Clinical trials
Pain, Chronic Disease clinical trials
Below are recruiting pain, chronic disease clinical trials, each written for real people, not researchers. We’re tracking 467 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06426316Recruiting
Immune cells and migraines study
This study looks at how certain immune cells and inflammatory chemicals relate to migraines. If you have migraines or an autoimmune condition (like lupus, rheumatoid arthritis, or Crohn's disease), you may be able to participate. The goal is to understand what causes migraines.
Clermont-Ferrand, AURAAges 18–50 - NCT06980948RecruitingPhase 1/Phase 2
Gene therapy study for nerve pain from small fiber neuropathy
This trial tests a new gene therapy called ST-503 for people with long-lasting nerve pain from small fiber neuropathy that hasn't improved with standard treatments. The study will check if the treatment is safe and tolerable.
Scottsdale, ArizonaAges 18 years+ - NCT06637709Recruiting
Pain after osteoarthritis treatment: a 24-month study
This study looks at why some people still have pain after knee surgery or other treatments for osteoarthritis. It tests a marker in the blood to see if it relates to ongoing pain. You would be followed for 24 months.
Roma, RomaAges 18–99 - NCT07285018RecruitingPhase 2
Study of a new drug for diabetic nerve pain in legs
This trial tests an investigational drug for people with pain caused by nerve damage from diabetes (diabetic peripheral neuropathy). It may help reduce pain in your lower legs if other treatments haven't worked well.
Birmingham, AlabamaAges 18 years+ - NCT06187038Recruiting
Pain education study for knee osteoarthritis
This trial tests if learning about chronic pain can help people with knee osteoarthritis feel better. You'll join a program that teaches you about pain and how to manage it.
São PauloAges 40–80 - NCT05183503Enrolling by invitation
Study of pain, stress, anxiety, and depression in jaw disorder
This study looks at how chronic jaw pain from temporomandibular disorder (TMD) relates to stress, anxiety, and depression in adults. Your results may help researchers better understand what affects symptoms and how people respond to care.
WroclawAges 18–80 - NCT06084520Recruiting
Pain questionnaire study for opioid and non-opioid patients
This study tests two questionnaires for people with long-term pain. Researchers want to see if the tools work well for both those taking opioids and those who are not. Your answers can help improve pain care.
Uppsala, UpplandAges 18–75 - NCT05657964Recruiting
Study of a back pain exercise program for chronic low back pain
This trial tests whether a structured exercise/education program can help people with chronic lower back pain. You may qualify if your pain and disability scores are high enough and you can complete study activities in English.
Redwood City, CaliforniaAges 18–65 - NCT07030582Recruiting
Online therapy for back pain and recovery after spinal fusion
This trial tests if internet-based cognitive behavioral therapy can help people recover better after lumbar fusion surgery by reducing pain, strengthening back muscles, and improving outlook on recovery. You can participate from home using WiFi.
Nantong, JiangsuAges 18–55 - NCT06527183Recruiting
Fibromyalgia and small fiber nerve study
This study looks at whether people with fibromyalgia or long-term chronic pain have damage to the small nerve fibers in their skin. Understanding this could help develop better treatments.
Boulogne-BillancourtAges 18 years+ - NCT07677540Recruiting
Nerve blocks before chest surgery to prevent long-term pain
This study is looking at two different types of nerve blocks—one called an erector spinae block and one called thoracic epidural—given before chest surgery to see if either can help prevent long-term pain after the operation.
Kfar SabaAges 18–99 - NCT07621367Recruiting
Gut oxygen therapy for bowel problems from low oxygen
This trial tests a treatment that delivers oxygen directly to the gut through a small tube. It is for people with long-term heart failure or sleep apnea who also have belly pain, bloating, constipation, or diarrhea.
Nanjing, JiangsuAges 18 years+ - NCT07696923Recruiting
Treating frozen shoulder with microembolization or steroid injection
This trial compares two treatments for frozen shoulder: a new procedure that blocks tiny blood vessels (TAME) and a steroid injection. You must have had shoulder pain for at least a month and be willing to do physical therapy.
