Clinical trials
Rectal Cancer Patients clinical trials
Below are recruiting rectal cancer patients clinical trials, each written for real people, not researchers. We’re tracking 360 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06424522Recruiting
Enema program for bowel problems after rectal cancer surgery
This trial tests a special enema program to help people with ongoing bowel problems (called LARS) after rectal cancer surgery. If standard treatments haven't worked, this program might offer a new way to manage symptoms like urgency and leakage.
Columbus, OhioAges 18 years+ - NCT06366841Recruiting
Stigma and mental health in rectal and anal cancer patients
This study looks at how stigma (feeling judged or embarrassed) and mental health affect people with rectal or anal cancer who are getting long-course radiation. By answering questionnaires, you can help researchers understand these challenges and find better ways to support patients.
RomaAges 18–75 - NCT06263088Recruiting
Equity in GI Cancer Care Study
This trial is looking for Black patients newly diagnosed with any stage of gastrointestinal cancer to help improve cancer care and make sure research includes everyone. By joining, you help doctors learn how to better support patients like you.
Cleveland, OhioAges 18 years+ - NCT06274190Recruiting
Better bowel symptom tracking after rectal cancer treatment
This study develops an electronic diary to help track and manage bowel symptoms after rectal cancer surgery or active surveillance. It aims to create personalized care plans to improve your quality of life.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06205485RecruitingPhase 3
Chemotherapy and surgery vs chemoradiation for rectal cancer
This trial compares two approaches for early-stage rectal cancer: chemotherapy plus local surgery versus standard chemoradiotherapy. It aims to see if less intensive treatment can work just as well, reducing side effects.
Phoenix, ArizonaAges 18 years+ - NCT06162650RecruitingPhase 2
Pre-surgery chemo-radiation therapy for rectal cancer
This trial tests a combination of chemotherapy and radiation therapy before surgery for people with mid or low rectal cancer that hasn't spread. The goal is to see if this approach works better than current treatments.
TainanAges 20 years+ - NCT06123156RecruitingPhase 3
Early erectile rehabilitation after rectal cancer treatment
This trial tests if sildenafil (Viagra) given soon after surgery and radiation for rectal cancer can help preserve erectile function. It is for men with normal erectile function before treatment who have a regular partner.
AmiensAges 18–70 - NCT06052332Recruiting
Comparing two pre-surgery treatments for older adults with rectal cancer
This study compares two approaches to treating rectal cancer in people age 70 and older who have not yet had surgery. One approach gives chemotherapy and radiation before surgery, and the other adds more chemotherapy after radiation. The goal is to find which plan works better with fewer side effects.
Antwerp, AntwerpenAges 70 years+ - NCT05943210Recruiting
Molecular testing of rectal cancer after short-course radiation
This study looks at molecular (tumor biology) features of rectal cancer in people receiving standard short-course radiation. Your tissue and/or samples may be used to better understand the cancer and how it responds to treatment.
Chicago, IllinoisAges 18–90 - NCT05914766Recruiting
Support program for newly diagnosed rectal cancer patients
This trial tests an informational and supportive care program for people with newly diagnosed, locally advanced rectal cancer. It may help by providing education and practical support around next steps in treatment.
Boston, MassachusettsAges 18 years+ - NCT05868226RecruitingPhase 1/Phase 2
Personalized cancer treatment study for advanced solid tumors
This study tests different treatments tailored to your cancer's biology. It aims to find which therapy might work best for you, potentially improving outcomes. You'd receive one of the study drugs, with close monitoring and support.
Birmingham, AlabamaAges 18 years+ - NCT05672524RecruitingPhase 2
Tucatinib plus trastuzumab for HER2-positive rectal cancer
This Phase 2 study tests whether tucatinib combined with trastuzumab can slow or shrink rectal cancer that is HER2-positive and has certain genetic tumor features. If you qualify, you may benefit from a targeted treatment approach aimed at the HER2 pathway.
Basking Ridge, New JerseyAges 18 years+ - NCT05081024Recruiting
Blood test biomarker to help preserve organs in rectal cancer
This study looks at a blood test (ctDNA, a way to detect cancer DNA in the bloodstream) to help doctors choose treatment that may spare organs for people with stage II–III rectal cancer. You may be followed to see how well the blood test can guide treatment decisions.
