Clinical trials
Radiofrequency Ablation clinical trials
Below are recruiting radiofrequency ablation clinical trials, each written for real people, not researchers. We’re tracking 114 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05301881RecruitingPhase 2
Keep the same treatment after limited metastatic growth
This study tests whether continuing your current systemic (whole-body) therapy is safe and helpful when only 1–2 metastatic spots start growing. It also checks whether adding local treatment (such as radiation or ablation) to those spots can better control the cancer.
AlkmaarAges 18 years+ - NCT07033572Recruiting
Hybrid scope surgery and ablation for both sides of thyroid cancer
This study tests a combined approach—removing the main thyroid cancer with a tiny camera (endoscope) and using targeted heat to destroy a small nodule on the opposite side. It aims to treat both sides of the thyroid at once with less scarring and faster recovery.
Fuzhou, FujianAges 18–65 - NCT04520932Recruiting
Radiofrequency treatment for small nonfunctioning pancreatic tumors
This trial tests whether heating (radiofrequency) treatment guided by a special ultrasound scope can control small pancreatic neuroendocrine tumors. It may help patients whose tumors are very small and do not release hormones.
MarseilleAges 18–80 - NCT06253000Recruiting
Heat vs. Freezing for the Back of the Heart
This trial tests two ways to treat the back wall of the heart's left chamber in people with stubborn atrial fibrillation. It compares radiofrequency (heat) and cryoablation (freezing) to see which is safer and works better.
MoscowAges 18–80 - NCT07034976Recruiting
Radiofrequency treatment for menopause symptoms in breast cancer survivors
This trial tests a non-surgical radiofrequency treatment, combined with pelvic floor exercises, to help with vaginal dryness and other menopause symptoms in breast cancer survivors. It may be an option if you are free of cancer and have bothersome vaginal dryness.
Madrid, MadridAges 18–75 - NCT06732388RecruitingPhase 2
Itraconazole with ablation to prevent esophageal cancer in Barrett's esophagus
This trial tests if adding the antifungal drug itraconazole to standard ablation therapy can help prevent esophageal cancer in people with high-risk Barrett's esophagus. You must have a confirmed diagnosis of Barrett's esophagus with low- or high-grade dysplasia or early-stage cancer, and be planning to have ablation treatment.
Kansas City, KansasAges 18 years+ - NCT04798898Recruiting
RFA plus immune stimulation during liver surgery for colon cancer spread
This trial looks at whether using a heat-based treatment (RFA) to trigger the immune system before or during liver surgery can improve outcomes for people with colon cancer that has spread to the liver. It’s aimed at people who plan to have the liver tumors removed because they look treatable.
AarhusAges 18–99 - NCT05189821Recruiting
Study treatment for tiny thyroid cancer without surgery
This trial studies a treatment option for papillary thyroid microcarcinoma in adults who either do not want surgery or cannot safely have surgery. It may help people find a non-surgical approach for a very small thyroid cancer.
New York, New YorkAges 18 years+ - NCT04990609RecruitingPhase 2
Study for pancreatic cancer using a biopsy-confirmed treatment approach
This Phase 2 trial is for people with pancreatic ductal adenocarcinoma (a type of pancreatic cancer) confirmed by biopsy. It tests a new treatment strategy after the cancer is diagnosed and considers people who haven’t had certain chemotherapy yet.
Houston, TexasAges 18 years+ - NCT06283498Enrolling by invitation
Radiofrequency treatment for overactive bladder
This study tests a new non-surgical treatment for overactive bladder using radiofrequency energy delivered through the vagina to calm the nerves that cause urgency and leaking. It is for people who have urge incontinence and have not found relief from medication.
Corona del Mar, CaliforniaAges 21–80 - NCT04472702Recruiting
Ultrasound vs X-ray guidance for knee pain ablation
This trial compares two ways (ultrasound or X-ray guidance) to place a treatment for painful knee arthritis. It aims to see whether one guidance method works as well as the other for reducing knee pain.
Sacramento, CaliforniaAges 35–99 - NCT04698252RecruitingPhase 2
Local treatment for ER/PR-positive limited spread breast cancer
This Phase 2 study tests whether treating a small number of metastatic spots with a local approach (like targeted radiation, surgery, or ablation) can help people with ER/PR-positive breast cancer. It aims to help when the cancer has spread only to a few areas and has not significantly worsened after initial whole-body treatment.
