Clinical trials
Plaque clinical trials
Below are recruiting plaque clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05367297Recruiting
Registry study of heart plaque in South Asian adults
This study tracks coronary plaque (fatty deposits in heart arteries) in South Asian adults and compares them with people of other backgrounds. You may be asked to have a special heart CT scan and basic measurements to help researchers understand differences in heart disease risk.
Dallas, TexasAges 18 years+ - NCT05384132Recruiting
Dental gel trial with deep cleaning for gum disease
This study tests whether a new dental gel used along with deep gum cleaning (scaling and root planing) can improve periodontitis. If you qualify, you would receive standard gum treatment plus the study gel, then be followed over time.
Birmingham, AlabamaAges 18–85 - NCT05438121Recruiting
Tests a drug-coated balloon to stabilize clogged heart arteries
This trial studies whether a drug-coated balloon can better treat new, narrowed spots in multiple coronary arteries and “stabilize” the plaque. It may help improve blood flow after a procedure called balloon angioplasty for selected patients.
Ansan-si, Gyeonggi-doAges 18–85 - NCT05462106RecruitingPhase 1/Phase 2
ACI-24.060 study for early Alzheimer’s in adults and Down syndrome
This Phase 1/2 study tests an Alzheimer’s treatment called ACI-24.060 to see if it affects the disease in people with early Alzheimer’s changes. It includes two groups: older adults with early symptoms and people with Down syndrome who also show Alzheimer’s-related changes on brain scans.
Phoenix, ArizonaAges 35–85 - NCT05470023Recruiting
Imaging study of gum health and mouth biofilm
This study uses imaging to look at how healthy your gums are and how much “plaque/biofilm” is in your mouth. It may help researchers better understand gum health and how oral hygiene affects it.
Irvine, CaliforniaAges 18 years+ - NCT05509010Recruiting
AI registry using CT scan to assess coronary artery disease
This trial builds and tests an AI system using information from a heart CT scan to help evaluate coronary artery disease (clogged heart arteries). If you need a CT coronary angiography for medical reasons, this may help improve how such scans are analyzed and used in care.
SingaporeAges 21–80 - NCT05550077Recruiting
Imaging study for narrowed brain arteries after stroke
This trial uses a detailed eye/brain imaging test (optical coherence tomography) to study people with significantly narrowed brain arteries after certain stroke-like events. It may help researchers better understand and monitor this condition to improve care.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05642182RecruitingPhase 1
Study drug trial for mild to moderate plaque psoriasis
This Phase 1 study tests a new drug (SFA002) in adults with stable plaque psoriasis. It mainly focuses on safety and how the body responds, and may eventually help people with psoriasis plaques.
Pompano Beach, FloridaAges 18 years+ - NCT05681858Recruiting
Testing heart inflammation and reduced blood flow in MINOCA
This study looks at why some people have chest pain and heart injury signs, but their heart arteries are not blocked. It tests scans of blood flow and heart tissue to better understand the cause and guide care.
BergenAges 18 years+ - NCT05744466Recruiting
Compare two psoriasis medicines using real-world patient data
This study looks at how well two common plaque psoriasis medicines—deucravacitinib and apremilast—work in everyday care. It may help researchers understand which option performs better in real patients outside of a traditional drug trial.
Waltham, MassachusettsAges 18 years+ - NCT05850247RecruitingPhase 2
Study brain inflammation in carotid artery narrowing after stroke or TIA
This Phase 2 study looks at a protein called ficolin-2 and whether it relates to brain inflammation after a short stroke-like event or eye blood vessel blockage caused by narrowed carotid arteries. If you recently had symptoms from the carotid artery and meet imaging and health criteria, you may be offered study-related assessments to better understand the cause and help future treatment decisions.
BronAges 18 years+ - NCT05852145RecruitingPhase 1/Phase 2
Testing sweet drinks effect on children’s mouth health
This early-stage study looks at how drinking soft drinks with and without sweeteners affects children’s mouths and teeth. It may help researchers understand which types of sweet drinks contribute to more tooth damage.
