Clinical trials
Pleural Effusion clinical trials
Below are recruiting pleural effusion clinical trials, each written for real people, not researchers. We’re tracking 49 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06734481Recruiting
Baking soda lung wash for complicated pleural effusion
This trial tests if washing the lung lining with a baking soda solution safely helps clear complicated fluid build-up. It may reduce infection and improve drainage.
Ningbo, ZhejiangAges 18–80 - NCT07192900RecruitingPhase 1
Fast TILs for metastatic cancer with pleural disease
This trial tests a new therapy using your own immune cells (called TILs) to treat cancer that has spread to the lining of the lungs. The goal is to see if these cells can shrink tumors and help you feel better.
Pittsburgh, PennsylvaniaAges 18–79 - NCT05945043Recruiting
Study breathing signals during fluid drain in pleural effusion
This trial looks at how a breathing control system (called neural respiratory drive) changes when doctors remove lung lining fluid using a thoracocentesis, chest drain, or an indwelling pleural catheter. It may help improve how safe breathing measurements are taken during these common procedures.
London, LondonAges 18 years+ - NCT05543330RecruitingPhase 1/Phase 2
M701 for lung cancer with pleural effusion
This trial tests a new drug called M701 for people with non-small cell lung cancer that has spread to the lining of the lung, causing fluid buildup (pleural effusion). It aims to see if M701 can help control the fluid and improve symptoms.
Hangzhou, ZhejiangAges 18–75 - NCT06713382RecruitingPhase 2
Saline rinse for trapped lung infections
This trial tests if adding a simple saltwater rinse to standard chest tube drainage helps clear stubborn lung infections. It might be an option if you have an infected fluid pocket in your chest that isn't draining well.
Boston, MassachusettsAges 18 years+ - NCT06892691Recruiting
Pleuroscopy vs. Thoracentesis for Possible Cancer-Related Fluid in Lung
This trial compares two approaches to diagnosing fluid around the lung that may be caused by cancer: starting with a camera scope (pleuroscopy) versus starting with a needle drainage (thoracentesis). It aims to see which method leads to a quicker and clearer diagnosis.
New York, New YorkAges 18 years+ - NCT06946498Recruiting
Local anesthesia thoracoscopy for diagnosing unknown fluid around the lung
This study tests a newer, less invasive procedure to diagnose the cause of fluid buildup around the lung. It uses local anesthesia and a small camera to look inside the chest, which may make diagnosis faster and more comfortable.
Athens, AtticaAges 18–90 - NCT07095361RecruitingPhase 4
Daily enzyme therapy for infected pleural fluid
This trial tests a once-daily enzyme treatment given through a chest tube to clear infected fluid from around the lungs. It may help people with complicated pneumonia or empyema who still have fluid buildup after initial drainage.
New Haven, ConnecticutAges 18 years+ - NCT07120867Recruiting
Pleural pressure measurement in malignant pleural effusion
This trial tests a procedure called pleural manometry, which measures pressure in the chest during fluid drainage, to see if it helps doctors better assess and treat malignant pleural effusion (fluid buildup around the lung caused by cancer). The goal is to improve symptom relief and treatment decisions.
BarcelonaAges 18 years+ - NCT07248774Recruiting
Breathing exercises for children with pleural effusion
This trial compares three types of breathing exercises to help children with pleural effusion (fluid around the lungs) recover after a chest tube is placed. The exercises aim to improve lung function and make breathing easier.
Lahore, Punjab ProvinceAges 5–16 - NCT07443020RecruitingPhase 1
Fast immune cells for fluid build-up from cancer
This trial tests a treatment using your own immune cells (T cells) to fight cancer that has spread to the lining of the lung and is causing fluid buildup. It may help if other standard treatments have stopped working.
Pittsburgh, PennsylvaniaAges 18–79 - NCT06740019RecruitingPhase 1
JMKX000197 for malignant pleural effusion in advanced cancer
This trial tests an investigational drug called JMKX000197 given into the chest to control fluid buildup caused by cancer. It is for people with advanced solid tumors that have led to a moderate or large pleural effusion requiring drainage.