Portland, OregonAges 18 years+ - NCT05024097RecruitingPhase 2
New medicines with chemotherapy after short radiation for rectal cancer
This trial tests two new immune-related medicines (an anti–PD-1 drug and an adenosine blocker) added to standard chemotherapy after a short course of radiation for rectal cancer. It aims to improve cancer control while checking safety.
New York, New YorkAges 18–90 - NCT04907643Recruiting
Virtual reality program to reduce stomach-cancer pain
This trial tests whether virtual reality (VR) can improve pain and other day-to-day symptoms in people with certain gastrointestinal cancers. You’d use VR for pain relief while researchers measure how you’re feeling.
Los Angeles, CaliforniaAges 18–99 - NCT04804956Recruiting
Testing gut microbes and metabolites to predict rectal cancer outcomes
This study looks at patterns in the gut microbiome (gut bacteria) and gut chemicals (metabolites) to predict how rectal cancer may do after planned surgery. By understanding these markers, researchers hope to better forecast prognosis and tailor follow-up.
Girona, GironaAges 18–18 - NCT04095299RecruitingPhase 3
Standard vs high-dose radiotherapy for rectal cancer
This Phase 3 trial compares standard-dose and higher-dose radiotherapy given along with chemotherapy in people with rectal cancer. The goal is to see whether a higher dose can improve rectal cancer outcomes while keeping the rectum functioning and avoiding too much harm.
AalborgAges 18 years+ - NCT04703101RecruitingPhase 1
Short radiation plus chemo for stage II–III rectal cancer
This trial tests a short course of radiation therapy combined with chemotherapy for people with stage II or III rectal cancer. It’s designed to see whether this approach is safe and effective before or around cancer surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT04643041Recruiting
Watch-and-wait after PD-1 for certain rectal cancer
This study looks at whether people with a very strong response to a PD-1 antibody can safely delay or avoid more standard rectal cancer treatment (a “watch-and-wait” approach). It may help some people avoid surgery, radiation, or ongoing treatment while still closely monitoring the cancer.
Guangzhou, GuangdongAges 18–80 - NCT04643366RecruitingPhase 2
Total treatment with chemotherapy and short radiation before surgery
This trial tests whether combining chemotherapy (mFOLFOX6) and a short course of radiation before surgery improves outcomes for people with resectable rectal cancer. The goal is to shrink and control the cancer early and then remove it with curative surgery.
Richmond, VirginiaAges 18 years+ - NCT04674267Recruiting
Health and well-being study for older adults with gastrointestinal cancer
This study looks at how older adults with gastrointestinal cancer manage their health and well-being. It aims to understand and improve care for this group.
Boston, MassachusettsAges 65 years+ - NCT03875781RecruitingPhase 3
Chemo before rectal surgery, without pelvic radiation
This Phase 3 study tests whether giving chemotherapy before rectal surgery can work as well as standard treatment that usually includes pelvic radiation. It aims to reduce the need for pelvic radiation while still keeping the cancer under control.
Le Kremlin-Bicêtre, Île-de-France RegionAges 18 years+ - NCT04339374Recruiting
Ultrasound and light imaging during rectal cancer surgery
This study tests a newer kind of imaging (ultrasound plus light-based measurements) to help doctors tell rectal cancer apart from other tissue during surgery. You may be able to take part if you’re having surgery for rectal cancer and the tumor is close enough to the anus.
St Louis, MissouriAges 19 years+ - NCT04215731RecruitingPhase 3
Chemo plus targeted drug before surgery for high-risk rectal cancer
This trial tests giving chemotherapy (mFOLFOXIRI) plus bevacizumab before surgery for rectal cancer that has higher-risk features. It aims to shrink or control the cancer early to improve outcomes after treatment.
Guangzhou, GuangdongAges 18–70
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Common questions
- Are there clinical trials for rectal cancer patients?
- Yes. Clin2 currently lists 360 recruiting rectal cancer patients studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a rectal cancer patients trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a rectal cancer patients trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.