Mexico City, CuahutemocAges 12–18 - NCT05897645Recruiting
MRI study of artery plaque after recent stroke
This trial uses special brain MRI to look closely at plaque in certain brain arteries after an ischemic stroke (when a blood vessel is blocked). It may help researchers better understand which plaques are most dangerous soon after stroke.
ShenyangAges 40 years+ - NCT05965076Recruiting
Test glycine powder and a special brush for oral care
This trial studies whether using glycine powder and an angled implant brush helps keep dental implants healthy in people following the Columbus Bridge ProtocolTM. It may help by improving daily oral hygiene around implants and reducing implant problems.
TorinoAges Any age - NCT05994976Recruiting
Collecting skin samples from people with skin conditions
This study collects skin samples (like small biopsies or swabs) from people with certain skin conditions and from healthy volunteers. The samples help researchers learn more about these conditions and may lead to better treatments.
Montreal, QuebecAges 18 years+ - NCT06182293Recruiting
Mouth bacteria in early systemic sclerosis
This study looks at the bacteria in the mouth (periodontal microbiota) of people with early systemic sclerosis compared to those without the condition. It may help understand if there is a link between oral health and systemic sclerosis.
StrasbourgAges 18 years+ - NCT06214429Recruiting
Shear wave test for carotid plaque stiffness
This trial uses a special ultrasound technique called shear wave elastography to measure how stiff fatty deposits (plaques) are in your neck arteries. It aims to see whether plaque stiffness can help doctors better understand your stroke risk.
Botucatu, São PauloAges 18 years+ - NCT06275399Recruiting
Study of plaque and platelets in narrowed heart arteries
This study looks at how plaque buildup and blood platelets interact in partially blocked heart arteries. It might help find better ways to treat people with chronic coronary syndrome.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT06286501Recruiting
Preventive treatment for teens at risk of oral diseases
This trial tests a new preventive treatment for teenagers at risk of tooth decay and gum disease. It uses a special mouthpiece device (Lumoral) to clean teeth better and see if it can prevent oral health problems.
Tampere, PirkanmaaAges 14–16 - NCT06291350Recruiting
Mouth bacteria in gum disease with blistering condition
This study looks at the bacteria in the mouth and gut of people with a blistering gum condition (mucous membrane pemphigoid) and gum disease. It aims to understand if certain bacteria are linked to the disease, which could lead to better treatments.
NiceAges 18 years+ - NCT06303661Recruiting
Radiofrequency and shock wave therapy for Peyronie's plaque
This study tests if two non-invasive treatments—radiofrequency energy and low-intensity shock waves—can help soften the hard plaque and reduce penile curvature caused by Peyronie's disease. It is open to men at any stage of the condition.
Salvador, Estado de BahiaAges 18–80 - NCT06313645Recruiting
Blood vessel aging and heart attack risk study
This study looks at how blood vessel aging relates to the type of fatty buildup in your arteries that can cause heart attacks. If you've had a recent heart attack, chest pain (angina), or minor artery disease and do not have advanced heart failure, kidney failure, active cancer, or prior bypass surgery, you may be able to join.
Milan, LombardyAges 18–75 - NCT06382051Recruiting
Improving Psoriatic Arthritis Screening in Psoriasis
This study tests a new way to screen for psoriatic arthritis (a type of joint inflammation) in people with psoriasis. It looks at a tool called PEST and aims to improve early detection.
Calgary, AlbertaAges 18 years+ - NCT06338293RecruitingPhase 4
Inclisiran plus statins for fragile heart plaque
This trial tests if adding inclisiran to your current statin can reduce dangerous, rupture-prone plaque in your heart arteries. It may help if you have a moderate blockage with thin-cap plaque and your LDL cholesterol stays high despite statins.
Nanjing, JiangsuAges 18–80
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Common questions
- Are there clinical trials for plaque?
- Yes. Clin2 currently lists 181 recruiting plaque studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a plaque trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a plaque trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.