
Québec, QuebecAges 18 years+ - NCT06367491Recruiting
National database of bone metastases
This study is a national database that collects information from people with cancer that has spread to their bones from a solid tumor. By joining, you will help doctors learn more about bone metastases and improve care for future patients.
Imola, BolognaAges 18 years+ - NCT07845617Recruiting
Liver pump chemotherapy for cancer that has spread to the liver
This trial tests a treatment that delivers chemotherapy directly to the liver through a small pump. It is for people whose pancreatic or duodenal cancer has spread mainly to the liver, after they have had or are still getting treatment to try to cure the cancer.
Orlando, FloridaAges 18–80 - NCT04678583Recruiting
Surgery plan for RAS-mutant colon cancer liver metastases
This trial studies an approach to surgically removing liver metastases from colon (or rectal) cancer that has an RAS gene mutation (KRAS or NRAS). If you qualify, you would be evaluated for whether a “complete” (R0) liver operation is planned and technically possible, aiming to improve cancer control by how the liver is cut.
Mannheim, Baden-WurttembergAges 18 years+ - NCT07835893RecruitingPhase 2
Lenvatinib plus chemotherapy for pancreatic neuroendocrine tumors with liver spread
This trial tests a new combination of lenvatinib (a targeted therapy) plus standard chemotherapy for pancreatic neuroendocrine tumors that have spread to the liveraging after first-line treatment. The goal is to see if this combination can shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges 18–75 - NCT07830576Recruiting
Predicting survival after liver surgery for colorectal cancer
This study uses your liver MRI scans and medical information to build a tool that predicts survival after surgery for colorectal cancer that has spread to the liver. It may help doctors better understand your outlook and plan care.
Hefei, AnhuiAges 18–80 - NCT06476093Recruiting
Radiation plus anlotinib for lung cancer brain spread
This trial tests a combination of focused radiation (stereotactic radiosurgery) and an oral targeted therapy called anlotinib for people with non-small cell lung cancer that has spread to the brain. It may offer a way to control brain metastases without more invasive procedures.
Lianyungang, JiangsuAges 18–80 - NCT04520737Recruiting
Exercise coaching during chemotherapy for liver metastases
This trial studies whether a “prehab” program—structured exercise and preparation—can help people keep up function while they are on chemotherapy for colorectal cancer that has spread to the liver. If you can safely exercise, the program may help you tolerate treatment and stay active.
TarragonaAges 18 years+ - NCT07809672Recruiting
Stereotactic body radiation therapy for spinal metastases
This trial tests a precise type of radiation therapy for cancer that has spread to the spine. The goal is to see if this treatment is safe and effective in reducing the tumor while protecting your spinal cord and improving your quality of life.
TianjinAges 18 years+ - NCT07801274Recruiting
Focused radiation after spine surgery for metastatic tumors
This trial tests a precise type of radiation therapy given after spine surgery to treat cancer that has spread to the spine. The goal is to reduce pressure on the spinal cord and help control the disease with fewer side effects.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT03488953Recruiting
Two-step liver surgery using a living donor transplant
This study looks at a specialized liver transplant approach using a living donor, for people with colorectal cancer that has spread only to the liver and cannot be removed by standard surgery. It’s meant for cases where chemotherapy has helped stop or shrink the tumors, to improve the chance of successful treatment.
JenaAges 18 years+ - NCT07781306Recruiting
Imaging study for liver metastasis surgery
This study looks at how well imaging predicts the outcome of surgery for liver metastases from colorectal or breast cancer. If you are having surgery to remove liver metastases, you may be able to participate.
Wilrijk, AntwerpAges 18 years+ - NCT06185556RecruitingPhase 2/Phase 3
New treatments for liver tumors near blood vessels or bile ducts
This trial tests two procedures—irreversible electroporation and stereotactic body radiotherapy—for people whose colorectal cancer has spread to the liver (1–3 tumors near major blood vessels or bile ducts) and can't be surgically removed or treated with heat. The goal is to see if these approaches can safely destroy those hard-to-reach tumors.
Amsterdam, North HollandAges 18 years+
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Common questions
- Are there clinical trials for metastases?
- Yes. Clin2 currently lists 449 recruiting metastases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metastases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metastases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.