Clinical trials
Persistent Atrial Fibrillation clinical trials
Below are recruiting persistent atrial fibrillation clinical trials, each written for real people, not researchers. We’re tracking 213 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04947657Recruiting
Atrial fibrillation blood and heart scan pilot during ablation
This study looks at blood-related “clotting” signs and heart scan results in people with atrial fibrillation (AF) who are getting a catheter ablation. It may help doctors better understand AF and choose treatments more precisely.
New Orleans, LouisianaAges 18–120 - NCT04529785Recruiting
Tested added ethanol vein treatment during repeat atrial fibrillation ablation
This trial compares two ways to help stop atrial fibrillation during a repeat procedure: standard vein isolation only versus standard isolation plus an added medicine (ethanol) into the vein of Marshall. It aims to see whether the added step improves results when atrial fibrillation returns after a previous successful treatment.
Bruges, Please SelectAges 18 years+ - NCT06212791Recruiting
Exercise MRI Study of Heart Function After Ablation
This study uses an exercise MRI to look at how the upper chambers of the heart (left atrium) work after ablation for atrial fibrillation. It may help doctors understand if the procedure improves heart function during exercise.
Richmond, VirginiaAges 18 years+ - NCT07580547Recruiting
Atrial fibrillation ablation: study on sex differences
This research compares how atrial fibrillation (AF) affects men and women differently. If you are having your first catheter ablation for AF and are between 18 and 80, this study may help doctors understand outcomes better.
Be’er Ya‘aqovAges 18–80 - NCT07430956RecruitingPhase 3
Stroke prevention in atrial fibrillation without standard blood thinners
This trial tests a new medication to prevent strokes and blood clots in people with atrial fibrillation (an irregular heartbeat) who cannot safely take standard blood thinners. The drug works by blocking a different clotting factor, which may lower bleeding risks.
Dothan, AlabamaAges 18 years+ - NCT07430007Recruiting
Exercise and diet to reduce AFib burden
This study tests whether a program of exercise and healthy eating changes can reduce how often atrial fibrillation (AFib) happens and help you lose weight. It may be a good fit if you are overweight, have AFib, and are ready to make lifestyle changes.
Jyväskylä, Central FinlandAges 18–75 - NCT07444372Recruiting
Starting CPAP therapy after atrial fibrillation ablation
This study tests whether starting CPAP therapy soon after a heart procedure called catheter ablation helps people with sleep apnea and atrial fibrillation (an irregular heartbeat) recover better and stay in normal rhythm. CPAP is a machine that helps keep your airway open while you sleep.
Beijing, Beijing MunicipalityAges 18–75 - NCT06125925Recruiting
Ablation for AFib in patients with heart failure and preserved ejection fraction
This study tests whether a catheter ablation procedure can help people with atrial fibrillation and a kind of heart failure where the heart pumps normally but doesn't relax properly (HFpEF). It looks at whether the procedure can improve symptoms and heart function.
NanjingAges 18–80 - NCT07320560Recruiting
Personalized afib ablation using body surface mapping
This trial uses a special body-surface mapping technique to guide personalized ablation for persistent atrial fibrillation (afib). It aims to improve outcomes for people with an enlarged left atrium who have not had prior ablation.
BerlinAges 18 years+ - NCT05955365RecruitingPhase 4
Single anticoagulant blood thinner after stent in atrial fibrillation
This trial tests whether taking a single “P2Y12 inhibitor” blood thinner (instead of multiple medicines) is safe and effective after you get a coronary stent. It’s for people with atrial fibrillation who need long-term blood thinning and have recently had a successful stent procedure.
HasseltAges 18 years+ - NCT07776054RecruitingPhase 4
SGLT2 inhibitor after heart shock for atrial fibrillation with heart failure
This study tests whether a diabetes drug called an SGLT2 inhibitor can help keep your heart in a normal rhythm after a procedure to shock it back into rhythm. It is for people with persistent atrial fibrillation and a type of heart failure where the heart is stiff.
Seoul, SeoulAges 19 years+ - NCT03444337Recruiting
High-resolution MRI before a special heart ablation for atrial fibrillation
This study uses high-resolution MRI scans to get a detailed picture of the heart before a special type of ablation for atrial fibrillation (an irregular heartbeat). The goal is to help doctors target the treatment more precisely.
