Clinical trials
Persistent Atrial Fibrillation clinical trials
Below are recruiting persistent atrial fibrillation clinical trials, each written for real people, not researchers. We’re tracking 216 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05434819Recruiting
Ablation study during heart surgery for atrial fibrillation
This trial looks at whether a special heart rhythm treatment called “ablation” works well when done during certain heart operations. It may help reduce atrial fibrillation (AF) symptoms or future abnormal rhythm episodes for people who are already having surgery.
Hamilton, OntarioAges 18 years+ - NCT05610215Recruiting
Hybrid or catheter ablation for atrial fibrillation in hypertrophic heart
This trial compares two procedures to treat atrial fibrillation (an irregular heartbeat) in people who also have hypertrophic cardiomyopathy (thickened heart muscle). It looks at whether the hybrid approach or a catheter-based approach works better for controlling symptoms and heart rhythm.
BeijingAges 18 years+ - NCT05679024RecruitingPhase 3
Apixaban to prevent stroke in atrial fibrillation and kidney failure
This trial tests apixaban (a blood thinner) to prevent stroke in people with atrial fibrillation or atrial flutter who have very poor kidney function or are on dialysis. If you qualify, you may help researchers find a safer way to lower stroke risk for this higher-risk group.
HelsinkiAges 18 years+ - NCT06021808Recruiting
LAA clip vs. blood thinners to prevent stroke in non-paroxysmal AF
This study compares two ways to prevent stroke in people with persistent or long-standing atrial fibrillation (AF): taking a blood thinner (NOAC) or having a minimally invasive procedure to clip off the left atrial appendage (LAA). The goal is to see which approach works better at preventing stroke without causing major bleeding.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06499857RecruitingPhase 3
Semaglutide for atrial fibrillation and weight loss
This study tests whether a weekly injection of semaglutide (the same drug in Wegovy and Ozempic) can help people with atrial fibrillation lose weight and improve their heart condition. It's for people with AF who also have obesity, and may or may not plan to have a heart procedure called catheter ablation.
Phoenix, ArizonaAges 18–75 - NCT06500988Recruiting
Smartphone app for atrial fibrillation and weight management
This study uses a smartphone app and activity tracker to help people with atrial fibrillation (an irregular heartbeat) and a higher body weight manage their condition through tailored exercise guidance.
Baltimore, MarylandAges 18 years+ - NCT06696079Recruiting
Early vs later blood thinner restart after brain bleed surgery in atrial fibrillation
This trial compares restarting a blood thinner early (within a few days) versus later (after about a week) in people who have a chronic subdural hematoma drained and also have atrial fibrillation. The goal is to find out which timing helps prevent both new bleeding and blood clots.
Oulu, North OstrobothniaAges 18 years+ - NCT07139314Recruiting
Timing of blood thinners after stroke clot removal
This trial is testing the best time to start blood thinners (anticoagulation) after emergency stroke treatment in people who have atrial fibrillation. It is for patients who had a certain type of bleeding in the brain after the procedure.
Ma’anshan, AnhuiAges 18 years+ - NCT07380620Enrolling by invitation
Step-by-step treatment for persistent atrial fibrillation
This trial tests a step-by-step treatment plan for people with persistent atrial fibrillation (a type of irregular heartbeat) who live in Southwest China. The goal is to find a better way to manage and possibly fix this heart condition.
ChongqingAges 18 years+ - NCT07453940Enrolling by invitation
Closing off heart pouch with or without pulsed energy in atrial fibrillation
This study tests if adding a special energy treatment (pulsed field ablation) to a standard heart pouch closure is safe and works better for people with persistent atrial fibrillation who have few symptoms but a high risk of stroke.
Hangzhou, ZhejiangAges 18 years+ - NCT07096219Enrolling by invitation
Catheter Ablation for Leaky Mitral Valve in Persistent Atrial Fibrillation
This trial tests if catheter ablation—a procedure to fix heart rhythm—can help people with a leaky mitral valve that is caused by atrial fibrillation (functional mitral regurgitation). If you have persistent atrial fibrillation and moderate leaky valve, you may benefit from this treatment.
Guangzhou, GuangdongAges 18–75 - NCT06529978Recruiting
CoreMap heart mapping for atrial fibrillation ablation
This study tests a new mapping system that helps doctors see the electrical signals in your heart more clearly during a standard ablation for persistent atrial fibrillation. It may improve the accuracy of the treatment.
