Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,142 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07585721Recruiting
Pain Relief After Root Canal Treatment: Two Different Medications
This study compares two types of medications placed inside a tooth after root canal treatment to see which one reduces pain better. You'll be asked about your pain levels after treatment, and researchers will measure a pain-related substance in your saliva.
CairoAges 18–45 - NCT06723730Recruiting
Mobilization and core strength for rotator cuff pain
This trial tests if adding a specific type of shoulder movement therapy and upper body core exercises can reduce pain and improve function in people with rotator cuff-related shoulder pain. It may help you if you have had shoulder pain for more than 6 weeks and it started after an injury.
Rawalpindi, Punjab ProvinceAges 18–65 - NCT06723353Recruiting
Combined therapy for belly separation in new mothers
This trial tests if a gentle hands-on treatment (visceral manipulation) plus special tape (kinesio taping) can help close the gap in your belly muscles, reduce pain, stop bladder leaks, and improve your pelvic floor strength and overall well-being after childbirth.
Karachi, SindhAges 35–45 - NCT07577154Recruiting
Brain-Monitoring Anesthesia for Pediatric Throat Surgery
This trial tests a special brain-monitoring device (called Conox) during anesthesia for children having their tonsils and adenoids removed. The goal is to help doctors give the right amount of anesthetic medicine by watching your child's brain activity in real time.
KayseriAges 3–12 - NCT05816226RecruitingPhase 3
Topical cream for jaw joint pain
This Phase 3 study tests a skin-applied treatment (a cream or gel) to reduce pain in the jaw joint (TMJ). You may benefit if you have TMJ pain and can safely use the study medication without conflicting treatments.
San Francisco, CaliforniaAges 18 years+ - NCT07574216Recruiting
DHEA vs Estradiol for Vaginal Symptoms After Menopause
This study compares two vaginal treatments—DHEA and estradiol—to help relieve common menopause symptoms like dryness, itching, or discomfort during sex. You'll use vaginal therapy (applied directly where symptoms occur) and help researchers understand which works better.
Phoenix, ArizonaAges 40–90 - NCT07576582Recruiting
Mud therapy for jaw joint pain
This trial tests whether a special mud treatment (peloid therapy) can reduce jaw joint pain and improve function in people with temporomandibular joint disorder. It is a non-drug approach that may help those who have had jaw pain for at least 4 weeks.
Uşak, MerkezAges 18–65 - NCT07571122Recruiting
Brain Training to Help Heel Pain and Balance
This study tests whether cognitive training (exercises that challenge your thinking and memory) combined with physical exercises can reduce heel pain, improve balance, and strengthen foot function in people with plantar fasciitis. The goal is to see if training your brain alongside your body helps more than physical therapy alone.
CairoAges 18–60 - NCT07575230Enrolling by invitationPhase 4
Pain relief after skin cancer surgery: new drug vs standard
This study compares a new pain medication (suzetrigine) to a common pain reliever (Norco) for people recovering from Mohs micrographic surgery, a specialized procedure to remove skin cancer. The goal is to see if the new medication works better and is safer for post-surgery pain.
Dallas, TexasAges 18–89 - NCT07575555Recruiting
Lipedema's role in knee arthritis in women
This study compares women with knee arthritis who do or don't have lipedema (a condition causing painful fat buildup, usually in the legs) to understand how lipedema affects knee joint health. Results may help doctors better treat knee arthritis in women with lipedema.
Izmir, İzmirAges 30–65 - NCT07576985Enrolling by invitation
IV Tylenol for Pain and Agitation After Throat Surgery in Young Children
This study tests whether giving acetaminophen (Tylenol) through an IV (a vein) instead of by mouth helps reduce pain and fussiness after tonsil and adenoid removal in children age 7 and under. The goal is to find better ways to keep children comfortable during recovery.
Cleveland, OhioAges Up to 8 years - NCT07568418Recruiting
Skin Response Monitoring in Ventilated Premature Babies
This study measures how a premature baby's skin responds to stress while on a breathing machine. Researchers want to understand if skin conductance (electrical activity of the skin) is a good way to detect pain and discomfort in ventilated babies.
