Clinical trials
Radical Prostatectomy clinical trials
Below are recruiting radical prostatectomy clinical trials, each written for real people, not researchers. We’re tracking 93 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07847385Recruiting
MRI-guided nerve-sparing for prostate cancer surgery
This study tests whether using special MRI scans to map nerves before surgery helps keep erectile function after prostate removal. It may help men who are having surgery for prostate cancer and want to preserve sexual function.
Geneva, Canton of GenevaAges 18 years+ - NCT06521710Recruiting
Nerve grafting to preserve erections after prostate removal
This trial tests if a nerve grafting technique can help preserve erectile function after robotic surgery for high-risk localized prostate cancer. It may be an option for men with good preoperative erectile function.
Montreal, QuebecAges 18 years+ - NCT07617272RecruitingPhase 2
Testing a drug to shrink high-risk prostate cancer before surgery
This trial tests whether a hormone-blocking drug called darolutamide can shrink aggressive prostate cancer before surgery. Researchers will also use a special blood test to predict who benefits most from the treatment.
GothenburgAges 18 years+ - NCT07541911Recruiting
Confocal Microscopy to Check Prostate Cancer Surgery Margins
This study tests whether a special microscope can help surgeons see cancer margins (edges) during prostate removal surgery to make sure all cancer is removed. It may help surgeons make real-time decisions about how much tissue to remove.
LondonAges 18 years+ - NCT06754488Recruiting
New Surgical Technique for Bladder Control After Prostate Removal
This trial tests a new surgical technique during laparoscopic prostate removal to help patients regain bladder control (urinary continence) faster. It's for men with early-stage prostate cancer who are good candidates for surgery.
Suzhou, JiangsuAges Up to 79 years - NCT06758882RecruitingPhase 2
Surgery with or without apalutamide for high-risk prostate cancer that has spread a little
This trial tests whether adding the drug apalutamide before and after surgery helps men with high-risk prostate cancer that has spread to a few spots (seen on a special PET scan). You would also receive standard hormone therapy.
Torino, ToAges 18–80 - NCT07500701RecruitingPhase 3
Comparing two radiation schedules for rising PSA after prostate surgery
This trial is testing two types of radiation therapy for men whose PSA level rises after prostate removal, but without clear signs of cancer spread on a PSMA PET scan. The goal is to see which radiation schedule works better to control the cancer.
Seoul, Gangnam-guAges 20 years+ - NCT06784986RecruitingPhase 4
Low-pressure gas system for robotic prostate surgery
This trial tests whether a special gas system (Airseal) used with very low air pressure during robotic prostate removal surgery can help patients recover better. It compares this to standard methods for men with prostate cancer.
Salvador, Estado de BahiaAges 18–65 - NCT07455903RecruitingPhase 2
Hormone therapy before surgery for high-risk prostate cancer
This trial tests whether giving hormone therapy (androgen deprivation therapy) before surgery can improve outcomes for men with high-risk prostate cancer. You will receive a special PSMA PET/CT scan to see how the cancer responds.
Miami, FloridaAges 18 years+ - NCT07431008Recruiting
Safety follow-up for Cellgram-ED in erectile dysfunction
This trial is a follow-up study for people who received the experimental cell therapy (Cellgram-ED) in a previous trial for erectile dysfunction after prostate removal. It checks on your long-term safety and how you are doing.
SeoulAges 19–80 - NCT05169112RecruitingPhase 3
Hormone therapy to prevent prostate cancer coming back
This trial studies whether hormone therapy (also called ADT) after prostate surgery lowers the chance that prostate cancer will return. It targets people with very low PSA after surgery but with a higher predicted risk of recurrence.
Halifax, Nova ScotiaAges 18 years+ - NCT07247175RecruitingPhase 2
Testing force feedback in robotic prostate cancer surgery
This trial is looking at whether a new force-feedback feature in the da Vinci robotic system helps surgeons learn and operate more safely when removing the prostate for prostate cancer.
SoeulAges 19 years+ - NCT07208240RecruitingPhase 1/Phase 2
PSMA-targeted radiation before prostate removal for advanced cancer
This trial tests giving a radioactive drug (PSMA-targeted) before surgery for prostate cancer that has spread locally but not to other parts of the body. The goal is to see if it helps lower the risk of the cancer coming back.
