Clinical trials
Metastases clinical trials
Below are recruiting metastases clinical trials, each written for real people, not researchers. We’re tracking 448 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07028268RecruitingPhase 2
Testing a new drug for bone metastases from solid tumors
This trial tests a new drug called SHR-2017 for people with solid tumors that have spread to the bones. The study aims to see if the drug can help manage pain and other effects of bone metastases.
Guangzhou, GuangdongAges 18 years+ - NCT07391410Recruiting
A registry study for bone metastases
This study is creating a registry to track information about people with bone metastases (cancer that has spread to the bones) who need treatment for symptoms. It may help researchers learn more about these conditions.
Basking Ridge, New JerseyAges 22 years+ - NCT06918860Recruiting
Nail vs. replacement for bone metastases in upper thigh
This trial looks back at past patients to compare two types of surgery for broken or weak thigh bones caused by cancer that spread. It helps doctors understand which option—a metal nail or a joint replacement—works better.
Bologna, Emilia-RomagnaAges 18 years+ - NCT06787183RecruitingPhase 2
Short-course radiation with chemoimmunotherapy for rectal cancer that has spread to the liver
This trial tests whether combining short-course radiation with a chemotherapy regimen (CAPOX) and an immunotherapy drug (QL1706) can help treat rectal cancer that has spread to the liver. It is designed for patients who have not had any prior cancer treatment.
Fuzhou, FujianAges 18–75 - NCT07202273Recruiting
Simpler radiation for painful bone tumors
This study tests a single, quick radiation treatment for one or two painful bone spots where cancer has spread. It aims to reduce pain and avoid multiple hospital visits.
Salt Lake City, UtahAges 18 years+ - NCT06805396RecruitingPhase 2
Adding palliative care support during radiation for bone cancer pain
This study tests whether adding a palliative care team early while you receive radiation for bone metastases can improve your quality of life and reduce symptoms.
AmersfoortAges Any age - NCT06470503Enrolling by invitation
Exercise after radiation for bone metastases
This study tests whether a supervised exercise program helps people with cancer that spread to their bones feel stronger and move better after radiation treatment. It is designed for people who can walk independently and have stable bones.
Toronto, OntarioAges 18 years+ - NCT05742425RecruitingPhase 2
Immunotherapy with chemo and targeted drug for colon cancer in the belly
This Phase 2 trial tests serplulimab (immunotherapy) combined with FOLFIRI chemo plus bevacizumab for colon cancer that has spread to the lining of the abdomen (peritoneal metastases). It aims to shrink these tumors and improve outcomes when surgery can’t fully remove them.
Huzhou, ZhejiangAges 18–75 - NCT07607873Recruiting
Transplant vs surgery after chemo for liver-only colorectal cancer
This trial compares liver transplant versus liver surgery for people whose colorectal cancer has spread only to the liver and cannot be removed initially. You would first receive chemotherapy to shrink the tumors, and if they become removable, you may be randomly assigned to have a liver transplant or standard liver surgery.
MilanAges 18 years+ - NCT07441369Enrolling by invitationPhase 2
Abemaciclib with chemotherapy for advanced colorectal liver metastases
This trial tests combining the targeted drug abemaciclib with standard chemotherapy (FOLFOX or FOLFIRI) for people whose colorectal cancer has spread to the liver and cannot be removed surgically. It may be an option if you've already tried two or three prior treatments without success.
ShanghaiAges 18–75 - NCT07146074Recruiting
Early radiation vs. observation for high-risk bone metastases
This trial tests whether giving radiation therapy early to high-risk but pain-free or nearly pain-free bone metastases can prevent future problems, compared to waiting and monitoring them. It is for people whose cancer has spread to multiple bones and who have certain risky features in those spots.
Wilrijk, AntwerpAges 18 years+ - NCT01697371Recruiting
Proton beam radiation for liver metastases
This trial tests whether proton beam therapy can control cancer that has spread to the liver. It may help shrink liver tumors or slow their growth while aiming to reduce harm to nearby organs.
Loma Linda, CaliforniaAges 18 years+ - NCT06987370Recruiting
Radiation study for bone metastases with soft tissue mass
This trial tests a new way of giving radiation (SFRT and SCART) to bone metastases that have a soft tissue mass. It may be an option if you have limited spread and your organs are working well.
