Clinical trials
Malignant Pleural Effusion clinical trials
Below are recruiting malignant pleural effusion clinical trials, each written for real people, not researchers. We’re tracking 34 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06184321RecruitingEarly Phase 1
Alteplase through chest tube for trapped fluid
This trial tests whether a clot-busting medicine called alteplase, given through an existing chest tube (indwelling pleural catheter), can help drain fluid that has become trapped by fibrous bands. It may help relieve symptoms like shortness of breath.
Baltimore, MarylandAges 18 years+ - NCT07192900RecruitingPhase 1
Fast TILs for metastatic cancer with pleural disease
This trial tests a new therapy using your own immune cells (called TILs) to treat cancer that has spread to the lining of the lungs. The goal is to see if these cells can shrink tumors and help you feel better.
Pittsburgh, PennsylvaniaAges 18–79 - NCT03465774Recruiting
Doxycycline added to a chest drain for cancer fluid buildup
This trial studies whether adding an antibiotic called doxycycline to an indwelling chest drain improves symptoms and fluid control in people with cancer-related fluid around the lungs. It’s mainly for patients who are getting this drain placed and can complete brief symptom check-in questions.
Houston, TexasAges 18 years+ - NCT04684459RecruitingEarly Phase 1
CAR-T therapy for tumors with HER2 and PD-L1 markers
This early-phase trial tests CAR-T cells designed to attack tumors that have high HER2 and PD-L1. It may help people with certain solid cancers that have not responded well to standard treatment.
Chengdu, SichuanAges 18–75 - NCT04806412Recruiting
Gene testing in lung cancer fluid samples
This study looks at fluid from around the lungs (pleural fluid) to find gene changes (oncodrivers) in people with non-small cell lung cancer. The goal is to see if this fluid can replace a tissue biopsy for testing.
Næstved, Region SjællandAges 18 years+ - NCT05188859RecruitingPhase 2
Testing sintilimab, anlotinib, and chemo for pleural mesothelioma
This Phase 2 study tests whether adding three medicines—sintilimab, anlotinib, and standard platinum chemo—can control malignant pleural mesothelioma that cannot be removed by surgery. It may help shrink tumors and slow disease progression, but you must meet specific health and prior-treatment requirements.
Taiyuan, ShanxiAges 18 years+ - NCT05797649Recruiting
Test a pleural fluid blood marker to tell heart failure vs others
This study checks whether a substance called NT-proBNP in pleural fluid can better identify if fluid around the lung is caused by heart failure. If you fit, the results may help doctors choose faster, more accurate diagnosis for your pleural effusion.
Hong Kong, New TerritoriesAges 18 years+ - NCT06016179RecruitingPhase 1
Tocilizumab given through fluid-draining tubes for advanced cancer
This trial tests a drug called tocilizumab, which is given through the tube that drains fluid from your chest or belly. The goal is to see if it can help control cancer-related fluid buildup and improve symptoms.
Pittsburgh, PennsylvaniaAges 18–89 - NCT05543330RecruitingPhase 1/Phase 2
M701 for lung cancer with pleural effusion
This trial tests a new drug called M701 for people with non-small cell lung cancer that has spread to the lining of the lung, causing fluid buildup (pleural effusion). It aims to see if M701 can help control the fluid and improve symptoms.
Hangzhou, ZhejiangAges 18–75 - NCT06682936Recruiting
Outpatient talc procedure for cancer-related fluid buildup
This trial tests whether a talc procedure to seal the lung (pleurodesis) can be done safely in an outpatient setting for people with fluid buildup from cancer. It aims to make the treatment more convenient.
Stockton-on-Tees, County DurhamAges 18 years+ - NCT06713382RecruitingPhase 2
Saline rinse for trapped lung infections
This trial tests if adding a simple saltwater rinse to standard chest tube drainage helps clear stubborn lung infections. It might be an option if you have an infected fluid pocket in your chest that isn't draining well.
Boston, MassachusettsAges 18 years+ - NCT06726564RecruitingPhase 1
Study of MT027 for malignant pleural effusion
This trial tests a new drug called MT027 for people with advanced cancer that has spread to the lining around the lungs (pleura) and caused fluid buildup. The drug targets a marker on cancer cells called B7-H3. It may help control the fluid and the cancer.
