Clinical trials · Pennsylvania
Pediatrics clinical trials in Pennsylvania
We’re tracking 138 recruiting pediatrics studies with a site in Pennsylvania — including Early Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT05367609Recruiting
Personalized pain plan for kids getting spine fusion surgery
This trial tests a personalized plan to manage pain around the time of pediatric posterior-lateral spinal fusion surgery. It aims to improve comfort and reduce the chance of pain or opioid problems after surgery by tailoring pain medicines to the child.
Pittsburgh, PennsylvaniaAges 10–21 - NCT04604418Recruiting
Tracking outcomes during non-heart procedures in children with heart defects
This study looks at how children with congenital heart disease do during routine non-heart procedures, including medical or minor treatments that are not heart-related. It also measures how much health care they use afterward, which may help improve care planning for families.
Philadelphia, PennsylvaniaAges Up to 21 years - NCT05645523RecruitingEarly Phase 1
ICG dye mapping to find lymph nodes in some childhood tumors
This early study tests using a special dye (indocyanine green, or ICG) to help surgeons find the correct “sentinel” lymph nodes during surgery in children with certain suspected tumors. If successful, it may improve how doctors remove and check lymph nodes while reducing the chance of missing important areas.
Pittsburgh, PennsylvaniaAges Up to 20 years - NCT05550298Recruiting
Study of virus infections after pediatric transplants
This study looks at how respiratory viruses behave and how the body responds in children who are about to receive, or have recently received, a transplant. It may help doctors better diagnose and treat viral infections in transplant patients by studying blood samples and test results.
Pittsburgh, PennsylvaniaAges Up to 18 years - NCT04914507Recruiting
Tracking long-term results of spine tethering in growing teens
This study follows kids who have a surgery called anterior vertebral body tethering (AVBT) for growing-related, idiopathic scoliosis. It looks at how well the curve stays corrected over time and how the spine grows, which may help improve future care decisions.
Philadelphia, PennsylvaniaAges Up to 18 years - NCT04775485RecruitingPhase 2
Targeted medicine for children with certain brain or solid tumors
This Phase 2 study tests tovorafenib, a targeted cancer medicine, in children and young adults whose tumors have specific BRAF or RAF changes. It is for cancers that have come back or grown despite previous treatment, with measurable signs on scans.
Philadelphia, PennsylvaniaAges 6 months–25 years - NCT05019716RecruitingPhase 1/Phase 2
Adding ZEN003694 to chemo for NUT cancer
This early-phase study tests whether adding ZEN003694 to standard chemotherapy (cisplatin/etoposide or carboplatin/paclitaxel) is safe and can help control NUT carcinoma. It enrolls people ages 12–17 and adults, including some patients whose cancer has spread or can’t be safely removed.
Pittsburgh, PennsylvaniaAges 12 years+ - NCT04276870RecruitingPhase 2
CD19 gene-modified cells for high-risk B-cell leukemia
This Phase 2 trial studies CD19 “redirected” cells made from your own blood to treat certain high-risk or relapsed B-cell acute lymphoblastic leukemia (B-ALL). It may help by targeting cancer cells that carry a protein called CD19.
Philadelphia, PennsylvaniaAges birth–29 years - NCT04639830Recruiting
Testing how sleep patterns relate to child brain development
This study looks at how a child’s sleep looks on a sleep-monitoring test and how that relates to brain/learning growth over time. It includes some children without known risks and some children with known developmental or learning risks, to better understand sleep’s role.
Danville, PennsylvaniaAges 6 months–8 years - NCT02493478Recruiting
Improve safety during placing breathing tubes in children
This trial looks at ways to improve the safety and quality of emergency breathing tube placement in pediatric critical care and emergency settings. It may help reduce complications and improve how clinicians do these urgent procedures.
Pittsburgh, PennsylvaniaAges Any age - NCT00670735Recruiting
Research registry collecting data on hydrocephalus treatment
This study collects information about people with hydrocephalus when they have certain brain fluid (CSF) procedures. The goal is to better understand different patient groups and treatments across multiple centers.
Pittsburgh, PennsylvaniaAges Up to 18 years - NCT06773026RecruitingPhase 2
Sodium Phenylbutyrate for MCADD in Children and Adults
This trial tests a medicine called sodium phenylbutyrate (ACER-001) to see if it helps people with MCADD, a genetic condition that affects how your body breaks down fats. If you have MCADD and the common gene change, you might be able to join.
