Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07696923Recruiting
Treating frozen shoulder with microembolization or steroid injection
This trial compares two treatments for frozen shoulder: a new procedure that blocks tiny blood vessels (TAME) and a steroid injection. You must have had shoulder pain for at least a month and be willing to do physical therapy.
TaipeiAges 18–80 - NCT05720065RecruitingPhase 2
Testing botulinum toxin A for jaw muscle pain
This trial studies whether botulinum toxin A (a type of muscle-relaxing medicine) can reduce jaw muscle pain and help explain why it happens. It focuses on people with specific jaw muscle pain patterns and tests outcomes after injection/biopsy.
Huddinge, Stockholm CountyAges 20–45 - NCT06153277Recruiting
Does swelling affect TENS treatment after knee replacement?
This trial studies how swelling (edema) in the knee after replacement surgery might change the way a TENS machine works. TENS is a device that uses mild electrical pulses to help with pain. The results could help doctors set the right TENS level for each patient.
KaramanAges 40 years+ - NCT06848023Enrolling by invitation
Shoulder replacement vs tendon repair in older adults
This study compares how well two different shoulder surgeries—reverse total shoulder replacement and rotator cuff repair—work for people 60 and older, at least one year after the operation. If you meet the age and surgery requirements, your results could help doctors decide which procedure is better for older adults.
Germantown, TennesseeAges 60–95 - NCT07388745Recruiting
Comparing two pain blocks for heart bypass surgery
This study compares two different nerve-block injections (one near the spine, one under the shoulder blade) to see which provides better pain relief after heart bypass surgery. If you are scheduled for a planned bypass and are in reasonably good health, you might be able to join.
KütahyaAges 45–85 - NCT07744269Recruiting
Hand therapy for early complex regional pain syndrome
This trial compares two hand therapy techniques — contrast baths (alternating warm and cool water) and compression with whirlpool therapy — to see which better eases early-stage complex regional pain syndrome (CRPS) after a hand or wrist injury. If you've had hand or wrist trauma and are still in pain, this study might help you find a treatment that reduces discomfort and improves hand use.
Ankara, YenimahalleAges 18–80 - NCT07743736Recruiting
Aromatherapy and massage after cesarean delivery
This trial tests whether aromatherapy and massage help new mothers recover after a cesarean birth. It may reduce pain and improve well-being after delivery.
Uşak, UşakAges 18–40 - NCT07016581Enrolling by invitation
Best length for a spinal cord stimulation test
This study is testing how long a spinal cord stimulation trial should last to best diagnose whether it will help your chronic pain. It compares different trial lengths to see which one gives the most accurate result.
Baltimore, MarylandAges 18 years+ - NCT07740967Recruiting
Collagen and omega supplements for middle-aged women
This study tests whether daily collagen and omega-3 supplements can improve health in healthy middle-aged women. You would take the supplements for a period and have your health measured.
LoughboroughAges 35–65 - NCT07502157Recruiting
Massage for pain and anxiety during first cancer infusion
This study tests whether massage therapy can help reduce pain and anxiety in people with gynecologic cancer who are getting their first infusion treatment. You may be eligible if you are about to receive your first infusion and haven't had any in the past 2 years.
Lexington, KentuckyAges 18–85 - NCT07740915Enrolling by invitation
Pain relief after heart surgery in children
This study compares two types of pain blocks for children having heart surgery for the first time. The goal is to see which block provides better pain relief after surgery, which could help your child recover more comfortably.
Diyarbakır, DiyarbakırAges birth–18 years - NCT06067893Enrolling by invitationPhase 4
Low dose sedation medicine for pain after scoliosis surgery
This trial tests a low dose of a sedative medicine, dexmedetomidine, given during and after spine surgery to see if it helps with pain. It is for teens and adults with scoliosis having back fusion surgery.
Kansas City, MissouriAges 10–21 - NCT07740759Enrolling by invitation
Educational videos for pre-surgery anxiety
This trial tests whether watching educational videos before your laparoscopic surgery helps reduce anxiety. It may help you feel more prepared and calm before your procedure.
Farmington, ConnecticutAges 18 years+ - NCT06994442RecruitingPhase 3
Best pain relief for children on a breathing tube
This study tests adding extra pain medicines (acetaminophen or an NSAID) to usual opioid pain treatment for children on a breathing machine. The goal is to find the safest and most effective way to manage pain.
Little Rock, ArkansasAges 2 months–17 years - NCT07434635RecruitingPhase 4
Atropine for pain after vitrectomy surgery
This study tests whether atropine eye drops can reduce pain and prevent scar tissue (called posterior synechiae) after vitrectomy surgery. The goal is to see if this treatment helps you recover more comfortably.
San Francisco, CaliforniaAges 18 years+ - NCT05833048Recruiting
Pain-relief nerve block during cardiac surgery
This study tests whether a numbing “nerve block” placed in the rectus sheath area can reduce pain for people having certain heart surgeries with chest tubes. If you qualify, it may help your comfort during recovery, but it also depends on how suitable you are for local anesthesia.
New York, New YorkAges 18–85 - NCT07716540Recruiting
Pain relief injection for hip fracture surgery
This study tests whether a special numbing injection (deep iliacus plane block) can better control pain after hip fracture surgery. If you're having hip surgery under spinal anesthesia, researchers want to see if this extra block helps you recover with less pain.
Istanbul, IstanbulAges 18 years+ - NCT07716566Recruiting
Nerve block for pain after kidney transplant
This trial tests a nerve block called a quadroiliac plane block to see if it helps control pain after kidney transplant surgery. If you are having a kidney transplant, this study might help reduce your pain and need for pain medication.
Istanbul, IstanbulAges 18–80 - NCT07520851Recruiting
Does Buzzy help reduce pain during elbow pin removal?
This study tests whether a vibrating device called Buzzy can help reduce pain and fear when children have pins removed from their elbow after a fracture. Buzzy uses gentle vibration and cold to distract from discomfort during the procedure.
Oklahoma City, OklahomaAges 3–10 - NCT07695987Recruiting
Nerve block for pain relief after back surgery
This trial tests a nerve block called Quadro-Iliac Plane Block to reduce pain after a single-level lumbar microdiscectomy (back surgery). The block is given before surgery and may help you need less pain medicine and recover more comfortably.
Istanbul, IstanbulAges 18–75 - NCT07733128Recruiting
Pain relief with buprenorphine patch after lung surgery
This study tests a skin patch that releases buprenorphine, a pain medicine, to control pain after lung surgery. It may help reduce pain and the need for other pain medicines.
Santiago, Santiago MetropolitanAges 18 years+ - NCT04371445RecruitingPhase 4
Dextenza drops after eye surgery to reduce post-op pain
This trial studies whether Dextenza (a steroid pain-relief eye insert) can improve comfort after a specific type of retina surgery (pars plana vitrectomy). It looks at people getting surgery for conditions like macular hole, epiretinal membrane, or vitreomacular traction.
Cleveland, OhioAges 18 years+ - NCT02447874RecruitingPhase 1/Phase 2
Arginine treatment for children’s sickle cell pain
This early-phase study tests whether arginine can help control pain in children with sickle cell disease. You may be considered if your child is having a sickle cell pain episode that needs stronger pain medicine given through an IV.
Atlanta, GeorgiaAges 7–21 - NCT03716167Recruiting
Near-infrared laser for healing and pain in leg vein ulcers
This study tests whether a near-infrared laser can improve healing and reduce pain in chronic venous leg ulcers. If you qualify, you may receive laser treatment and will be checked over time for wound healing and pain levels.
Winston-Salem, North CarolinaAges 18 years+
Hear when a new Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.