Clinical trials
Pain, Chronic Disease clinical trials
Below are recruiting pain, chronic disease clinical trials, each written for real people, not researchers. We’re tracking 457 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06913868Recruiting
Comparing two types of physical therapy for fibromyalgia pain
This study compares a standard physical therapy approach with one based on group consensus to see which works better for fibromyalgia pain. It may help find a more personalized treatment for your condition.
CairoAges 18–65 - NCT07198750Recruiting
Pulsed magnetic field therapy for knee osteoarthritis in older adults
This trial tests two types of high-intensity pulsed electromagnetic field therapy (one using two modes, another using one mode) to see if they can reduce pain and improve function in older adults with knee osteoarthritis. You would attend 9 treatment sessions and do exercises at home.
Guadalajara, JaliscoAges 60 years+ - NCT07030582Recruiting
Online therapy for back pain and recovery after spinal fusion
This trial tests if internet-based cognitive behavioral therapy can help people recover better after lumbar fusion surgery by reducing pain, strengthening back muscles, and improving outlook on recovery. You can participate from home using WiFi.
Nantong, JiangsuAges 18–55 - NCT06239649Recruiting
Nerve block before knee replacement for faster recovery
This trial tests whether a numbing injection (nerve block) around the knee before surgery can help you recover faster and feel less pain after a total knee replacement. It is for people with knee osteoarthritis who are ready for their first knee replacement surgery.
Denizli, PamukkaleAges 40–85 - NCT06960018Recruiting
Ennovate minimally invasive spinal screw placement study
This study tests a new, less invasive method for placing screws in the cervical spine (upper back and neck). It is designed for patients who need spinal stabilization after injury or degeneration.
AachenAges 18 years+ - NCT06915363Recruiting
BioPoly implant for knee cartilage repair
This trial tests a BioPoly implant to repair a small damaged cartilage spot in your knee. If you have a specific type of cartilage injury that didn't get better with other treatments, this implant may help relieve pain and improve function.
Fort Wayne, IndianaAges 30–65 - NCT06527183Recruiting
Fibromyalgia and small fiber nerve study
This study looks at whether people with fibromyalgia or long-term chronic pain have damage to the small nerve fibers in their skin. Understanding this could help develop better treatments.
Boulogne-BillancourtAges 18 years+ - NCT06484322Recruiting
Online occupational therapy for better everyday life with chronic illness
This trial tests an internet-based program to help people with chronic conditions build strategies for a more active daily life. It may be right for you if you're struggling with everyday activities and are open to change.
Luleå, None SelectedAges 18–75 - NCT06350409Recruiting
Opioid use after surgery in teens
This study looks at how teens aged 12–17 use opioids after a scheduled surgery. It aims to understand outcomes and help improve pain management.
Aurora, ColoradoAges 12–17 - NCT06297200Recruiting
Ultrasound treatment for complex back pain patients
This study tests a new, non-invasive ultrasound treatment for people with long-term back pain who also have opioid use disorder and anxiety. It aims to see if this gentle brain stimulation can reduce pain and improve quality of life.
Roanoke, VirginiaAges 18–65 - NCT06213233RecruitingPhase 2
CBD oil for veterans with chronic pain
This study tests whether CBD oil can help veterans manage chronic pain. You would take a daily dose of CBD and report your symptoms using a smartphone app.
Ann Arbor, MichiganAges 18 years+ - NCT05761015RecruitingPhase 4
Test of an NSAID to help osteoarthritis pain when walking
This trial studies whether taking an anti-inflammatory pain medicine (an NSAID) can reduce hip or knee osteoarthritis pain during walking. It may help people who have had walking pain for at least 3 months and don’t already take NSAIDs.
Clermont-FerrandAges 50–70 - NCT05585229RecruitingPhase 2
Psilocybin therapy to help you taper opioid pain medicine
This Phase 2 study tests a structured, therapist-led treatment using standardized natural psilocybin to help people reduce or stop long-term opioid use for chronic (non-cancer) pain. It’s mainly for those who have tried tapering before but couldn’t, and who are motivated to try again.
