Clinical trials
Open Surgery clinical trials
Below are recruiting open surgery clinical trials, each written for real people, not researchers. We’re tracking 103 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03849443RecruitingEarly Phase 1
Testing tranexamic acid to reduce bleeding after spine fusion
This trial studies whether a single dose or multiple doses of tranexamic acid (TXA) can reduce the chance you need a blood transfusion after spine fusion surgery. It also compares two different ways TXA may be given (by mouth and through a vein) to see which approach works best and is safe.
Chicago, IllinoisAges 18 years+ - NCT07580443Recruiting
Quality of Life After Open Surgery for Complex Aortic Aneurysms
This study follows patients who have had open surgery to repair complex abdominal aortic aneurysms—bulges in the main blood vessel in the belly. Researchers will ask you about your quality of life after surgery to understand how well people recover and feel.
LucerneAges 18 years+ - NCT06664788Recruiting
Comparing two hemostatic agents for bleeding during open surgery
This trial tests a new hemostatic agent called ETHIZIA against the standard SURGICEL Original to see if it works better at stopping bleeding from soft tissues during planned open surgeries. If you need a more effective way to control bleeding during your procedure, this study might help.
Los Angeles, CaliforniaAges 22 years+ - NCT03797690Recruiting
Needle procedure for Dupuytren’s hand contracture
This trial looks at whether a minimally invasive needle procedure can improve hand stiffness caused by Dupuytren’s disease. It may help reduce finger bending that affects how you use your hand.
ParisAges 18 years+ - NCT06725030Recruiting
Robotic surgery for lymphedema (Symani System)
This trial uses a robotic arm called Symani to help surgeons perform more precise microsurgery (working on tiny blood vessels and lymph channels). It is for adults with moderate lymphedema in one arm or leg who have already tried standard lymphedema therapy and still have swelling.
Beverly Hills, CaliforniaAges 22 years+ - NCT05375292Recruiting
Pre-surgery fitness program for recovery after aneurysm surgery
This study tests whether a supervised “prehabilitation” program before planned open surgery helps you recover better after abdominal aortic aneurysm surgery. It’s mainly about improving outcomes when you have time to prepare for at least 6 weeks.
ToulouseAges 18–100 - NCT06253312Recruiting
Comparing treatments for severe pelvic artery blockages
This study looks back at adults treated for severe blockages in the large arteries of the pelvis and lower belly. Researchers want to compare how well different treatments (minimally invasive procedures, open surgery, or a mix) worked over time.
BelgradeAges 18–100 - NCT06720922Recruiting
Laser surgery for drug-resistant epilepsy
This trial tests a new, less invasive surgery called MRI-guided laser ablation (MRgLITT) for people with drug-resistant mesial temporal lobe epilepsy. It aims to stop or reduce seizures by using a laser to destroy the tiny area of the brain causing them.
Beijing, Beijing MunicipalityAges Any age - NCT07048522Recruiting
Nimodipine before bowel cancer surgery
This trial tests if giving nimodipine before and after surgery for bowel cancer can help improve recovery and reduce pain. It may be a good fit if you meet the age and health requirements.
Pátrai, AchaeaAges 18–75 - NCT07134361Recruiting
Ultrasound study for carpal tunnel syndrome
This study uses hand ultrasound to evaluate carpal tunnel syndrome before and after surgery. It may help doctors understand how the wrist changes after treatment.
São Paulo, São PauloAges 18 years+ - NCT05624398Recruiting
Hydrus stent plus cataract surgery for mild glaucoma
This study looks at outcomes for people with mild glaucoma who need cataract surgery, comparing how well the Hydrus stent works when placed during cataract surgery. The goal is to see whether this combined approach keeps eye pressure and vision stable with fewer issues.
Fayetteville, ArkansasAges 45 years+ - NCT06738654Recruiting
Robot-assisted scarless breast-conserving surgery for breast cancer
This trial uses a robotic arm through the armpit to remove breast cancer while leaving no visible scar on the chest. It is for women with early-stage breast cancer who want to keep their breast and avoid a scar.