Pittsburgh, PennsylvaniaAges 4 years+ - NCT05711394RecruitingPhase 3
Atogepant for preventing episodic migraine in children
This study tests whether an oral medicine called atogepant can reduce migraine activity in children ages 6–17 and checks its side effects. It’s meant for kids with episodic migraine (not the more constant types) who may benefit from preventive treatment.
Philadelphia, PennsylvaniaAges 6–17 - NCT05312879RecruitingPhase 2/Phase 3
Test drug VX-147 for APOL1-related protein in urine kidney disease
This trial studies whether VX-147 can improve kidney disease caused by an APOL1 gene change, which often leads to protein leaking into the urine. It includes both adults and children and focuses on safety and effectiveness over time.
Philadelphia, PennsylvaniaAges 10–65 - NCT07432880Recruiting
Study of children with severe MMA linked to the MMUT gene
This study is for children up to 16 years old with a severe form of methylmalonic acidemia (MMA) caused by a specific gene change (MMUT). It aims to better understand the disease and may lead to future treatments. Both children who have had a liver transplant and those who have not can join, as long as certain criteria are met.
Philadelphia, PennsylvaniaAges Up to 16 years - NCT07080385RecruitingPhase 2/Phase 3
Study of encaleret in children with a rare calcium disorder
This trial tests a medicine called encaleret in children with a rare genetic condition that causes low calcium levels. The goal is to see if it safely helps control calcium and reduce symptoms.
Philadelphia, PennsylvaniaAges birth–17 years - NCT07071298Recruiting
AERA pediatrics registry study
This registry tracks children who have a procedure called endoscopic transforaminal balloon dilation (ETBD) using the AERA device. The goal is to learn more about how this treatment works for young patients.
Philadelphia, PennsylvaniaAges Up to 18 years - NCT06582693Recruiting
Tobacco treatment for families through children's hospital
This study offers proactive, personalized help to stop smoking for adults who smoke and have a child who is a patient at Children's Hospital of Philadelphia. It aims to see if this approach works better than usual care.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07211997Recruiting
FebriDx test for fever and cold symptoms in children
This study tests a finger-prick blood test (FebriDx) to see if it can quickly tell whether a child's fever and cold symptoms are caused by a bacterial or viral infection. If it works, it could help doctors decide whether antibiotics are needed.
Pittsburgh, PennsylvaniaAges 2–11 - NCT07108374Enrolling by invitation
Improving blood transfusion practices in children's ICUs
This study tests whether a new set of guidelines can help doctors and nurses give red blood cell transfusions more consistently in pediatric intensive care. It aims to make transfusion decisions safer and more uniform for children in the ICU.
Philadelphia, PennsylvaniaAges Any age - NCT05905926Enrolling by invitationPhase 3
Tenapanor safety study for teens with constipation-predominant IBS
This trial checks the safety of tenapanor in children and teens (ages 6 to under 18) with IBS-C. It is only for people who finished a previous related study and agreed to continue follow-up.
Scottdale, PennsylvaniaAges 6–18 - NCT06997588RecruitingPhase 2
Alpelisib for pediatric and adult PROS
This trial tests a drug called alpelisib for children and adults with a rare overgrowth condition called PROS that is caused by a PIK3CA gene change. It aims to see if the drug can safely shrink overgrowth and improve symptoms.
Pittsburgh, PennsylvaniaAges 2–100 - NCT05039619RecruitingPhase 2
Obinutuzumab trial for adolescents with active lupus kidney inflammation
This Phase 2 study tests obinutuzumab, a targeted antibody medicine, in teens with active lupus nephritis (inflammation in the kidney). It looks at whether it helps kidney disease and is safe, including how the body handles the drug.
Philadelphia, PennsylvaniaAges 5–17 - NCT07019922RecruitingPhase 3
A study of elsunersen for children with SCN2A-related epilepsy
This trial tests an experimental drug called elsunersen in children with a specific type of epilepsy caused by changes in the SCN2A gene. It aims to see if the drug can reduce seizures and be safe for children.
Philadelphia, PennsylvaniaAges 1 day–18 years
Pediatrics trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting pediatrics studies listed above.
- Children's Hospital of Philadelphia · 12 studies
- UPMC Children's Hospital of Pittsburgh · 8 studies
- Frontier Clinical Research
- Frontier Clinical Research, LLC
- Geisinger Medical Center
- PAS Research
- Penn State Health Children's Hospital
- Penn State Milton S Hershey Medical Center
What taking part in a pediatrics study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Pediatrics trials in other states
Common questions
- Are there pediatrics clinical trials in Pennsylvania?
- Yes. We're currently tracking 138 recruiting pediatrics studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a pediatrics study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a pediatrics trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New pediatrics studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.