Jinan, ShandongAges 18–75 - NCT06480955Recruiting
Freezing bone tumors to cure them: a registry study
This trial is studying the use of a freezing treatment called cryoablation to completely destroy bone tumors that have spread from other cancers. It is for people who have only a few tumors or whose tumors are mostly stable, and who are healthy enough to undergo the procedure.
BordeauxAges 18 years+ - NCT06132698RecruitingPhase 2
Immunotherapy injected into spinal fluid for lung cancer that has spread to the brain lining
This trial tests giving an immunotherapy drug directly into the spinal fluid for people with non-small cell lung cancer that has spread to the lining of the brain or spinal cord. The goal is to see if this approach can help control the cancer while allowing you to continue other treatments you may already be taking.
Chengdu, SichuanAges 18–75 - NCT07021534RecruitingPhase 1
CAR-NK and CAR-T cells for cancer with liver spread
This trial tests a new treatment that uses special immune cells (CAR-NK and CAR-T cells) given directly into the liver artery, then through a vein, to fight advanced solid tumors that have spread to the liver. It is for people who have already tried standard treatments and need new options.
Hangzhou, ZhejiangAges 18–75 - NCT07247396RecruitingPhase 1
CEA CAR-T therapy after surgery for colorectal cancer spread
This trial tests a special immune cell therapy (CAR-T) that targets a protein called CEA on cancer cells. It is for people with colorectal cancer that has spread to the lining of the belly (peritoneum) and who have already had surgery to remove as much of the spread as possible.
Hangzhou, ZhejiangAges 18–75 - NCT07135817Recruiting
Pre-surgery radiation for spinal tumors
This trial tests whether giving focused radiation before surgery can improve treatment for spinal tumors that have spread from other cancers. It may help people who need surgery for a spinal tumor and have a life expectancy of more than 6 months.
GöttingenAges 18 years+ - NCT07171996Recruiting
Radioactive seed therapy for spinal tumors
This trial tests a procedure where tiny radioactive seeds are placed into spinal tumors to relieve pain and control growth. It is for people with cancer that has spread to the bone and who are able to undergo the procedure safely.
Jinan, ShandongAges 18–55 - NCT07058428RecruitingPhase 3
FSRT with Avastin for multiple brain tumors from lung cancer
This trial tests giving focused radiation (FSRT) along with Avastin (bevacizumab) to people with multiple brain metastases from lung adenocarcinoma. It aims to see if combining these treatments is safe and effective for tumors that are too large or numerous for standard one-time radiation.
Guangzhou, GuangdongAges 18 years+ - NCT07402343RecruitingPhase 2
Tarlatamab for small cell lung cancer brain metastases
This trial tests a new drug, tarlatamab, for people with small cell lung cancer that has spread to the brain. It aims to see if the drug can shrink brain tumors and help you live longer, especially if you have not had brain radiation before.
AmsterdamAges 18 years+ - NCT07717437Recruiting
Liver cancer registry for patients who had vein embolization
This registry collects medical images and health information from patients with liver cancer or liver metastases who had a procedure to block certain liver veins (PVE/HVE). The goal is to learn more about this technique and help future patients.
Chicago, IllinoisAges 18 years+ - NCT03222895Recruiting
Mapping lymph node spread in resectable esophageal cancer
This study looks at how esophageal (or esophagus-stomach junction) cancer spreads to nearby lymph nodes. Results may help doctors understand where cancer cells are likely to be, potentially improving future surgery planning.
Houston, TexasAges 18 years+ - NCT03449238RecruitingPhase 1/Phase 2
Pembrolizumab with focused brain radiation for breast cancer brain spread
This trial studies whether pembrolizumab (an immune therapy medicine) plus stereotactic radiosurgery (focused radiation) can better control brain metastases from breast cancer. It may help shrink or slow growth of multiple brain spots with minimal treatment to surrounding tissue.
New York, New YorkAges 19–90
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Common questions
- Are there clinical trials for metastases?
- Yes. Clin2 currently lists 448 recruiting metastases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metastases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metastases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.