BeijingAges 18 years+ - NCT06740019RecruitingPhase 1
JMKX000197 for malignant pleural effusion in advanced cancer
This trial tests an investigational drug called JMKX000197 given into the chest to control fluid buildup caused by cancer. It is for people with advanced solid tumors that have led to a moderate or large pleural effusion requiring drainage.
BeijingAges 18–75 - NCT06892691Recruiting
Pleuroscopy vs. Thoracentesis for Possible Cancer-Related Fluid in Lung
This trial compares two approaches to diagnosing fluid around the lung that may be caused by cancer: starting with a camera scope (pleuroscopy) versus starting with a needle drainage (thoracentesis). It aims to see which method leads to a quicker and clearer diagnosis.
New York, New YorkAges 18 years+ - NCT06946498Recruiting
Local anesthesia thoracoscopy for diagnosing unknown fluid around the lung
This study tests a newer, less invasive procedure to diagnose the cause of fluid buildup around the lung. It uses local anesthesia and a small camera to look inside the chest, which may make diagnosis faster and more comfortable.
Athens, AtticaAges 18–90 - NCT06959719Recruiting
Air entrainment vs standard drainage for non-expandable lung
This trial tests whether a new method called 'air entrainment' (adding air during drainage) works better than standard drainage for people with a lung that doesn't fully expand. If you have persistent fluid buildup around the lung and are scheduled for drainage, you may be able to join.
Cambridge, CambridgeshireAges 18 years+ - NCT07120867Recruiting
Pleural pressure measurement in malignant pleural effusion
This trial tests a procedure called pleural manometry, which measures pressure in the chest during fluid drainage, to see if it helps doctors better assess and treat malignant pleural effusion (fluid buildup around the lung caused by cancer). The goal is to improve symptom relief and treatment decisions.
BarcelonaAges 18 years+ - NCT07332858RecruitingPhase 1/Phase 2
Study of an experimental drug for lung cancer with fluid in the chest
This trial tests a new drug given directly into the chest cavity to treat fluid buildup caused by non-small cell lung cancer. It may help ease breathing problems and control the fluid.
Beijing, Beijing MunicipalityAges 18–75 - NCT02092155Enrolling by invitation
Testing fluid biomarkers from a chest drain in pleural effusion
This trial studies specific markers (biomarkers) found in fluid from a chest drain to better understand pleural effusions (fluid around the lungs), especially when fluid keeps coming back after treatment. You may be helped by contributing to research that could improve how these effusions are diagnosed and managed.
Baltimore, MarylandAges 18–99 - NCT07443020RecruitingPhase 1
Fast immune cells for fluid build-up from cancer
This trial tests a treatment using your own immune cells (T cells) to fight cancer that has spread to the lining of the lung and is causing fluid buildup. It may help if other standard treatments have stopped working.
Pittsburgh, PennsylvaniaAges 18–79 - NCT05655078Recruiting
Proton radiation for one-sided malignant pleural mesothelioma
This study tests proton beam radiation aimed at one side of the chest in people with malignant pleural mesothelioma who are not yet having chemotherapy. The goal is to control the cancer while preserving breathing and quality of life for the right patients.
Eastbourne, East SussexAges 18 years+ - NCT05620329Recruiting
Pleural fluid registry for drainage in adults
This registry collects information from adults who have fluid around the lungs (pleural effusion) and need clinically indicated drainage because of infection or cancer. It helps researchers better understand these conditions and improve future care.
Chapel Hill, North CarolinaAges 18 years+ - NCT05477927RecruitingPhase 1
CAR-T therapy for cancers spread to lining of lungs, belly, or brain
This trial tests an experimental CAR-T cell treatment that targets proteins on cancer cells that have spread to the lining of the lungs, belly, or brain. It may help people whose cancer has not responded to standard treatments.
Chengdu, SichuanAges 18–80 - NCT07147270Recruiting
Patient Position Effect on Pleurodesis for Pleural Effusion
This trial looks at how your body position during a procedure called pleurodesis (which helps prevent fluid from building up around your lungs) affects the outcome. It may help if you have fluid in the chest caused by cancer and are scheduled for this treatment.
CairoAges Any age
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Malignant Pleural Effusion trials by city
Studies with a site in or near these metro areas.
Malignant Pleural Effusion trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for malignant pleural effusion?
- Yes. Clin2 currently lists 34 recruiting malignant pleural effusion studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a malignant pleural effusion trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a malignant pleural effusion trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.