TaipeiAges 18–80 - NCT04427709RecruitingPhase 2
Testing a brain-activity measure using oxytocin and eye movements
This study tests whether a particular brain-activity signal—seen in small rhythmic eye movements—can be measured reliably. It also looks at how oxytocin (a hormone used in medical settings) affects that signal.
Winston-Salem, North CarolinaAges 18–75 - NCT05068791RecruitingEarly Phase 1
Psilocybin-assisted treatment for long-term body pain
This early trial studies whether psilocybin, given in a supported setting, can reduce long-term widespread musculoskeletal pain (including fibromyalgia-like symptoms). You would be monitored closely and need someone to take you home after the medicine session.
Birmingham, AlabamaAges 25–65 - NCT05555485Recruiting
Check if ear stimulation can help chronic pain and reduce opioids
This study tests whether a device that stimulates the ear (through the skin) can reduce chronic pain and help people lower their opioid pain medicine. It may help you manage pain with less opioid use if you meet their safety and medication criteria.
Galveston, TexasAges 18–65 - NCT05580419Recruiting
Program training to improve chronic pain care
This trial tests whether a 4PCP training program for primary care clinicians improves both clinician and patient outcomes for people living with chronic non-cancer pain. If you have long-lasting pain and can take part in questionnaires and visits, your participation may help evaluate whether this program leads to better care and results.
Cleveland, OhioAges 14–80 - NCT05585229RecruitingPhase 2
Psilocybin therapy to help you taper opioid pain medicine
This Phase 2 study tests a structured, therapist-led treatment using standardized natural psilocybin to help people reduce or stop long-term opioid use for chronic (non-cancer) pain. It’s mainly for those who have tried tapering before but couldn’t, and who are motivated to try again.
Kelowna, British ColumbiaAges 19–75 - NCT05596591Recruiting
Shockwave treatment for knee arthritis pain with MRI-confirmed lesions
This trial tests whether focused shockwave therapy (a non-surgical treatment) can reduce knee arthritis pain. It specifically targets people whose MRI shows a small bone problem in one area of the knee.
Cedar Knolls, New JerseyAges 30–80 - NCT05761015RecruitingPhase 4
Test of an NSAID to help osteoarthritis pain when walking
This trial studies whether taking an anti-inflammatory pain medicine (an NSAID) can reduce hip or knee osteoarthritis pain during walking. It may help people who have had walking pain for at least 3 months and don’t already take NSAIDs.
Clermont-FerrandAges 50–70 - NCT05981573Recruiting
Measuring methadone doses for chronic pain
This trial is for people with chronic pain who take daily methadone. It aims to measure how much methadone is in your body to help doctors find the right dose.
Lemon Grove, CaliforniaAges 18–70 - NCT06213233RecruitingPhase 2
CBD oil for veterans with chronic pain
This study tests whether CBD oil can help veterans manage chronic pain. You would take a daily dose of CBD and report your symptoms using a smartphone app.
Ann Arbor, MichiganAges 18 years+ - NCT06239649Recruiting
Nerve block before knee replacement for faster recovery
This trial tests whether a numbing injection (nerve block) around the knee before surgery can help you recover faster and feel less pain after a total knee replacement. It is for people with knee osteoarthritis who are ready for their first knee replacement surgery.
Denizli, PamukkaleAges 40–85 - NCT06297200Recruiting
Ultrasound treatment for complex back pain patients
This study tests a new, non-invasive ultrasound treatment for people with long-term back pain who also have opioid use disorder and anxiety. It aims to see if this gentle brain stimulation can reduce pain and improve quality of life.
Roanoke, VirginiaAges 18–65
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Common questions
- Are there clinical trials for pain, chronic disease?
- Yes. Clin2 currently lists 467 recruiting pain, chronic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain, chronic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain, chronic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.