Clinical trials
Pleural Effusion clinical trials
Below are recruiting pleural effusion clinical trials, each written for real people, not researchers. We’re tracking 49 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06180603Recruiting
Draining lung fluid safely in the ER
This trial tests a better way to drain fluid from around the lung while you are in the emergency department. It can help you breathe easier and find out what is causing the fluid buildup.
Aarhus, Central JutlandAges 18 years+ - NCT02092155Enrolling by invitation
Testing fluid biomarkers from a chest drain in pleural effusion
This trial studies specific markers (biomarkers) found in fluid from a chest drain to better understand pleural effusions (fluid around the lungs), especially when fluid keeps coming back after treatment. You may be helped by contributing to research that could improve how these effusions are diagnosed and managed.
Baltimore, MarylandAges 18–99 - NCT06727578Recruiting
Pleural irrigation with a new device
This trial tests a new device to wash out fluid that stays in the chest after a chest tube is placed. It might help people who cannot receive standard medication to break up this fluid within the first day after their chest tube is inserted.
Boston, MassachusettsAges 18 years+ - NCT06427538Recruiting
Chest drain flushing for lung infections
This study tests whether regularly flushing the chest tube with a small amount of liquid helps prevent blockages in people who have a severe lung infection that spreads to the chest cavity. If you need a chest tube for this type of infection, you may be able to join.
Sterling Heights, MichiganAges 18 years+ - NCT06184321RecruitingEarly Phase 1
Alteplase through chest tube for trapped fluid
This trial tests whether a clot-busting medicine called alteplase, given through an existing chest tube (indwelling pleural catheter), can help drain fluid that has become trapped by fibrous bands. It may help relieve symptoms like shortness of breath.
Baltimore, MarylandAges 18 years+ - NCT05620329Recruiting
Pleural fluid registry for drainage in adults
This registry collects information from adults who have fluid around the lungs (pleural effusion) and need clinically indicated drainage because of infection or cancer. It helps researchers better understand these conditions and improve future care.
Chapel Hill, North CarolinaAges 18 years+ - NCT06016179RecruitingPhase 1
Tocilizumab given through fluid-draining tubes for advanced cancer
This trial tests a drug called tocilizumab, which is given through the tube that drains fluid from your chest or belly. The goal is to see if it can help control cancer-related fluid buildup and improve symptoms.
Pittsburgh, PennsylvaniaAges 18–89 - NCT06434324Recruiting
Saline rinse for lung infection treatment
This study tests whether rinsing the infected space around the lung with salt water (saline) before giving enzyme medicine helps clear the infection better than just the enzyme medicine alone. It's for people with a serious lung infection (empyema) that requires a chest tube.
Rochester, MinnesotaAges 18 years+ - NCT04684459RecruitingEarly Phase 1
CAR-T therapy for tumors with HER2 and PD-L1 markers
This early-phase trial tests CAR-T cells designed to attack tumors that have high HER2 and PD-L1. It may help people with certain solid cancers that have not responded well to standard treatment.
Chengdu, SichuanAges 18–75 - NCT05960747Recruiting
Training for thoracentesis using an augmented reality simulator
This study tests whether a specific training using an augmented reality (AR) simulator helps medical students perform thoracentesis more safely and effectively. It also involves patients getting a first-time thoracentesis as part of routine care.
Strasbourg, Bas-RhinAges 18 years+ - NCT06247800Recruiting
Virtual reality to help during chest drain placement
This trial tests whether using a virtual reality (VR) headset during a chest drain procedure can help you feel less anxious or uncomfortable. The VR shows calming scenes to distract you while the doctor inserts a small tube to drain fluid or air from around your lung.
Kuala Lumpur, Kuala LumpurAges Any age - NCT06314620Recruiting
Comparing two ways to flush your chest tube
This trial compares two ways of flushing a small chest tube used to drain fluid from around the lung: one uses plain salt water (normal saline), and the other uses a salt water solution that contains a blood thinner (heparin). The goal is to see which method keeps the tube from clogging better.