Kelowna, British ColumbiaAges 19–75 - NCT05657964Recruiting
Study of a back pain exercise program for chronic low back pain
This trial tests whether a structured exercise/education program can help people with chronic lower back pain. You may qualify if your pain and disability scores are high enough and you can complete study activities in English.
Redwood City, CaliforniaAges 18–65 - NCT05596591Recruiting
Shockwave treatment for knee arthritis pain with MRI-confirmed lesions
This trial tests whether focused shockwave therapy (a non-surgical treatment) can reduce knee arthritis pain. It specifically targets people whose MRI shows a small bone problem in one area of the knee.
Cedar Knolls, New JerseyAges 30–80 - NCT05555485Recruiting
Check if ear stimulation can help chronic pain and reduce opioids
This study tests whether a device that stimulates the ear (through the skin) can reduce chronic pain and help people lower their opioid pain medicine. It may help you manage pain with less opioid use if you meet their safety and medication criteria.
Galveston, TexasAges 18–65 - NCT05068791RecruitingEarly Phase 1
Psilocybin-assisted treatment for long-term body pain
This early trial studies whether psilocybin, given in a supported setting, can reduce long-term widespread musculoskeletal pain (including fibromyalgia-like symptoms). You would be monitored closely and need someone to take you home after the medicine session.
Birmingham, AlabamaAges 25–65 - NCT07622121RecruitingPhase 3
Treatment for long-term thyroid eye disease
This trial tests a new medication for people with long-term thyroid eye disease that has lasted over a year. The aim is to see if it can reduce symptoms like bulging and discomfort.
Coral Gables, FloridaAges 18–75 - NCT07119255Recruiting
PRP acupuncture for long-term neck pain from muscle tightness
This study tests whether a treatment called platelet-rich plasma (PRP) acupuncture — using your own blood proteins — can reduce chronic neck pain caused by a common muscle condition. It may be a good option if you have had neck pain for months and want a non-surgical approach.
JakartaAges 18–59 - NCT06757491Recruiting
Low frequency brain stimulation for diarrhea-predominant IBS pain
This trial tests if a type of brain stimulation called low-frequency repetitive transcranial magnetic stimulation (lf-rTMS) can reduce belly pain in people with irritable bowel syndrome that causes diarrhea (IBS-D). It is a non-invasive treatment that uses magnetic pulses to target areas of the brain involved in pain perception.
Suzhou, JiangsuAges 18–75 - NCT07764354Recruiting
Patient education for sticking with home exercises
This study tests whether extra education helps people with chronic musculoskeletal conditions—like long-term back pain, knee arthritis, or partial rotator cuff tears—stick with their home exercise routines to feel better. If you have one of these conditions and are willing to follow a home exercise plan, this could help you manage pain.
Dammam, Eastern ProvinceAges Any age - NCT05345015Recruiting
Radio waves for muscle or low back pain and function
This trial tests whether a high-frequency radio-wave treatment can reduce pain and improve movement in adults with a muscle strain (hamstring) or acute or chronic low back pain. It may help you feel less pain and function better, depending on your specific injury and medical details.
KavalaAges 18–65 - NCT05100381Recruiting
Dry needling for long-lasting lower back muscle pain
This study tests whether dry needling (thin needles placed into specific muscles) can reduce moderate, long-lasting lower back pain. It focuses on people who have pain from trigger points in a specific back muscle, rather than pain caused by other medical problems.
Tehran, Tehran ProvinceAges 18–45 - NCT06709391Recruiting
Spinal fusion vs. no surgery for chronic low back pain
This trial tests whether a spinal fusion surgery is better than staying with non-surgical treatments for people with long-term, severe low back pain from worn-out discs in the lower spine. It aims to find out which approach offers better pain relief and quality of life.
GothenburgAges 25–65
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Common questions
- Are there clinical trials for pain, chronic disease?
- Yes. Clin2 currently lists 457 recruiting pain, chronic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain, chronic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain, chronic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.