Clinical trials
Radiation Therapy clinical trials
Below are recruiting radiation therapy clinical trials, each written for real people, not researchers. We’re tracking 675 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02559752Recruiting
Computer brain testing during proton radiation for childhood tumors
This trial studies how children’s thinking and learning skills change while they receive proton beam radiation for a brain/spinal cord tumor. It uses computer-based cognitive tests to better understand brain effects during treatment, which may help future care.
St Louis, MissouriAges 4–21 - NCT02468024RecruitingPhase 3
Surgery or focused radiation for early lung cancer
This study compares two treatments—removing only part of the lung (sublobar resection) versus a focused radiation approach (stereotactic ablative radiotherapy)—for early-stage non-small cell lung cancer. It aims to see which option works better with fewer problems for the right patients.
La Jolla, CaliforniaAges 18 years+ - NCT01834001Recruiting
MRI checks how prostate cancer responds to radiation
This study uses MRI scans to see how prostate cancer changes after radiation treatment, especially in the local (prostate-area) response. It may help doctors better judge treatment effectiveness and plan care more precisely.
Bethesda, MarylandAges 18–120 - NCT00992303Recruiting
Collecting tissue samples during radiation for people with cancer
This study collects tissue samples from people with cancer while they are getting radiation therapy. It also includes healthy participants, to help researchers compare samples and better understand cancer and treatment.
Dallas, TexasAges 18 years+ - NCT00083512Recruiting
Blood and Urine Collection in Glioblastoma Radiation Therapy
This study collects blood and urine samples from patients receiving radiation treatment for glioblastoma (a serious brain tumor) to help researchers understand how the body responds to radiation therapy. Participating is straightforward—you provide samples during your regular treatment.
Bethesda, MarylandAges 18–120 - NCT00027326Enrolling by invitation
Blood and Urine Study During Radiation Therapy
This study collects blood and urine samples from patients receiving radiation therapy to understand how the body responds to treatment. It may help researchers improve radiation therapy in the future.
Bethesda, MarylandAges 18–120 - NCT03686709Recruiting
Extra scan and blood testing with Y90 radioembolization
This study looks at how well Y90 “radioembolization” treatment delivers radiation and how much radiation reaches your body. If you can safely get extra PET/CT scans and blood tests around your treatment, you may be invited to participate.
Knoxville, TennesseeAges 18 years+ - NCT04793737Recruiting
Targeted radiation for melanoma that won’t respond to immunotherapy
This study tests a very focused form of radiation for melanoma that has spread and has stopped responding to PD-1 (and sometimes CTLA-4) immunotherapy. It may help by shrinking progressing spots while keeping the immune treatment going.
StockholmAges 18 years+ - NCT04852887RecruitingPhase 3
Testing shorter breast radiation after low-risk hormone breast cancer
This Phase 3 trial studies whether “less intense” radiation can work as well as standard radiation for certain early-stage hormone receptor–positive, HER2-negative breast cancers that have a low Oncotype DX score. It may help reduce treatment burden while keeping cancer control strong.
Birmingham, AlabamaAges 50–70 - NCT07600957Recruiting
Polarized Light Therapy to Ease Radiation Skin Damage
This trial tests whether a special type of light therapy can reduce skin damage and irritation that happens during radiation treatment for breast cancer. If it works, it could help patients feel more comfortable during and after their radiation therapy.
Banī SuwayfAges 35–55 - NCT05717166RecruitingPhase 3
Stereotactic radiation for limited metastases with a main tumor
This trial tests whether a precise type of radiation can control cancer that has spread to a limited number of sites (1–10) while you also have the main tumor. It aims to improve outcomes by treating all visible cancer spots with stereotactic ablative radiotherapy.
Prince George, British ColumbiaAges 18 years+ - NCT05829291Recruiting
Alpha Radiation Seeds for Liver Cancer Spread Treatment
This trial tests a new treatment called DaRT (alpha radiation seeds) implanted directly into liver tumors that have spread from colorectal cancer. The seeds deliver targeted radiation to shrink tumors while reducing damage to healthy liver tissue, as part of a two-stage surgical plan.