São Paulo, São PauloAges 18 years+ - NCT05189314Recruiting
Study of life quality changes with benign thyroid nodules
This study looks at how benign (non-cancer) thyroid nodules affect people’s day-to-day life and health outcomes. It may help doctors better understand what changes matter most to patients.
New York, New YorkAges 18 years+ - NCT05311137Recruiting
Closed-loop monitoring for atrial fibrillation
This study tests a “closed-loop” approach to treating atrial fibrillation, meaning the care plan may adjust based on how you’re doing. It may help improve how heart rhythm problems are managed over time.
Shanghai, Shanghai MunicipalityAges 18–100 - NCT05368090Recruiting
Ultrasound-guided ablation for primary aldosteronism
This trial studies whether a procedure called endoscopic ultrasound–guided radiofrequency ablation can treat primary aldosteronism (a hormone condition that can raise blood pressure and potassium issues). It may help shrink an overactive adrenal growth and reduce the need for surgery for some people.
BergenAges 18–80 - NCT05723107RecruitingPhase 1
Testing an endoscopic treatment for pancreatic cancer that can't be removed
This early-phase trial is testing a new endoscopic (from inside the stomach) approach for pancreatic ductal adenocarcinoma that is locally advanced and cannot be removed with surgery. It may help some people who have already tried first chemotherapy and still have a tumor confined to the pancreas area (no spread).
New York, New YorkAges 18 years+ - NCT05799664Recruiting
Radiofrequency treatment for COPD using a breathing tube
This trial tests whether a special radiofrequency treatment delivered through a bronchoscope (a thin camera tube) is safe and works better than standard care for people with COPD. It focuses on people with moderate-to-severe COPD symptoms who can follow study visits and tests.
Chengdu, SichuanAges 40–75 - NCT05903196Recruiting
Radiofrequency treatment for non-cancer thyroid lumps in LatinX adults
This study looks at radiofrequency ablation, a heat-based procedure, to shrink a benign (non-cancer) thyroid nodule in adults who identify as LatinX. It may help reduce symptoms from the lump while tracking safety and results.
New York, New YorkAges 18–90 - NCT06094660Recruiting
Nerve blocking for knee arthritis pain
This study tests two treatments for knee arthritis pain when knee replacement isn't an option: a nerve block using heat (radiofrequency ablation) or a chemical injection (phenol), compared to standard care. It aims to find a better way to reduce pain and improve daily function.
Hoorn, North HollandAges 35–90 - NCT06204874Recruiting
Nerve stimulation for bladder pain in women
This trial tests a new nerve stimulation approach for women with bladder pain syndrome. It aims to find a gentler way to reduce pain and urgency without surgery.
Bethesda, MarylandAges 18 years+ - NCT06239649Recruiting
Nerve block before knee replacement for faster recovery
This trial tests whether a numbing injection (nerve block) around the knee before surgery can help you recover faster and feel less pain after a total knee replacement. It is for people with knee osteoarthritis who are ready for their first knee replacement surgery.
Denizli, PamukkaleAges 40–85 - NCT06294028Recruiting
Ablation vs Defibrillator for Well-Tolerated Fast Heartbeat
This study compares two treatments for a fast heartbeat called ventricular tachycardia in people with prior heart attacks and relatively preserved heart function: one uses heat energy (ablation) to fix the electrical problem, and the other places an implantable defibrillator that shocks the heart to restore normal rhythm. The goal is to find which approach works better for people whose symptoms are well-tolerated.
Toulouse, FranceAges 18–90 - NCT06440993RecruitingPhase 2
Durvalumab with bile duct heat therapy for bile duct cancer
This trial tests a combination of a drug (durvalumab) that helps your immune system fight cancer, plus a special heat treatment applied inside the bile duct. It is for people with bile duct cancer that cannot be removed by surgery and who need a stent to open the bile duct.
AachenAges 18 years+ - NCT06476678Recruiting
Testing a new ablation knife for esophageal growths
This study tests a new tool that uses radiofrequency energy to remove precancerous growths from the esophagus. It may be an option if you have a surface-level polyp in your esophagus that hasn't been treated before.
Houston, TexasAges 18 years+
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Common questions
- Are there clinical trials for radiofrequency ablation?
- Yes. Clin2 currently lists 114 recruiting radiofrequency ablation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a radiofrequency ablation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a radiofrequency ablation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.