Petah TikvaAges 18 years+ - NCT06945315RecruitingPhase 3
Nerve-Sparing Surgery Guided by Micro-Ultrasound
This study tests whether using a special ultrasound tool during prostate cancer surgery helps protect the nerves that control erections. If you have good erectile function and are scheduled for nerve-sparing prostate removal, this trial may be a good fit for you.
New York, New YorkAges 18 years+ - NCT07182279RecruitingPhase 1/Phase 2
Internal radiation before prostate surgery for high-risk cancer
This trial tests a treatment approach for newly diagnosed, high-risk prostate cancer. You would receive a short course of internal radiation (high-dose-rate brachytherapy) before surgery to remove your prostate. The goal is to see if this combination is safe and works better than surgery alone.
Houston, TexasAges 40 years+ - NCT04833426RecruitingPhase 3
Testosterone levels around prostate surgery and recovery outcomes
This trial studies whether testosterone levels before and around radical prostate surgery affect cancer control and sexual/physical recovery. It may help doctors understand who benefits from testosterone replacement and who should not.
AmsterdamAges 18 years+ - NCT07163910RecruitingPhase 2
Homoharringtonine plus hormone therapy before prostate surgery
This trial tests whether adding a drug called homoharringtonine (a type of chemotherapy) to standard hormone therapy before prostate surgery can improve outcomes for men with certain stages of prostate cancer. It's for men who haven't had any previous treatment and plan to have their prostate removed.
Nanjing, JiangsuAges 18–85 - NCT07162194Recruiting
Testing AI for reading prostate MRI scans
This study uses an artificial intelligence (AI) program to read MRI scans of the prostate and compare its findings with those of expert radiologists. The goal is to see if the AI can detect prostate cancer as accurately as the human experts, which might help in future diagnosis and treatment planning.
Los Angeles, CaliforniaAges 20 years+ - NCT07115992Recruiting
Surgery with or without radiation for prostate cancer
This trial compares radical prostatectomy (surgery to remove the prostate) alone versus surgery plus pelvic lymph node removal, with or without additional radiation, for men with intermediate- or high-risk prostate cancer that has not spread. It aims to see which approach is more effective and safe.
ShanghaiAges 18–80 - NCT06992232RecruitingPhase 2
Radiation or surgery plus hormone therapy for prostate cancer that has spread
This trial tests whether giving intense hormone therapy along with either radiation or surgery can help men with prostate cancer that has spread to a limited number of spots (10 or fewer) but not to organs like the liver or lungs. The goal is to treat both the main tumor and the visible metastatic spots more aggressively.
Nanjing, JiangsuAges 18–80 - NCT07025369RecruitingPhase 2
Hormone pill before PSMA scan for high-risk prostate cancer
This trial tests if giving a short-term hormone pill (relugolix) before a special PSMA PET/CT scan makes the scan clearer for men with high-risk prostate cancer. It may help doctors better see where the cancer is.
Scottsdale, ArizonaAges 18 years+ - NCT06968494Recruiting
Implantable device to preserve erections after prostate surgery
This trial tests a new implantable device designed to help men keep their erections after nerve-sparing prostate surgery. If you are having surgery for early-stage prostate cancer and have good erectile function now, this device might help you maintain it.
Baltimore, MarylandAges 30–75 - NCT06861192RecruitingPhase 2/Phase 3
Fasudil and immunotherapy with hormone therapy for prostate cancer
This trial tests a new combination of drugs (Fasudil, a PD1 inhibitor, and hormone therapy) before prostate cancer surgery to see if it works better than standard treatment. It's for patients with early metastatic or locally advanced prostate cancer who haven't had any prior treatment.
Nanjing, JiangsuAges 18–85 - NCT06776172Recruiting
Lymph node removal during prostate surgery: a comparison study
This trial tests whether removing pelvic lymph nodes during prostate cancer surgery improves outcomes for men with high-risk prostate cancer. If you have high-risk prostate cancer and no signs of spread, you may be able to join.
AarauAges 18 years+
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Common questions
- Are there clinical trials for radical prostatectomy?
- Yes. Clin2 currently lists 93 recruiting radical prostatectomy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a radical prostatectomy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a radical prostatectomy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.