Clinical trials
Metastases clinical trials
Below are recruiting metastases clinical trials, each written for real people, not researchers. We’re tracking 452 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07202273Recruiting
One-time radiation treatment for painful bone metastases
This trial tests a single session of radiation therapy to relieve pain and improve stability in up to two bone spots where cancer has spread. The goal is to make treatment faster and more convenient for patients.
Salt Lake City, UtahAges 18 years+ - NCT07277322RecruitingPhase 1/Phase 2
Two immunotherapy drugs before surgery for MSS colorectal cancer with liver spots
This trial tests a combination of two immunotherapy drugs (Dupilumab and Toripalimab) before surgery for people with MSS colorectal cancer that has spread to the liver. The goal is to see if this treatment can shrink the liver tumors and help the body's immune system fight the cancer.
New York, New YorkAges 18 years+ - NCT06848842RecruitingPhase 2
Ivonescimab and chemotherapy for colorectal cancer that spread only to the liver
This trial tests a new drug called ivonescimab combined with chemotherapy for people whose colorectal cancer has spread only to the liver and cannot be surgically removed right away. The goal is to see if this combination can shrink the tumors enough to allow surgery or other treatments.
BeijingAges 18 years+ - NCT06524843Recruiting
Evaluating fracture risk from cancer spread to bone
This study looks at people with cancer that has spread to the bones. It uses your medical imaging and records to understand your risk of bone fracture, without testing any new treatment.
Bologna, Emilia-RomagnaAges 18 years+ - NCT06189079Recruiting
Arterial embolization for painful bone metastases
This study tests a procedure called arterial embolization, which blocks blood flow to bone tumors, to see if it can reduce pain or prevent fractures. It is for people with bone cancer that has spread from another cancer (metastases).
Bologna, Emilia-RomagnaAges 18 years+ - NCT06078813RecruitingPhase 1/Phase 2
Higher dose spine radiation for limited spread cancers
This trial tests a higher dose of focused radiation (SABR) for people whose solid cancer has spread to the spine in a few spots. The goal is to control those tumors with fewer side effects.
CorkAges 18 years+ - NCT05481658RecruitingPhase 1
DPCP plus immunotherapy for skin cancer spread to the skin
This Phase 1 study tests a skin-applied treatment called DPCP added to standard PD-1/PD-L1 immunotherapy for cancers that have spread to the skin. It aims to improve control of skin tumors while checking safety and how well the immune system responds.
New York, New YorkAges 18 years+ - NCT05495399Recruiting
Radiation after limited spine surgery for spine metastases
This study tests whether radiation given after limited surgery helps control cancer that has spread to a small area of the spine. It may help reduce tumor growth in the treated spine area and improve local control after operation.
TaipeiAges 20 years+ - NCT04742621Recruiting
Liver transplant for colon cancer that spread only to the liver
This trial studies using a liver transplant to treat colon or rectal cancer that has spread to the liver but not anywhere else. It may help people with limited liver-only spread whose disease hasn’t worsened for a while.
New York, New YorkAges 18–65 - NCT05589701Recruiting
Compare two radiation plans for painful spinal cancer spread
This study compares two different radiation approaches—SBRT and CRT—for people with painful cancer that has spread to the spine. It may help determine which plan controls pain and tumor growth while limiting side effects to nearby organs.
Toronto, OntarioAges 18–100 - NCT04020276Recruiting
Adaptive MRI radiation for liver metastases
This study tests a radiation treatment that uses real-time MRI (an imaging scan) to guide the dose for liver metastases. It may help control tumors while aiming to better protect nearby healthy liver tissue.
Madison, WisconsinAges 18 years+ - NCT05062317RecruitingPhase 2
Blood test-guided chemotherapy after liver tumor removal
This trial uses a blood test (ctDNA, a sign of cancer cells shedding into the blood) to help guide chemotherapy after surgery to remove colorectal liver metastases. It may help patients get the right chemotherapy plan after their operation, potentially based on whether cancer material is still detectable.
Houston, TexasAges 18 years+ - NCT04143516RecruitingPhase 2/Phase 3
Test tissue testing right after liver tumor ablation
This study looks at liver metastases treated with a procedure that destroys tumors (ablation) and then checks tumor tissue right away. The team wants to see whether the tissue results can guide immediate retreatment to better control cancer in the liver.