Kuala Lumpur, Kuala LumpurAges Any age - NCT06538376Recruiting
New portable chest X-ray for ICU patients
This study tests a new portable chest X-ray that can be used in the ICU to check for problems like fluid in the lungs, trouble breathing, or swallowing issues. It is designed to help doctors see these problems more easily without moving you to the radiology department.
Boston, MassachusettsAges 18 years+ - NCT06682936Recruiting
Outpatient talc procedure for cancer-related fluid buildup
This trial tests whether a talc procedure to seal the lung (pleurodesis) can be done safely in an outpatient setting for people with fluid buildup from cancer. It aims to make the treatment more convenient.
Stockton-on-Tees, County DurhamAges 18 years+ - NCT06686251Recruiting
AI assistant for reading chest X-rays in breathing problems
This study tests a computer program that helps doctors read chest X-rays faster and more accurately. It is for adults who had an X-ray because of breathing problems like a cough or fever.
Curitiba, ParanáAges 18 years+ - NCT06958848Recruiting
Comparing two chest tube sizes after minimally invasive lung cancer surgery
This trial compares two sizes of chest tubes (16F and 24F) placed after minimally invasive lung cancer surgery. The goal is to see which size leads to better recovery and less pain, while still draining fluid and air effectively.
BaselAges 18 years+ - NCT06959173Recruiting
Personalized treatment for fluid around the lungs
This study uses lab-grown miniature versions of your cancer cells (organoids) to find which treatment might work best for you. It's for people with fluid around the lungs caused by cancer (malignant pleural effusion).
Zhengzhou, HenanAges 18 years+ - NCT06983366Recruiting
Lung sliding index for diagnosing lung conditions
This study uses an ultrasound-based measurement called the Lung Sliding Index to help tell different lung diseases apart. Researchers want to see if it can be a useful and simple tool for doctors.
AsyutAges 18 years+ - NCT07147270Recruiting
Patient Position Effect on Pleurodesis for Pleural Effusion
This trial looks at how your body position during a procedure called pleurodesis (which helps prevent fluid from building up around your lungs) affects the outcome. It may help if you have fluid in the chest caused by cancer and are scheduled for this treatment.
CairoAges Any age - NCT07186933Recruiting
Ventilator settings to protect lungs during high-risk surgery
This study compares two ways of setting the ventilator during surgery to reduce lung complications. Researchers will test whether using a lower 'driving pressure' (a setting on the breathing machine) helps protect the lungs better than usual care. It is for adults having high-risk surgeries under general anesthesia with a breathing tube.
PátraiAges 18 years+ - NCT07211529Recruiting
Nerve block during chest surgery to reduce complications
This trial tests whether a numbing injection near the spine (paravertebral block) given during keyhole chest surgery can lower the risk of problems after surgery. It might help patients recover more comfortably.
Wuhan, HubeiAges 18–80 - NCT01789229Recruiting
Tumor and inflammation sample bank for one specific condition
This study builds a secure “tumor sample bank” using tissue collected from people who currently have one diagnosed condition, either cancer (malignant disease) or an ongoing inflammatory condition. Your samples could help researchers study your disease and develop better treatments in the future.
ViennaAges 18 years+ - NCT07636252Recruiting
Testing lung cancer drugs on your fluid sample
This study collects fluid that builds up around your lungs (pleural effusion) during a drainage procedure you already need. Researchers test how different drugs affect your cancer cells in the lab to help predict which treatments might work best for you.
Ramat Gan, IsraelAges 18 years+ - NCT05766124RecruitingPhase 2/Phase 3
Lower-dose clot-busting medicine for infected chest fluid
This study tests whether a lower dose of alteplase (a clot-busting medicine) given into the chest can improve healing of infected pleural fluid when drainage is incomplete. It may help reduce dosing-related side effects while still helping clear the infection-related fluid.
Hong Kong, Hong KongAges 18 years+
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Common questions
- Are there clinical trials for pleural effusion?
- Yes. Clin2 currently lists 49 recruiting pleural effusion studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pleural effusion trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pleural effusion trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.