Naples, FloridaAges 18–80 - NCT07405359Recruiting
Comparing ablation methods for persistent atrial fibrillation
This trial tests a newer, possibly safer way to treat persistent atrial fibrillation using pulsed field ablation. It compares standard vein isolation alone to adding extra ablation spots to improve success.
San Francisco, CaliforniaAges 18 years+ - NCT05264831Recruiting
Ablation treatment after failed electric heart shock
This trial tests whether blocking faulty heart signals from the pulmonary veins (with or without additional “substrate” modification) works better when electric cardioversion doesn’t stop persistent atrial fibrillation. It may help people who remain in atrial fibrillation after cardioversion by reducing symptoms and abnormal rhythm over time.
Caluire-et-CuireAges 18–80 - NCT06445439Recruiting
Finding the Best Pacemaker Rate for Heart Failure
This study tests whether adjusting the pacing rate on a special pacemaker (CRT or conduction system pacing) can improve heart function and daily symptoms in people with atrial fibrillation and heart failure.
Washington D.C., District of ColumbiaAges 18–90 - NCT06747091Recruiting
Ablation study for people with persistent atrial fibrillation
This trial tests a catheter ablation procedure for people with persistent atrial fibrillation (a type of irregular heartbeat that lasts more than 7 days but less than a year). It aims to see if the procedure is safe and effective for restoring a normal heart rhythm.
Manhasset, New YorkAges 18–80 - NCT07173998Recruiting
Quality of life after heart surgery with irregular heartbeat
This study looks at quality of life in people who develop atrial fibrillation (an irregular heartbeat) after heart surgery. Researchers will ask you to fill out surveys to understand how this condition affects your daily life.
Boston, MassachusettsAges 18–100 - NCT07227532Recruiting
Testing a new catheter for atrial fibrillation treatment
This study tests a new catheter system, called Varipulse, to see if it's safe and effective for treating atrial fibrillation (AF), a heart rhythm problem. People with short-lasting AF who haven't been helped by medication may be able to join.
Phoenix, ArizonaAges 22 years+ - NCT03912324Recruiting
CT-guided heart imaging to guide treatment for atrial fibrillation
This trial studies whether using a special CT scan map of the heart muscle thickness can help doctors choose the best strategy during a cryoballoon procedure for paroxysmal atrial fibrillation. It may help improve effectiveness by tailoring treatment instead of using a standard approach.
SeoulAges 20–80 - NCT06618417Recruiting
Home sleep test for sleep apnea in atrial fibrillation
This study is using a smartphone app and a home sleep test to see if checking for sleep apnea helps people with atrial fibrillation feel better and have fewer heart rhythm episodes. The goal is to make monitoring easier for you at home.
HellerupAges 18 years+ - NCT07403760Recruiting
Ablation for atrial fibrillation in patients 80 and older
This study investigates whether a catheter ablation procedure can improve wellbeing and reduce the risk of serious events for people 80 and older with symptomatic atrial fibrillation. The goal is to see if this treatment offers better outcomes than standard care in this age group.
BeijingAges 80 years+ - NCT06953752Recruiting
Music during atrial fibrillation ablation under light sedation
This study tests whether listening to music during a common heart procedure for atrial fibrillation (called catheter ablation) can improve your experience while you are awake but relaxed. It may help you feel calmer and more comfortable.
Shaoxing, ZhejiangAges 18–80 - NCT05116384Recruiting
Renal nerve ablation plus AF ablation for persistent AF
This study tests whether treating kidney-related nerves along with the usual AF (irregular heartbeat) catheter procedure works better than the usual procedure alone. It may help some people with persistent AF, but you must meet specific heart and kidney safety requirements.
Short Hills, New JerseyAges 18 years+ - NCT06099730Recruiting
Pulsed field ablation for atrial fibrillation
This trial tests a new method called pulsed field ablation to treat atrial fibrillation (AF), a type of irregular heartbeat. It aims to safely stop AF episodes by targeting specific areas in the heart, and may help people with paroxysmal (coming and going) or persistent AF who haven't had this procedure before.
Jonesboro, ArkansasAges 18–80
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Common questions
- Are there clinical trials for persistent atrial fibrillation?
- Yes. Clin2 currently lists 216 recruiting persistent atrial fibrillation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a persistent atrial fibrillation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a persistent atrial fibrillation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.