Columbus, OhioAges 18 years+ - NCT07807423Recruiting
Artificial intelligence guidance for atrial fibrillation ablation
This study tests whether an AI software can help doctors identify which people with persistent atrial fibrillation might need more than just a standard ablation procedure. The software analyzes heart signals during the ablation to guide treatment, potentially improving outcomes for people whose condition is more complex.
AvignonAges 18 years+ - NCT05508256RecruitingPhase 4
Ablation for atrial fibrillation in heart failure with preserved function
This trial tests whether a catheter procedure that treats atrial fibrillation works better than standard care for people with heart failure with preserved ejection fraction. It aims to improve heart rhythm symptoms and overall outcomes compared with conventional treatment.
BerlinAges 18 years+ - NCT04823299Recruiting
Atrial fibrillation ablation using two different energy types
This trial tests whether one ablation approach works better than another for paroxysmal (intermittent) atrial fibrillation by targeting the heart’s “triggers” and “substrate” (where the rhythm problem is). If you qualify, you’ll be randomly assigned to one of two ablation energy methods during a pulmonary vein isolation procedure.
Ottawa, OntarioAges 18 years+ - NCT07621055Recruiting
AI software to guide heart rhythm ablation treatment
This study tests new AI software (Volta AF-Xplorer II) that helps doctors guide catheter ablation—a procedure to treat irregular heartbeats like atrial fibrillation. The software may help doctors perform the procedure more effectively and safely in real-world settings.
MarseilleAges 18 years+ - NCT05136131Recruiting
Quality-of-life support after cardioversion for persistent AF
This study looks at how a heart rhythm procedure (cardioversion) affects quality of life in people with persistent atrial fibrillation (AF). It may help you understand whether a specific approach can improve day-to-day symptoms and well-being after treatment.
Newmarket, OntarioAges 18 years+ - NCT07617974Recruiting
Heart valve changes in atrial fibrillation patients
This study looks at how atrial fibrillation (a common heart rhythm problem) affects the tricuspid valve—one of your heart's four valves. Researchers will use special ultrasound imaging to understand these changes and help improve future treatment.
Milan, MilanAges 18 years+ - NCT07353775Recruiting
Heart procedure using imaging and pulsed energy
This trial uses a special imaging tool inside the heart to guide a new type of energy (pulsed field) to treat a specific area in the heart that can cause atrial fibrillation (an irregular heartbeat). It may help people with paroxysmal or persistent atrial fibrillation who need a procedure called CTI ablation.
BeijingAges 18 years+ - NCT07278869Recruiting
Study of Append system for atrial fibrillation patients
This trial tests a new device, the Append System, to close off the left atrial appendage (a small pouch in the heart) in people with atrial fibrillation. The goal is to reduce stroke risk without needing long-term blood thinners.
Jonesboro, ArkansasAges 18 years+ - NCT04298723Recruiting
Left atrial appendage closure vs blood thinners after brain bleed
This trial compares a procedure that blocks a heart blood-choke point (the left atrial appendage) versus taking blood thinners by mouth. It is for people with atrial fibrillation who have had a brain bleed and may be safer avoiding long-term blood thinners.
Mannheim, Baden-WurttembergAges 18 years+ - NCT07840365RecruitingPhase 3
Finding the best blood-thinner plan after a Watchman device procedure
This study tests which blood-thinner approach works best after a procedure to close a small heart pouch (left atrial appendage) with a Watchman device. It aims to prevent strokes while reducing bleeding risks.
Austin, TexasAges 18 years+ - NCT07815119Recruiting
Comparing two heart imaging methods before a stroke-prevention procedure
This study compares two imaging methods (TEE and CCTA) used before a procedure to close a small pouch in the heart, which helps prevent strokes in people with atrial fibrillation. Participants will be randomly assigned to one method, and both groups will be checked after 3 months to see which imaging works better.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07385599Recruiting
Study of a new heart device for atrial fibrillation patients
This trial tests a new device called LAmbre™ II that closes off a part of the heart called the left atrial appendage to help prevent strokes in people with atrial fibrillation who cannot take blood thinners.
ShatinAges 18 years+
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Common questions
- Are there clinical trials for persistent atrial fibrillation?
- Yes. Clin2 currently lists 213 recruiting persistent atrial fibrillation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a persistent atrial fibrillation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a persistent atrial fibrillation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.