Montreal, QuebecAges 18 years+ - NCT05047094Recruiting
DaRT radiation plus pembrolizumab for head and neck cancer
This trial tests whether a targeted internal radiation treatment (DaRT) combined with pembrolizumab (an immune therapy) can shrink recurrent or metastatic head and neck squamous cell cancer that cannot be fully removed with surgery. It may help by making cancer more visible to the immune system while delivering localized radiation to a tumor area.
JerusalemAges 18 years+ - NCT05929612RecruitingPhase 2
Low-dose targeted radiation alone for marginal zone lymphoma
This Phase 2 study tests whether very low-dose radiation (adjusted based on how you respond) can treat marginal zone lymphoma without adding other medicines at first. It may help some people by reducing radiation exposure while still controlling the cancer.
Houston, TexasAges 18 years+ - NCT06521866RecruitingPhase 2
Study of serplulimab plus standard therapy for advanced colorectal cancer
This trial tests an immunotherapy drug (serplulimab) combined with targeted therapy, chemo, and radiation as a first treatment for people with advanced colorectal cancer that has spread and cannot be surgically removed. It aims to see if this combination can help control the cancer.
Fuzhou, FujianAges 18 years+ - NCT07488754Recruiting
Targeted radiation therapy for new glioma (grade 3-4)
This trial tests a new type of targeted radiation therapy for people with high-grade glioma (grade 3 or 4) that has not progressed after standard treatment. The therapy uses a radioactive substance attached to a protein that targets tumor cells, aiming to deliver radiation directly to the cancer.
Warsaw, PolandAges 18–80 - NCT07685938RecruitingPhase 2
Medicines to prevent heart damage from radiation
This trial tests whether common heart medicines (statins or ACE-inhibitors) can protect the heart during cancer radiation therapy. It is for adults who are about to start chest radiation and have not taken these drugs before.
Chapel Hill, North CarolinaAges 18 years+ - NCT06897488RecruitingPhase 2
Omitting endocrine therapy and radiation in low-risk breast cancer
This trial tests whether older women with very low-risk, hormone-positive breast cancer can safely skip endocrine therapy (hormone-blocking pills) and radiation after lumpectomy. It aims to maintain quality of life while keeping cancer from coming back.
Houston, TexasAges 60 years+ - NCT06544798Enrolling by invitationPhase 2
Long-term follow-up of gene therapy for dry mouth
This study follows patients who previously received gene therapy for dry mouth caused by radiation. It aims to track long-term safety and any lasting benefits.
Gilbert, ArizonaAges 18 years+ - NCT06356779Recruiting
Studying local treatment for a few cancer spots
This study is for people with solid tumors that have spread to a few spots (5 or fewer) in the body. It tests whether using a focused treatment like radiation or ablation on those spots can help control the cancer long-term.
Copenhagen, Capital Region of DenmarkAges 18 years+ - NCT07368647Recruiting
Hyperbaric oxygen for radiation cystitis symptoms
This trial tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve symptoms and reduce inflammation in people with bladder damage from past pelvic radiation. It compares patients with radiation cystitis to those without it.
Lebanon, New HampshireAges 18 years+ - NCT06171269Recruiting
MRI-guided radiation dose reduction for prostate cancer
This trial tests whether using MRI scans to guide radiation can allow lower doses to the healthy parts of the prostate, potentially reducing side effects. It is for men with intermediate- or high-risk prostate cancer that can be seen on MRI and has not spread.
Chicago, IllinoisAges 18 years+ - NCT06974123Enrolling by invitationPhase 1/Phase 2
Testing a new oral drug for radiation proctitis
This trial tests an oral drug called Teslanbaicin for people who have pelvic cancer and developed radiation proctitis (inflammation of the rectum from radiation therapy). The goal is to see if it is safe and helps heal the inflammation.
Xinxiang, HenanAges 18 years+ - NCT02634645Recruiting
Treatment study for Barrett’s pre-cancer or esophageal cancer
This study looks at treatment options for people with Barrett’s esophagus that has progressed to abnormal cell growth (dysplasia) or cancer. It may help doctors compare approaches that use procedures to remove and/or destroy abnormal tissue in the esophagus.
Los Angeles, CaliforniaAges 18–100
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Common questions
- Are there clinical trials for radiation therapy?
- Yes. Clin2 currently lists 675 recruiting radiation therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a radiation therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a radiation therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.