Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06214949Recruiting
Personalized brain stimulation for chronic neck pain
This study tests if a personalized type of magnetic brain stimulation called PrTMS can help reduce chronic neck pain. It is for military health care beneficiaries who have had neck pain for at least 3 months.
Bethesda, MarylandAges 18–65 - NCT06215937Recruiting
Pain testing study for endometriosis patients
This study uses special tests to measure how your body processes pain and whether you have heightened pain sensitivity (central sensitization). It may help researchers understand pain in endometriosis better.
Vancouver, British ColumbiaAges 19–49 - NCT06218121Recruiting
Frailty detection trial for older adults
This trial aims to improve how frailty is detected in older adults. It tests a new approach to identify frailty early, which could help prevent health problems.
Madrid, Outside of the USAges 62 years+ - NCT06223659RecruitingPhase 2
EMLA cream for pain during lymphoscintigraphy for skin cancer
This trial tests whether EMLA cream can reduce pain from injections needed to map lymph nodes for certain skin cancers. If you are scheduled for lymphoscintigraphy and sentinel lymph node biopsy, you may be eligible.
Columbus, OhioAges 18–99 - NCT06224933Recruiting
Augmented reality for MRI-guided procedures in children
This study tests if augmented reality (a type of computer overlay) can help doctors perform MRI-guided needle procedures more accurately in children and young adults. It may lead to safer and more precise treatments.
Washington D.C., District of ColumbiaAges 3–21 - NCT06239649Recruiting
Nerve block before knee replacement for faster recovery
This trial tests whether a numbing injection (nerve block) around the knee before surgery can help you recover faster and feel less pain after a total knee replacement. It is for people with knee osteoarthritis who are ready for their first knee replacement surgery.
Denizli, PamukkaleAges 40–85 - NCT06240260Recruiting
TENS unit for pain relief during IUD insertion
This study tests whether a small device called a TENS unit can reduce pain during IUD insertion. The TENS unit sends gentle electrical pulses through pads on your skin to help block pain signals, and you'll be part of a group that uses it during the procedure.
Boston, MassachusettsAges 12–50 - NCT06242821Recruiting
Yoga for back pain in teen scoliosis
This study tests whether yoga can help reduce back pain in teens with scoliosis (curved spine). You would practice yoga at home through online sessions, as an alternative to or alongside physical therapy.
Baltimore, MarylandAges 10–20 - NCT06243718Recruiting
Surgery for paralyzed diaphragm nerve
This trial looks at how patients feel and recover after surgery to fix the nerve that controls the diaphragm. It aims to learn about people's experiences to improve care for diaphragmatic paralysis.
Red Bank, New JerseyAges 18–70 - NCT06245109RecruitingPhase 4
Pain medicine study for knee osteoarthritis
This study tests how well different pain medicines work for knee osteoarthritis and looks at brain patterns to understand why some people get more relief. It may help you find a treatment that works best for you.
Chicago, IllinoisAges 41 years+ - NCT06246669Recruiting
Exercise and fear after concussion in college athletes
This study looks at whether prescribed exercise can help college athletes feel less afraid of pain after a concussion. It aims to see if exercise helps them recover better.
Charlottesville, VirginiaAges 18–25 - NCT06248216Recruiting
Virtual reality therapy for cancer treatment side effects
This study tests whether virtual reality (VR) can help ease common cancer-treatment side effects like pain, anxiety, sleep trouble, fatigue, or numbness. You may be able to join if you finished your main cancer treatment at least 3 months ago and have one of these symptoms.
Baltimore, MarylandAges 18–88 - NCT06255769Recruiting
Magnetic heart scan for diagnosing reduced blood flow
This study tests a new, noninvasive way to detect reduced blood flow to the heart (myocardial ischemia) using a magnetic heart scan called MCG. If you have chest pain or similar symptoms but your narrowed arteries are not severely blocked, this trial may help diagnose your condition more accurately.
Jinan, ShandongAges 18 years+ - NCT06264297Recruiting
Nerve radiofrequency treatment for chronic leg pain
This trial tests a new type of treatment (high-voltage pulsed radiofrequency) that uses a special needle to deliver energy to the nerve root in your lower back. The goal is to see if it can reduce chronic leg pain caused by a pinched or irritated nerve.
Terrassa, BarcelonaAges 18 years+ - NCT06265636Recruiting
Nerve stimulation for jaw pain and function in TMD
This trial tests whether gentle electrical stimulation of a nerve in your jaw can reduce pain and improve chewing, talking, and mouth opening for people with temporomandibular joint disorder (TMD).
Alcorcón, MadridAges 18–65 - NCT06266611RecruitingPhase 2
Cannabis for cancer symptom relief
This trial tests whether cannabis can help cancer patients manage symptoms like sleep trouble, pain, and mood changes. It's for people who are new to using cannabis for these issues.
Aurora, ColoradoAges 25 years+ - NCT06270121Recruiting
Mobile health app for healthy aging at home
This study is testing a mobile health app designed to help seniors live independently at home. If you join, you will use the app and answer surveys to see if it supports healthy aging.
SeoulAges 65 years+ - NCT06270147RecruitingPhase 2
Timing of nerve blocks for weight loss surgery pain
This trial tests whether giving a nerve block before or after bariatric surgery works better for pain control. It could help you have less pain and use fewer painkillers after your procedure.
Hamilton, OntarioAges 18 years+ - NCT06271265RecruitingPhase 1
Testing EXPAREL for pain after heart surgery in children
This study tests a long-acting pain medicine (EXPAREL) given during heart surgery to see how it works in young children. The goal is to help control pain after surgery with fewer side effects.
Indianapolis, IndianaAges birth–6 years - NCT06272786Recruiting
Nerve Block for Recovery After Rotator Cuff Surgery
This study tests whether a nerve block (an injection to numb a nerve in the shoulder) can improve recovery after rotator cuff repair surgery. It is for people who recently had this surgery and have no other problems with their shoulder or health that might affect the results.
Kirşehir, City CentreAges 18–65 - NCT06276257Recruiting
Pain block for mastectomy with immediate reconstruction
This trial tests a nerve block to reduce pain after breast removal surgery with immediate reconstruction. It may help you recover with less discomfort.
Québec, QuebecAges 18–70 - NCT06277401Recruiting
Exercise for people with loose joints and knee pain
This study tests whether a specific exercise program can help people with loose joints (hypermobility) who have knee pain. If you have had knee pain for at least 3 months and your knees are very flexible, this could be a way to strengthen your knees and reduce pain.
Odense, FynAges 18–45 - NCT06283862Recruiting
Virtual cannabis coaching for veterans with chronic pain
This study tests a virtual program to help veterans with chronic pain who are using (or planning to use) CBD or cannabis. You'll join educational sessions and track your symptoms and cannabis use on your smartphone.
Ann Arbor, MichiganAges 18 years+ - NCT06284473RecruitingPhase 4
Ketamine with numbing medicine for minor emergency procedures
This study tests whether adding ketamine to the usual numbing medicine makes minor procedures in the emergency department less painful. You may be a good fit if you are having a small procedure like stitches or abscess drainage.
Maywood, IllinoisAges 7–70
Hear when a new Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.