Chongqing, Chongqing MunicipalityAges 18–65 - NCT07510451Recruiting
Predicting low blood pressure during major aortic surgery
This trial tests a new monitoring tool that predicts drops in blood pressure before they happen during major aortic surgery. It may help doctors keep your blood pressure more stable during the procedure.
Poznan, PoznańAges 18 years+ - NCT04962776RecruitingPhase 4
Carb plus nitrate drinks before gynecologic surgery
This trial compares two pre-surgery drink plans: a low-sugar/low-concentration carbohydrate drink plus nitrates versus a carbohydrate drink alone. It aims to see which plan works better for patients having open gynecologic surgery.
CairoAges 18–60 - NCT02996656Recruiting
Antibiotic prevention for skin bacteria in shoulder surgery
This study checks whether giving an antibiotic “ahead of surgery” can reduce problems from common skin bacteria (Propionibacterium acnes) during primary shoulder surgery. It may help lower the risk of infection around the new joint/repair.
Montreal, QuebecAges 18 years+ - NCT05786313Recruiting
Open-door neck surgery plan for cervical spinal narrowing
This study looks at a more tailored and standardized surgical approach for people with neck spinal narrowing and spinal cord symptoms. It may help doctors compare and improve how well surgery works for different patients.
Xi'an, Shannxi ProvinceAges 28–85 - NCT07477977Recruiting
Finding the right dose of protamine to reverse heparin after heart bypass
This study is testing different doses of a medication called protamine, which is given after heart surgery to reverse the effects of heparin (a blood thinner). The goal is to find the safest and most effective dose for patients who have had a heart-lung bypass machine during surgery.
SohagAges 18 years+ - NCT06233318Recruiting
Pain block for open heart surgery recovery
This study tests a nerve block given during open heart surgery to improve pain control. It might help patients recover with less discomfort.
Columbus, OhioAges 18 years+ - NCT05927233RecruitingPhase 4
Methylprednisolone in children after open-heart surgery
This trial tests whether giving methylprednisolone (a steroid medicine) can lower the body’s inflammatory response in children during the first day after congenital open-heart surgery. It may help reduce harmful inflammation and improve recovery for some children undergoing their first surgery.
Karachi, SindhAges 1 month–18 years - NCT07385430RecruitingPhase 1
Study of LGW16-03 to highlight nerves during surgery
This trial tests a dye called LGW16-03 that may help surgeons see nerves more clearly during open surgery. It is for people who are already scheduled for surgery where a major nerve will be exposed.
Lebanon, New HampshireAges 18 years+ - NCT06828432Enrolling by invitation
Device study for heart surgery patients in the heart intensive care unit
This trial tests a new device that measures heart function closely after heart surgery. It may help doctors give better care if you are in the heart intensive care unit after your operation.
Pittsburgh, PennsylvaniaAges 18–105 - NCT07351253Recruiting
Nerve block comparison for open appendix surgery
This study tests two types of nerve blocks (Erector Spinae Plane Block and Lateral Transversus Abdominis Plane Block) to see which provides better pain relief after open appendectomy. This could help reduce pain and the need for stronger painkillers after surgery.
Cairo, Cairo GovernorateAges 21 years+ - NCT06322810Recruiting
Pain relief methods for open heart surgery: ESP vs PIFB
This study compares two ways to manage pain after open-heart surgery. It looks at using an injection near the spine (ESP block) versus a needle placed through the chest wall (PIFB) to help reduce pain and the need for strong pain medicines.
Taichung, TaiwanAges 18 years+ - NCT06935708RecruitingPhase 4
Comparing morphine to epidural pain relief for colon surgery
This study compares two pain relief methods—morphine given through a spinal needle versus pain medicine delivered through a tiny tube in the back—after colorectal cancer surgery. It aims to see which approach works better for controlling pain.
SplitAges 18–80
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Common questions
- Are there clinical trials for open surgery?
- Yes. Clin2 currently lists 103 recruiting open surgery studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a open surgery trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a open surgery trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.