Uppsala, UpplandAges 5 months+ - NCT07576829Recruiting
Wrist and shoulder exercises for tennis elbow pain
This study tests whether specific wrist and shoulder exercises can reduce pain and improve grip strength in people with tennis elbow (pain on the outside of the elbow). You'd do resistance exercises and stabilization work to see if they help you regain function.
SādiqābādAges 30–50 - NCT07574476Enrolling by invitation
Fasting Time and Pain After Tonsil Surgery
This study looks at whether the length of time patients fast (don't eat or drink) before tonsil removal surgery affects how much pain they experience afterward. Researchers hope to find the best fasting approach to reduce post-surgery discomfort.
Columbus, OhioAges Up to 18 years - NCT06719232Recruiting
Testing a new way to give bladder treatment without a catheter
This study tests a catheter-free method for delivering medication directly into the bladder. It may help patients with bladder pain, recurrent infections, bladder cancer, or cystitis after radiation or chemotherapy.
BudapestAges 18–80 - NCT06479161RecruitingPhase 2
Oral tranexamic acid study for knee replacement patients
This trial tests if taking tranexamic acid (TXA) as a pill can reduce bleeding after total knee replacement surgery. It may help you if you have knee osteoarthritis and are scheduled for a first-time knee replacement.
Hartford, ConnecticutAges 18–89 - NCT06506565RecruitingPhase 4
Low-dose ketamine for burn wound pain
This trial tests a low-dose ketamine infusion during burn wound dressing changes to see if it reduces pain. It might help people who are hospitalized with a thermal burn injury.
Memphis, TennesseeAges 18 years+ - NCT07561489Enrolling by invitation
Study of OsteoPearl Implants for Spine Fractures
This study observes how a biological implant called OsteoPearl helps people recover from recent spine fractures in the mid or lower back. Researchers will track your pain relief and ability to function over time after a minimally invasive procedure to stabilize the fracture.
Williamsville, New YorkAges 50 years+ - NCT06731985Recruiting
Shorter sling tape follow-up study
This study looks at how well and how safely a shorter type of sling tape (used to treat stress urinary incontinence) works over time. It may help women who had this specific surgery between 2009 and 2020 understand their long-term results.
LorenskogAges 25–90 - NCT06191159Recruiting
Comparing scar looks after different mastectomy incision methods
This trial compares three different ways surgeons make the incision (cut) during a mastectomy to see which one leads to the best-looking scar. You may be eligible if you are having a mastectomy without immediate reconstruction.
Vancouver, British ColumbiaAges Any age - NCT07566663Recruiting
Pain Relief Before Gallbladder Removal Surgery
This study tests whether a pain-relief medication called Anrikefon, given before laparoscopic gallbladder removal surgery, helps reduce pain after the procedure. Laparoscopic surgery uses small cuts and a camera, so it's less invasive than open surgery.
Beijing, Beijing MunicipalityAges 18–65 - NCT07561853Recruiting
Nerve block comparison for pain relief after mastectomy
This study compares two different numbing treatments (nerve blocks) to see which provides better pain relief during and after breast surgery. If you are having a mastectomy, this trial may help reduce your pain after the operation.
SakaryaAges 25–65 - NCT07564882Recruiting
Music and Mobile Apps to Help Babies With Heart Surgery Pain
This study tests whether music and a mobile app can help reduce pain and stress in babies aged 2–12 months who have had heart surgery. Researchers will measure pain levels and vital signs like heart rate and breathing.
AnkaraAges 2 months–1 year - NCT07561333Recruiting
Pain Relief Methods for Knee Replacement Surgery
This study compares two different nerve-blocking anesthesia techniques to see which one controls pain better after knee replacement surgery. Both methods are designed to numb the area around your knee so you need less pain medication afterward.
Çorum, CentreAges 18–80
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Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,142 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.