New York, New YorkAges 18 years+ - NCT04218617RecruitingPhase 2
One vs two radiation treatments for spine metastases
This trial tests whether giving radiation to a spine metastasis in one dose works as well as giving it in two smaller doses. It aims to control tumors while keeping side effects and risk to the spinal cord low.
Cleveland, OhioAges 18 years+ - NCT04678583Recruiting
Surgery plan for RAS-mutant colon cancer liver metastases
This trial studies an approach to surgically removing liver metastases from colon (or rectal) cancer that has an RAS gene mutation (KRAS or NRAS). If you qualify, you would be evaluated for whether a “complete” (R0) liver operation is planned and technically possible, aiming to improve cancer control by how the liver is cut.
Mannheim, Baden-WurttembergAges 18 years+ - NCT04520737Recruiting
Exercise coaching during chemotherapy for liver metastases
This trial studies whether a “prehab” program—structured exercise and preparation—can help people keep up function while they are on chemotherapy for colorectal cancer that has spread to the liver. If you can safely exercise, the program may help you tolerate treatment and stay active.
TarragonaAges 18 years+ - NCT03488953Recruiting
Two-step liver surgery using a living donor transplant
This study looks at a specialized liver transplant approach using a living donor, for people with colorectal cancer that has spread only to the liver and cannot be removed by standard surgery. It’s meant for cases where chemotherapy has helped stop or shrink the tumors, to improve the chance of successful treatment.
JenaAges 18 years+ - NCT06487013Recruiting
Focused ultrasound for painful bone metastases
This trial tests a focused ultrasound treatment called ArcBlate to relieve pain from bone cancer that has spread. It is for people who have moderate to severe pain despite cancer therapy and have chosen not to have surgery or radiation for that pain.
New Taipei CityAges 18 years+ - NCT06367491Recruiting
National database of bone metastases
This study is a national database that collects information from people with cancer that has spread to their bones from a solid tumor. By joining, you will help doctors learn more about bone metastases and improve care for future patients.
Imola, BolognaAges 18 years+ - NCT05872347RecruitingPhase 2
Brain metastasis breast cancer trial with hormone therapy plus SPH4336
This trial tests whether SPH4336, added to standard hormone (endocrine) therapy, can improve outcomes for people with breast cancer that has spread to the brain. It also looks closely at safety and side effects.
Hefei, AnhuiAges 18–75 - NCT05794971RecruitingPhase 3
Regorafenib with irinotecan beads for colorectal liver spread
This Phase 3 trial tests whether adding a pill called regorafenib to irinotecan “drug-eluting” beads placed in the liver can shrink colorectal cancer that has spread mainly to the liver after standard chemotherapy stops working. If you qualify, it may offer a new combination approach for controlling liver tumors.
Guangdong, GuangzhouAges 18–70 - NCT05575323Recruiting
Same-day radiation and stabilization for spine metastases
This trial tests whether giving focused radiation (SBRT) on the same day as spine surgery to stabilize the spine helps control symptoms from spinal metastases. It may help reduce pain and improve stability, especially when tumors threaten or affect the spine’s strength.
UtrechtAges 18 years+ - NCT06163820RecruitingPhase 1/Phase 2
Bevacizumab and immunotherapy with radiation for melanoma brain metastases
This trial tests a combination of a drug that stops blood vessel growth (bevacizumab), immunotherapy, and focused radiation to treat melanoma that has spread to the brain and is causing symptoms. The goal is to see if this approach shrinks tumors and improves outcomes.
Melbourne, VictoriaAges 18 years+ - NCT05265169Recruiting
Tested microwave ablation to treat liver metastases from colon cancer
This study tests whether a specific heating treatment (microwave ablation) can completely destroy small colon cancer spots in the liver. It may help patients who have limited liver tumors and need a precise, minimally invasive option.
Miami, FloridaAges 18 years+
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Common questions
- Are there clinical trials for metastases?
- Yes. Clin2 currently lists 452 recruiting metastases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metastases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metastases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.