BeijingAges 18–75 - NCT06959719Recruiting
Air entrainment vs standard drainage for non-expandable lung
This trial tests whether a new method called 'air entrainment' (adding air during drainage) works better than standard drainage for people with a lung that doesn't fully expand. If you have persistent fluid buildup around the lung and are scheduled for drainage, you may be able to join.
Cambridge, CambridgeshireAges 18 years+ - NCT07332858RecruitingPhase 1/Phase 2
Study of an experimental drug for lung cancer with fluid in the chest
This trial tests a new drug given directly into the chest cavity to treat fluid buildup caused by non-small cell lung cancer. It may help ease breathing problems and control the fluid.
Beijing, Beijing MunicipalityAges 18–75 - NCT05797649Recruiting
Test a pleural fluid blood marker to tell heart failure vs others
This study checks whether a substance called NT-proBNP in pleural fluid can better identify if fluid around the lung is caused by heart failure. If you fit, the results may help doctors choose faster, more accurate diagnosis for your pleural effusion.
Hong Kong, New TerritoriesAges 18 years+ - NCT07419360Recruiting
Draining fluid from lungs in heart failure
This study tests whether draining fluid from around the lungs can help people with heart failure who are in the hospital. It looks at how this procedure affects breathing and recovery.
Albany, New YorkAges 18 years+ - NCT06741839Recruiting
CLE-guided thoracoscopy for diagnosing pleural disease
This trial uses a special microscope (confocal laser endomicroscopy) during a procedure called medical thoracoscopy to help doctors see and diagnose unclear pleural fluid or problems in the lining around the lungs. It may help find a specific diagnosis when other tests have not.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06726564RecruitingPhase 1
Study of MT027 for malignant pleural effusion
This trial tests a new drug called MT027 for people with advanced cancer that has spread to the lining around the lungs (pleura) and caused fluid buildup. The drug targets a marker on cancer cells called B7-H3. It may help control the fluid and the cancer.
BeijingAges 18 years+ - NCT06709456Recruiting
Draining fluid from lungs in the ICU
This trial tests whether draining fluid that builds up around the lungs helps patients with breathing problems in the intensive care unit. You may be eligible if you are in the ICU, have at least 2 cm of fluid on an ultrasound or CT scan, and need extra oxygen or a breathing machine.
AalborgAges 18 years+ - NCT07140003Enrolling by invitation
Comparing fluid and tissue cultures for pleural infection
This study compares how well cultures from the fluid around the lung work versus cultures from a tissue sample in people with infected pleural fluid. It may help doctors choose the best way to diagnose and treat the infection.
Alexandria, Chest DepartmentAges Any age - NCT07012759Recruiting
Study of fluid markers in lung adenocarcinoma
This study is looking at certain substances in the fluid around the lungs (pleural effusion) of people with lung adenocarcinoma. It may help doctors understand this condition better and find new ways to treat it.
New Taipei CityAges 18 years+ - NCT07625176Enrolling by invitation
App-guided decisions for lung lining disease
This trial tests whether a decision-support app helps doctors better manage conditions affecting the pleura (the lining around your lungs)—like collapsed lung, fluid buildup, or infection. You'd be randomly assigned to use the app approach or standard care, and the study tracks how well each works.
AalborgAges 18 years+ - NCT04806412Recruiting
Gene testing in lung cancer fluid samples
This study looks at fluid from around the lungs (pleural fluid) to find gene changes (oncodrivers) in people with non-small cell lung cancer. The goal is to see if this fluid can replace a tissue biopsy for testing.
Næstved, Region SjællandAges 18 years+ - NCT03465774Recruiting
Doxycycline added to a chest drain for cancer fluid buildup
This trial studies whether adding an antibiotic called doxycycline to an indwelling chest drain improves symptoms and fluid control in people with cancer-related fluid around the lungs. It’s mainly for patients who are getting this drain placed and can complete brief symptom check-in questions.
Houston, TexasAges 18 years+
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Common questions
- Are there clinical trials for pleural effusion?
- Yes. Clin2 currently lists 49 recruiting pleural effusion studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pleural effusion trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pleural effusion trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.